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1. 发明公开

EP2264631A1 Method, device and computer program product for monitoring a subject 审中-公开
标题翻译： Verfahren，Vorrichtung und Computerprogrammprodukt zurÜberwachungeines Subjekts
公开(公告)号：EP2264631A1
公开(公告)日：2010-12-22
申请号：EP10164210.6
申请日：2010-05-28
申请人： General Electric Company
发明人： Sarkela, Mika
IPC分类号： G06F19/00
CPC分类号： G06F19/30 , A61B5/0476 , A61B5/72 , A61B5/7221 , A61B5/7235 , A61B5/743 , A61B2505/01 , A61B2505/03 , A61B2505/05 , G06F19/00 , G06F19/34 , G16H15/00 , G16H40/63 , G16H50/20 , G16H50/30 , Y10S128/923 , Y10S128/925
摘要： A method, device, and computer program product for monitoring the physiological state of a subject is disclosed. A first plurality of physiological signals are acquired from the subject and a second plurality of signal parameters are determined (31) based on the first plurality of physiological signals. Relevant signal information is selected (32) from among the signal information produced and at least one screen page is displayed at a time, thereby to make at least part of the signal information visible to a user. The signal information visible to the user on the at least one screen page may then be revised (33, 34) based on the selection and without user interaction, thereby to accelerate clinical decision-making and to diminish the possibility of undetected changes in the state of the subject.
摘要翻译：公开了一种用于监测对象的生理状态的方法，装置和计算机程序产品。从对象获取第一多个生理信号，并且基于第一多个生理信号确定第二多个信号参数（31）。从产生的信号信息中选择相关的信号信息（32），并且每次显示至少一个屏幕页面，从而使至少部分信号信息对用户可见。然后可以基于选择而不用户交互来对用户在至少一个屏幕页面上可见的信号信息进行修改（33,34），从而加速临床决策并减少状态未被检测到的变化的可能性的主题。

2. 发明公开

EP1586344A2 Ventilator monitor system 有权
标题翻译： Überwachungssystemfür呼吸机
公开(公告)号：EP1586344A2
公开(公告)日：2005-10-19
申请号：EP05010602.0
申请日：2000-06-30
申请人： University of Florida Research Foundation, Inc.
发明人： Banner, Michael J. , Blanch, Paul Bradford , Eulinao, Neil Russell , Principe, Jose C.
IPC分类号： A61M16/00
CPC分类号： G06F19/3481 , A61B5/0205 , A61B5/0836 , A61B5/087 , A61B5/7264 , A61B5/7267 , A61M16/0051 , A61M16/026 , A61M16/12 , A61M2016/0021 , A61M2016/0036 , A61M2205/3553 , A61M2230/06 , A61M2230/205 , A61M2230/30 , A61M2230/432 , A61M2230/435 , A61M2230/50 , G06F19/00 , G06F19/3456 , G16H40/63 , Y10S128/924 , Y10S128/925 , A61M2230/005
摘要： Embodiments of the present invention include a system and method for monitoring the ventilation support provided by a ventilator (20) that is supplying a breathing gas to a patient (p) via a breathing circuit (22) that is in fluid communication with the lungs of the patient (p). The ventilator (20) has a plurality of selectable ventilator setting controls (30) governing the supply of ventilation from the ventilator (20), each setting control (30) selectable to a level setting. The ventilator support monitor system (10) preferably receives at least one ventilator setting parameter signal (42), each ventilator setting parameter signal (42) indicative of the level settings of one ventilator setting control (30), monitors a plurality of sensors (52-58), each sensor (52-58) producing an output signal (51) indicative of a measured ventilation support parameter, to determine the sufficiency of the ventilation support received by the patient (p), and determines the desired level settings of the ventilator setting controls (30) in response to the received ventilator setting parameter signal (42) and the output signals (51). The ventilator support monitor system (10) preferably utilizes a trainable neural network (82) to determine the desired level settings of the ventilator setting controls (30).
摘要翻译：本发明的实施例包括一种用于监测通气机构（20）提供的通气支架的系统和方法，所述呼吸机（20）通过呼吸回路（22）向呼吸气体供给呼吸气体，呼吸回路与肺病人（p）。所述呼吸机（20）具有多个可选择的呼吸机设定控制装置（30），其控制从呼吸机（20）供应通气，每个设定控制装置（30）可选择为电平设定。呼吸机支持监视器系统（10）优选地接收至少一个呼吸机设定参数信号（42），指示一个呼吸机设定控制（30）的电平设定的每个呼吸机设定参数信号（42）监视多个传感器 -58），每个传感器（52-58）产生指示测量的通气支持参数的输出信号（51），以确定患者（p）接收到的通气支持的充足性，并确定患者响应于所接收的呼吸机设定参数信号（42）和输出信号（51），呼吸机设定控制（30）。呼吸机支持监视器系统（10）优选地利用可训练神经网络（82）来确定呼吸机设置控制（30）的期望水平设置。

