专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP0984929B1 NAPHTHOPYRAN DERIVATIVES, COMPOSITIONS AND (CO)POLYMER MATRICES CONTAINING THE SAME 失效
标题翻译： NAPHTHOPYRANDERIVATE，制剂和含有SAMe（CO）聚合物基质
公开(公告)号：EP0984929B1
公开(公告)日：2002-09-11
申请号：EP98911739.5
申请日：1998-03-17
申请人： Corning S.A.
发明人： BREYNE, Olivier , CHAN, You-Ping
IPC分类号： C07D205/02 , C07D207/02 , C07D223/04 , C07D225/02 , C07D311/92 , C07D313/18 , C07D333/02 , C07D337/04 , C07D337/16 , C07D409/10 , C08K5/15 , G02B5/23
CPC分类号： C08F24/00 , C03C1/10 , C03C4/06 , C03C14/008 , C03C2214/17 , C07D311/92 , C09K9/02
摘要： For subject, the present invention has novel naphthopyran derivatives of formula (I) optionally substituted in position(s) 2, 3, 4, 6, 7, 8, 9 or/and 10; the substituent Z in position 5 being of formula -C(R1)(R2)(OR3). The invention also relates to compositions and (co)polymer matrices containing such derivatives. Said derivatives have interesting photochromic properties.

2. 发明公开

EP0984929A1 NAPHTHOPYRAN DERIVATIVES, COMPOSITIONS AND (CO)POLYMERS MATRICES CONTAINING SAME 失效
标题翻译： NAPHTHOPYRANDERIVATE，制剂和含（共）聚合物基质
公开(公告)号：EP0984929A1
公开(公告)日：2000-03-15
申请号：EP98911739.5
申请日：1998-03-17
申请人： CORNING INCORPORATED
发明人： BREYNE, Olivier , CHAN, You-Ping
IPC分类号： C07D205/02 , C07D207/02 , C07D223/04 , C07D225/02 , C07D311/92 , C07D313/18 , C07D333/02 , C07D337/04 , C07D337/16 , C07D409/10 , C08K5/15 , G02B5/23
CPC分类号： C08F24/00 , C03C1/10 , C03C4/06 , C03C14/008 , C03C2214/17 , C07D311/92 , C09K9/02
摘要： For subject, the present invention has novel naphthopyran derivatives of formula (I) optionally substituted in position(s) 2, 3, 4, 6, 7, 8, 9 or/and 10; the substituent Z in position 5 being of formula -C(R1)(R2)(OR3). The invention also relates to compositions and (co)polymer matrices containing such derivatives. Said derivatives have interesting photochromic properties.

3. 发明公开

EP3583099A1 CYCLIZATION PROCESSES OF HYDROXYALKENOIC AICDS AND PRODUCTS THEREOF 无效
公开(公告)号：EP3583099A1
公开(公告)日：2019-12-25
申请号：EP18712023.3
申请日：2018-02-14
申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
发明人： TSVELIKHOVSKY, Dmitry
IPC分类号： C07D309/32 , C07D313/04 , C07D313/18 , C07D407/04 , C07D409/06 , C07C51/347 , C07D307/33

4. 发明公开

EP1153022A4 PROTHEASE INHIBITORS 审中-公开
标题翻译：蛋白酶抑制剂
公开(公告)号：EP1153022A4
公开(公告)日：2002-03-27
申请号：EP00910222
申请日：2000-02-17
申请人： SMITHKLINE BEECHAM CORP
发明人： MARQUIS ROBERT WELLS JR , VEBER DANIEL FRANK
IPC分类号： A61K31/335 , A61K31/34 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/4709 , A61K31/498 , A61P1/02 , A61P19/02 , A61P19/08 , A61P19/10 , A61P29/00 , A61P43/00 , C07D313/18 , C07D405/12 , C07D407/12 , C07D409/12 , C07D498/04 , C07D313/04 , A61K31/336 , A61K31/38 , A61K31/40 , A61K31/47 , A61K31/495 , C07D209/42 , C07D241/36 , C07D333/70
CPC分类号： C07D405/12 , C07D313/18 , C07D407/12 , C07D409/12

5. 发明公开

EP0548774A1 Process for producing a lactone or an ester 失效
标题翻译： Verfahren zur Herstellung von einem Lacton oder von einem Ester。
公开(公告)号：EP0548774A1
公开(公告)日：1993-06-30
申请号：EP92121383.1
申请日：1992-12-16
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED
发明人： Murahashi, Shun-Ichi , Oda, Yoshiaki
IPC分类号： C07D309/30 , C07D313/04 , C07D313/18 , C07C67/42 , C07J63/00 , C07B41/12
CPC分类号： C07D315/00 , C07B41/12 , C07C67/42 , C07J73/003
摘要： A process for producing a lactone or an ester represented by the following general formula (2), wherein R¹ and R², identical or different, each represents (C₁-C₂₀) alkyl group; alkyl group substituted with a terminal alkenyl, halogen, alkoxy, phenoxy or acyloxy; phenyl group; or phenyl group substituted with alkyl, halogen, alkoxy, phenoxy or acyloxy; phenylalkyl group; or phenylalkyl group substituted with alkyl, halogen, alkoxy, phenoxy or acyloxy; provided that when R¹ and R², identical or different, each represents unsubstituted alkyl group or alkyl group substituted with a terminal alkenyl, halogen, alkoxy, phenoxy, acyloxy or phenyl, the respective alkyl parts of R¹ and R² may be conjunct to each other; which comprises reacting a ketone represented by the following general formula (1), wherein R¹ and R² are as defined above, with oxygen in the presence of an aldehyde either in the absence of catalyst or in the presence of a heterogeneous iron-containing or ruthenium-containing catalyst:

