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1. 发明公开

EP4060672A1 METHOD FOR PREDICTION OF GENETIC MUTATION AND RECOMBINATION OF VIRUSES WITH DEEP LEARNING 无效
公开(公告)号：EP4060672A1
公开(公告)日：2022-09-21
申请号：EP21163329.2
申请日：2021-03-18
申请人： Jacobs, Ivan
发明人： Jacobs, Ivan
IPC分类号： G16B20/50 , G16B40/20
摘要： There are two major sources of change in nucleotide sequences over time: mutation and recombination. Mutation occurs when a mistake during replication or a physical or chemical assault changes a nucleotide to something different from that in the ancestral genome. Cellular DNA polymerases have editing functions that keep the intrinsic rate of nucleotide substitutions very low, but many viral polymerases have no editing functions. Editing refers to the process of excising a misincorporated nucleotide and replacing it with the correct nucleotide during replication. Because the viral polymerases lack editing functions, viruses that rely on viral polymerases accumulate mutations at a much higher rate per generation than cells do.
Recombination occurs when two viruses co-infect the same cell and an offspring virus contains a combination of genes that originate with both parents instead of just one parent. These are larger-scale genetic changes than those typically classified as mutations. They may enable viruses to jump from species or result in a pandemic because an adaptive immune response against one of the parent viruses is not effective against the recombinant offspring.
Mutations and recombination causing for large genetic variations of viruses result in difficulties to create sustainable treatment. The invention discloses a method to predict possible new genetic variants of viruses.

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