专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

2. 发明公开

EP4324478A3 EPITOPE MIMICS 审中-实审
公开(公告)号：EP4324478A3
公开(公告)日：2024-05-15
申请号：EP23199107.6
申请日：2017-03-10
申请人： Iogenetics, LLC.
发明人： BREMEL, Robert D. , HOMAN, Jane
IPC分类号： A61K38/17 , A61K39/00 , A61P25/16 , G06N3/08 , A61K39/12 , G16B50/00 , G16B50/30 , G16B20/20 , G16B20/00 , G16B20/30 , G16B20/50
CPC分类号： A61K39/00 , A61K39/0008 , A61K39/12 , C12N2710/1613420130101 , C12N2710/1663420130101 , C12N2760/1413420130101 , C12N2760/1843420130101 , C12N2760/1873420130101 , C12N2770/2413420130101 , C12N2770/3623420130101 , G16B20/00 , G16B50/00 , A61K38/17 , A61P25/16 , G16B20/30 , G16B20/50 , G16B50/30 , G16B20/20
摘要： This invention pertains to the identification of antibody mediated epitope mimics and applications of the identification of said mimic peptides in the design of biotherapeutics and vaccines.

3. 发明公开

EP4353832A1 METHOD AND KIT FOR DETECTING N6-METHYLADENOSINE IN NUCLEIC ACID MOLECULES 审中-实审
公开(公告)号：EP4353832A1
公开(公告)日：2024-04-17
申请号：EP21944432.0
申请日：2021-11-12
申请人： Peking University
发明人： YI, Chengqi , WANG, Jing
IPC分类号： C12Q1/6809 , G16B20/50
CPC分类号： Y02P20/55 , C12Q1/6869 , G16B20/50 , C12Q1/6809
摘要： The present application provides a method and kit for detecting N6-methyladenine in a nucleic acid molecule.

4. 发明公开

EP4334946A1 ARTIFICIAL KETOREDUCTASE VARIANTS AND DESIGN METHODOLOGY THEREOF 审中-实审
公开(公告)号：EP4334946A1
公开(公告)日：2024-03-13
申请号：EP22798574.4
申请日：2022-04-20
申请人： Enzymaster (Ningbo) Bio-Engineering Co., Ltd.
发明人： SHI, Shumin , XU, Junpeng , BOCOLA, Marco , CAI, Baoqin , CHEN, Haibin , YU, Mengying , LUO, Xiao , LIANG, Yafang , HE, Kuifang , PENG, Qinli
IPC分类号： G16B20/50 , C12P7/26

5. 发明公开

EP4187551A1 REPORT GENERATING METHOD OF GENERATING A REPORT REPORTING A LEVEL OF PATHOGENICITY OF A GENETIC MUTATION, AND A REPORT GENERATING DEVICE 审中-实审
公开(公告)号：EP4187551A1
公开(公告)日：2023-05-31
申请号：EP22210086.9
申请日：2022-11-29
申请人： SYSMEX CORPORATION
发明人： Izumi, Yuuki , Niiro, Hayato , Washio, Takanori
IPC分类号： G16H50/20 , G16B20/50 , G16H70/20 , G16H70/60
摘要： A report generating method generates a report for reporting a level of pathogenicity of a genetic mutation. The report generating method comprising obtaining information on a genetic mutation detected in a gene panel test; generating an evaluation result for a plurality of evaluation items based on a first criterion for evaluating each of the evaluation items and at least the information on the genetic mutation; determining the level of pathogenicity based on a second criterion for determining the level of pathogenicity and the evaluation result; determining an undetermined item for which the evaluation result is undetermined among the plurality of evaluation items, and determining whether the level of pathogenicity is tentative based on a result of the determination of the undetermined item, and generating the report that reports the level of pathogenicity according to a result of the determination on whether the level of pathogenicity is tentative.

