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1. 发明公开

EP1208851A2 A medicament for pulmonary drug delivery 失效
标题翻译：药物对肺部给药
公开(公告)号：EP1208851A2
公开(公告)日：2002-05-29
申请号：EP02002978.1
申请日：1992-10-22
申请人： ALLIANCE PHARMACEUTICAL CORPORATION
发明人： Schutt, Ernest G.
IPC分类号： A61K45/06 , A61M16/00
CPC分类号： A61K9/0026 , A61M16/0051 , A61M16/0054 , A61M16/021 , A61M16/0463 , A61M16/0486 , A61M16/107 , A61M2202/0476 , Y10S128/913
摘要： The invention relates to a medicament for pulmonary drug delivery comprising a fluorocarbon liquid in combination with a bioactive agent for delivery to the lung.

2. 发明公开

EP0910423A4 LIQUID VENTILATION METHOD AND APPARATUS 失效
标题翻译： VERFAHREN UND VORRICHTUNG ZURFLÜSSIGENBEATMUNG
公开(公告)号：EP0910423A4
公开(公告)日：1999-12-29
申请号：EP97914885
申请日：1997-03-07
申请人： LIFE RESUSCITATION TECH
发明人： FEDEROWICZ MICHAEL G , KLATZ RONALD M
IPC分类号： A61M3/02 , A61M16/00 , A61M16/04
CPC分类号： A61M16/0054 , A61M3/0258 , A61M3/0283 , A61M16/042 , A61M16/1065 , A61M2202/0476 , Y10S128/913
摘要： This invention is a method and apparatus for liquid ventilation to increase the efficacy of cardiopulmonary resuscitation (CPR). The method includes replacing gas in the lungs with an oxygen and carbon dioxide carrying liquid to eliminate the decreased pumping efficiency of the heart seen during conventional or active compression/decompression (ACD) closed chest CPR without a mechanical respirator. An advantage is provided by supplying a continuous flow of liquid (or gaseous) ventilation medium throughout the entire chest compression/re-expansion cycle, accelerating both gas exchange and cooling or warming of the patient or animal subject. In the apparatus (100), breathing liquid returns from a patient via tube (101) and is supplied via tube (190), tubes (101, 190) being connected to an endotracheal tube (200). The apparatus includes a reservoir (110), an oxygenator (120), and a heater (130).
摘要翻译：本发明是一种用于液体通气以提高心肺复苏（CPR）功效的方法和设备。该方法包括用携带氧气和二氧化碳的液体替换肺中的气体以消除在没有机械呼吸器的常规或主动压缩/减压（ACD）闭合胸部CPR过程中看到的心脏泵送效率降低。通过在整个胸部压缩/再膨胀循环中提供连续的液体（或气体）通气介质流来提供优势，加速患者或动物受试者的气体交换和冷却或加热。在装置（100）中，呼吸液体经由管（101）从患者返回并经由管（190）供应，管（101,190）连接至气管内导管（200）。该设备包括储器（110），充氧器（120）和加热器（130）。

3. 发明公开

EP0582570A1 PERFLUOROCARBON ASSOCIATED GAS EXCHANGE 失效
标题翻译：全球卫生组织气候变化专业委员会
公开(公告)号：EP0582570A1
公开(公告)日：1994-02-16
申请号：EP91920110.0
申请日：1991-09-27
申请人： UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人： FUHRMAN, Bradley, P.
IPC分类号： A61K31 , A61M16 , A61P11 , C07D307 , C07D309
CPC分类号： A61M16/0054 , A61M16/0833 , A61M16/0841 , A61M2016/0027 , A61M2202/0476 , Y10S128/913
摘要： Procédé et dispositif servant à maintenir un échange respiratoire gazeux au moyen de l'introduction dans les voies aériennes pulmonaires (18) d'un mammifère d'un volume de liquide à base de carbone perfluoré sensiblement équivalent à la capacité pulmonaire fonctionnelle et résiduelle dudit mammifère, du maintien de l'échange respiratoire gazeux dans les voies aériennes pulmonaires (18) chargées de carbone perfluoré liquide, au moyen d'une respiration par pression positive continue ou autre, effectuée au moyen d'un respirateur classique (12) pendant une heure ou davantage, et, enfin, de l'évaporation provoquée dudit carbone perfluoré liquide des voies aériennes pulmonaires. Ce procédé et ce dispositif sont efficaces dans le traitement de déficiences ou de dysfonctionnements du surfactant pulmonaire.
摘要翻译：用于维持呼吸气体交换的方法和装置，通过向哺乳动物宿主的肺空气通道中引入一定体积的全氟化碳液体，其基本上等于宿主的肺功能残留能力，维持全氟化碳液体充满的肺空气通道中的呼吸气体交换通过用常规呼吸器连续正压呼吸达一个小时以上，然后从肺部空气通道中蒸发全氟化碳液体。用于治疗肺表面活性物质缺乏或功能障碍。

