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1. 发明公开

EP1208851A2 A medicament for pulmonary drug delivery 失效
标题翻译：药物对肺部给药
公开(公告)号：EP1208851A2
公开(公告)日：2002-05-29
申请号：EP02002978.1
申请日：1992-10-22
申请人： ALLIANCE PHARMACEUTICAL CORPORATION
发明人： Schutt, Ernest G.
IPC分类号： A61K45/06 , A61M16/00
CPC分类号： A61K9/0026 , A61M16/0051 , A61M16/0054 , A61M16/021 , A61M16/0463 , A61M16/0486 , A61M16/107 , A61M2202/0476 , Y10S128/913
摘要： The invention relates to a medicament for pulmonary drug delivery comprising a fluorocarbon liquid in combination with a bioactive agent for delivery to the lung.

2. 发明公开

EP0910423A4 LIQUID VENTILATION METHOD AND APPARATUS 失效
标题翻译： VERFAHREN UND VORRICHTUNG ZURFLÜSSIGENBEATMUNG
公开(公告)号：EP0910423A4
公开(公告)日：1999-12-29
申请号：EP97914885
申请日：1997-03-07
申请人： LIFE RESUSCITATION TECH
发明人： FEDEROWICZ MICHAEL G , KLATZ RONALD M
IPC分类号： A61M3/02 , A61M16/00 , A61M16/04
CPC分类号： A61M16/0054 , A61M3/0258 , A61M3/0283 , A61M16/042 , A61M16/1065 , A61M2202/0476 , Y10S128/913
摘要： This invention is a method and apparatus for liquid ventilation to increase the efficacy of cardiopulmonary resuscitation (CPR). The method includes replacing gas in the lungs with an oxygen and carbon dioxide carrying liquid to eliminate the decreased pumping efficiency of the heart seen during conventional or active compression/decompression (ACD) closed chest CPR without a mechanical respirator. An advantage is provided by supplying a continuous flow of liquid (or gaseous) ventilation medium throughout the entire chest compression/re-expansion cycle, accelerating both gas exchange and cooling or warming of the patient or animal subject. In the apparatus (100), breathing liquid returns from a patient via tube (101) and is supplied via tube (190), tubes (101, 190) being connected to an endotracheal tube (200). The apparatus includes a reservoir (110), an oxygenator (120), and a heater (130).
摘要翻译：本发明是一种用于液体通气以提高心肺复苏（CPR）功效的方法和设备。该方法包括用携带氧气和二氧化碳的液体替换肺中的气体以消除在没有机械呼吸器的常规或主动压缩/减压（ACD）闭合胸部CPR过程中看到的心脏泵送效率降低。通过在整个胸部压缩/再膨胀循环中提供连续的液体（或气体）通气介质流来提供优势，加速患者或动物受试者的气体交换和冷却或加热。在装置（100）中，呼吸液体经由管（101）从患者返回并经由管（190）供应，管（101,190）连接至气管内导管（200）。该设备包括储器（110），充氧器（120）和加热器（130）。

