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1. 发明公开

EP1565483A2 NEW BIOPOLYMERS OBTAINED BY SOLID STATE IRRADIATION IN AN UNSATURATED GASEOUS ATMOSPHERE 审中-公开
标题翻译：由不饱和固态辐射气体环境有了新的生物聚合物
公开(公告)号：EP1565483A2
公开(公告)日：2005-08-24
申请号：EP02735796.1
申请日：2002-03-12
申请人： SAN-EI GEN F.F.I., INC.
发明人： PHILLIPS,Glyn Owen , DU PLESSIS, Tiaart Andries , AL-ASSAF, Saphwam , WILLIAMS, Peter Anthony
IPC分类号： C07K1/00 , C08F2/46 , C08H1/00 , C08J3/28
CPC分类号： C08B37/0009 , C08B11/20 , C08B37/00 , C08B37/006 , C08B37/0087 , C08H1/06 , Y10S530/827 , Y10S530/832 , Y10S530/839 , Y10S530/84 , Y10S530/841 , Y10S530/842
摘要： Disclosed is a method for modifying naturally occuring biocompatible biopolymers of plant and animal origin by subjecting same to ionizing radiation in the presence of a mediating gas, typically acetylene to enable one to selectively enhance and modify one or more of the physiochemical properties of the starting materials which have a wide range of uses in medicine, food technology and other industrial applications. Notwithstanding the modifications, the biocompatibility of the biopolymer remains unchanged and no new or additional functional groups are introduced into the starting biopolymer.

2. 发明公开

EP1557431A1 Assay and reagents for quantifying hBNP 失效
标题翻译： Testverfahren und Reagenzien zur Quantifizierung von hbnp
公开(公告)号：EP1557431A1
公开(公告)日：2005-07-27
申请号：EP05007745.2
申请日：1997-03-04
申请人： SCIOS INC.
发明人： Mischak, Ronald P. , Lim, Garret A. , Scardina, Jan Marian
IPC分类号： C07K16/26 , G01N33/577 , C07K14/58
CPC分类号： C07K14/58 , C07K16/26 , C07K2317/34 , Y10S530/839 , Y10S530/841
摘要： The invention relates to an in vitro method of diagnosing congestive heart disease by quantifying hBNP in a sample. The method comprises: contacting a sample of the biological fluid with a first antibody, wherein the first antibody is monospecifically reactive to an hBNP fragment; forming a complex comprising hBNP in the biological fluid, the first antibody and a second antibody, wherein the second antibody is immunoreactive with hBNP or the first antibody, and wherein the second antibody comprises a label; and determining the amount of hBNP in the sample by quantifying the label in the complex.
摘要翻译：本发明涉及通过定量样品中的hBNP来诊断充血性心脏病的体外方法。该方法包括：使生物流体的样品与第一抗体接触，其中第一抗体与hBNP片段具有一体反应性; 在所述生物流体中形成包含hBNP的复合物，所述第一抗体和第二抗体，其中所述第二抗体与hBNP或所述第一抗体具有免疫反应性，并且其中所述第二抗体包含标记物; 并通过量化复合物中的标记来确定样品中hBNP的量。

