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1. 发明公开

EP4189082A1 COMPOSITIONS, SYSTEMS, AND METHODS FOR ARTIFICIAL CARBON FIXATION, CHEMICAL SYNTHESIS, AND/OR PRODUCTION OF USEFUL PRODUCTS 审中-实审
公开(公告)号：EP4189082A1
公开(公告)日：2023-06-07
申请号：EP21848529.0
申请日：2021-07-26
申请人： Rubi Laboratories, Inc.
发明人： MASHOUF, Neeka Alison
IPC分类号： C12N15/03

2. 发明公开

EP4139447A1 CRISPR SYSTEMS IN PLANTS 审中-实审
公开(公告)号：EP4139447A1
公开(公告)日：2023-03-01
申请号：EP21793745.7
申请日：2021-04-20
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： JACOBSEN, Steve, E. , LI, Zheng , DOUDNA, Jennifer , PAUSCH, Patrick , AL-SHAYEB, Basem
IPC分类号： C12N9/22 , C12N15/03 , C12N15/19

3. 发明公开

EP3877507A1 MINIMAL BIOMARKERS AND RELATED NEXT-GENERATION SEQUENCING KIT FOR DIAGNOSING ALZHEIMER'S DISEASE FROM INTESTINAL MICROBIOME 审中-实审
公开(公告)号：EP3877507A1
公开(公告)日：2021-09-15
申请号：EP19894370.6
申请日：2019-11-27
申请人： T.C. Erciyes Universitesi
发明人： NALBANTOGLU, Özkan Ufuk , GÜNDOGDU, Aycan , KÖSEOGLU, Emel
IPC分类号： C12N1/20 , C12N15/03 , C12Q1/04 , C12Q1/24 , G16B40/00

5. 发明公开

EP2912173A1 PROCESS FOR PREPARATION AND PURIFICATION OF RECOMBINANT HUMAN ONCOSTATIN M PROTEIN 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG REINIGUNG VON REKOMBINANTEM MENSCHLICHEM ONCOSTATIN-M-PROTEIN
公开(公告)号：EP2912173A1
公开(公告)日：2015-09-02
申请号：EP13760127.4
申请日：2013-07-10
申请人： UAB Biotechnologines Farmacijos Centras "Biotechpharma"
发明人： BUMELIS, Vladas Algirdas , SUDZIUVIENE, Saule , MAKAUSKAS, Nerijus , PUKAITE, Lina
IPC分类号： C12N15/03 , C12N15/70
摘要： The invention relates to a process for cloning gene of human mature OSM protein; producing the culture of recombinant bacterial strain and expressing the polypeptide into inclusion bodies. The invention also provides a method for fermentation process. The invention also relates to a process for isolating and purifying said protein from insoluble fraction of bacterial strain by subjecting the material to chromatography. Recovered protein is formulated for stability.˙
摘要翻译：本发明涉及克隆人成熟OSM蛋白基因的方法。产生重组细菌菌株的培养物并将其表达为包涵体。本发明还提供了一种发酵方法。本发明还涉及通过对材料进行色谱分离和纯化所述蛋白质从细菌菌株不溶性部分中分离和纯化的方法。回收的蛋白质被配制为稳定性

6. 发明公开

EP2823312A2 IN VITRO POTENCY ASSAY FOR PROTEIN-BASED MENINGOCOCCAL VACCINES 有权转让
标题翻译：血管内皮生长因子
公开(公告)号：EP2823312A2
公开(公告)日：2015-01-14
申请号：EP13710328.9
申请日：2013-03-08
申请人： Novartis AG
发明人： GIULIANI, Marzia , MORI, Elena
IPC分类号： G01N33/569 , G01N33/577 , C12N15/03
CPC分类号： G01N33/577 , C07K16/1217 , C07K2317/33 , C07K2317/56 , G01N33/56911 , G01N2333/22
摘要： The invention uses ELISA or similar assays for analysing a meningococcal vaccine. The assay uses antibodies which bind to meningococcal proteins within the vaccine, and in particular monoclonal antibodies which are bactericidal for meningococcus and/or which recognise conformational epitopes within the meningococcal proteins. By performing the assay on a series of dilutions of a test vaccine, and by comparing the results with those obtained using a reference vaccine of known potency, it is possible to determine the relative potency of the test vaccine. This value can be used as a parameter for determining whether a manufactured batch of a vaccine is suitable for release to the public, or whether it has experienced a production failure and so should not be used.
摘要翻译：本发明使用ELISA或类似的测定来分析脑膜炎球菌疫苗。该测定使用与疫苗内的脑膜炎球菌蛋白结合的抗体，特别是对脑膜炎球菌具有杀菌性和/或识别脑膜炎球菌蛋白质内的构象表位的单克隆抗体。通过对测试疫苗的一系列稀释液进行测定，并且通过将结果与使用已知效价的参考疫苗获得的结果进行比较，可以确定测试疫苗的相对效价。该值可以用作确定制造的疫苗批次是否适合向公众释放的参数，或者是否已经经历生产故障，因此不应该使用。