4. 发明授权

EP2143458B1 Can fixture 有权
标题翻译：可以夹具
公开(公告)号：EP2143458B1
公开(公告)日：2017-05-10
申请号：EP09172349.4
申请日：2003-03-17
申请人： Clinical Designs Limited
发明人： Bacon, Raymond
IPC分类号： A61M15/00 , B65D83/00
CPC分类号： A61M15/009 , A61M15/0026 , A61M15/0091 , A61M15/0093 , A61M2210/0618 , B65D83/206 , Y10S128/913

5. 发明公开

EP1487523A1 CAN FIXTURE 有权
标题翻译：夹具用于容器
公开(公告)号：EP1487523A1
公开(公告)日：2004-12-22
申请号：EP03708349.0
申请日：2003-03-17
申请人： Clinical Designs Limited
发明人： BACON, Raymond John
IPC分类号： A61M15/00 , B65D83/16
CPC分类号： A61M15/009 , A61M15/0026 , A61M15/0091 , A61M15/0093 , A61M2210/0618 , B65D83/206 , Y10S128/913
摘要： A dispenser (1) comprises a can (2) and a body (3). The can is an aluminium extrusion with a valve crimped into its mouth, the valve having an outlet spout (4). The crimped region (5) of the can surrounding the valve has a lesser diameter than the can has through the main part (6) of its length. The body has a mouthpiece (11) with a pivotal cover (12) drivingly connected to a cam (13). This bears on the underside of a junction member (14), into a socket (15) of which the spout 4 fits. A breath actuated dose release mechanism (16) is provided. The body has a tubular section (7) for receiving the necked down region (5) of the can. The tubular section and the main part of the can having the same external diameter. A printed paper label (21) coated with self-adhesive is wrapped around the joint between the body and the can to unite the can to the body in position such that when the cover is opened, a dose is dispensed by the cam (13) lifting the junction member and depressing the spout. In order to establish correct positioning of the can with respect to the body, prior to positioning of the label, a predetermined force (F) is applied to ensure that the spout is fully depressed. This causes the can to release into the release mechanism a dose, which will usually be a metered dose. Thus in this position of the can in the body, when the cover is opened in use, another dose will be released. With the force still applied the label is applied to the can and the body fixing their relative position.

6. 发明公开

EP1453524A2 BREATHABLE GAS MIXTURES TO CHANGE BODY TEMPERATURE 审中-公开
标题翻译： ATEMBARE GASGEMISCHE ZUR REGELUNG DERKÖRPERTEMPERATUR
公开(公告)号：EP1453524A2
公开(公告)日：2004-09-08
申请号：EP02797171.2
申请日：2002-12-04
申请人： Minnesota High-Tech Resources, LLC
发明人： KUMAR, Matthew, M. , JOHNSON, Larry, D.
IPC分类号： A61K33/00 , A61M16/10 , A61M16/00 , A61P9/10
CPC分类号： A61K33/00 , A61M16/0054 , A61M16/0075 , A61M16/0081 , A61M16/0833 , A61M16/1075 , A61M16/14 , A61M16/22 , A61M19/00 , A61M2202/0476 , A61M2230/50 , Y10S128/913
摘要： Devices and methods to heat and cool human beings, including inducing and maintaining hypothermia in human patients. Methods include inducing hypothermia to treat ischemic events, including heart attack and stroke, to limit damage caused by the ischemic event. Methods can include: using the lungs for heat exchange; using cooled gases for ventilation; using helium in the ventilation gas mixture, using medications to control reflex heat production; and injecting a perfluorocarbon mist into the gas stream to increase the cooling rate. The high thermal conductivity and diffusivity of helium results in greater inspired gas temperature equalization toward body temperature. Due to the latent heat of vaporization, addition of even small quantity of phase-change perfluorocarbon dramatically increases the heat carrying capacity of the respiratory gases. Hypothermia may be terminated by discontinuing the medications and warming the patient using a warmed helium-oxygen mixture.
摘要翻译：用于加热和冷却人类的装置和方法，包括诱导和维持人类患者的体温过低。方法包括诱导低温治疗缺血事件，包括心脏病发作和中风，以限制由缺血事件引起的损伤。方法可以包括：使用肺进行热交换; 使用冷却气体进行通风; 在通风气体混合物中使用氦气，使用药物来控制反射热产生; 并将全氟化碳雾注入到气流中以提高冷却速率。氦气的高导热性和扩散性导致更大的启发气体温度均衡到体温。由于蒸发的潜热，加入少量的相变全氟化碳会大大增加呼吸气体的承载能力。可以通过中断药物并使用温热的氦 - 氧混合物使患者变暖来终止低体温。

