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1. 发明授权

EP3468988B1 PEPTIDES FOR THE INHIBITION OF PARASITE INFECTION 有权转让
公开(公告)号：EP3468988B1
公开(公告)日：2024-01-31
申请号：EP17737651.4
申请日：2017-06-09
发明人： MCKINLEY, Scott
IPC分类号： C12N9/76 , C07K14/81

2. 发明公开

EP3121272A1 NOVEL FISH TRYPSIN ISOFORMS AND THEIR USE 审中-公开
标题翻译：神经病毒感染病毒（DEREN VERWENDUNG）
公开(公告)号：EP3121272A1
公开(公告)日：2017-01-25
申请号：EP15178208.3
申请日：2015-07-24
申请人： Zymetech ehf.
发明人： GUDMUNDSDOTTIR, Agusta , ASGEIRSSON, Asgeir , STEFANSSON, Bjarki
IPC分类号： C12N9/76
CPC分类号： C12N9/6427
摘要： The present invention relates to the field of treatment and prevention of diseases and to the cosmetic field. In particular, the invention relates to novel cod trypsin isoforms, useful as pharmaceuticals, in medical devices, and cosmetics. Further, there are provided pharmaceutically or cosmetically active compositions comprising as an active component, novel cod trypsin isoforms.
摘要翻译：本发明涉及疾病和化妆品领域的治疗和预防领域。特别地，本发明涉及用作医疗器械和化妆品中的药物的新型鳕鱼胰蛋白酶同种型。此外，提供药物或化妆活性组合物，其包含作为活性成分的新型鳕鱼胰蛋白酶同种型。

3. 发明公开

EP3052623A1 HUMAN TRYPSINOGEN WITH REDUCED AUTOACTIVATION AND ITS USE IN AN IMMUNOASSAY 有权
标题翻译：美容美体麻醉师麻醉师减肥药AUTOSKTIVIERUNG UND DESSEN VERWENDUNG IN EINEM IMMUNSTST
公开(公告)号：EP3052623A1
公开(公告)日：2016-08-10
申请号：EP14781104.6
申请日：2014-09-25
申请人： Universität Leipzig
发明人： BÜTTNER, Karin , PRASSE, Agneta , ZÜCHNER, Thole
IPC分类号： C12N9/76 , C12Q1/37 , G01N33/542 , G01N33/58
CPC分类号： C12N9/6427 , C12Q1/37 , C12Y304/21004 , G01N33/542
摘要： The present invention relates to a polypeptide consisting of or comprising a variant of human trypsinogen-1, wherein the variant is characterized in that an amino acid residue selected from A16, A17, K64, K138, N139, L142 and L147 is replaced by an amino acid residue with a negatively charged side chain and/or H18 is replaced by a glutamine or asparagine residue and/or L107 is replaced by an amino acid residue with a positively charged side chain and/or N139 is replaced by an amino acid residue with an aromatic side chain, wherein the variant is cleavable into a polypeptide having a native-like enzymatic activity when compared to human trypsin-1. The present invention further relates to means and method for manufacturing the polypeptide as well as the use of the polypeptide, particularly in an immunoassay.
摘要翻译：本发明涉及由胰蛋白酶原-1变体组成或包含人胰蛋白酶原-1变体的多肽，其特征在于，选自A16，A17，K64，K138，N139，L142和L147的氨基酸残基被氨基酸具有带负电荷侧链和/或H18的酸残基被谷氨酰胺或天冬酰胺残基替代，和/或L107被具有带正电荷侧链的氨基酸残基替代，和/或N139被氨基酸残基替代，芳族侧链，其中当与人胰蛋白酶-1相比时，该变体可切割成具有天然样酶活性的多肽。本发明还涉及用于制备多肽的方法和方法以及多肽的使用，特别是在免疫测定中。