7. 发明授权

EP2367938B1 GENETIC CLUSTER OF STRAINS OF STREPTOCOCCUS THERMOPHILUS HAVING UNIQUE RHEOLOGICAL PROPERTIES FOR DAIRY FERMENTATION 有权转让
标题翻译：嗜热链球菌株具有独特的流变性能牛奶SKINS遗传CLUSTER
公开(公告)号：EP2367938B1
公开(公告)日：2014-06-11
申请号：EP09799319.0
申请日：2009-12-14
申请人： DuPont Nutrition Biosciences ApS
发明人： MANOURY, Elise , HORVATH, Philippe , FREMAUX, Christophe , FOURCASSIE, Pascal
IPC分类号： C12N15/00 , C12N15/03
CPC分类号： A23C9/1238 , A23C11/106 , A23C19/00 , A23Y2240/75 , C12R1/46

8. 发明公开

EP2367938A1 GENETIC CLUSTER OF STRAINS OF STREPTOCOCCUS THERMOPHILUS HAVING UNIQUE RHEOLOGICAL PROPERTIES FOR DAIRY FERMENTATION 有权转让
标题翻译：嗜热链球菌株具有独特的流变性能牛奶SKINS遗传CLUSTER
公开(公告)号：EP2367938A1
公开(公告)日：2011-09-28
申请号：EP09799319.0
申请日：2009-12-14
申请人： Danisco A/S
发明人： MANOURY, Elise , HORVATH, Philippe , FREMAUX, Christophe , FOURCASSIE, Pascal
IPC分类号： C12N15/00 , C12N15/03
CPC分类号： A23C9/1238 , A23C11/106 , A23C19/00 , A23Y2240/75 , C12R1/46
摘要： The invention relates to a genetic cluster of strains of S.
thermophilus , wherein the milk fermented with said strains is highly viscous and weakly ropy. The invention also relates to a genetic cluster of strains of S.
thermophilus , wherein the genome of said strains comprises a CRISPR locus having the nucleotide sequence of SEQ ID N° 1.

9. 发明公开

EP2279747A1 Immunogenic bacterial vesicles with outer membrane proteins 有权
标题翻译： Imunogene bakterielle Vesikel mitäusserenMembranproteinen
公开(公告)号：EP2279747A1
公开(公告)日：2011-02-02
申请号：EP10183544.5
申请日：2005-10-28
申请人： Novartis Vaccines and Diagnostics S.r.l.
发明人： Adu-Bobie, Jeannette , Pizza, Mariagrazia , Norais, Nathalie , Ferrari, Germano , Grandi, Guido
IPC分类号： A61K39/095 , C12N15/03
CPC分类号： C07K14/245 , A61K39/00 , A61K39/0258 , A61K39/095 , C07K14/22 , C12N9/1051 , Y02A50/474
摘要： Knockout of the mltA gene gives bacteria that spontaneously release vesicles that are rich in immunogenic outer membrane proteins and that can elicit cross-protective antibody responses with higher bactericidal titres than OMVs prepared by normal production processes. Thus the invention provides a bacterium, such as an E.coli, having a knockout mutation of its mltA gene. The invention also provides a Escherichia bacterium, wherein the bacterium: (i) has a cell wall that includes peptidoglycan; and (ii) does not express a protein having the lytic transglycosylase activity of MItA protein. Tol-Pal knockouts of pathogenic E.coli are also disclosed. The invention also provides compositions comprising vesicles that, during culture of bacteria of the invention, are released into the culture medium.
摘要翻译： mltA基因的敲除使自发释放富含免疫原性外膜蛋白的囊泡的细菌，并且能够以比正常生产过程制备的OMV更高的杀菌滴度引发交叉保护性抗体应答。因此，本发明提供了具有其mltA基因的敲除突变的细菌，例如大肠杆菌。本发明还提供了一种埃希氏菌属细菌，其中所述细菌：（i）具有包含肽聚糖的细胞壁; 和（ii）不表达具有MItA蛋白的裂解转糖基酶活性的蛋白质。还公开了致病性大肠杆菌的Tol-Pal敲除。本发明还提供包含囊泡的组合物，其在本发明的细菌培养过程中释放到培养基中。

10. 发明授权

EP1487982B1 CONSTRUCTION OF NOVEL STRAINS CONTAINING MINIMIZED GENOME BY Tn5-COUPLED Cre/loxP EXCISION SYSTEM 有权
标题翻译：建设新菌株MINIMALISIERUNGSGENOM的使用Tn5的GEKOPPTELTEN的Cre / loxP位斑块切除术
公开(公告)号：EP1487982B1
公开(公告)日：2010-09-29
申请号：EP02790956.3
申请日：2002-10-31
申请人： Korea Advanced Institute of Science and Technology
发明人： KIM, Sun-Chang , YU, Byung-Jo
IPC分类号： C12N15/63 , C12N15/03
CPC分类号： C12N15/63 , C12N15/90

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