3. 发明授权

EP0167575B2 CARDIODILATIN, NEUES PEPTIDHORMON UND VERFAHREN ZU SEINER HERSTELLUNG 失效
标题翻译： Cardiodilatin，新的肽类激素及其制造方法
公开(公告)号：EP0167575B2
公开(公告)日：1999-10-27
申请号：EP85900447.5
申请日：1984-12-21
申请人： FORSSMANN, Wolf-Georg, Prof. Dr. med.
发明人： FORSSMANN, Wolf-Georg
IPC分类号： C07K14/58 , C07K7/08 , A61K38/17
CPC分类号： C07K14/58 , A61K38/00 , G01N33/74 , Y10S530/841
摘要： New peptide hormone (cardiodilatine) and production process. Its amino acid sequence is as follows: Asn-Pro-Val-Tyr-Gly-Ser-Val-Ser-Asn-Ala-Asp-Leu-Met-Asp-Phe-Lys-Asn-Leu-Leu-Asp-His-leu-Glu-Asp-Lys-Met-Pro-Leu-Glu-Asp-GLu-Ala-Met-Pro-Pro-Gln-Val-Leu-Ser-Glu-Gln-Asp-Glu-Val-Leu-Ser-Glu-Gln-Asn-Glu-Glu-Val-Gly-Ala-Pro-Leu-Pro-Leu-Leu-Glu-Glu-Val-Pro-Pro-Trp-Thr-Gly-Glu-Val-Asn-Pro. Its composition is as follows: Asp/Asn 14, Thr 3, Ser 15, Glu/Gln 12, Pro 10, Gly 12, Ala 10, Val 7, Met 4, Ile 1, Leu 15, Tyr 2, Phe 3, Lys 4, His 2, Arg 10, Trp 2. It has a molecular weight of 13,000 daltons and an isoelectric point from 6 to 6.5. This peptide hormone, as well as its C-termination fragments obtained by partial bromcyan separation between the Met groups and behind the latter, has a strong relaxation activity on smooth vasomuscles.

4. 发明授权

EP0009715B1 Neues ubiquitäres Gewebsprotein PP8 und Verfahren zu seiner Anreicherung 失效
标题翻译： UBIQUITARY组织蛋白PP8及其制备方法
公开(公告)号：EP0009715B1
公开(公告)日：1982-06-16
申请号：EP79103517.3
申请日：1979-09-19
申请人： BEHRINGWERKE Aktiengesellschaft
发明人： Bohn, Hans, Dr.
IPC分类号： C07G7/00 , G01N33/48
CPC分类号： C07K14/4715 , A61K39/00 , C07K16/18 , Y10S530/806 , Y10S530/834 , Y10S530/836 , Y10S530/838 , Y10S530/839 , Y10S530/841 , Y10S530/844 , Y10S530/846 , Y10S530/848 , Y10S530/851 , Y10S530/854

5. 发明公开

EP0009715A1 Neues ubiquitäres Gewebsprotein PP8 und Verfahren zu seiner Anreicherung 失效
标题翻译：新的无处不在的组织蛋白PP8和富集的方法。
公开(公告)号：EP0009715A1
公开(公告)日：1980-04-16
申请号：EP79103517.3
申请日：1979-09-19
申请人： BEHRINGWERKE Aktiengesellschaft
发明人： Bohn, Hans, Dr.
IPC分类号： C07G7/00 , G01N33/48
CPC分类号： C07K14/4715 , A61K39/00 , C07K16/18 , Y10S530/806 , Y10S530/834 , Y10S530/836 , Y10S530/838 , Y10S530/839 , Y10S530/841 , Y10S530/844 , Y10S530/846 , Y10S530/848 , Y10S530/851 , Y10S530/854
摘要： Es wird ein neues lösliches Gewebsprotein (PP 8 ) und ein Verfahren zu seiner Herstellung aus manschlichen Organen beschrieben. Das Protein hat antigene Eigenschaften. Bei Erkrankungen, die mit Gewebszerfall verbunden sind, ist es in erhöhter Konzentration im Blut nachweisbar.
摘要翻译：本发明公开了一种新颖的可溶性组织蛋白（PP8）和用于从manschlichen器官及其制备方法。该蛋白具有抗原性。在与组织破坏有关的疾病，它是在升高的浓度在血液中检测到。

