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1. 发明授权

EP2245123B1 METHODS FOR PRODUCING ALKYLATED 1,3 BENZENEDIAMINE COMPOUNDS 有权
标题翻译：生产烷基化1,3-苯二胺化合物的方法
公开(公告)号：EP2245123B1
公开(公告)日：2017-07-19
申请号：EP08860711.4
申请日：2008-12-01
申请人： Chemtura Corporation
发明人： STIEBLER, Joseph, F. , PRATT, Clifford, M. , ABBOTT, Ronald, D. , ROWLAND, Robert, G.
IPC分类号： C07C209/24 , C09K15/18 , C09K15/30 , C10M177/00 , C07C211/51
CPC分类号： C10L1/223 , C07C209/24 , C07C211/51 , C09K15/18 , C09K15/30 , C10L10/00 , C10L10/04 , C10M133/12 , C10M133/40 , C10M177/00 , C10M2215/066 , C10M2215/221 , C10N2230/10 , C10N2240/04 , C10N2240/08 , C10N2240/10 , C10N2240/30 , C10N2270/00

2. 发明公开

EP2548868A4 METHOD AND PROCESS FOR PREPARATION AND PRODUCTION OF DEUTERATED -DIPHENYLUREA 有权
标题翻译：用于生产氘化OMEGA二苯基脲
公开(公告)号：EP2548868A4
公开(公告)日：2015-07-08
申请号：EP11755684
申请日：2011-03-17
申请人： SUZHOU ZELGEN BIOPHARMACEUTICAL CO LTD
发明人： FENG WEIDONG , GAO XIAOYONG , DAI XIAOJUN
IPC分类号： C07D213/81 , A61K31/44 , A61K51/04 , A61P35/00 , C07B59/00 , C07C209/24 , C07C275/30 , C07D209/48 , C07D213/68
CPC分类号： A61K51/0455 , C07B59/002 , C07C209/24 , C07D209/48 , C07D213/68 , C07D213/81
摘要： Methods and processes for preparation and production of deuterated É-diphenylurea are disclosed. Especially, a kind of deuterated É-diphenylurea compounds which can inhibit phosphokinase and the preparation method of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N- d3 -methylcarbamoyl)-4-pridinylox y)phenyl)urea are disclosed. The said deuterated diphenylurea compounds can be used for treating or preventing tumors and relative diseases.

3. 发明授权

EP1421055B1 METHODS FOR THE SYNTHESIS OF AMINES SUCH AS EPHEDRINE AND INTERMEDIATES 有权
标题翻译：方法合成麻黄素一样和中间体胺
公开(公告)号：EP1421055B1
公开(公告)日：2008-04-09
申请号：EP02764370.9
申请日：2002-08-26
申请人： Victoria University
发明人： SMALLRIDGE, Andrew, John , TREWHELLA, Maurice, Arthur , WILKINSON, Kylie, Anne
IPC分类号： C07C209/24
CPC分类号： C07C213/02 , C07C209/26 , C07C249/02 , C07C2601/14 , Y02P20/544 , C07C211/17 , C07C211/27 , C07C211/29 , C07C215/30 , C07C215/60
摘要： A method for the preparation of a compound of formula (VI): in which R2 is an optionally substituted C1-C6 alkyl; R4 is H, OH, an optionally substituted C1-C6 alkyl or an optionally substituted C1-C6 alkoxy; R5 is an optionally substituted aryl, an optionally substituted aralkyl, or an optionally substituted alkyl; and R6 is H or an optionally substituted C1-C6 alkyl; the method including the step of subjecting a ketone of formula (V) in which R2, R4 and R5 are as defined above, to reductive animation with an amine of formula R3NH2 in which R3 is an optionally substituted alkyl, and a reductant to form the compound of formula (VI), wherein the reaction is conducted in the presence of a supercritical fluid or a liquefied gas.

4. 发明公开

EP1458668A4 PROCESS FOR PREPARING TERBINAFINE AND HCI SALT THEREOF 审中-公开
标题翻译：用于生产特比萘芬及其HCl盐
公开(公告)号：EP1458668A4
公开(公告)日：2005-02-02
申请号：EP02793522
申请日：2002-12-26
申请人： YUHAN CORP LTD
发明人： LEE TAI-AU , WANG KYU-JUNG , KIM HONG-BAE , KWON KYOUNG-CHAN , KU CHANG-HOE
IPC分类号： C07C209/24 , C07C209/28 , C07C211/30
CPC分类号： C07C209/28 , C07C211/30
摘要： Provided are a process for preparing terbinafine or its HCl salt, which comprises: (a) reacting a furan derivative with a base; (b) performing a reductive alkylation of the resulting compound obtained in the step (a) with N-methyl-1-naphthalenemethylamine or its HCl salt; and (c) purifying the resulting compound obtained in the step (b).

