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1. 发明公开

EP1153917A1 P-Aminophenol-Derivate und diese enthaltende Färbemittel 有权
标题翻译：对氨基苯酚 - 衍生物和衍生物Färbemittel
公开(公告)号：EP1153917A1
公开(公告)日：2001-11-14
申请号：EP01103708.2
申请日：2001-02-15
申请人： Wella Aktiengesellschaft
发明人： Chassot, Laurent , Braun, Hans-Jürgen
IPC分类号： C07D207/335 , C07D307/72 , C07D333/20 , C07D333/22 , C07D333/28 , C07D333/32 , C07D333/42 , A61K7/13
CPC分类号： C07D207/323 , C07D207/335 , C07D307/52 , C07D333/12 , C07D333/20 , C07D333/22 , C07D333/28
摘要： Gegenstand der Erfindung sind p-Aminophenol-Derivate der allgemeinen Formel (I) oder deren physiologisch verträgliche, wasserlösliche Salze,
sowie Oxidationshaarfärbemittel auf der Basis einer Entwicklersubstanz-Kupplersubstanz-Kombination, welche mindestens ein p-Aminophenol-Derivat der Formel (I) enthalten.
摘要翻译： 4-氨基-2-（2-呋喃基，2-噻吩基和2-吡咯基） - 酚衍生物（Ⅰ）及其生理上相容的水溶性盐是新的。式（I）的4-氨基-2-（呋喃-2-基 - ，噻吩-2-基 - 和吡咯-2-基） - 苯酚衍生物及其生理上相容的水溶性盐是新的。 X =氧（O），硫（S）或亚氨基（NR 5）; R 1 =氢（H），卤素，1-4碳（C）（羟基）烷基或1-4 C烷氧基; R 2，R 4 = H，羟基（OH），卤素，氰基（CN），1-4C烷氧基，1-6C烷基，1-4C烷硫基，巯基，硝基（NO2）（-C（O）CH 3），三氟乙酰基（-C（O）CF 3），三（甲氧基羰基）（CH 3）3），1-4 C羟基烷基，3-4 C二羟基烷基，（取代）乙烯基（-CH = CHR 6）， - （CH 2）p -CO 2 R 7， - （CH 2）p R 8 >，-C（R 9）= NR 10或C（R 11）H-NR 12 R 13; R 3 = H，卤素，C 1-6烷基或-C（O）H; R 5 = H，1-6 C烷基，1-4 C羟基烷基，苯基或乙酰基; R 6 = H，OH，NO 2，氨基，-CO 2 R 7或-C（O）CH 3; R 7，R 9，R 11 = H或1-4 C烷基; R 8 =氨基或CN; R 10，R 12，R 13 = H，OH，1-4 C（羟基）烷基，3-4 C二羟基烷基，苯基，氨基苯基或羟基苯基。还包括基于显影剂物质 - 成色剂物质组合的角蛋白纤维的氧化着色剂的独立权利要求，其中使用至少一种化合物（I）作为显影剂物质。

2. 发明公开

EP1631560A2 C-FMS KINASE INHIBITORS 审中-公开
标题翻译： C-FMS-KINASEINHIBITOREN
公开(公告)号：EP1631560A2
公开(公告)日：2006-03-08
申请号：EP04750617.5
申请日：2004-04-26
申请人： 3-DIMENSIONAL PHARMACEUTICALS, INC.
发明人： PLAYER, Mark, R. , BAINDUR, Nand , BRANDT, Benjamin, M. , CHADHA, Naresh , PATCH, Raymond, J. , ASGARI, Davoud , GEORGIADIS, Taxiarchis
IPC分类号： C07D307/72 , C07D307/68 , C07D261/18 , C07D213/81 , C07D295/14 , C07D231/16 , C07D405/12 , C07D207/42 , C07D401/12 , C07D491/04 , A61K31/55 , A61P35/00
CPC分类号： C07D213/81 , C07D231/38 , C07D265/02 , C07D307/68 , C07D307/71 , C07D405/12 , C07D491/04
摘要： The invention is directed to compounds of formulae (I), (II) and (III), wherein A, R1, R2, R3, R4, X, Y and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.

