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1. 发明授权

EP0801682B1 PROCESS FOR THE PRODUCTION OF PROTEINS 失效
标题翻译：工艺生产蛋白
公开(公告)号：EP0801682B1
公开(公告)日：2001-10-24
申请号：EP96900977.8
申请日：1996-01-26
申请人： Novartis AG , BEHRINGWERKE Aktiengesellschaft , Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.
发明人： MEYHACK, Bernd , BRÖKER, Michael
IPC分类号： C12N15/81 , C07K14/81 , C07K14/555
CPC分类号： C12N15/81 , C07K14/555 , C07K14/8132

2. 发明公开

EP0961783A1 POLYSACCHARIDE CONJUGATES OF BIOMOLECULES 失效
标题翻译：多糖和生物分子的结合物
公开(公告)号：EP0961783A1
公开(公告)日：1999-12-08
申请号：EP97937122.0
申请日：1997-08-08
申请人： BEHRINGWERKE Aktiengesellschaft , Mehta, Harshvardhan
发明人： MEHTA, Harshvardhan , SINGH, Rajendra
IPC分类号： A61K47 , C08B37
CPC分类号： C08B37/00 , A61K47/61 , C08B37/0021
摘要： Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method for introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.

3. 发明授权

EP0710360B1 HOMOGENEOUS IMMUNOASSAYS USING MUTANT GLUCOSE-6-PHOSPHATE DEHYDROGENASES 失效
标题翻译：均相免疫测定使用变异葡萄糖-6-磷酸脱氢酶
公开(公告)号：EP0710360B1
公开(公告)日：1999-11-10
申请号：EP94923147.6
申请日：1994-04-07
申请人： BEHRINGWERKE Aktiengesellschaft , GENENCOR INTERNATIONAL, INC.
发明人： JAKOBOVITS, Edward, B. , SILEN, Joy, L. , LEVY, Mark, J. , GOODMAN, Thomas, C. Research Corp. Techn. , BECKER, Martin, J. , ULLMAN, Edwin, F. , CALDWELL, Robert, M. , BOTT, Richard, R. , BARNETT, Christopher, Charles
IPC分类号： G01N33/542 , G01N33/573 , G01N33/53 , G01N33/58 , C12N9/04
CPC分类号： C12N9/0006 , C12Q1/28 , G01N33/535 , G01N33/56911 , G01N33/581 , G01N33/78 , G01N33/94 , G01N2333/904

4. 发明公开

EP0920532A1 DETECTION OF DIFFERENCES IN NUCLEIC ACIDS 失效
标题翻译：检测在DNA差异的
公开(公告)号：EP0920532A1
公开(公告)日：1999-06-09
申请号：EP96945386.0
申请日：1996-12-20
申请人： BEHRINGWERKE Aktiengesellschaft , Ullman, Edwin F.
发明人： ULLMAN, Edwin, F. , LISHANSKI, Alla , KURN, Nurith
IPC分类号： C12Q1
CPC分类号： C12Q1/6823 , C12Q1/6813 , C12Q1/6818 , C12Q1/6827 , Y10S435/808
摘要： A method is disclosed for detecting the presence of a difference between two related nucleic acid sequences. In the method a complex is formed comprising both strands of each sequence. Each member of at least one pair of non-complementary strands within the complex has labels. The association of the labels as part of the complex is determined as an indication of the presence of a difference between the two related sequences. The complex generally comprises a Holliday junction. In one aspect a medium suspected of containing said two related nucleic acid sequences is treated to provide partial duplexes having non-complementary tailed portions at one end. The double stranded portions of the partial duplexes are identical except for said difference. One of the strands of one of the partial duplexes is complementary to one of the strands of the other of the partial duplexes and the other of the strands of one of the partial duplexes is complementary to the other of the strands of the other of the partial duplexes. The medium is subjected to conditions that permit the binding of the tailed portions of the partial duplexes to each other. If there is a difference in the related nucleic acid sequences, a stable complex is formed comprising a Holliday junction. If no difference exists, the complex dissociates into duplexes. A determination is made whether the stable complex is formed, the presence thereof indicating the presence of the related nucleic acid sequences. The method has application in detecting the presence of a mutation in a target sequence or in detecting the target sequence itself.

