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1. 发明公开

EP3066681A4 FLOW THROUGH MS3 FOR IMPROVED SELECTIVITY 审中-公开
标题翻译： DURCHFLUSS-MS3FÜRVERBESSERTESELEKTIVITÄT
公开(公告)号：EP3066681A4
公开(公告)日：2017-09-20
申请号：EP14859827
申请日：2014-10-07
申请人： DH TECHNOLOGIES DEV PTE LTD
发明人： COLLINGS BRUCE ANDREW , THOMSON BRUCE A
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/0045 , H01J49/0063 , H01J49/04 , H01J49/063 , H01J49/40 , H01J49/4215 , H01J49/4225 , H01J49/4285
摘要： Systems and methods are provided for selecting and fragmenting a first precursor ion in an MS3 experiment. One or more first excitation parameters are calculated that define a first dipole excitation using a processor. The first dipole excitation is used to select a first precursor ion and fragment the first precursor ion to produce a second precursor ion. The first dipole excitation is applied to the continuous beam of ions by sending a first set of data including the first excitation parameters to a mass spectrometer. The first set of data is sent so that a first quadrupole applies the first dipole excitation to a continuous beam of ions. The mass spectrometer includes an ion source that provides the continuous beam of ions and the first quadrupole that receives the continuous beam of ions and is adapted to apply dipole excitation to the continuous beam of ions.
摘要翻译：提供了用于在MS3实验中选择和碎裂第一前体离子的系统和方法。计算一个或多个第一激励参数，其使用处理器来限定第一偶极子激励。第一偶极激发用于选择第一前体离子并且使第一前体离子碎裂以产生第二前体离子。通过将包括第一激励参数的第一组数据发送到质谱仪，将第一偶极子激励施加到离子的连续束。发送第一组数据，以便第一个四极将第一偶极子激发应用于连续的离子束。质谱仪包括提供连续离子束的离子源和接收连续离子束的第一四极杆，并适于将偶极子激发应用于连续离子束。

2. 发明公开

EP3157043A1 MULTIPLEXED PRECURSOR ISOLATION FOR MASS SPECTROMETRY 审中-公开
标题翻译：用于质谱分析的多重前体分离
公开(公告)号：EP3157043A1
公开(公告)日：2017-04-19
申请号：EP16201479.9
申请日：2014-10-07
申请人： DH Technologies Development Pte. Ltd.
发明人： BABA, Takashi
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/0036 , H01J49/0031 , H01J49/004 , H01J49/04 , H01J49/067 , H01J49/4285
摘要： Systems and methods for multiplexed precursor ion selection are provided. A mass isolator includes a selection region of rods, a transmission region of rods, and a barrier electrode lens separating the selection and transmission regions. Two or more different precursor ions are selected by applying two or more different AC voltage frequencies to rods of a selection region in order to resonate the two or more different precursor ions from a continuous beam of ions. The two or more different precursor ions are transmitted by applying a DC voltage to the barrier electrode lens, creating an electric field potential barrier over which only the resonating ions are transmitted. Precursor ions of product ions from combined product ion spectra produced by multiplexed precursor ion selection are identified by grouping the target precursor ions.
摘要翻译：提供了用于多路复用前体离子选择的系统和方法。质量隔离器包括杆的选择区域，杆的传输区域以及分隔选择区域和透射区域的屏障电极透镜。通过对选择区域的棒施加两个或更多个不同的AC电压频率来选择两个或更多个不同的前体离子，以便使来自连续离子束的两种或更多种不同的前体离子共振。通过向阻挡电极透镜施加直流电压来传输两种或更多种不同的前体离子，从而形成只有谐振离子才透过的电场势垒。通过对靶前体离子进行分组来鉴定来自通过多重前体离子选择产生的组合产物离子谱的产物离子的前体离子。

3. 发明公开

EP2601672A4 A LINEAR ION TRAP FOR RADIAL AMPLITUDE ASSISTED TRANSFER 审中-公开
标题翻译：线性离子阱由径向幅度支转拨
公开(公告)号：EP2601672A4
公开(公告)日：2017-03-29
申请号：EP11813986
申请日：2011-08-03
申请人： DH TECHNOLOGIES DEV PTE LTD
发明人： LOBODA ALEXANDRE
IPC分类号： H01J49/42
CPC分类号： H01J49/36 , H01J49/0031 , H01J49/4225 , H01J49/4285
摘要： Systems, methods and apparatus for radial amplitude assisted transfer (RAAT) in mass spectrometers are provided in which ions for RAAT are accelerated along a longitudinal axis of a mass spectrometer in order to decrease the magnitude of excitation energy of radially excited ions in an ion trap that allows the radially excited ions to exit the ion trap. Hence, the radially excited ions exit the ion trap with reduced radial energy thereby decreasing the exit angle of the radially exited ions from the ion trap. Furthermore, combined forces on the ions are such that radially excited ions exit the ion trap while unexcited ions remain in the ion trap.

