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1. 发明公开

EP4365912A3 FLEXIBLE ANALYTE SENSORS 审中-实审
公开(公告)号：EP4365912A3
公开(公告)日：2024-07-17
申请号：EP24151950.3
申请日：2018-01-18
申请人： DexCom, Inc.
发明人： Wang, Shanger , Headen, Devon, M. , Böhm, Sebastian , Lee, Ted Tang , Hughes, Jonathan , Simpson, Peter C. , Zou, Jiong
IPC分类号： A61B5/145 , A61B5/1486 , C12Q1/02 , A61B5/00 , C12Q1/00 , G01N27/327 , G16H40/67
CPC分类号： A61B5/14865 , G01N27/3271 , A61B5/0022 , C12Q1/006 , A61B2562/12520130101 , C12Q1/002 , A61B5/14532 , A61B2562/16420130101 , A61B5/14546 , G16H40/67 , Y02A90/10
摘要： Flexible analyte sensors are provided. Flexible analyte sensors may be flexible continuous analyte sensors that facilitate continuous monitoring of an analyte such as blood glucose. The flexible analyte sensor may have a relatively flexible conductive or non-conductive core, may be formed from a plurality of substantially planar layers, or may be configured to transform from a freestanding sensor ex vivo to a non-freestanding sensor in vivo.

2. 发明授权

EP3156788B1 BIOSENSOR 有权转让
公开(公告)号：EP3156788B1
公开(公告)日：2018-12-26
申请号：EP16194027.5
申请日：2016-10-14
申请人： ARKRAY, Inc. , Ultizyme International Ltd.
发明人： SAEDA, Megumi , SHIMAZAKI, Junko
IPC分类号： G01N27/327 , C12Q1/00
CPC分类号： G01N27/3272 , C12Q1/006 , G01N27/3271 , G01N2333/902
摘要： A biosensor includes: a working electrode; a counter electrode; a reference electrode; and a detection layer contacting the working electrode and containing a crosslinking agent, an electrically conductive polymer, and an enzyme transferring and receiving electrons to and from the working electrode, the reference electrode being a polarized electrode.

3. 发明授权

EP1639353B8 TEST STRIP WITH FLARED SAMPLE RECEIVING CHAMBER 有权转让
公开(公告)号：EP1639353B8
公开(公告)日：2018-07-25
申请号：EP04755692.3
申请日：2004-06-18
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG
发明人： BHULLAR, Raghbir, Singh , SURRIDGE, Nigel, A. , FUNKE, Tom , RIGGLES, Randall, K. , WALLING, Paul, Douglas
IPC分类号： G01N27/30 , C12Q1/00
CPC分类号： G01N33/558 , G01N27/3271 , Y10T156/1059 , Y10T156/1084
摘要： The present invention concerns a reagent coating mass which can be used in slot-die-coating of flat support materials in the manufacturing processes of test strips. Advantageously, the reagent mass of the invention exhibits certain superior rheological properties such as viscosity, surface tension and thixotropy. The reagent mass is preferably used to coat thin, narrow and homogeneous stripes of reagent material onto flat web material.

4. 发明授权

EP1639352B8 METHOD AND REAGENT FOR PRODUCING NARROW, HOMOGENOUS REAGENT STRIPS 有权转让
公开(公告)号：EP1639352B8
公开(公告)日：2018-07-11
申请号：EP04755635.2
申请日：2004-06-18
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG
发明人： WILSEY, Christopher, D. , MOSOIU, Dan
IPC分类号： G01N27/30 , C12Q1/00 , B05C5/02
CPC分类号： G01N33/558 , G01N27/3271 , Y10T156/1059 , Y10T156/1084
摘要： The present invention concerns a reagent coating mass which can be used in slot-die-coating of flat support materials in the manufacturing processes of test strips. Advantageously, the reagent mass of the invention exhibits certain superior rheological properties such as viscosity, surface tension and thixotropy. The reagent mass is preferably used to coat thin, narrow and homogeneous stripes of reagent material onto flat web material.