3. 发明公开

EP1382294A3 Proportional pressure assist ventilation controlled by a diaphragm electromyographic signal 有权
标题翻译：比例压力辅助通气由膈肌肌电信号控制
公开(公告)号：EP1382294A3
公开(公告)日：2004-01-28
申请号：EP03102702.2
申请日：1999-06-04
申请人： UNIVERSITE DE MONTREAL
发明人： SINDERBY, Christer , BECK, Jennifer
IPC分类号： A61B5/0488 , A61B5/04
CPC分类号： A61B5/0492 , A61M16/0051 , A61M16/026 , A61M2210/1014 , A61M2230/08 , A61M2230/60 , Y10S128/925
摘要： A closed loop system uses (a) the intensity of the diaphragm electromyogram (EMG) for a given inspiratory volume ; (b) the inspiratory volume for a given EMG intensity ; or (c) a combination of (a) and (b) ; in view of controlling the level of gas flow, gas volume or gas pressure delivered by a mechanical (lung) ventilator. The closed loop ventilator system enables for automatic or manual adjustment of the level of inspiratory support in proportion to changes in the neuro-ventilatory efficiency such that the neural drive remains stable at a desired target level. Futhermore, a method and apparatus for substantially removing a common noise signal portion from electrical signals produced by an electrical signal source having a polarity reversal region with a centre, said electrical signals having inverse polarities on opposite sides of the centre.
摘要翻译：闭环系统使用（a）针对给定吸气量的膈肌肌电图（EMG）的强度; （b）给定肌电图强度的吸气量; 或（c）（a）和（b）的组合; 考虑到控制由机械（肺）呼吸机输送的气体流量，气体体积或气体压力的水平。闭环呼吸机系统能够与神经通气效率的变化成比例地自动或手动调节吸气支持的水平，使得神经驱动保持稳定在期望的目标水平。此外，还提供了一种用于从由具有带有中心的极性反转区域的电信号源产生的电信号中基本去除公共噪声信号部分的方法和设备，所述电信号在中心的相对侧具有相反的极性。

4. 发明授权

EP0739181B1 SUDDEN CARDIAC DEATH PREDICTION 有权
标题翻译：心脏性猝死预测
公开(公告)号：EP0739181B1
公开(公告)日：2001-09-19
申请号：EP95905301.8
申请日：1994-11-30
申请人： GEORGETOWN UNIVERSITY
发明人： VERRIER, Richard L. , NEARING, Bruce D.
IPC分类号： A61B5/0452 , G06F19/00
CPC分类号： A61B5/0452 , A61B5/02405 , A61B5/04525 , A61B5/046 , A61B5/4035 , Y10S128/925
摘要： A method and apparatus for predicting susceptibility to sudden cardiac death (208) involves simultaneously assessing cardiac electrical stability (206), represented by either the beat-to-beat alternation in the T-wave of the patient's ECG or dispersion of the QT interval and the autonomic influence on the heart (204), represented by either the magnitude of heart rate variability in the ECG or by baroreceptor sensitivity.