The above-mentioned process of this invention is an advantageous process for producing lactones or esters by the oxidation of ketones with oxygen either using no catalyst or using a readily available and recoverable catalyst.
摘要翻译：由下列通式（2）表示的内酯或酯的制造方法相同或不同，分别表示（C1-C20）烷基; 被末端烯基，卤素，烷氧基，苯氧基或酰氧基取代的烷基; 苯基; 或被烷基，卤素，烷氧基，苯氧基或酰氧基取代的苯基; 苯基烷基; 或被烷基，卤素，烷氧基，苯氧基或酰氧基取代的苯基烷基; 条件是当R 1和R 2相同或不同时，各自表示未取代的烷基或被末端烯基，卤素，烷氧基，苯氧基，酰氧基或苯基取代的烷基，R 1的各个烷基部分和R 2可以彼此结合; 其中包括使下列通式（1）表示的酮，其中R 1和R 2如上定义，在不存在催化剂的情况下，在醛的存在下，或在存在不同含铁或含钌催化剂：本发明的上述方法是通过用氧氧化酮或不使用催化剂或使用容易获得和可回收的催化剂来生产内酯或酯的有利方法。

6. 发明公开

EP3174867A1 NOVEL ANTIBIOTIC 审中-公开
标题翻译：中性抗生素
公开(公告)号：EP3174867A1
公开(公告)日：2017-06-07
申请号：EP15767346.8
申请日：2015-07-30
申请人： Koninklijke Nederlandse Akademie van Wetenschappen
发明人： DEN HERTOG, Jeroen , VAN DER VELDEN, Gisela Johanna , HOEKSMA, Jelmer
IPC分类号： C07D313/18 , A61K31/365 , A61P31/04
摘要： The present invention relates to novel compounds, comprising an 8- or 9-membered cyclic structure, wherein an (E)-1,4-dioxo-but-2-ene moiety is embedded in said cyclic structure and to pharmaceutical compositions comprising these compounds. The compounds may be used as medicaments, in particular as medicaments for treating and preventing microbial infections, such as infections by multidrug resistant and/or Gram-positive bacteria. The invention further relates to fermentation processes wherein fungi of the genus Ulocladium are used for producing the novel compounds.
摘要翻译：本发明涉及包含8-或9-元环结构的新化合物，其中（E）-1,4-二氧代丁-2-烯部分嵌入所述环状结构中，以及包含这些化合物的药物组合物。这些化合物可以用作药物，特别是用作治疗和预防微生物感染的药物，例如多药耐药和/或革兰氏阳性细菌的感染。本发明还涉及其中使用Ulocladium属的真菌来生产新化合物的发酵方法。

7. 发明公开

EP1468990A4 PIPERAZINE DERIVATIVE 审中-公开
标题翻译： PIPERAZINDERIVAT
公开(公告)号：EP1468990A4
公开(公告)日：2006-01-04
申请号：EP02805485
申请日：2002-12-19
申请人： TAISHO PHARMA CO LTD
发明人： NAKAZATO ATSURO , ISHII TAKAAKI , NOZAWA DAI
IPC分类号： A61K31/496 , A61K31/517 , A61P3/04 , A61P25/22 , A61P25/24 , A61P43/00 , C07D209/48 , C07D225/02 , C07D231/12 , C07D233/70 , C07D233/84 , C07D239/26 , C07D239/96 , C07D261/08 , C07D263/32 , C07D277/28 , C07D277/34 , C07D277/40 , C07D277/56 , C07D295/02 , C07D295/13 , C07D307/91 , C07D311/90 , C07D313/18 , C07D211/26 , C07D239/42
CPC分类号： C07D239/26 , A61K31/496 , A61K31/517 , C07D209/48 , C07D231/12 , C07D233/70 , C07D233/84 , C07D239/96 , C07D261/08 , C07D263/32 , C07D277/28 , C07D277/34 , C07D277/40 , C07D277/56 , C07D295/02 , C07D295/13 , C07D307/91 , C07D311/90 , C07D313/18
摘要： A piperazine derivative represented by the formula (1) [wherein n is an integer of 1 to 8; R1 represents hydrogen or C1-10 alkyl; A represents CH or nitrogen; Ar1 represents phenyl or substituted phenyl; and Y represents a group represented by the formula Y1-Y2-Ar2 or Y3-Y4(Ar5)-Ar6] or a pharmaceutically acceptable salt of the derivative. The novel piperazine derivative has MC4 receptor antagonistic activity.

