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    • 1. 发明公开
    • MULTIPLE MODIFIED DERIVATIVES OF GELATIN AND CROSSLINKED MATERIAL THEREOF
    • MEHRFACH MODIFIZIERTE DERIVATE DER GELATINE UND VERNETZTES MATERIAL DARAUS
    • EP2103662A1
    • 2009-09-23
    • EP07816477.9
    • 2007-09-29
    • Bioregen Biomedical (Changzhou) Co., Ltd.
    • SONG, Chan
    • C09H5/00C08H1/06C09J189/00A61K8/98A61K9/40
    • A61K47/42A01N1/0231A61K9/06A61L27/222C08H1/06
    • The disclosed is a kind of multiple modified derivatives of gelatin having not only the structure of formula (I) but also one of structures of formula (II), (III), and (IV) as well. Wherein, G refers to gelatin residue comprising type A, type B and the type of gene recombination; R 1 refers to allylene, or a linkage group with amide; R 2 refers to alkyl, or aryl; R 3 refers to alkylene; R 4 refers to carboxyl or carboxylate. The multiple modifying ways of gelatin comprise the hydrophobic modification on the amino group of gelatin through amide bond, carboxylation on the amino group of gelatin through amide bond, thiolation on the carboxyl group of gelatin, and thiolation following carboxylation on amino group of gelatin through amide bond. In addition, the invention also discloses the crosslinked material made of multiple modified derivatives of gelatin. The multiple modified derivatives of gelatin have flexible chemical structures and many properties. Their crosslinked gelatin material can be used the matrix for cell growth etc.
    • 所公开的是一种具有不仅结构式(I)的明胶的多重改性衍生物,而且也是式(II),(III)和(IV)的结构之一。 其中,G指包含A型,B型的明胶残基和基因重组的类型; R 1是指烯丙基或与酰胺的连接基团; R 2是指烷基或芳基; R 3表示亚烷基; R 4表示羧基或羧酸酯。 明胶的多重修饰方式包括通过酰胺键对明胶氨基进行疏水修饰,通过酰胺键在明胶羧基化,明胶羧基上硫醇化,羧甲基化作用于明胶通过酰胺氨基上的硫醇化 键。 此外,本发明还公开了由明胶的多种改性衍生物制成的交联材料。 明胶的多重改性衍生物具有灵活的化学结构和许多性质。 它们的交联明胶材料可用于细胞生长等的基质
    • 2. 发明公开
    • Oil-water emulsions for photographic applications comprising gelatin having high stability
    • 高稳定性的明胶适用于照相应用中,含有油 - 水乳液
    • EP0971262A1
    • 2000-01-12
    • EP99202265.7
    • 1999-07-09
    • Fuji Photo Film B.V.
    • Olijve, Joseph Hubertus
    • G03C1/047G03C1/005G03C7/388C09H5/00
    • G03C1/047G03C1/005G03C7/388G03C2001/0473
    • An oil-water emulsion for photographic application said emulsion comprising oil, water, gelatin and a surfactant, said gelatin consisting of

      a) a fraction of gelatin molecules with a molecular weight smaller than 70 kDa, said fraction forming 30-90% by weight on the basis of the total weight of gelatin in the emulsion,
      b) a fraction of gelatin molecules with a molecular weight higher than 130 kDa, said fraction forming 5-38% by weight on the basis of the total weight of gelatin in the emulsion,
      c) the fractions of gelatin molecules with a molecular weight higher than 130 kDa and with a molecular weight smaller than 70 kDa are further related by having as lower limit % fraction > 130 kDa = 0.455 x (100-[% fraction and as upper limit % fraction > 130 kDa = 0.606 x (100-[% fraction d) whereby in total [% fraction 130 kDa] ≤ 100% .
    • 用于摄影应用的油 - 水乳液所述乳液包括油,水,明胶和表面活性剂,所述的明胶由...组成)明胶分子的一小部分的分子量小于70kDa的,所述级分上形成30-90%(重量) 明胶的总重量的在乳液中的基础上,b)中的明胶分子与分子量大于130kDa的高的馏分,所述馏分明胶的总重量的在乳液中的基础上,形成按重量计5-38%, c)中的明胶分子与分子量大于130 kDa的和具有分子量小于70kDa的进一步由具有作为下限%分数的相关较高的级分> 130 kDa的= 0455×(100--A%组分<70kDaÜ) 和作为上限%馏分> 130 kDa的= 0.606×(100--A%组分<70kDaÜ)D)其中在总Ä%组分<70kDaÜ+ A%馏分> 130kDaÜ≤100%。