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1. 发明授权

EP2647617B1 NUCLEOSIDE ANALOG OR SALT THEREOF, OLIGONUCLEOTIDE ANALOG, GENE EXPRESSION INHIBITOR, AND NUCLEIC-ACID PROBE FOR DETECTING GENE 有权
标题翻译：核苷类似物或其盐，寡核苷酸类似物，基因表达抑制剂和核酸探针基因检测
公开(公告)号：EP2647617B1
公开(公告)日：2016-07-13
申请号：EP11844449.6
申请日：2011-11-30
申请人： Japan Science and Technology Agency
发明人： UENO, Yoshihito
IPC分类号： C07C33/044 , C07D213/73 , C07D229/02 , C07D239/47 , C07D239/54 , C07F9/564 , C07F9/58 , C07F9/6512 , C12N15/09 , C12Q1/68 , C07H21/00
CPC分类号： C12N15/113 , C07C33/044 , C07D213/73 , C07D229/02 , C07D239/47 , C07D239/54 , C07F9/2408 , C07F9/2412 , C07F9/2458 , C07F9/564 , C07F9/582 , C07F9/65122 , C07H21/02 , C12Q1/6876 , Y02P20/55

2. 发明公开

EP2647617A4 NUCLEOSIDE ANALOG OR SALT THEREOF, OLIGONUCLEOTIDE ANALOG, GENE EXPRESSION INHIBITOR, AND NUCLEIC-ACID PROBE FOR DETECTING GENE 有权
标题翻译：核苷类似物或其盐，寡核苷酸类似物，基因表达抑制剂和核酸探针基因检测
公开(公告)号：EP2647617A4
公开(公告)日：2014-06-18
申请号：EP11844449
申请日：2011-11-30
申请人： JAPAN SCIENCE & TECH AGENCY
发明人： UENO YOSHIHITO
IPC分类号： C07C33/044 , C07D213/73 , C07D229/02 , C07D239/47 , C07D239/54 , C07F9/564 , C07F9/58 , C07F9/6512 , C07H21/00 , C12N15/09 , C12Q1/68
CPC分类号： C12N15/113 , C07C33/044 , C07D213/73 , C07D229/02 , C07D239/47 , C07D239/54 , C07F9/2408 , C07F9/2412 , C07F9/2458 , C07F9/564 , C07F9/582 , C07F9/65122 , C07H21/02 , C12Q1/6876 , Y02P20/55