3. 发明授权

EP2654455B1 USE OF NITROOXY ORGANIC MOLECULES IN FEED FOR REDUCING METHANE EMISSION IN RUMINANTS 有权
公开(公告)号：EP2654455B1
公开(公告)日：2018-10-24
申请号：EP11819164.2
申请日：2011-12-20
申请人： DSM IP Assets B.V.
发明人： DUVAL, Stephane , KINDERMANN, Maik
IPC分类号： A23K20/111 , A23K20/121 , A23K20/10 , A23K20/105 , A23K50/10 , A61K31/04 , A61K31/045 , A61K31/08 , A61K31/18 , A61K31/21 , A61K31/216 , A61K31/22 , A61K31/24 , A61K31/275 , A61K31/34 , A61K31/345 , A61K31/4406 , C07D213/82 , C07D493/04 , C07D307/72
CPC分类号： C07C203/04 , A23K20/10 , A23K20/105 , A23K20/111 , A23K20/121 , A23K50/10 , A61K31/04 , A61K31/045 , A61K31/08 , A61K31/18 , A61K31/21 , A61K31/216 , A61K31/22 , A61K31/24 , A61K31/275 , A61K31/34 , A61K31/345 , A61K31/4406 , A61K45/06 , C07C207/02 , C07C207/04 , C07C255/11 , C07C311/03 , C07C311/24 , C07D213/82 , C07D307/72 , C07D493/04 , Y02P60/56
摘要： The present invention relates to a method for reducing the production of methane emanating from the digestive activities of a ruminant and/or for improving ruminant animal performance by using, as active compound at least one organic molecule substituted at any position with at least one nitrooxy group, or a salt thereof, which is administrated to the animal together with the feed. The invention also relates to the use of these compounds in feed and feed additives such as premix, concentrates and total mixed ration (TMR) or in the form of a bolus.

4. 发明授权

EP1153917B1 p-Aminophenol-Derivate und diese enthaltende Färbemittel 有权
标题翻译：对 - 氨基酚衍生物和含有着色剂的
公开(公告)号：EP1153917B1
公开(公告)日：2005-04-13
申请号：EP01103708.2
申请日：2001-02-15
申请人： Wella Aktiengesellschaft
发明人： Chassot, Laurent , Braun, Hans-Jürgen
IPC分类号： C07D207/335 , C07D307/72 , C07D333/20 , C07D333/22 , C07D333/28 , C07D333/32 , C07D333/42 , A61K7/13
CPC分类号： C07D207/323 , C07D207/335 , C07D307/52 , C07D333/12 , C07D333/20 , C07D333/22 , C07D333/28

6. 发明公开

EP2332905A1 BCRP/ABCG3 Inhibitor 有权
标题翻译： BCRP / ABCG3抑制剂
公开(公告)号：EP2332905A1
公开(公告)日：2011-06-15
申请号：EP11000788.7
申请日：2006-03-29
申请人： Kabushiki Kaisha Yakult Honsha
发明人： Yamazaki, Ryuta , Nishiyama, Yukiko , Furuta, Tomio , Matsuzaki, Takeshi , Hatano, Hiroshi , Yoshida, Oh , Nagaoka, Masato , Aiyama, Ritsuo , Hashimoto, Shusuke , Sugimoto, Yoshikazu
IPC分类号： C07C255/37 , C07D209/18 , C07D213/57 , C07D215/14 , C07D215/18 , C07D233/64 , C07D233/84 , C07D235/16 , C07D261/08 , C07D277/30 , C07D277/64 , C07D307/54 , C07D307/56 , C07D307/66 , C07D307/72 , C07D307/79 , C07D307/81 , C07D333/28 , C07D333/36 , C07D333/44 , C07D333/60 , C07D401/04 , C07D401/06 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/06 , C07D207/337
CPC分类号： C07C255/37 , A61K9/2009 , A61K9/2018 , A61K9/2054 , A61K9/2059 , A61K31/277 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/4164 , A61K31/4184 , A61K31/42 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4409 , A61K31/4525 , A61K31/4535 , A61K31/47 , A61K31/5377 , A61K31/661 , C07C2603/26 , C07D207/337 , C07D209/18 , C07D213/57 , C07D215/14 , C07D215/18 , C07D233/64 , C07D233/84 , C07D235/16 , C07D261/08 , C07D277/30 , C07D277/64 , C07D307/54 , C07D307/56 , C07D307/66 , C07D307/72 , C07D307/79 , C07D307/81 , C07D333/28 , C07D333/36 , C07D333/44 , C07D333/60 , C07D401/04 , C07D401/06 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/06 , C07F9/65586
摘要： A BCRP inhibitor comprising, as an active ingredient, an acrylonitrile derivative represented by formula (1):