5. 发明授权

EP1802962B1 CONCENTRATION DETERMINATION IN A DIFFUSION BARRIER LAYER 有权转让
公开(公告)号：EP1802962B1
公开(公告)日：2018-06-06
申请号：EP05810138.7
申请日：2005-10-12
申请人： Ascensia Diabetes Care Holdings AG
发明人： WU, Huan-Ping
IPC分类号： G01N27/327 , C12Q1/00
CPC分类号： G01N27/3271 , B32B38/18 , B32B2307/202 , C12Q1/004 , C12Q1/005 , C12Q1/006 , C12Q1/6813 , C12Q1/6825 , G01N27/3272 , G01N27/3276 , G01N27/3277 , G01N27/40 , G01N33/5438
摘要： The present invention relates to improved electrochemical biosensor strips and methods for determining the concentration of an analyte in a sample. By selectively measuring a measurable species residing in a diffusion barrier layer, to the substantial exclusion of the measurable species residing exterior to the diffusion barrier layer, measurement errors introduced by sample constituents, such as red blood cells, and manufacturing variances may be reduced.

6. 发明公开

EP3308706A1 BIOSENSOR AND METHOD FOR FORMING SAME AND GLUCOSE CONTROL SYSTEM, METHOD FOR FORMING THE GLUCOSE CONTROL SYSTEM, AND METHOD FOR CONTROLLING GLUCOSE THEREBY 审中-公开
标题翻译：生物传感器及其形成方法和葡萄糖控制系统，形成葡萄糖控制系统的方法以及用于控制其葡萄糖的方法
公开(公告)号：EP3308706A1
公开(公告)日：2018-04-18
申请号：EP16807744.4
申请日：2016-06-03
申请人： Seoul National University R&DB Foundation , Institute for Basic Science
发明人： KIM, Daehyeong , HYEON, Taeghwan , CHOI, Seunghong , LEE, Hyunjae , CHOI, Taekyu
IPC分类号： A61B5/145 , A61B5/00 , G01N27/327 , G01N27/48 , G01N33/53 , G01N33/66 , H01L51/00 , G01N27/30
CPC分类号： A61M5/1723 , A61B5/00 , A61B5/145 , A61B5/14532 , A61B5/1477 , A61B5/1486 , A61B5/4266 , A61B2562/0261 , A61B2562/12 , A61M5/00 , A61M37/0015 , A61M2205/3368 , A61M2205/3569 , A61M2205/36 , A61M2230/201 , A61M2230/208 , C12Q1/006 , G01N27/3271 , G01N27/3278 , G01N33/66 , G01N33/84
摘要： Provided are a biosensor and a method for forming the same, a glucose control system, a method for forming the glucose control system, and a method for controlling glucose using the glucose control system. The biosensor comprises at least one sensor comprising a sensing unit, a bridge unit connected to the sensing unit, and an electrode unit connected to the bridge unit, wherein the sensing unit comprises a graphene layer. The method for forming the biosensor that comprises at least one sensor comprising a sensing unit, a bridge unit connected to the sensing unit and an electrode unit connected to the bridge unit, comprises forming a lower insulation layer, forming a conductive electrode layer on the lower insulation layer, forming a graphene layer on the conductive electrode layer and forming a reaction layer on the graphene layer.
The glucose control system comprises a sensor unit comprising a glucose sensor, a glucose regulation unit regulating glucose concentration in a body of a user and a control unit controlling the sensor unit and the glucose regulation unit. The method for forming a glucose control system comprises forming a sensor unit comprising a glucose sensor, forming a glucose regulation unit and packaging the sensor unit and the glucose regulation unit.
摘要翻译：本发明提供生物传感器及其形成方法，葡萄糖控制系统，葡萄糖控制系统的形成方法以及使用葡萄糖控制系统的葡萄糖控制方法。生物传感器包括至少一个传感器，其包括感测单元，连接到感测单元的桥单元以及连接到桥单元的电极单元，其中感测单元包括石墨烯层。用于形成包括至少一个传感器的生物传感器的方法包括感测单元，连接到感测单元的桥单元和连接到桥单元的电极单元，包括形成下绝缘层，在下部形成导电电极层绝缘层，在导电电极层上形成石墨烯层，并在石墨烯层上形成反应层。葡萄糖控制系统包括传感器单元，控制单元控制传感器单元和葡萄糖调节单元，所述传感器单元包括葡萄糖传感器，葡萄糖调节单元，用于调节用户体内的葡萄糖浓度。形成葡萄糖控制系统的方法包括形成包括葡萄糖传感器的传感器单元，形成葡萄糖调节单元并封装传感器单元和葡萄糖调节单元。