5. 发明公开

EP1082158A1 PROPORTIONAL PRESSURE ASSIST VENTILATION CONTROLLED BY A DIAPHRAGM ELECTROMYOGRAPHIC SIGNAL 审中-公开
标题翻译：压力支持呼吸控制的由信号隔膜肌电
公开(公告)号：EP1082158A1
公开(公告)日：2001-03-14
申请号：EP99924617.6
申请日：1999-06-04
申请人： UNIVERSITE DE MONTREAL
发明人： SINDERBY, Christer , BECK, Jennifer
IPC分类号： A61M16/00 , A61B5/0488
CPC分类号： A61B5/0492 , A61M16/0051 , A61M16/026 , A61M2210/1014 , A61M2230/08 , A61M2230/60 , Y10S128/925
摘要： A closed loop system uses (a) the intensity of the diaphragm electromyogram (EMG) for a given inspiratory volume; (b) the inspiratory volume for a given EMG intensity; or (c) a combination of (a) and (b); in view of controlling the level of gas flow, gas volume or gas pressure delivered by a mechanical (lung) ventilator. The closed loop ventilator system enables for automatic or manual adjustment of the level of inspiratory support in proportion to changes in the neuro-ventilatory efficiency such that the neural drive remains stable at a desired target level. An alarm can also be used to detect changes in neuroventilatory efficiency in view of performing manual adjustments.

6. 发明授权

EP0586025B1 Reliable noninvasive measurement of blood gases 失效
标题翻译：血液气体的无血再现性的测定
公开(公告)号：EP0586025B1
公开(公告)日：2000-04-12
申请号：EP93250195.0
申请日：1993-06-30
申请人： Robinson, Mark R. , UNIVERSITY OF NEW MEXICO , SANDIA CORPORATION
发明人： Thomas, Edward V. , Robinson, M.R. , Haaland, David M. , Alam, Mary K.
IPC分类号： A61B5/00
CPC分类号： A61B5/1491 , A61B5/02007 , A61B5/0456 , A61B5/14539 , A61B5/14546 , A61B5/14551 , A61B5/416 , A61B5/6826 , A61B5/6838 , A61B5/7264 , A61B2503/40 , Y10S128/925

7. 发明公开

EP0967918A1 SPECTROSCOPIC DETECTION OF CERVICAL PRE-CANCER USING RADIAL BASIS FUNCTION NETWORKS 失效
标题翻译：宫颈癌前的光谱测定的神经网络的合奏
公开(公告)号：EP0967918A1
公开(公告)日：2000-01-05
申请号：EP97949505.8
申请日：1997-11-20
申请人： THE UNIVERSITY OF TEXAS SYSTEM
发明人： TUMER, Kagan , RAMANUJAM, Nirmala , RICHARDS-KORTUM, Rebecca , GHOSH, Joydeep
IPC分类号： A61B6/00
CPC分类号： A61B5/0084 , A61B5/0071 , A61B5/0075 , A61B5/7267 , G01J2003/2866 , Y10S128/925
摘要： This invention is an apparatus and methods for spectroscopic detection of tissue abnormality, particularly pre-cancerous cervical tissue, using neural networks (1000) to analyze in vivo measurements of fluorescence spectra. The invention excites fluorescence intensity spectra in both normal and abnormal tissue. This fluorescence spectroscopy data is used to train a group of neural networks, preferably radial basis function neural networks. Once trained, fluorescence spectroscopy data from unknown tissues samples is classified by the neural networks. This process is used to differentiate pre-cancers from normal tissues, and can also be used to differentiate high grade pre-cancers from low grade pre-cancers. One embodiment of the invention is able to distinguish pre-cancerous tissue from both normal squamous tissue and normal columnar tissue in a single stage analysis. The invention demonstrates significantly smaller variability in classification accuracy, resulting in more reliable classification, with superior sensitivity. Moreover, the signal stage embodiment of the invention simplifies the decision making process as compared to a two-stage embodiment.