5. 发明公开

EP0446554A1 Preparation of a N-substituted phenylenediamine 失效
标题翻译： Herstellung eine N-取代的苯基。
公开(公告)号：EP0446554A1
公开(公告)日：1991-09-18
申请号：EP90630234.4
申请日：1990-12-18
申请人： THE GOODYEAR TIRE & RUBBER COMPANY
发明人： Cottmann, Kirkwood Storer
IPC分类号： C07C209/24 , C07C213/02 , C07C217/08 , C07C211/55
CPC分类号： C07C209/24 , C07C249/02
摘要： The present invention relates to a process for the preparation of a N-substituted phenylenediamine of the formula:

comprising reacting N-phenylquinoneimine of the formula:

with a primary amine of the formula:

R-NH₂ (III)

,

wherein the molar ratio of II to III in the reaction mixture ranges from about 1:1 to 1:10; and wherein R is selected from the group of radicals consisting of alkyls having 1 to 20 carbon atoms, cycloalkyls having 6 to 8 carbon atoms and radicals of the structural formula:

wherein R² may be the same or different and is independently selected from the group of radicals consisting of hydrogen and an alkyl having 1 carbon atom, R³ is selected from the group of radicals consisting of an alkyl having 1 to 12 carbon atoms and n is an integer of from 0 to 6. The present process is characterized by its excellent yields of high purity N-substituted phenylenediamines.
摘要翻译：本发明涉及制备下式的N-取代苯二胺的方法：包括使下式的N-苯基醌亚胺与下式的伯胺反应：式中：R-NH 2（III），其中反应混合物中II与III的摩尔比为约1:1至1:10; 并且其中R选自具有1至20个碳原子的烷基，具有6至8个碳原子的环烷基和具有以下结构式的基团的基团：CHEM，其中R 2可以相同或不同，并且为独立地选自氢和具有1个碳原子的烷基组成的基团，R 3选自由具有1至12个碳原子的烷基和n是0至6的整数组成的基团。本发明方法的特征在于其高纯度N-取代苯二胺的优异产率。

6. 发明授权

EP0162891B1 Mixture of amines and process for producing it 失效
标题翻译：氨基酸和其生产工艺的混合物
公开(公告)号：EP0162891B1
公开(公告)日：1990-05-23
申请号：EP84904252.8
申请日：1984-11-02
申请人： MONSANTO COMPANY
发明人： FORSTER, Denis
IPC分类号： C07C2/34 , C07C2/24 , C07C45/50 , C07C45/45 , C07C45/63 , C07C209/24 , C07C211/08 , C07C211/62 , C07C239/08
CPC分类号： D06M13/388 , C07C45/50 , C07C45/74 , C07C47/21 , C07C209/26 , C07C291/04 , C11D1/40 , C07C47/02
摘要： Novel isomeric amine mixtures, characterized by amines with N-alkyl groups in the C10-C18 range with a main branch at the 2-position and moderate additional branching in most isomers. The amines are produced from lower olefins by a series of oxo, aldol and reductive amination reactions. The amines and their oxide and quaternary ammonium salt derivatives are of interest in surfactant uses.

7. 发明公开

EP0233510A1 Verfahren zur Herstellung von Di-tert.-butyl-ethylendiamin 失效
标题翻译：一种用于二叔丁基乙二胺的制备方法。
公开(公告)号：EP0233510A1
公开(公告)日：1987-08-26
申请号：EP87101006.2
申请日：1987-01-24
申请人： BASF Aktiengesellschaft
发明人： Müller, Herbert, Dr. , Mesch, Walter, Dr.
IPC分类号： C07C211/10 , C07C209/24 , C07C209/26
CPC分类号： C07C209/26
摘要： Es wird vorgeschlagen, ein Verfahren zur Herstellung von Di-tert.-butyl-ethylendiamin durch Umsetzung von tert.-Butylamin mit Glyoxal unter Bildung von Di-tert.-butyl-glyoxaldiimin und Wasser und ausschließende Hydrierung des Diimins, das dadurch gekennzeichnet ist, daß man

