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    • 1. 发明授权
    • PROCESS FOR THE PREPARATION OF AMINES
    • 胺的制备方法
    • EP1963251B1
    • 2012-08-15
    • EP06829477.6
    • 2006-12-11
    • Syngenta Participations AG
    • TOBLER, HansWALTER, HaraldCORSI, CamillaEHRENFREUND, JosefGIORDANO, FannyZELLER, Martin
    • C07C17/23C07C23/10C07C17/354C07C25/22C07C17/30C07C25/24C07C209/10C07C209/62C07C209/70C07C211/61
    • C07C209/62C07B2200/09C07C17/23C07C17/30C07C17/354C07C25/22C07C25/24C07C209/10C07C209/70C07C211/61C07C2603/66C07C23/10
    • The present invention relates to a novel a process for the preparation of the compound of the general formula (I), wherein R1 and R2 are independently H or C1-6 alkyl, which comprises treating with a reducing agent either a compound of the general formula (II), wherein R1 and R2 have the meanings given for the compound of the formula (I), R3 is H or C1-4alkyl and Ph is phenyl, or a compound of the general formula (III), wherein R1, R2, R3 and Ph have the meanings given for the compound of the formula (II), the reducing agent being effective to cleave the benzyl moiety Ph-CH(R3)- from the benzylamino moiety PhCH(R3)NH- in the compound of the formula (II) or in the compound of the formula (III) to leave an amino group and, in addition, in the case of the compound of the formula (III), to reduce both the 2,3-double bond and the double bond joining the R1R2C- moiety to the 9-position of the benzonorbornene ring to single bonds. It also relates to processes for the preparation of the compounds (II) and (III) and their precursors and to the compounds (II) and (III) themselves and certain of their precursors, which are novel compounds. The compounds (I) are useful for the preparation of various fungicidal heterocyclyl-carboxylic acid benzonorbornen-5-yl-amides.
    • 本发明涉及一种制备通式(I)化合物的方法,其中R 1和R 2独立地为H或C 1-6烷基,该方法包括用还原剂处理通式 (II)化合物,其中R1和R2具有对式(I)化合物给出的含义,R3是H或C1-4烷基,Ph是苯基或通式(III)的化合物,其中R1,R2, R3和Ph具有式(II)化合物的含义,该还原剂能有效地从苄基氨基部分PhCH(R3)NH-上裂解苄基部分Ph-CH(R3) - 在式 (II)化合物或在式(III)化合物中留下氨基,另外,在式(III)化合物的情况下,还原2,3-双键和双键 将R1R2C-部分连接至苯并降冰片烯环的9-位成为单键。 它还涉及制备化合物(II)和(III)及其前体和化合物(II)和(III)本身及其某些前体(它们是新化合物)的方法。 化合物(I)可用于制备各种杀真菌的杂环基 - 羧酸苯并降冰片烷-5-基 - 酰胺。