8. 发明公开

EP0784493A4 IMPEDANCE MONITORING SYSTEM 失效
标题翻译：监测系统的阻抗
公开(公告)号：EP0784493A4
公开(公告)日：1998-01-14
申请号：EP95932469
申请日：1995-09-11
申请人： IVAC CORP
发明人： VOSS GREGORY I , BUTTERFIELD ROBERT D , BAURA GAIL D , BARNES CASPER W
IPC分类号： A61M5/00 , A61M5/168 , A61M31/00
CPC分类号： A61M5/16859 , Y10S128/13 , Y10S128/925
摘要： Impedance to fluid flow in a fluid delivery line is measured. Two techniques are used depending on the flow rate selected. For high flow rates, the pump (18) is controlled to vary the flow rate and the change in pressure is divided by the change in flow to directly determine the resistance. For low flow rates, a processor (14) controls the pump (18) to pump flow quantities in accordance with a pseudo-random binary code. The resulting pressure signal sensed at the conduit (22) is decoded in accordance with that code. Pressures received during code periods of no flow are subtracted from pressures received during code periods of flow. Pressure offset is also removed and a least squares estimation approach is used with a linear prediction model to determine impedance. The coefficients determined in the model are used to calculate the resistance to fluid flow of the system. A quality supervisor monitors the resistance determination process and controls the display (28) of resistance depending on the quality determined. A resistance display (28) continuously displays the resistance of the system.

9. 发明公开

EP0764003A1 SYSTEM AND METHOD FOR MEASURING ACOUSTIC REFLECTANCE 失效
标题翻译：方法和测量系统的声反射资产
公开(公告)号：EP0764003A1
公开(公告)日：1997-03-26
申请号：EP95922874.0
申请日：1995-06-06
申请人： University of Washington
发明人： KEEFE, Douglas H.
IPC分类号： A61B5 , G01H15
CPC分类号： A61B5/121 , A61B5/12 , A61B5/7232 , G01H15/00 , G01N2291/02491 , G01N2291/02872 , Y10S128/925
摘要： A system and method of measuring the linear and nonlinear response of an unknown acoustic termination uses a small probe assembly containing a sound source and microphone to determine the reflection function of the unknown acoustic termination. The probe assembly is used with a calibration tube to calculate an electrical signal that will provide a desired acoustic stimulus signal to the acoustic termination. The calibration tube is also used to characterize the signal processing properties of the sound source and microphone, as well as other associated signal processing circuits such as amplifiers, filters, and the like. The calibrated system is subsequently coupled to the unknown acoustic termination to deliver the acoustic stimulus signal. The reflection function is indicative of the power transferred to the unknown acoustic termination. The measurement of the linear transfer characteristic is applicable to any unknown acoustic termination such as a musical instrument or the auditory system. The probe assembly is sized to be positioned directly within the outer portion of the ear and measure the linear characteristics of the ear. The system is further able to measure the nonlinear transfer characteristics of the ear by measuring the linear response at multiple levels of the acoustic stimulus. The system is particularly useful in testing the response of the middle ear and inner ear of humans or other animals.

10. 发明公开

EP0653224A3 A method of classifying heart rhythms by means of electrogram morphology 失效
标题翻译：一种是由于电图的形状心脏节律分类的方法。
公开(公告)号：EP0653224A3
公开(公告)日：1996-12-27
申请号：EP94307674.5
申请日：1994-10-19
申请人： TELECTRONICS N.V.
发明人： Murphy, Anthony Joseph , Bassin, David , Wickham, John Peter
IPC分类号： A61N1/365 , A61N1/368 , A61N1/39
CPC分类号： A61N1/3956 , A61B5/04525 , A61B5/7264 , Y10S128/925
摘要： A method, useable in implantable cardioverter defibrillators, for classifying heart rhythms of a patient by means of electrogram morphology. A number of features (metrics) of the electrogram are measured to form a description of the shape of individual electrograms, and the metrics are then converted into a cardiac rhythm diagnosis by means of a pattern classification technique.

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