8. 发明公开

EP1052982A4 AMINOTETRALINS AS 5-HT 1D$g(a)? AGONISTS 失效
标题翻译： AMINOTETRALINE ALS 5HT1D-αAGONISTEN
公开(公告)号：EP1052982A4
公开(公告)日：2004-10-06
申请号：EP98918773
申请日：1998-04-27
申请人： LILLY CO ELI
发明人： SCHAUS JOHN MEHNERT , WALKER CLINT DUANE , XU YAO-CHANG
IPC分类号： C07D307/16 , A61K31/135 , A61K31/341 , A61K31/351 , A61P13/00 , A61P13/08 , A61P15/10 , A61P25/00 , A61P25/06 , A61P25/16 , A61P25/22 , A61P25/28 , A61P43/00 , C07C211/42 , C07C215/42 , C07C217/52 , C07C217/74 , C07D307/14 , C07D309/04 , A61K31/335 , A61K31/34 , A61K31/35 , C07D305/08 , C07D305/10 , C07D307/22 , C07D307/30 , C07D309/14 , C07D309/28 , C07D313/04 , C07D313/18
CPC分类号： C07D309/04 , A61K31/135 , A61K31/341 , A61K31/351 , C07C211/42 , C07C215/42 , C07C217/74 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07D307/14

9. 发明公开

EP1052982A1 AMINOTETRALINS AS 5-HT 1D$g(a)? AGONISTS 失效
标题翻译：氨基萘满ALS 5HT1Dα激动剂
公开(公告)号：EP1052982A1
公开(公告)日：2000-11-22
申请号：EP98918773.7
申请日：1998-04-27
申请人： ELI LILLY AND COMPANY
发明人： SCHAUS, John, Mehnert , WALKER, Clint, Duane , XU, Yao-Chang
IPC分类号： A61K31/135 , A61K31/335 , A61K31/34 , A61K31/35 , C07C211/42 , C07D305/08 , C07D305/10 , C07D307/22 , C07D307/30 , C07D309/14 , C07D309/28 , C07D313/04 , C07D313/18
CPC分类号： C07D309/04 , A61K31/135 , A61K31/341 , A61K31/351 , C07C211/42 , C07C215/42 , C07C217/74 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07D307/14
摘要： A class of novel aminotetralins is disclosed useful as 5-HT1Dα agonists.

10. 发明公开

EP1468990A1 PIPERAZINE DERIVATIVE 审中-公开
标题翻译： PIPERAZINDERIVAT
公开(公告)号：EP1468990A1
公开(公告)日：2004-10-20
申请号：EP02805485.6
申请日：2002-12-19
申请人： Taisho Pharmaceutical Co. Ltd.
发明人： NAKAZATO, Atsuro, Taisho Pharmaceutical Co., Ltd. , ISHII, Takaaki, Taisho Pharmaceutical Co., Ltd. , NOZAWA, Dai, c/o Taisho Pharmaceutical Co., Ltd.
IPC分类号： C07D209/48 , C07D211/26 , C07D231/12 , C07D233/70 , C07D233/84 , C07D239/26 , C07D239/42 , C07D261/08 , C07D263/32 , C07D277/40 , C07D277/56 , C07D295/12 , C07D295/14 , C07D307/91 , C07D313/18 , A61K31/496 , A61K31/517 , A61P3/04 , A61P25/22 , A61P25/24 , A61P43/00
CPC分类号： C07D239/26 , A61K31/496 , A61K31/517 , C07D209/48 , C07D231/12 , C07D233/70 , C07D233/84 , C07D239/96 , C07D261/08 , C07D263/32 , C07D277/28 , C07D277/34 , C07D277/40 , C07D277/56 , C07D295/02 , C07D295/13 , C07D307/91 , C07D311/90 , C07D313/18
摘要： A piperazine derivative represented by the formula (1):
wherein n is an integer of 1 to 8; R 1 represents hydrogen or C 1-10 alkyl; A represents CH or nitrogen; Ar 1 represents phenyl or substituted phenyl; and Y represents a group represented by the formula Y 1 -Y 2 -Ar 2 or Y 3 -Y 4 (Ar 5 )-Ar 6 or a pharmaceutically acceptable salt of the derivative. The novel piperazine derivative has MC4 receptor antagonistic activity.
摘要翻译：由式（1）表示的哌嗪衍生物：其中n为1至8的整数; R 1表示氢或C 1-10烷基; A表示CH或氮; Ar 1表示苯基或取代的苯基; Y表示由式Y 1 -Y 2 -Ar 2或Y 3 -Y 4（Ar 5）-Ar 6表示的基团或其药学上可接受的盐衍生品。新型哌嗪衍生物具有MC4受体拮抗作用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式