3. 发明公开

EP0582570A1 PERFLUOROCARBON ASSOCIATED GAS EXCHANGE 失效
标题翻译：全球卫生组织气候变化专业委员会
公开(公告)号：EP0582570A1
公开(公告)日：1994-02-16
申请号：EP91920110.0
申请日：1991-09-27
申请人： UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人： FUHRMAN, Bradley, P.
IPC分类号： A61K31 , A61M16 , A61P11 , C07D307 , C07D309
CPC分类号： A61M16/0054 , A61M16/0833 , A61M16/0841 , A61M2016/0027 , A61M2202/0476 , Y10S128/913
摘要： Procédé et dispositif servant à maintenir un échange respiratoire gazeux au moyen de l'introduction dans les voies aériennes pulmonaires (18) d'un mammifère d'un volume de liquide à base de carbone perfluoré sensiblement équivalent à la capacité pulmonaire fonctionnelle et résiduelle dudit mammifère, du maintien de l'échange respiratoire gazeux dans les voies aériennes pulmonaires (18) chargées de carbone perfluoré liquide, au moyen d'une respiration par pression positive continue ou autre, effectuée au moyen d'un respirateur classique (12) pendant une heure ou davantage, et, enfin, de l'évaporation provoquée dudit carbone perfluoré liquide des voies aériennes pulmonaires. Ce procédé et ce dispositif sont efficaces dans le traitement de déficiences ou de dysfonctionnements du surfactant pulmonaire.
摘要翻译：用于维持呼吸气体交换的方法和装置，通过向哺乳动物宿主的肺空气通道中引入一定体积的全氟化碳液体，其基本上等于宿主的肺功能残留能力，维持全氟化碳液体充满的肺空气通道中的呼吸气体交换通过用常规呼吸器连续正压呼吸达一个小时以上，然后从肺部空气通道中蒸发全氟化碳液体。用于治疗肺表面活性物质缺乏或功能障碍。

4. 发明授权

EP0848961B1 Device intended for use in a therapeutic system for respiratory care with a liquid 失效
标题翻译：一种用于在处理系统液体通气
公开(公告)号：EP0848961B1
公开(公告)日：2003-02-26
申请号：EP97118282.9
申请日：1997-10-21
申请人： Siemens-Elema AB
发明人： Högnelid, Kurt
IPC分类号： A61M16/00
CPC分类号： A61M16/0054 , A61H23/02 , A61M2202/0476 , Y10S128/913

5. 发明公开

EP0904122A1 METHODS AND APPARATUS FOR REDUCING LOSS OF RESPIRATORY PROMOTERS 失效
标题翻译：方法和装置以降低呼吸发起人的损失
公开(公告)号：EP0904122A1
公开(公告)日：1999-03-31
申请号：EP97927878.0
申请日：1997-05-29
申请人： ALLIANCE PHARMACEUTICAL CORPORATION
发明人： WALTERS, Mark, A. , SCHUTT, Ernest, G. , HOFFMAN, John, K. , WYZGALA, Mark, H. , KIRKLAND, W., Dean.
IPC分类号： A61M16
CPC分类号： A61M16/009 , A61M16/0093 , A61M16/0833 , Y10S128/913
摘要： A system (100) for performing partial liquid ventilation comprising a patient connector (114) capable of establishing fluid conducting communication with pulmonary air passages of a patient (112), a ventilating circuit sealingly affixed to said patient connector (114) whereby a gas flow path capable of transporting an inspiratory gas into the pulmonary air passages and removing subsequently generated expiratory gases, said ventilating circuit operably associated with a mechanical ventilator (120); a vapor retainer (160) in fluid conducting communication with said gas flow path whereby said inspiratory gas and said expiratory gas alternately pass through said vapor retainer (160); and a liquid or vapor respiraroty promoter dispersed in said gas flow path.
摘要翻译：方法和设备的呼吸促进养护跟随他们的肺是引进游离缺失盘。在优选的实施方案，本发明提供在医疗过程的方法和用于减小呼吸启动子的损耗的装置，并且特别fluorochemcials，：诸如液体通气。盘游离缺失方法包括使用的蒸气保持组件，其可以是常规的热湿交换器，以被动地保留呼吸启动子和它返回到在随后的呼吸肺部。新颖蒸气保持组件，其包括亲氟交换元件因此是游离缺失盘。