4. 发明公开

EP1956082A1 Reversibly inactivated acidified plasmin 审中-公开
标题翻译： Reversibel inaktiviertes saures Plasmin
公开(公告)号：EP1956082A1
公开(公告)日：2008-08-13
申请号：EP08010118.1
申请日：2000-11-13
申请人： Talecris Biotherapeutics, Inc.
发明人： Zimmermann, Thomas P. , Novokhatny, Valery , Jiang, Shan , Colandene, James
IPC分类号： C12N9/48 , C12N9/72 , C12N9/68 , C12N9/96 , C12N9/76 , A61K38/48 , A61K9/50
CPC分类号： C12N9/6435 , A61K38/4833 , A61K38/484 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/26 , C12N9/96 , C12N9/99 , C12Y304/21007
摘要： The present invention provides a fibrinolytic composition useful as a therapeutic for administration to a patient having a thrombotic occlusion. In one aspect of the present invention, the fibrinolytic composition comprises a reversibly inactivated acidified serine protease substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. In another aspect of the invention, the fibrinolytic composition of the present invention comprises a reversibly inactivated acidified plasmin substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent.
摘要翻译：本发明提供一种纤维蛋白溶解组合物，其可用作用于给予具有血栓闭塞的患者的治疗剂。在本发明的一个方面，纤维蛋白溶解组合物包含可逆地灭活的酸性丝氨酸蛋白酶，其基本上不含纤溶酶原激活剂，低缓冲能力的缓冲液和任选的稳定剂。在本发明的另一方面，本发明的纤维蛋白溶解组合物包含基本上不含纤溶酶原激活剂，低缓冲能力缓冲液和任选的稳定剂的可逆灭活的酸化纤溶酶。

5. 发明公开

EP1847600A1 Specific protease for inactivation of human tumour necrosis factor-alpha 审中-公开
标题翻译： Spezifische蛋白酶zur Inaktivierung von Tumornekrosefaktor alpha
公开(公告)号：EP1847600A1
公开(公告)日：2007-10-24
申请号：EP06112706.4
申请日：2006-04-18
申请人： Direvo Biotech AG
发明人： Kettling, Ulrich , Koltermann, André , Haupts, Ulrich , Rarbach, Markus , Tebbe, Jan , Votsmeier, Christian , Scheidig, Andreas , Coco, Wayne M. , Da Silva, Antonio , Hesse, Oliver , Scholz, Peter , Gritzan, Uwe , Zeidler, Georg , Kalmbach, Rolf
IPC分类号： C12N9/76 , A61K38/48 , C07K14/525
CPC分类号： C07K14/525 , A61K38/00 , C12N9/6424 , C12N9/6427 , Y02A50/411
摘要： The present invention is directed to specific proteases, fragments and derivatives thereof that specifically inactivate tumour necrosis factor-alpha, methods for their preparation, pharmaceutical and diagnostic compositions comprising such a protease. The proteases of the invention are useful for the treatment of clinical conditions resulting from the detrimental activity of tumour necrosis factor. The invention further relates to nucleotide sequences thereof encoding the protease, as well as vectors and hosts containing such sequences.
摘要翻译：本发明涉及特异性灭活肿瘤坏死因子-α的特异性蛋白酶，其片段和衍生物，其制备方法，包含这种蛋白酶的药物和诊断组合物。本发明的蛋白酶可用于治疗由肿瘤坏死因子的有害活性引起的临床病症。本发明还涉及其编码蛋白酶的核苷酸序列，以及含有这些序列的载体和宿主。

6. 发明公开

EP1532239A4 METHODS AND COMPOSITIONS FOR TARGETING SECRETORY LYSOSOMES 有权
标题翻译：方法和组合物靶向分泌溶酶体
公开(公告)号：EP1532239A4
公开(公告)日：2007-06-20
申请号：EP03788380
申请日：2003-08-12
申请人： BOEHRINGER INGELHEIM PHARMA
发明人： RAJOTTE DANIEL , KABCENELL ALISA
IPC分类号： C12N15/09 , C07K14/435 , C07K19/00 , C12N5/10 , C12N9/64 , C12Q1/02 , G01N33/50 , G01N33/53 , G01N33/567 , C12N9/14 , C07H21/04 , C07K17/00 , C12N9/48 , C12N9/50 , C12N9/76 , C12P21/06 , C12Q1/34 , C12Q1/37
CPC分类号： G01N33/5005 , C07K14/43595 , C07K2319/055 , C07K2319/60
摘要： This invention relates to methods and compositions for targeting proteins to secretory lysosomes. The invention further provides methods of use in drug screening assays, and methods of purifying secretory lysosomes.

