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1. 发明公开

EP1453524A2 BREATHABLE GAS MIXTURES TO CHANGE BODY TEMPERATURE 审中-公开
标题翻译： ATEMBARE GASGEMISCHE ZUR REGELUNG DERKÖRPERTEMPERATUR
公开(公告)号：EP1453524A2
公开(公告)日：2004-09-08
申请号：EP02797171.2
申请日：2002-12-04
申请人： Minnesota High-Tech Resources, LLC
发明人： KUMAR, Matthew, M. , JOHNSON, Larry, D.
IPC分类号： A61K33/00 , A61M16/10 , A61M16/00 , A61P9/10
CPC分类号： A61K33/00 , A61M16/0054 , A61M16/0075 , A61M16/0081 , A61M16/0833 , A61M16/1075 , A61M16/14 , A61M16/22 , A61M19/00 , A61M2202/0476 , A61M2230/50 , Y10S128/913
摘要： Devices and methods to heat and cool human beings, including inducing and maintaining hypothermia in human patients. Methods include inducing hypothermia to treat ischemic events, including heart attack and stroke, to limit damage caused by the ischemic event. Methods can include: using the lungs for heat exchange; using cooled gases for ventilation; using helium in the ventilation gas mixture, using medications to control reflex heat production; and injecting a perfluorocarbon mist into the gas stream to increase the cooling rate. The high thermal conductivity and diffusivity of helium results in greater inspired gas temperature equalization toward body temperature. Due to the latent heat of vaporization, addition of even small quantity of phase-change perfluorocarbon dramatically increases the heat carrying capacity of the respiratory gases. Hypothermia may be terminated by discontinuing the medications and warming the patient using a warmed helium-oxygen mixture.
摘要翻译：用于加热和冷却人类的装置和方法，包括诱导和维持人类患者的体温过低。方法包括诱导低温治疗缺血事件，包括心脏病发作和中风，以限制由缺血事件引起的损伤。方法可以包括：使用肺进行热交换; 使用冷却气体进行通风; 在通风气体混合物中使用氦气，使用药物来控制反射热产生; 并将全氟化碳雾注入到气流中以提高冷却速率。氦气的高导热性和扩散性导致更大的启发气体温度均衡到体温。由于蒸发的潜热，加入少量的相变全氟化碳会大大增加呼吸气体的承载能力。可以通过中断药物并使用温热的氦 - 氧混合物使患者变暖来终止低体温。

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