3. 发明公开

EP1425258A4 HYDROXYEICOSENOIC ACID ANALOGS 审中-公开
标题翻译： HYDROXYEICOSEINSÄUREANALOGA
公开(公告)号：EP1425258A4
公开(公告)日：2005-02-16
申请号：EP02761383
申请日：2002-09-09
申请人： TAISHO PHARMA CO LTD , UNIV TEXAS
发明人： FALCK JOHN R , MIYATA NORIYUKI , ONO NAOYA , CHONAN TOMOMICHI , HIRANO HITOMI , TODA YOSHIHISA , TANAMI TOHRU , OKUYAMA SHIGERU
IPC分类号： C07D277/20 , A61K31/047 , A61K31/08 , A61K31/16 , A61K31/18 , A61K31/185 , A61K31/201 , A61K31/231 , A61K31/275 , A61K31/41 , A61K31/426 , A61P1/02 , A61P1/04 , A61P1/16 , A61P1/18 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P11/08 , A61P13/12 , A61P15/00 , A61P15/06 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61P37/02 , A61P37/06 , A61P43/00 , C07C33/04 , C07C33/044 , C07C33/42 , C07C59/01 , C07C59/42 , C07C59/46 , C07C59/60 , C07C69/708 , C07C69/732 , C07C235/28 , C07C255/15 , C07C255/16 , C07C259/06 , C07C309/08 , C07C309/10 , C07C309/20 , C07C309/23 , C07C309/24 , C07C309/68 , C07C311/04 , C07C311/17 , C07C311/51 , C07C317/44 , C07C323/52 , C07C323/66 , C07D257/04 , C07D277/34 , C07C59/00 , A61K31/42 , A61K31/425 , C07C255/00 , C07D277/00
CPC分类号： C07D257/04 , C07C33/044 , C07C33/423 , C07C33/426 , C07C59/42 , C07C59/46 , C07C59/60 , C07C69/708 , C07C235/28 , C07C255/15 , C07C259/06 , C07C309/10 , C07C309/20 , C07C309/23 , C07C309/24 , C07C309/68 , C07C311/17 , C07C311/51 , C07C317/44 , C07C323/52 , C07C323/66 , C07C2601/08 , C07C2601/14 , C07D277/34
摘要： A hydroxyeicosenoic acid analog represented by the following Formula (I), the bond represents a cis-vinylene group or an ethynylene group; Y represents CH2, O or S(O)p wherein p is 0, 1 or 2; m represents an integer of 1 to 4 inclusive; n represents an integer of 0 to 3 inclusive; the sum of m and n is an integer of 3 to 7 inclusive; R1 represents a C1-4 alkyl group or a C3-8 cycloalkyl group; R2 represents a hydrogen atom or a methyl group; R3 represents COR4, a nitrile group, a halogen atom, a tetrazole group or a thiazolidinedione group; R4 represents OR6, NHR6, N(OH)R?6, NHSO2R5¿, glycerol or functionalized glycerols; R5 represents a C¿1-15? alkyl group, a C6-10 aryl group or a C7-14 aryl group substituted with alkyl groups, halogens or amino groups; R?6¿ represents a hydrogen, a C¿1-10? alkyl group or a C1-10 alkyl group substituted with a hydroxyl group, or a pharmaceutically acceptable salt or hydrate thereof. The compounds of the present invention are useful as an elastase release inhibitor.
摘要翻译：由下式（I）表示的羟基二十碳烯酸类似物，该键代表顺式亚乙烯基或亚乙炔基; Y代表CH 2，O或S（O）p，其中p是0,1或2; m表示1〜4的整数， n表示0〜3的整数， m和n的总和是3〜7的整数， R1代表C1-4烷基或C3-8环烷基; R2代表氢原子或甲基; R3代表COR4，腈基，卤素原子，四唑基或噻唑烷二酮基; R4代表OR6，NHR6，N（OH）R6 6，NHSO2R5，甘油或官能化甘油; R5代表C 1-15？烷基，被烷基，卤素或氨基取代的C 6-10芳基或C 7-14芳基; R 6表示氢，C 1-10 - 烷基或被羟基取代的C1-10烷基，或其药学上可接受的盐或水合物。本发明的化合物可用作弹性蛋白酶释放抑制剂。