6. 发明公开

EP2292662A3 Assay and reagents for quantifying hBNP 失效
标题翻译：试验方法和试剂HBNP的量化
公开(公告)号：EP2292662A3
公开(公告)日：2011-07-13
申请号：EP10013178.8
申请日：1997-03-04
申请人： SCIOS INC.
发明人： Mischak, Ronald P. , Lim, Garret A. , Scardina, Jan Marian
IPC分类号： C07K16/26 , G01N33/577 , C07K14/58 , C07K7/00
CPC分类号： C07K14/58 , C07K16/26 , C07K2317/34 , Y10S530/839 , Y10S530/841
摘要： The invention relates to an in vitro method of diagnosing congestive heart disease by quantifying hBNP in a sample. The method comprises: contacting a sample of the biological fluid with a first antibody, wherein the first antibody is monospecifically reactive to an hBNP fragment; forming a complex comprising hBNP in the biological fluid, the first antibody and a second antibody, wherein the second antibody is immunoreactive with hBNP or the first antibody, and wherein the second antibody comprises a label; and determining the amount of hBNP in the sample by quantifying the label in the complex.

7. 发明公开

EP2172776A1 Method to diagnose heart muscle damage 失效
标题翻译： Verfahren zur Bestimm Hertz-Muskel-Schaden
公开(公告)号：EP2172776A1
公开(公告)日：2010-04-07
申请号：EP09016084.7
申请日：1997-12-15
申请人： Biosite Incorporated
发明人： Buechler, Kenneth F. , McPherson, Paul H.
IPC分类号： G01N33/68 , G01N33/545 , G01N33/543
CPC分类号： G01N33/54366 , G01N33/6887 , G01N33/6893 , G01N2333/4712 , G01N2800/32 , G01N2800/324 , Y10S435/96 , Y10S435/962 , Y10S435/975 , Y10S436/808 , Y10S436/811 , Y10S436/824 , Y10S530/81 , Y10S530/811 , Y10S530/829 , Y10S530/83 , Y10S530/841
摘要： A method for the diagnosis of heart muscle damage comprising:
using an immunoassay system to determine the amount of cardiac troponin I in a blood, plasma, or serum sample supspected of containing troponin from damaged heart muscle, said system comprising (a) formation of an antibody conjugate comprising an antibody coupled to a signal generating element, said antibody being capable of specifically binding to cardiac specific regions of the troponin I complexes and of unbound troponin I, (b) formation of a reaction mixture comprising said whole blood, plasma or serum sample incubated with said antibody conjugate, (c) application of said reaction mixture to a surface to which is bound at least one capture antibody capable of specifically binding to cardiac specific regions of troponin I, said capture antibody binding said antibody conjugate, whereby the immobilized conjugate produces a detectable signal upon formation of sandwich complexes, and (d) relating of the detectable signal to the amount of cardiac troponin I present in said sample, wherein said antibody is insensitive with respect to the free troponin I and cardiac troponin I complexed with troponin C and troponin T, i.e. yields an assay response for said free and complexed forms of cardiac troponin I that is the same within a factor of 2; and
relating the amount of cardiac troponin I present in said sample to the occurrence or non-occurrence of heart muscle damage.
摘要翻译：一种用于诊断心脏肌肉损伤的方法，包括：使用免疫测定系统来测定血液，血浆或血清样品中含有肌钙蛋白的损伤心脏肌肉中肌钙蛋白I的量，所述系统包括（a）形成抗体结合物，其包含与信号产生元件偶联的抗体，所述抗体能够特异性结合肌钙蛋白I复合物和未结合的肌钙蛋白I的心脏特异性区域，（b）形成包含所述全血，血浆或血清的反应混合物样品与所述抗体缀合物孵育，（c）将所述反应混合物施用于结合有至少一种能够特异性结合肌钙蛋白I的心脏特异性区域的捕获抗体的表面，所述捕获抗体结合所述抗体缀合物，由此固定化共轭物在形成夹心复合物时产生可检测的信号，和（d）将可检测信号与t相关他存在于所述样品中的心肌肌钙蛋白I的量，其中所述抗体相对于与肌钙蛋白C和肌钙蛋白T复合的游离肌钙蛋白I和心肌肌钙蛋白I不敏感，即产生所述游离和复合形式的心肌肌钙蛋白I的测定响应在2的范围内是相同的; 并将所述样品中存在的心肌肌钙蛋白I的量与心肌损伤的发生或不发生相关联。