7. 发明公开

EP3116396A4 ELECTROCHEMICAL SENSING SYSTEM 审中-公开
公开(公告)号：EP3116396A4
公开(公告)日：2018-02-14
申请号：EP15760625
申请日：2015-03-12
申请人： GLUCOVATION INC
发明人： SURI JEFF T , BOOCK ROBERT
IPC分类号： A61B5/145 , A61B5/1468 , C12Q1/00 , G01N27/327
CPC分类号： A61B5/1468 , G01N27/28 , G01N27/327 , G01N27/3271 , G01N27/416
摘要： In some embodiments, an electrochemical sensing system includes a working electrode and a reference electrode. At least a portion of the working electrode includes rhodium. An electrical circuit is electronically coupled to the working electrode and the reference electrode. The electrical circuit is configured to bias the working electrode at voltage of less than about 0.4 V which is sufficient to electrochemically decompose a target analyte, and to measure a current corresponding to the concentration of the target analyte. In some embodiments, a biosensing molecule can be disposed on the working electrode and is operative to catalytically decompose a non-electroactive target analyte to yield and an electroactive by-product. In some embodiment, the reference electrode can include rhodium and its oxides.

8. 发明公开

EP3276340A1 ELECTRODE AND MANUFACTURING METHOD THEREOF, ENZYME SENSOR, GLUCOSE SENSOR AND IN-VIVO COMPONENT MEASURING DEVICE 审中-公开
标题翻译：电极及其制造方法，酶传感器，葡萄糖传感器和体内组件测量装置
公开(公告)号：EP3276340A1
公开(公告)日：2018-01-31
申请号：EP17183246.2
申请日：2017-07-26
申请人： SYSMEX CORPORATION
发明人： Hori, Nobuyasu , Kojima, Junko , Morishita, Yu
IPC分类号： G01N27/327
CPC分类号： C12Q1/006 , G01N27/3271 , G01N27/3273
摘要： In a hydrogen peroxide electrode 100 used as a working electrode 30 of an enzyme sensor 20, an intermediate layer 101 containing particles and a retentive substance for holding the particles are provided on a substrate 21, and an electrode layer 107 is provided on the intermediate layer 101. In this way, according to the hydrogen peroxide electrode 100, hydrogen peroxide can be detected with high sensitivity even when an applied voltage that is not susceptible to interference by interference substances present in the living body is used.
摘要翻译：在作为酶传感器20的工作电极30使用的过氧化氢电极100中，在基板21上设置含有粒子和保持粒子的保持物质的中间层101，在该中间层上设置电极层107 这样，根据过氧化氢电极100，即使在使用不易受到存在于生物体内的干扰物质的干扰的施加电压的情况下，也能够高灵敏度地检测过氧化氢。