5. 发明公开

EP0732102A3 Composite for the treatment of acute myocardial infarction containing hirudin and acetylsalicyclic acid 失效
标题翻译：包括急性心肌梗死的治疗和水蛭素Acetylsalicylsaüre装置
公开(公告)号：EP0732102A3
公开(公告)日：1999-01-27
申请号：EP96103821.3
申请日：1996-03-12
申请人： BEHRINGWERKE Aktiengesellschaft , BRIGHAM AND WOMEN'S HOSPITAL
发明人： Heinrichs, Hubert, Dr. , Hennekens, Charles H.
IPC分类号： A61K31/58
CPC分类号： A61K38/58 , A61K31/616 , A61K2300/00
摘要： The invention relates to the discovery that the administration of a combination of hirudin and acetylsalicylic Acid (ASA) to patients not undergoing treatment with any thrombolytic agent, inhibits and/or prevents myocardial or cardiovascular events in the patient. The invention further relates to the pharmaceutical combination of a platelet inactivating drug, acetylsalicylic acid, and a direct thrombin inhibitor, hirudin, for the treatment of patients with acute myocardial infarction who are not undergoing thrombolysis. A pharmaceutical composition comprising the synergistic combination of hirudin and ASA, in the absence of any thrombolytic agent, is particularly useful in the therapeutic and prophylactic methods of the invention.

6. 发明授权

EP0522875B1 Method for detecting candida infection 失效
标题翻译：一种用于检测念珠菌感染的方法
公开(公告)号：EP0522875B1
公开(公告)日：1999-01-13
申请号：EP92306371.3
申请日：1992-07-10
申请人： BEHRINGWERKE Aktiengesellschaft
发明人： Miyada, Charles Garrett , Switchenko, Arthur C , Quong, Melanie W. , Wong, Man-Ying Laurie
IPC分类号： C12N9/04 , C12Q1/32 , G01N33/573
CPC分类号： C12N9/0006 , C12P19/02 , Y10S435/81 , Y10S435/921 , Y10S435/924

7. 发明授权

EP0561183B1 Monoklonaler Anti-Gangliosid-Antikörper, seine Herstellung und Verwendung als Tumortherapeutikum 失效
标题翻译：单克隆抗神经节苷脂抗体，其生产和使用作为抗癌剂
公开(公告)号：EP0561183B1
公开(公告)日：1998-08-19
申请号：EP93102895.5
申请日：1993-02-25
申请人： BEHRINGWERKE Aktiengesellschaft
发明人： Bosslet, Klaus , Seemann, Gerhard , Dippold, Wolfgang
IPC分类号： C12P21/08 , A61K39/395 , C07K2/00
CPC分类号： C07K16/30 , A61K38/00 , C07K2317/24 , C07K2319/00

8. 发明授权

EP0423747B1 Glycosyl-Etoposid-Prodrugs, Verfahren zu ihrer Herstellung und ihre Anwendung in Kombination mit funktionalisierten tumorspezifischen Enzym-Konjugaten 失效
标题翻译：糖基 - 依托泊苷前药，它们的制备方法和它们的结合的官能化的肿瘤特异性酶缀合物使用
公开(公告)号：EP0423747B1
公开(公告)日：1998-07-22
申请号：EP90119886.1
申请日：1990-10-17
申请人： BEHRINGWERKE Aktiengesellschaft
发明人： Kolar, Cenek, Dr. , Czech, Jörg, Dr. , Bosslet, Klaus, Dr. , Seemann, Gerhard, Dr. , Sedlacek, Hans Harald, Dr.
IPC分类号： C07H17/04 , A61K31/70 , A61K39/395
CPC分类号： B82Y5/00 , A61K47/6899 , C07H17/04

9. 发明公开

EP0661383A3 Verfahren zur Bestimmung der Thrombozytenaggregation 失效
标题翻译：一种用于血小板聚集的测定方法。
公开(公告)号：EP0661383A3
公开(公告)日：1997-12-17
申请号：EP94119803.8
申请日：1994-12-15
申请人： BEHRINGWERKE Aktiengesellschaft
发明人： Reers, Martin, Dr.
IPC分类号： C12Q1/56 , G01N33/86
CPC分类号： C12Q1/56 , G01N33/86 , G01N2333/75 , G01N2333/974 , Y10S530/829 , Y10S530/83
摘要： Die Erfindung betrifft ein Verfahren zur Bestimmung der Thrombozytenaggregation in Gegenwart eines Hemmers der Fibrinaggregation, welcher die Bildung eines störenden Fibrinclots verhindert sowie ein Diagnostikum zur Bestimmung der thrombozytenaggregationshemmenden Wirkung von Thrombininhibitoren.

10. 发明授权

EP0536564B1 Verfahren zur Reinigung von Streptolysin 0, intaktes Streptolysin 0 erhältlich nach diesem Verfahren und seine Verwendung 失效
标题翻译：一种用于链球菌溶血素0的纯化方法中，完整的链球菌溶血素0通过该方法和其使用获得的
公开(公告)号：EP0536564B1
公开(公告)日：1997-07-16
申请号：EP92115737.6
申请日：1992-09-15
申请人： BEHRINGWERKE Aktiengesellschaft
发明人： Althaus, Harald , Merle, Peter
IPC分类号： C07K1/00 , C07K14/315 , A61K39/09
CPC分类号： C07K14/315 , A61K39/00 , Y10S435/885

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