wherein one of R 1 and R 2 represents a cyano group and the other represents a hydrogen atom;
Ar 1 represents a group selected from among the groups represented by formulas (2) to (4):

wherein R 7 and R 8 , which are identical to or different from each other, each represent a hydrogen atom, a halogen atom, or a lower alkoxy group;
A represents an oxygen atom, a sulfur atom, or NR 9 ; and
R 9 represents a hydrogen atom or a lower alkyl group;
Ar 2 represents a group selected from among the groups represented by formulas (5) to (15):

wherein R 3 represents a hydrogen atom, an oxygen atom (as N-oxide), a lower alkyl group, a lower alkoxy group, a halogen atom, a nitro group, a methylsulfanyl group, a lower hydroxyalkyl group, an aromatic hydrocarbon group which may have a substituent, or NR 5 (R 6 )
R 5 and R 6 , which are identical to or different from each other, each represent a hydrogen atom, a lower alkyl group which may have a substituent, a lower hydroxyalkyl group, or an aromatic hydrocarbon group which may have a substituent or heterocyclic group; R 5 and R 6 may form, with their adjacent nitrogen atom, a heterocyclic ring which may have a substituent; and the hydroxyl group of the lower hydroxyalkyl group or the heterocyclic ring substituted by a hydroxyl group or a lower hydroxyalkyl group may form an ester bond with a phosphoric acid group or a salt thereof or with an acyl group which may have a substituent;
R 4 represents a hydrogen atom, a lower alkyl group, a phenyl group which may have a substituent, or a benzyl group;
X represents a carbon atom, CH, or a nitrogen atom, provided that when A is an oxygen atom, X is not a nitrogen atom; and
A, R 7 , R 8 , and R 9 have the same meanings as defined above; or a salt thereof.
摘要翻译：一种BCRP抑制剂，其含有式（1）所示的丙烯腈衍生物作为有效成分，式中，R 1和R 2中的一个表示氰基，另一个表示氢原子。 Ar 1表示选自由式（2）至（4）表示的基团中的基团：其中R 7和R 8彼此相同或不同，各自表示氢原子，卤素原子或低级烷氧基 ; A表示氧原子，硫原子或NR 9; 和R9代表氢原子或低级烷基; Ar 2表示选自由式（5）至（15）表示的基团中的基团：其中R 3表示氢原子，氧原子（作为N-氧化物），低级烷基，低级烷氧基，卤素原子，硝基，甲基硫烷基，低级羟烷基，可以具有取代基的芳香族烃基或NR 5（R 6）R 5和R 6分别相同或不同，表示氢原子，可以具有取代基的低级烷基，低级羟烷基或可以具有取代基的芳香族烃基或杂环基; R5和R6可以与其相邻的氮原子一起形成可以具有取代基的杂环; 并且羟基或羟基烷基取代的低级羟烷基或杂环的羟基可以与磷酸基或其盐或与可以具有取代基的酰基形成酯键; R4表示氢原子，低级烷基，可以具有取代基的苯基或苄基; X代表碳原子，CH或氮原子，条件是当A是氧原子时，X不是氮原子; A，R 7，R 8和R 9具有与上述定义相同的含义; 或其盐。

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