9. 发明公开

EP3234566A1 HAND-HELD TEST METER WITH TEST STRIP ELECTRODE TO GROUND-REFERENCE SWITCH CIRCUIT BLOCK 审中-公开
标题翻译：手持式测试仪，带测试条电极接地参考开关电路模块
公开(公告)号：EP3234566A1
公开(公告)日：2017-10-25
申请号：EP15816437.6
申请日：2015-12-16
申请人： Lifescan Scotland Limited
发明人： HAMER, Malcolm , NELSON, Jonathan
IPC分类号： G01N27/327
CPC分类号： G01N27/3273 , G01N27/3271 , G01N27/3272 , G01N27/3274
摘要： A hand-held test meter for use with an electrochemical-based analytical test strip in the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes a housing, a micro-controller disposed in the housing, a test strip electrode to ground-reference switch circuit block disposed in the housing, a strip port connector configured for operational insertion of an electrochemical-based analytical test strip with an electrode (e.g., a reference electrode), and a ground-reference. In addition, the test strip electrode to ground-reference switch circuit block is configured to be in electrical communication with an electrode of an electrochemical-based analytical test strip inserted in the strip port connector. Moreover, the test strip electrode to ground-reference switch circuit block is configured to connect and disconnect the electrode of the inserted electrochemical-based analytical test strip to the ground-reference under operational control of the micro-controller.
摘要翻译：在测定体液样品（例如全血样品）中的分析物（例如葡萄糖）时，与基于电化学的分析测试条一起使用的手持式测试仪包括壳体，设置的微控制器在外壳中，测试条电极连接到设置在外壳中的接地参考开关电路块，被配置用于可操作地插入具有电极（例如参考电极）的基于电化学的分析测试条的带端口连接器，以及接地 -参考。此外，测试条电极到地参考开关电路块被配置为与插入到条端口连接器中的基于电化学的分析测试条的电极电连通。此外，测试条电极到接地参考开关电路块被配置为在微控制器的操作控制下将插入的基于电化学的分析测试条的电极连接到接地参考和将接地参考断开。

10. 发明公开

EP3163300A1 RESISTANCE STRUCTURE, RESISTANCE STRUCTURE UNIT, INFORMATION IDENTIFICATION DEVICE AND BIOSENSOR 有权
标题翻译： WIDERSTANDSSTRUKTUR，WIDERSTANDSSTRUKTUREINHEIT，INFORMATIONSIDENTIFIZIERUNGSVORRICHTUNG UND BIOSENSOR
公开(公告)号：EP3163300A1
公开(公告)日：2017-05-03
申请号：EP15810927
申请日：2015-05-30
申请人： VIVACHEK BIOTECH (HANGZHOU) CO LTD
发明人： YANG QINGGANG , YANG RONG
IPC分类号： G01N33/487 , G01N27/26
CPC分类号： H01C1/16 , G01N27/26 , G01N27/3271 , G01N33/487 , G01N33/48771 , H01C1/14
摘要： A resistance structure, a resistance structure unit, an information identification device and a biosensor. The resistance structure comprises: a first electrode (1); a second electrode (2); a plurality of first resistance elements (3), wherein one end of each of the first resistance elements (3) is connected to the first electrode (1), and the other end thereof is connected to the second electrode (2); a first fracture (11), the first fracture (11) dividing the first electrode (1) into a first part (111) and a second part (112), the first fracture (11) being located between two adjacent first resistance elements (3) or disconnecting at least one first resistance element (3) from the first electrode (1); and a fourth electrode (4), wherein the fourth electrode (4) is connected to the first part (111) of the first electrode (1).
摘要翻译：电阻结构，电阻结构单元，信息识别装置和生物传感器。该电阻结构包括：第一电极（1）; 第二电极（2）; 多个第一电阻元件（3），其中每个第一电阻元件（3）的一端连接到第一电极（1），并且其另一端连接到第二电极（2）; （11），所述第一裂缝（11）将所述第一电极（1）分成第一部分（111）和第二部分（112），所述第一裂缝（11）位于两个相邻的第一电阻元件 3）或从所述第一电极（1）断开至少一个第一电阻元件（3）; 和第四电极（4），其中第四电极（4）连接到第一电极（1）的第一部分（111）。

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