8. 发明公开

EP2102357A1 LTBP2 AS A BIOMARKER, THERAPEUTIC AND DIAGNOSTIC TARGET 有权
标题翻译： LTBP2作为生物标志物，治疗和诊断TARGET
公开(公告)号：EP2102357A1
公开(公告)日：2009-09-23
申请号：EP07818638.4
申请日：2007-10-02
申请人： Bayer Schering Pharma Aktiengesellschaft
发明人： GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT-KÜPPER, Barbara , KLEIN, Martina , STEPPAN, Sonja , ELLINGHAUS, Peter , D'URSO, Donatella , SEEWALD, Michael , MILTING, Hendrik
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , Y10S530/841
摘要： The invention provides LTBP2 which is associated with the cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of LTBP2 as well as pharmaceutical compositions comprising such compounds. The invention also provides LTBP2 as a biomarker for diseases as cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases and urological diseases

9. 发明公开

EP0783569A1 MONOCLONAL ANTIBODY TO HUMAN CARDIAC MYOGLOBIN 失效
标题翻译：单克隆抗体心脏的人肌红蛋白
公开(公告)号：EP0783569A1
公开(公告)日：1997-07-16
申请号：EP95931369.0
申请日：1995-09-28
申请人： SPECTRAL DIAGNOSTICS INC.
发明人： CARDONE, Beatrice , JACKOWSKI, George
IPC分类号： G01N33 , C07K16 , C12N5 , C12N15 , C12P21
CPC分类号： C07K16/18 , Y10S436/811 , Y10S530/809 , Y10S530/841
摘要： A monoclonal antibody having high affinity to human cardiac myoglobin, which has undergone a conformational change resulting from the binding of the molecule to another molecule is described. This monoclonal antibody can be used in a rapid format double antibody immunoassay system to identifiy blood, serum or plasma levels of cardiac myoglobin. Such an immunoassay system can be used for diagnosing and quantifying myocardial necrosis and infarction.

10. 发明公开

EP0672050A1 METHOD OF RECOVERING ENDOTHELIAL MEMBRANE FROM TISSUE AND APPLICATIONS THEREOF 失效
标题翻译：一种获得ENDOTHELMEMBRANE从面料及其用途。
公开(公告)号：EP0672050A1
公开(公告)日：1995-09-20
申请号：EP94908092.0
申请日：1993-08-10
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： SCHNITZER, Jan, E. 4019 Carmel View, , JACOBSON, Bruce, S. RFD 3
IPC分类号： G01N33 , A61K35 , C07K14 , G01N1
CPC分类号： A61K35/44 , Y10S436/813 , Y10S530/835 , Y10S530/837 , Y10S530/839 , Y10S530/841 , Y10S530/846 , Y10S530/849 , Y10S530/854 , Y10T436/24 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： The present invention provides methods for identifying molecular components (e.g. proteins and/or lipids) that are characteristic of vascular endothelia associated with a particular disease and are not also present in (i) normal (non-disease associated) vascular endothelia or (ii) non-disease associated vascular endothelia subjected to altered conditions that accompany the disease but are not unique to the disease. The methods include isolating plasma membrane fractions from disease-associated vascular endothelial cells, from normal (nondisease-associated) vascular endothelial cells and from nondisease-associated vascular endothelial cells subjected to at least one of the altered conditions; purifying and resolving molecular components from these membrane fractions; comparing the components resolved from each of the foregoing vascular endothelial cell sources and identifying components that are present in disease-associated endothelial cells and absent from the normal or otherwise conditioned endothelial cells. The resulting endothelial cell membrane components that are unique to the disease state can be used for diagnostic and/or therapeutic purposes.

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