(a) die Umsetzung des tert.-Butylamins mit dem Glyoxal in Gegenwart einer Kohlenwasserstoffphase durchführt,
(b) den Kohlenwasserstoff mit dem Umsetzungsprodukt von Wasser abtrennt, und
(c) das Umsetzungsprodukt in der Kohlenwasserstoffphase katalytisch hydriert.
摘要翻译：它提出了一种用于通过叔丁胺与乙二醛反应，以形成二亚胺，其特征在于二 - 叔丁基 - glyoxaldiimin和水及专用加氢制备二 - 叔丁基 - 乙二胺的方法，该方法包括：进行（a）用乙二醛的叔丁胺的反应中的烃相的存在，（b）分离与水的反应产物中的烃，和（c）氢化的反应产物在烃相中催化。

8. 发明公开

EP3848378A1 TETRADENTATE DIAMINODIPHOSPHINE LIGAND AND TRANSITION METAL COMPLEX, AND METHOD FOR MANUFACTURING SAME AND APPLICATION FOR SAME 审中-实审
公开(公告)号：EP3848378A1
公开(公告)日：2021-07-14
申请号：EP19858384.1
申请日：2019-09-03
申请人： Takasago International Corporation
发明人： FUNANE, Shigeru
IPC分类号： C07F9/50 , B01J31/24 , C07C29/149 , C07C33/22 , C07C45/29 , C07C47/54 , C07C67/00 , C07C69/78 , C07C209/24 , C07F9/576 , C07B61/00 , C07F15/00
摘要： The present invention relates to a transition metal complex having a PNNP4 ligand, which is easy to manufacture and handle and is relatively inexpensively available, and a method for manufacturing the same, as well as a method using this transition metal complex as a catalyst for hydrogenation reduction of ketones, esters and amides to manufacture corresponding alcohols, aldehydes, hemiacetals and hemiaminals, a method using this transition metal complex as a catalyst for oxidation of alcohols, hemiacetals and hemiaminals to manufacture corresponding carbonyl compounds, and a method using this transition metal complex as a catalyst for dehydrogenation condensation between alcohols and amines to manufacture alkylamines.

9. 发明授权

EP2321255B1 AMINIC ANTIOXIDANTS 有权
标题翻译：氨基抗氧化剂
公开(公告)号：EP2321255B1
公开(公告)日：2016-05-04
申请号：EP09789740.9
申请日：2009-06-02
申请人： Chemtura Corporation
发明人： NALESNIK, Theodore, E.
IPC分类号： C07C209/24 , C07C211/50 , C09K15/18 , C10M133/12
CPC分类号： C07C209/24 , C07C211/50 , C08K5/17 , C09K15/18 , C10L1/223 , C10L10/00 , C10M133/12 , C10M141/06 , C10M141/08 , C10M141/10 , C10M2201/065 , C10M2201/066 , C10M2207/026 , C10M2207/281 , C10M2215/06 , C10M2215/064 , C10M2215/066 , C10M2215/08 , C10M2219/022 , C10M2219/066 , C10M2219/087 , C10M2219/108 , C10M2223/045 , C10M2223/047 , C10N2220/022 , C10N2230/10 , C10N2230/42 , C10N2240/04 , C10N2240/08 , C10N2240/10 , C10N2240/30 , C10N2270/02 , C08L21/00 , C10N2210/06 , C10N2210/02

10. 发明公开

EP2706063A4 RUTHENIUM-DIAMINE COMPLEX AND METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG OPTISCH SUMMVER VERBINDUNGEN RUTHENIUM-DIAMIN-KOMPLEX
公开(公告)号：EP2706063A4
公开(公告)日：2015-03-25
申请号：EP12782585
申请日：2012-05-02
申请人： TAKASAGO PERFUMERY CO LTD
发明人： TOUGE TAICHIRO , HAKAMATA TOMOHIKO , NARA HIDEKI
IPC分类号： C07F15/00 , B01J31/18 , B01J31/22 , C07B53/00 , C07C29/143 , C07C33/18 , C07C33/20 , C07C33/22 , C07C33/34 , C07C33/46 , C07C35/28 , C07C41/26 , C07C43/23 , C07C209/24 , C07C209/52 , C07C211/42 , C07D311/22
CPC分类号： C07F15/0046 , B01J31/1805 , B01J31/2282 , B01J2231/643 , B01J2531/0205 , B01J2531/0216 , B01J2531/821 , C07B53/00 , C07B2200/07 , C07C29/143 , C07C41/26 , C07C209/52 , C07C2602/12 , C07D311/22 , C07C43/23 , C07C33/20 , C07C33/18 , C07C33/34 , C07C33/22 , C07C33/46 , C07C35/23

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