7. 发明公开

EP0908178A1 Partial liquid breathing of fluorocarbons 失效
标题翻译： Flukeohlenwasserstoffen的PartielleFlüssigkeitsbeatmung手套
公开(公告)号：EP0908178A1
公开(公告)日：1999-04-14
申请号：EP98107353.9
申请日：1992-05-01
申请人： ALLIANCE PHARMACEUTICAL CORPORATION
发明人： Faithfull, Nicholas Simon , Weers, Jeffry Greg, Ph.D.
IPC分类号： A61K31/02 , A61K31/08
CPC分类号： A61K31/135 , A61K31/02 , A61K31/025 , A61K31/035 , A61K31/08 , A61K31/13 , A61K31/685 , A61K45/06 , A61M2202/0476 , Y10S128/913 , A61K2300/00
摘要： The present invention includes the use of an oxygen-carrying breathable fluorocarbon liquid in the preparation of a medicament for delivering oxygen to a patient when administered as an aerosol to a patient breathing a breathing gas. It also includes a fluorocarbon liquid having a particulate pharmaceutical agent dispersed therein for use in partial liquid breathing.
摘要翻译：本发明包括使用载氧透气性碳氟化合物液体制备药物的药物，所述药物用于当向患者呼吸呼吸气体作为气溶胶施用时向患者输送氧气。它还包括其中分散有用于部分液体呼吸的颗粒药剂的氟碳液体。

8. 发明公开

EP0848961A1 Device intended for use in a therapeutic system for respiratory care with a liquid 失效
标题翻译：贝尔曼（Beatmung）在einem Behandlungssystem中的Vorrichtung zurflüssigenBeatmung
公开(公告)号：EP0848961A1
公开(公告)日：1998-06-24
申请号：EP97118282.9
申请日：1997-10-21
申请人： Siemens-Elema AB
发明人： Högnelid, Kurt
IPC分类号： A61M16/00
CPC分类号： A61M16/0054 , A61H23/02 , A61M2202/0476 , Y10S128/913
摘要： In respiratory care with liquids, the patient (2) is connected to a liquid apparatus (6) and a ventilator (10) for supplying and removing a treatment liquid and a breathing gas respectively to/from the patient (2). The exchange of gases between the breathing gas and the treatment liquid is improved with a device according to the invention. In one embodiment, the device consists of a breathing gas generator (12) which generates different frequencies to cause the breathing gas and treatment liquid to oscillate at appropriate frequencies. In an alternative embodiment, the device consists of a vibrator unit (22) which is applied to the chest to cause the treatment liquid to oscillate. In a third embodiment, the device consists of a magnetic field generator (26) for generating a magnetic field across the lungs and setting electrically conductive components in the treatment liquid in motion.
摘要翻译：在使用液体的呼吸护理中，患者（2）连接到液体装置（6）和通气机（10），用于分别向患者（2）提供和去除治疗液体和呼吸气体。使用根据本发明的装置改善呼吸气体和处理液体之间的气体交换。在一个实施例中，该装置由呼吸气体发生器（12）组成，其产生不同的频率以使呼吸气体和处理液体以适当的频率振荡。在替代实施例中，该装置由施加到胸部以使治疗液体振荡的振动器单元（22）组成。在第三实施例中，该装置由用于产生穿过肺部的磁场并设置运动中的处理液体中的导电部件的磁场发生器（26）组成。

9. 发明授权

EP0848961B1 Device intended for use in a therapeutic system for respiratory care with a liquid 失效
标题翻译：一种用于在处理系统液体通气
公开(公告)号：EP0848961B1
公开(公告)日：2003-02-26
申请号：EP97118282.9
申请日：1997-10-21
申请人： Siemens-Elema AB
发明人： Högnelid, Kurt
IPC分类号： A61M16/00
CPC分类号： A61M16/0054 , A61H23/02 , A61M2202/0476 , Y10S128/913

10. 发明公开

EP0904122A1 METHODS AND APPARATUS FOR REDUCING LOSS OF RESPIRATORY PROMOTERS 失效
标题翻译：方法和装置以降低呼吸发起人的损失
公开(公告)号：EP0904122A1
公开(公告)日：1999-03-31
申请号：EP97927878.0
申请日：1997-05-29
申请人： ALLIANCE PHARMACEUTICAL CORPORATION
发明人： WALTERS, Mark, A. , SCHUTT, Ernest, G. , HOFFMAN, John, K. , WYZGALA, Mark, H. , KIRKLAND, W., Dean.
IPC分类号： A61M16
CPC分类号： A61M16/009 , A61M16/0093 , A61M16/0833 , Y10S128/913
摘要： A system (100) for performing partial liquid ventilation comprising a patient connector (114) capable of establishing fluid conducting communication with pulmonary air passages of a patient (112), a ventilating circuit sealingly affixed to said patient connector (114) whereby a gas flow path capable of transporting an inspiratory gas into the pulmonary air passages and removing subsequently generated expiratory gases, said ventilating circuit operably associated with a mechanical ventilator (120); a vapor retainer (160) in fluid conducting communication with said gas flow path whereby said inspiratory gas and said expiratory gas alternately pass through said vapor retainer (160); and a liquid or vapor respiraroty promoter dispersed in said gas flow path.
摘要翻译：方法和设备的呼吸促进养护跟随他们的肺是引进游离缺失盘。在优选的实施方案，本发明提供在医疗过程的方法和用于减小呼吸启动子的损耗的装置，并且特别fluorochemcials，：诸如液体通气。盘游离缺失方法包括使用的蒸气保持组件，其可以是常规的热湿交换器，以被动地保留呼吸启动子和它返回到在随后的呼吸肺部。新颖蒸气保持组件，其包括亲氟交换元件因此是游离缺失盘。

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