6. 发明公开

EP0683683A4 PROCESS CONTROL FOR LIQUID VENTILATION. 失效
标题翻译： VERFAHRENSREGELUNG BEIFLÜSSIGKEITS通风。
公开(公告)号：EP0683683A4
公开(公告)日：1995-08-31
申请号：EP93923821
申请日：1993-10-08
申请人： UNIV TEMPLE
发明人： SHAFFER THOMAS H , WOLFSON MARLA R
IPC分类号： A61M16/00
CPC分类号： A61M16/0054 , A61M16/024 , A61M2016/1025 , A61M2202/0476 , Y10S128/913
摘要： A process is provided for controlling a ventilation procedure wherein a liquid ventilation system passes breathing liquid through at least a portion of a patient's pulmonary pathways. In this process, desired ranges for certain process parameters associated with the liquid ventilation system are established. These desired ranges are input into a central processing unit (50). Initial settings for the liquid ventilation system are then made such that the actual conditions which will initially occur during the liquid ventilation procedure fall within their respective desired ranges. Thereafter, the procedure is commenced. During the procedure, conditions are continually monitored by sensors (16, 21, 27). The CPU (50) compares the sensor readings with the desired ranges, and acts to correct any discrepancy. The CPU can trigger alarms (514).
摘要翻译：提供了用于控制通气过程的过程，其中液体通气系统使呼吸液体通过患者的肺通路的至少一部分。在此过程中，建立了与液体通风系统相关的某些过程参数的期望范围。这些期望的范围被输入到中央处理单元（50）。然后进行液体通气系统的初始设置，使得在液体通气过程中最初发生的实际状况落入其各自的期望范围内。此后，程序开始。在该过程中，通过传感器（16,21,27）持续监测条件。 CPU（50）将传感器读数与期望的范围进行比较，并用于纠正任何差异。 CPU可以触发警报（514）。

7. 发明公开

EP0582570A4 PERFLUOROCARBON ASSOCIATED GAS EXCHANGE 失效
标题翻译：全氟烃相关气体交换
公开(公告)号：EP0582570A4
公开(公告)日：1994-07-13
申请号：EP91920110
申请日：1991-09-27
申请人： UNIV PITTSBURGH
发明人： FUHRMAN BRADLEY P
IPC分类号： A61K31/02 , A61K31/025 , A61M16/00 , A61M16/14 , A61P11/00 , C07D307/18 , C07D309/08
CPC分类号： A61M16/0054 , A61M16/0833 , A61M16/0841 , A61M2016/0027 , A61M2202/0476 , Y10S128/913
摘要： Method and means for maintaining respiratory gas exchange by introducing into the pulmonary air passages (18) of a mammalian host a volume of perfluorocarbon liquid substantially equivalent to the pulmonary functional residual capacity of the host, maintaining respiratory gas exchange in the perfluorocarbon liquid-laden pulmonary air passages (18) by continuous positive pressure breathing or otherwise with a conventional gas respirator (12), for up to an hour or more, and thereafter evaporating the perfluorocarbon liquid from the pulmonary air passages. Useful for treating pulmonary surfactant deficiency or dysfunction.
摘要翻译：用于维持呼吸气体交换的方法和装置，通过向哺乳动物宿主的肺空气通道中引入一定体积的全氟化碳液体，其基本上等于宿主的肺功能残留能力，维持全氟化碳液体充满的肺空气通道中的呼吸气体交换通过用常规呼吸器连续正压呼吸达一个小时以上，然后从肺部空气通道中蒸发全氟化碳液体。用于治疗肺表面活性物质缺乏或功能障碍。

8. 发明授权

EP2143458B1 Can fixture 有权
标题翻译：可以夹具
公开(公告)号：EP2143458B1
公开(公告)日：2017-05-10
申请号：EP09172349.4
申请日：2003-03-17
申请人： Clinical Designs Limited
发明人： Bacon, Raymond
IPC分类号： A61M15/00 , B65D83/00
CPC分类号： A61M15/009 , A61M15/0026 , A61M15/0091 , A61M15/0093 , A61M2210/0618 , B65D83/206 , Y10S128/913