7. 发明公开

EP1535074A4 METHOD FOR DETECTION OF BIOACTIVE PEPTIDES 审中-公开
标题翻译：检测方法的生物活性肽
公开(公告)号：EP1535074A4
公开(公告)日：2006-08-23
申请号：EP03735191
申请日：2003-07-10
申请人： CRYPTOME PHARMACEUTICALS LTD
发明人： SMITH ALEXANDER IAN , BERNDT MICHAEL , AUTELITANO DOMINIC , CSAR XAVIER , TALBO GERT HOY
IPC分类号： G01N27/62 , C07K14/00 , C07K14/75 , C07K14/765 , C12Q1/02 , C12Q1/37 , C40B30/04 , G01N30/88 , G01N33/15 , G01N33/483 , G01N33/49 , G01N33/50 , G01N33/68 , C07K1/36 , C07K17/02 , C12N9/76 , C12Q1/56 , C12Q1/66 , G01N33/86
CPC分类号： C40B30/04 , C07K14/75 , C07K14/765
摘要： A method for the detection of bioactive peptides derived from a precursor protein or protein-containing biological extract, comprising the steps of: (i) providing a library of peptides derived from said precursor protein or protein-containing biological extract; (ii) optionally screening said library to confirm that it includes peptides exhibiting one or more biological activities; (iii) separating said library to provide fractions of the library; (iv) screening said fractions to identify active fractions which include peptides exhibiting said one or more biological activities; (v) optionally separating each said active fraction to provide sub-fractions thereof, and screening said sub-fractions to identify active sub-fractions which include peptides exhibiting said one or more biological activities; and (vi) isolating from said active fractions or active sub-fractions one or more peptides exhibiting said one or more biological activities.

8. 发明公开

EP1546302A4 METHODS FOR PRODUCING MAMMALIAN TRYPSINS 有权
标题翻译：用于生产SûUGER，胰蛋白酶
公开(公告)号：EP1546302A4
公开(公告)日：2006-08-16
申请号：EP03755759
申请日：2003-08-29
申请人： NOVOZYMES INC
发明人： BERKA RANDY , BROWN KIMBERLY
IPC分类号： C12N9/76 , C12N1/15 , C12N9/64 , C12N15/52 , C12N15/62 , C12N15/80 , C12P21/02
CPC分类号： C12N9/6427 , C12N9/6421 , C12N15/80 , C12Y304/21004

9. 发明公开

EP1549757A4 METHOD OF PURIFYING LANTIBIOTICS 审中-公开
标题翻译：程序对清洁羊毛硫
公开(公告)号：EP1549757A4
公开(公告)日：2006-03-15
申请号：EP03770702
申请日：2003-10-07
申请人： IMMUCELL CORP
发明人： COUGHLIN RICHARD T , CRABB JOSEPH H
IPC分类号： C07K14/315 , C12N9/70 , C12P21/04 , C12S3/14 , C12P21/06 , A61K38/00 , C07K1/00 , C12N9/48 , C12N9/50 , C12N9/66 , C12N9/68 , C12N9/72 , C12N9/74 , C12N9/76
CPC分类号： C07K14/315
摘要： Disclosed is a method for purifying a lantibiotic from a crude or partially purified solution containing the lantibiotic. In preferred embodiments, the lantibiotic is nisin, although the common structural features of lantibiotics dictate the effectiveness of the disclosed purification methods for other members of the lantibiotic genus. The method includes the step of forming an incubation mixture comprising the solution containing the lantibiotic and a proteolytic enzyme, and incubating the mixture under conditions optimized for selective proteolytic activity.

10. 发明授权

EP1012307B1 AUTOKATALYTISCH AKTIVIERBARE ZYMOGENE VORSTUFEN VON PROTEASEN UND DEREN VERWENDUNG 有权
标题翻译：蛋白酶及其使用活性炭催化前体酶原
公开(公告)号：EP1012307B1
公开(公告)日：2005-05-04
申请号：EP98945214.9
申请日：1998-08-12
申请人： Roche Diagnostics GmbH
发明人： KOPETZKI, Erhard , HOPFNER, Karl-Peter , BODE, Wolfram , HUBER, Robert
IPC分类号： C12N15/57 , C12N9/50 , C12N9/64 , C12N9/76 , C12P21/06
CPC分类号： C12N9/647 , C12N9/50 , C12N9/6427 , C12N9/6432 , C12Y304/21006
摘要： A process for the recombinant production of a protease is characterised by (a) transformation of a host cell with a recombinant nucleic acid which codes for a zymogenic protease precursor containing an autocatalytic cleavage site which does not occur naturally, this cleavage site being recognised by the active form of said protease, cleaving the zymogenic precursor into the active protease; (b) cultivation of the host cell such that the zymogenic protease precursor is created in the host cell in the form of inclusion bodies; (c) isolation and naturalisation of the inclusion bodies in such conditions that the protease part of the zymogenic precursor is produced with its natural conformation; and (d) autocatalytic cleavage of the naturalised zymogenic precursor to produce the active protease. This process is suitable to produce recombinant proteases in a simple manner and with high yields.

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