4. 发明公开

EP1436252A4 HYDROXYFATTYSULFONIC ACID ANALOGS 审中-公开
标题翻译： HYDROXYFETTSULFONSÄUREANALOGA
公开(公告)号：EP1436252A4
公开(公告)日：2005-02-09
申请号：EP02761382
申请日：2002-09-09
申请人： TAISHO PHARMA CO LTD , UNIV TEXAS
发明人： FALCK JOHN R , MIYATA NORIYUKI , ONO NAOYA , CHONAN TOMOMICHI , HIRANO HITOMI , TODA YOSHIHISA , TANAMI TOHRU , OKUYAMA SHIGERU
IPC分类号： C07D277/20 , A61K31/047 , A61K31/08 , A61K31/16 , A61K31/18 , A61K31/185 , A61K31/201 , A61K31/231 , A61K31/275 , A61K31/41 , A61K31/426 , A61P1/02 , A61P1/04 , A61P1/16 , A61P1/18 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P11/08 , A61P13/12 , A61P15/00 , A61P15/06 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61P37/02 , A61P37/06 , A61P43/00 , C07C33/04 , C07C33/044 , C07C33/42 , C07C59/01 , C07C59/42 , C07C59/46 , C07C59/60 , C07C69/708 , C07C69/732 , C07C235/28 , C07C255/15 , C07C255/16 , C07C259/06 , C07C309/08 , C07C309/10 , C07C309/20 , C07C309/23 , C07C309/24 , C07C309/68 , C07C311/04 , C07C311/17 , C07C311/51 , C07C317/44 , C07C323/52 , C07C323/66 , C07D257/04 , C07D277/34 , C07C309/01 , C07C303/36 , C07C309/02 , C07C309/03 , C07C309/04 , C07C309/07 , C07C309/63 , C07C309/64 , C07C309/65 , C07C309/67
CPC分类号： C07D257/04 , C07C33/044 , C07C33/423 , C07C33/426 , C07C59/42 , C07C59/46 , C07C59/60 , C07C69/708 , C07C235/28 , C07C255/15 , C07C259/06 , C07C309/10 , C07C309/20 , C07C309/23 , C07C309/24 , C07C309/68 , C07C311/17 , C07C311/51 , C07C317/44 , C07C323/52 , C07C323/66 , C07C2601/08 , C07C2601/14 , C07D277/34
摘要： A hydroxyfattysulfonic acid analog represented by Formula (I): wherein X is an ethylene group, a vinylene group or an ethynylene group; Y is an ethylene group, a vinylene group, an ethynylene group, OCH2 or S(O)pCH2 wherein p is 0, 1 or 2; m is an integer of 1 to 5 inclusive; n is an integer of 0 to 4 inclusive;R1 is a C¿1-8? alkyl group, a C3-8 cycloalkyl group, a C1-4 alkyl group substituted with a C3-8 cycloalkyl group, a C1-4 alkyl group substituted with an aryl group or a C1-4 alkyl group substituted with an aryloxy group; R?2¿ is a hydrogen atom or a methyl group; R?1 and R2¿ together with the carbon atom to which they are attached may form a C¿3-8? cycloalkyl group; R?3¿ is a hydrogen atom or a C¿2-8? acyl group; R?4 is OR5 or NHR6¿, wherein R5 is a hydrogen atom, a C¿1-4? alkyl group, an alkali metal, an alkaline earth metal or an ammonium group and R?6¿ is a hydrogen atom or a C¿1-4? alkyl group; or a pharmaceutically acceptable salt or a hydrate thereof. The compounds of the present invention are useful as an elastase release inhibitor.
摘要翻译：由式（I）表示的羟基甲磺酸类似物：其中X是亚乙基，亚乙烯基或亚乙炔基; Y是亚乙基，亚乙烯基，亚乙炔基，OCH 2或S（O）pCH 2，其中p是0,1或2; m是1〜5的整数， n是0〜4的整数，R 1是C 1-8〜烷基，C3-8环烷基，被C3-8环烷基取代的C1-4烷基，被芳基取代的C1-4烷基或被芳氧基取代的C1-4烷基; R 2是氢原子或甲基; R 1和R 2'与它们所连接的碳原子一起可形成C 3-8 - 环烷基; R 3是氢原子或C 2-8 - 酰基; R 4是OR 5或NHR 6，其中R 5是氢原子，C 1-4 - 烷基，碱金属，碱土金属或铵基，R 6是氢原子或C 1〜4 - 烷基; 或其药学上可接受的盐或水合物。本发明的化合物可用作弹性蛋白酶释放抑制剂。

5. 发明公开

EP1055655A3 Verfahren zur Herstellung von Alkindiolen 有权
标题翻译：一种制备炔二醇过程
公开(公告)号：EP1055655A3
公开(公告)日：2004-03-10
申请号：EP00110914.9
申请日：2000-05-24
申请人： BASF AKTIENGESELLSCHAFT
发明人： Kindler, Alois, Dr. , Preiss, Thomas, Dr. , Henkelmann. Jochem, Dr.
IPC分类号： C07C29/42 , C07C33/044
CPC分类号： C07C29/42 , C07C33/044 , C07C33/046
摘要： Das Verfahren zur Herstellung von Alkindiolen der allgemeinen Formel (I)R 1 R 2 C(OH)-C≡C-C(OH)R 1 R 2 mit der Bedeutung R 1 , R 2 unabhängig H oder C 1-20 -Kohlenwasserstoffrest, der ein- oder mehrfach durch C 1-6 -Alkyl substituiert und/oder von nicht benachbarten Heteroatomen unterbrochen sein und/oder C-C-Doppel- oder Dreifachbindungen enthalten kann, durch Umsetzung von Verbindungen der allgemeinen Formel (II)R 1 -C(=O)-R 2 mit Acetylen in einem polar aprotischen Lösungsmittel wird in Gegenwart von basischen Alkalimetallsalzen als Katalysatoren durchgeführt.