6. 发明公开

EP4180810A1 FLUORESCENT CROSS-LINKED RNASE H MUTANT CONJUGATE, MIRNA COMBINATION AND APPLICATION THEREOF 审中-实审
公开(公告)号：EP4180810A1
公开(公告)日：2023-05-17
申请号：EP21838258.8
申请日：2021-07-12
申请人： Shanghai Miran Biotech Co., Ltd.
发明人： WANG, Yiran
IPC分类号： G01N33/533 , C12N9/22 , C12Q1/6886 , G16B40/10 , G16B20/50
摘要： A fluorescent cross-linked RNase H mutant conjugate, a miRNA combination and an application thereof. The fluorescent cross-linked RNase H mutant conjugate (i) is as represented by RNase Hv-(Lx-SH-F)n or (ii) comprises an RNase Hv-Lx-ligand and receptor-F, wherein the ligand can bind to the receptor, RNase Hv is an RNase H mutant, which can bind to RNA or RNA-DNA hybrid strands, but cannot cleave RNA; L is a linker, and x is 1-10; SH is an amino acid containing a sulfhydryl group; F is a luminescent functional group, and n is 1-7. The fluorescent cross-linked RNase H mutant conjugate can directly recognize DNA/RNA hybrid strands and can be converted to generate detectable signals without PCR amplification, and can be applied to sensitively and quickly detect RNA.

7. 发明公开

EP4060672A1 METHOD FOR PREDICTION OF GENETIC MUTATION AND RECOMBINATION OF VIRUSES WITH DEEP LEARNING 无效
公开(公告)号：EP4060672A1
公开(公告)日：2022-09-21
申请号：EP21163329.2
申请日：2021-03-18
申请人： Jacobs, Ivan
发明人： Jacobs, Ivan
IPC分类号： G16B20/50 , G16B40/20
摘要： There are two major sources of change in nucleotide sequences over time: mutation and recombination. Mutation occurs when a mistake during replication or a physical or chemical assault changes a nucleotide to something different from that in the ancestral genome. Cellular DNA polymerases have editing functions that keep the intrinsic rate of nucleotide substitutions very low, but many viral polymerases have no editing functions. Editing refers to the process of excising a misincorporated nucleotide and replacing it with the correct nucleotide during replication. Because the viral polymerases lack editing functions, viruses that rely on viral polymerases accumulate mutations at a much higher rate per generation than cells do.
Recombination occurs when two viruses co-infect the same cell and an offspring virus contains a combination of genes that originate with both parents instead of just one parent. These are larger-scale genetic changes than those typically classified as mutations. They may enable viruses to jump from species or result in a pandemic because an adaptive immune response against one of the parent viruses is not effective against the recombinant offspring.
Mutations and recombination causing for large genetic variations of viruses result in difficulties to create sustainable treatment. The invention discloses a method to predict possible new genetic variants of viruses.

8. 发明授权

EP3474168B1 METHOD FOR MEASURING MUTATION RATE 有权
公开(公告)号：EP3474168B1
公开(公告)日：2021-04-14
申请号：EP17813518.2
申请日：2017-06-08
发明人： JEONG, Sangkyun , OH, Soo A
IPC分类号： C12Q1/6806 , C12Q1/6869 , C12Q1/6827 , G16B20/20 , G16B20/50 , G16B30/10

9. 发明公开

EP3759715A1 DETERMINING IMPACT ON PROPERTIES OF PROTEINS BASED ON AMINO ACID SEQUENCE MODIFICATIONS 审中-实审转让
公开(公告)号：EP3759715A1
公开(公告)日：2021-01-06
申请号：EP19713902.5
申请日：2019-02-26
申请人： Just Biotherapeutics, Inc.
发明人： SHAVER, Jeremy, Martin
IPC分类号： G16B20/50

10. 发明公开

EP4441742A1 NEXT GENERATION PRENATAL SCREENING 审中-实审
公开(公告)号：EP4441742A1
公开(公告)日：2024-10-09
申请号：EP22821583.6
申请日：2022-11-29
申请人： Congenica Ltd.
发明人： WATKINSON-POWELL, Benjamin Morgan , LENCH, Nicholas , DRURY, Suzanne
IPC分类号： G16B20/20 , G16B20/50 , G16B40/20
CPC分类号： G16B20/50 , G16B20/20 , G16B30/10 , G16B40/20

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式