9. 发明公开

EP1487523A1 CAN FIXTURE 有权
标题翻译：夹具用于容器
公开(公告)号：EP1487523A1
公开(公告)日：2004-12-22
申请号：EP03708349.0
申请日：2003-03-17
申请人： Clinical Designs Limited
发明人： BACON, Raymond John
IPC分类号： A61M15/00 , B65D83/16
CPC分类号： A61M15/009 , A61M15/0026 , A61M15/0091 , A61M15/0093 , A61M2210/0618 , B65D83/206 , Y10S128/913
摘要： A dispenser (1) comprises a can (2) and a body (3). The can is an aluminium extrusion with a valve crimped into its mouth, the valve having an outlet spout (4). The crimped region (5) of the can surrounding the valve has a lesser diameter than the can has through the main part (6) of its length. The body has a mouthpiece (11) with a pivotal cover (12) drivingly connected to a cam (13). This bears on the underside of a junction member (14), into a socket (15) of which the spout 4 fits. A breath actuated dose release mechanism (16) is provided. The body has a tubular section (7) for receiving the necked down region (5) of the can. The tubular section and the main part of the can having the same external diameter. A printed paper label (21) coated with self-adhesive is wrapped around the joint between the body and the can to unite the can to the body in position such that when the cover is opened, a dose is dispensed by the cam (13) lifting the junction member and depressing the spout. In order to establish correct positioning of the can with respect to the body, prior to positioning of the label, a predetermined force (F) is applied to ensure that the spout is fully depressed. This causes the can to release into the release mechanism a dose, which will usually be a metered dose. Thus in this position of the can in the body, when the cover is opened in use, another dose will be released. With the force still applied the label is applied to the can and the body fixing their relative position.

10. 发明公开

EP1453524A2 BREATHABLE GAS MIXTURES TO CHANGE BODY TEMPERATURE 审中-公开
标题翻译： ATEMBARE GASGEMISCHE ZUR REGELUNG DERKÖRPERTEMPERATUR
公开(公告)号：EP1453524A2
公开(公告)日：2004-09-08
申请号：EP02797171.2
申请日：2002-12-04
申请人： Minnesota High-Tech Resources, LLC
发明人： KUMAR, Matthew, M. , JOHNSON, Larry, D.
IPC分类号： A61K33/00 , A61M16/10 , A61M16/00 , A61P9/10
CPC分类号： A61K33/00 , A61M16/0054 , A61M16/0075 , A61M16/0081 , A61M16/0833 , A61M16/1075 , A61M16/14 , A61M16/22 , A61M19/00 , A61M2202/0476 , A61M2230/50 , Y10S128/913
摘要： Devices and methods to heat and cool human beings, including inducing and maintaining hypothermia in human patients. Methods include inducing hypothermia to treat ischemic events, including heart attack and stroke, to limit damage caused by the ischemic event. Methods can include: using the lungs for heat exchange; using cooled gases for ventilation; using helium in the ventilation gas mixture, using medications to control reflex heat production; and injecting a perfluorocarbon mist into the gas stream to increase the cooling rate. The high thermal conductivity and diffusivity of helium results in greater inspired gas temperature equalization toward body temperature. Due to the latent heat of vaporization, addition of even small quantity of phase-change perfluorocarbon dramatically increases the heat carrying capacity of the respiratory gases. Hypothermia may be terminated by discontinuing the medications and warming the patient using a warmed helium-oxygen mixture.
摘要翻译：用于加热和冷却人类的装置和方法，包括诱导和维持人类患者的体温过低。方法包括诱导低温治疗缺血事件，包括心脏病发作和中风，以限制由缺血事件引起的损伤。方法可以包括：使用肺进行热交换; 使用冷却气体进行通风; 在通风气体混合物中使用氦气，使用药物来控制反射热产生; 并将全氟化碳雾注入到气流中以提高冷却速率。氦气的高导热性和扩散性导致更大的启发气体温度均衡到体温。由于蒸发的潜热，加入少量的相变全氟化碳会大大增加呼吸气体的承载能力。可以通过中断药物并使用温热的氦 - 氧混合物使患者变暖来终止低体温。

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