6. 发明公开

EP0285755A3 Verfahren zur Herstellung von Alkindiolen durch Umsetzung von Ketonen mit Acetylen 失效
标题翻译：通过乙烯与乙烯的反应制备碱性二醇的方法
公开(公告)号：EP0285755A3
公开(公告)日：1990-05-09
申请号：EP88101430.2
申请日：1988-02-02
申请人： HÜLS AKTIENGESELLSCHAFT
发明人： Thelen, Gerhard, Dr.
IPC分类号： C07C33/044 , C07C29/42
CPC分类号： C07C33/044 , C07C29/42
摘要： Alkindiole werden durch Umsetzung von Ketonen mit Acetylen in Gegenwart einer Base erhalten, bisher in organischen Lösemitteln wie Acetaldehyddibutylacetal, Methylal, Dioxan, Diisopropylether, Tetrahydrofuran oder Kohlenwasserstoffen. Meist sind diese Suspensionen sehr viskos. Zudem ist der Umsatz des Ketons im allgemeinen unvollständig. Durch Verwendung von Alkyl-tert.-butylether, vorzugsweise Methyl-tert.-butylether, als Lösemittel beseitigt man die Nachteile und erhält bei guten Umsätzen hohe Ausbeuten. Herstellung von 2.4.7.9-Tetramethyldec-5-in-4.7-diol, 2.5.8.11-Tetramethyldodec-6-in-5,8-diol

7. 发明公开

EP0285755A2 Verfahren zur Herstellung von Alkindiolen durch Umsetzung von Ketonen mit Acetylen 失效
标题翻译： Verfahren zur Herstellung von Alkindiolen durch Umsetzung von Ketonen mit Acetylen。
公开(公告)号：EP0285755A2
公开(公告)日：1988-10-12
申请号：EP88101430.2
申请日：1988-02-02
申请人： HÜLS AKTIENGESELLSCHAFT
发明人： Thelen, Gerhard, Dr.
IPC分类号： C07C33/044 , C07C29/42
CPC分类号： C07C33/044 , C07C29/42
摘要： Alkindiole werden durch Umsetzung von Ketonen mit Acetylen in Gegenwart einer Base erhalten, bisher in organischen Lösemitteln wie Acetaldehyddibutylacetal, Methylal, Dioxan, Diisopropylether, Tetrahydrofuran oder Kohlenwasserstoffen. Meist sind diese Suspensionen sehr viskos. Zudem ist der Umsatz des Ketons im allgemeinen unvollständig.
Durch Verwendung von Alkyl-tert.-butylether, vorzugsweise Methyl-tert.-butylether, als Lösemittel beseitigt man die Nachteile und erhält bei guten Umsätzen hohe Ausbeuten.
Herstellung von 2.4.7.9-Tetramethyldec-5-in-4.7-diol, 2.5.8.11-Tetramethyldodec-6-in-5,8-diol
摘要翻译：在碱的存在下，通过酮与乙炔的反应获得炔基二醇，其先前在有机溶剂如乙醛二丁基缩醛，甲缩醛，二恶烷，二异丙基醚，四氢呋喃或烃中进行。在大多数情况下，这些悬浮液是高度粘稠的。此外，酮的转化通常是不完全的。使用烷基叔丁基醚，优选甲基叔丁基醚作为溶剂消除了缺点，并且与高转化率相结合产生高产率。 ...制备2,4,7,9-四甲基癸-5-炔-4,7-二醇，2,5,8,11-四甲基十二碳-6-炔-5,8-二醇。

8. 发明公开

EP3958989A1 NONFLUORINATED AGENT FOR LIQUID VEHICLE SYSTEMS 审中-公开
公开(公告)号：EP3958989A1
公开(公告)日：2022-03-02
申请号：EP20796223.4
申请日：2020-04-09
申请人： Tyco Fire Products LP
发明人： ZABRONSKY, Katherine L.
IPC分类号： A62D1/02 , A62D1/00 , C07C31/22 , C07C51/02 , C07C33/044

9. 发明公开

EP2459510A1 HYDROXY FATTY ACID COMPOUNDS AND USES THEREOF FOR DISEASE TREATMENT AND DIAGNOSIS 审中-公开
标题翻译：氢氧化物脂肪酸组合物及其应用治疗疾病和诊断
公开(公告)号：EP2459510A1
公开(公告)日：2012-06-06
申请号：EP10803779.7
申请日：2010-07-29
申请人： Phenomenome Discoveries Inc.
发明人： RITCHIE, Shawn , GOODENOWE, Dayan , KHAN, M. Amin , AHIAHONU, Pearson W. K.
IPC分类号： C07C59/42 , A61K31/202 , A61P29/00 , A61P35/00 , C07C33/044 , C07C51/00 , C07C69/606 , C07C69/65 , C07C69/732 , C07F7/18 , G01N33/50
CPC分类号： A61K31/202 , C07C33/048 , C07C59/42 , C07C67/303 , C07C67/347 , C07C69/606 , C07C69/65 , C07C69/732 , G01N33/57407 , G01N33/57419 , G01N33/6893 , G01N2800/24 , A61K2300/00
摘要： A compound of formula (I): wherein R represents a hydroxy substituted C
24 - C
40 straight chain aliphatic group containing at least one double bond in the carbon chain; and at least one carbon in the chain is substituted with a hydroxy group. Such compounds are useful for detecting inflammation, inflammatory disorders and cancer in a subject, and can also be used in therapeutic applications including treatment and/or prevention of these conditions. Pharmaceutical compositions, combinations and supplements, as well as methods of treatment using the described compounds are therefore also described.

10. 发明公开

EP1808426A1 Process for the preparation of alkynediols 审中-公开
标题翻译： Verfahren zur Herstellung von Alkindiolen
公开(公告)号：EP1808426A1
公开(公告)日：2007-07-18
申请号：EP06000825.7
申请日：2006-01-16
申请人： DSM IP Assets B.V.
发明人： Bonrath, Walter. , Gloor, Arnold. , Pace, Francesco.
IPC分类号： C07C29/42 , C07C33/044 , C11D3/20 , B01F17/38
CPC分类号： C11D3/2041 , B01F17/0021 , C07B2200/09 , C07C29/42 , C07C33/044 , C07C33/048
摘要： The present invention relates to a novel process for the manufacture of alkinediols of the formula I

wherein ketones of the formula II

are reacted with alkinols of the formula III

in liquid ammonia in the presence of potassium hydroxide, wherein R 1 and R 3 are independently from each other a linear, branched or cyclic C 2-25 -carbon-hydrogen moiety, optionally containing 1 to 10 non-conjugated double-bond(s), and R 2 and R 4 are independently from each other linear C 1-4 -alkyl.
The present invention also refers to the novel use of the alkindiols as emulgator, surfactant, dispersant, anti-foaming non-ionic agent, viscosity stabilizer, antistatic lubricant in the spinning of fibres, solvent, flavour, fragrance, wetting agent, sealing material or intermediate thereof and to the following novel alkindiols: 4,7-dihydroxy-2,4,7,9-tetramethyl-5-decine, 10, 13-dihydroxy-2,6,10,13,17,21-hexamethyl-11-docosine and 14, 17-dihydroxy-2,6,10,14,17,21,25,29-octamethyl-15-triacontine.
摘要翻译：本发明涉及一种用于制备式I的链烷醇的新方法，其中式II的酮在氢氧化钾存在下，在液氨中与式III的链醇反应，其中R 1和R 3独立地为彼此是任选含有1-10个非共轭双键的直链，支链或环状的C 2-25-碳 - 氢部分，R 2和R 4彼此独立地为直链C 1-4 - 烷基。本发明还涉及在纤维纺丝，溶剂，风味剂，香料，润湿剂，密封材料或纤维的纺丝中的烷二醇作为增效剂，表面活性剂，分散剂，消泡非离子剂，粘度稳定剂，抗静电润滑剂的新用途中间体和下列新的烷二醇：4,7-二羟基-2,4,7,9-四甲基-5-癸胺，10,13-二羟基-2,6,10,13,17,21-六甲基-11 - 二肌苷和14,17-二羟基-2,6,10,14,17,21,25,29-八甲基-15-三烯酮。

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