4. 发明公开

EP2740144A4 STEP-SCAN ION TRAP MASS SPECTROMETRY FOR HIGH SPEED PROTEOMICS 审中-公开
标题翻译：离子阱质谱至步骤WEISER扫描HIGH-SPEED蛋白质组学
公开(公告)号：EP2740144A4
公开(公告)日：2015-05-06
申请号：EP12822012
申请日：2012-08-03
申请人： ACADEMIA SINICA
发明人： CHEN CHUNG-HSUAN , LIN JUNG-LEE , CHU MING-LEE
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/4285 , H01J49/0031 , H01J49/424

5. 发明公开

EP2235739A2 LINEAR ION TRAP 有权转让
标题翻译：线性离子阱
公开(公告)号：EP2235739A2
公开(公告)日：2010-10-06
申请号：EP09701383.3
申请日：2009-01-12
申请人： Micromass UK Limited
发明人： GREEN, Martin, Raymond , KENNY, Daniel, James , LANGRIDGE, David , WILDGOOSE, Jason, Lee
IPC分类号： H01J49/42
CPC分类号： H01J49/4225 , H01J49/4285
摘要： A linear ion trap (6,7,8) is disclosed comprising a central quadrupole rod set (6) and a post-filter quadrupole rod set (8). A 180° phase difference is maintained between axially adjacent rod electrodes of the central quadrupole rod set (6) and the post-filter quadrupole (8) so that an axial pseudo-potential barrier is created between the central quadrupole rod set (6) and the post-filter quadrupole (8). A supplementary AC voltage is applied to the rods of the central quadrupole (6) in order to radially excite ions which are desired to be ejected from the ion trap. The ions are ejected from the ion trap (6,7,8) non-adiabatically in an axial direction.

6. 发明授权

EP2748836B1 ION TRAP WITH SPATIALLY EXTENDED ION TRAPPING REGION 有权
公开(公告)号：EP2748836B1
公开(公告)日：2018-02-21
申请号：EP12762364.3
申请日：2012-08-22
申请人： Micromass UK Limited
发明人： GILES, Kevin , GREEN, Martin Raymond , KENNY, Daniel James , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
IPC分类号： H01J49/42
CPC分类号： H01J49/424 , H01J49/421 , H01J49/422 , H01J49/4285
摘要： A mass or mass to charge ratio selective ion trap is disclosed having an increased charge storage capacity. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC voltage and/or an RF voltage acts to confine ions in a second (x) direction within the ion trap. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. Ions are excited in the third (z) direction and are caused to be mass or mass to charge ratio selectively ejected in the third (z) direction.

7. 发明公开

EP3147934A1 SYSTEMS AND METHODS FOR MULTIPOLE OPERATION 有权
标题翻译： SYSTEME UND VERFAHRENFÜRBETRIEB EINES MULTIPOLS
公开(公告)号：EP3147934A1
公开(公告)日：2017-03-29
申请号：EP16188899.5
申请日：2016-09-15
申请人： Thermo Finnigan LLC
发明人： REMES, Philip M.
IPC分类号： H01J49/42
CPC分类号： H01J49/4285 , H01J49/4245 , H01J49/425 , H01J49/4255
摘要： A method for identifying components of a sample includes providing a sample to an ion source and generating a plurality of ions from constituent components of the sample, applying a first RF waveform at a first RF amplitude to an ion trap with field resonances while directing the plurality of ions into the ion trap, and applying a second RF waveform at a second RF amplitude to the ion trap while focusing the plurality of ions towards the center of the ion trap along the longitudinal axis. The method further includes ejecting the plurality of ions from the ion trap into a mass analyzer, and using the mass analyzer to determine the mass-to-charge ratio of the ions.
摘要翻译：用于识别样品组分的方法包括将样品提供给离子源并从样品的构成组分产生多个离子，将第一RF振幅的第一RF波形施加到具有场谐振的离子阱，同时引导多个的离子进入离子阱，以及将第二RF振幅的第二RF波形施加到离子阱，同时沿着纵向轴线将多个离子聚焦到离子阱的中心。该方法还包括将多个离子从离子阱排出到质量分析器中，并且使用质量分析器确定离子的质荷比。

8. 发明公开

EP2047244A1 METHOD OF OPERATING A MASS SPECTROMETER TO PROVIDE RESONANT EXCITATION ION TRANSFER 审中-公开
标题翻译：一种用于操作质谱仪共振激发离子运输
公开(公告)号：EP2047244A1
公开(公告)日：2009-04-15
申请号：EP07800421.5
申请日：2007-07-17
申请人： MDS Analytical Technologies, a business unit of MDS INC., doing business through its SCIEX Division , Applied Biosystems Inc.
发明人： THOMSON, Bruce , HAGER, Jim
IPC分类号： G01N30/72 , H01J49/10 , H01J49/40
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/4265 , H01J49/4285
摘要： A method of operating a mass spectrometer having a rod set is provided. The rod set has a first end, a second end opposite to the first end, and a longitudinal axis extending between the first end and the second end. The method comprises a) admitting ions into the rod set; b) trapping at least some of the ions in the rod set by i) producing a first barrier field at a first end member adjacent to the first end of the rod set, ii) producing a second barrier field at a second end member adjacent to the second end of the rod set, and iii) providing an aggregate field comprising an RF field between the rods of the rod set; c) selecting a first selected mass to charge ratio of a first group of ions in the ions; d) determining a first excitement level of a selected characteristic of the aggregate field for the first group of ions; e) adjusting the selected characteristic of the aggregate field to the first excitement level to resonantly excite the first group of ions to mass selectively eject the first group of ions from the rod set past the barrier field; and, f) maintaining the selected characteristic of the aggregate field at the first excitement level during an excitement time interval wherein the excitation time interval is at least 1 millisecond.

9. 发明公开

EP0601118A4 MASS SPECTROMETRY METHOD USING SUPPLEMENTAL AC VOLTAGE SIGNALS. 失效
标题翻译：使用补充交流电压信号的质谱方法。
公开(公告)号：EP0601118A4
公开(公告)日：1995-08-23
申请号：EP92919964
申请日：1992-08-28
申请人： TELEDYNE MEC
发明人： KELLEY PAUL E
IPC分类号： G01N27/62 , H01J49/42
CPC分类号： H01J49/0063 , H01J49/424 , H01J49/4285
摘要： A mass spectrometry method in which a supplemental AC voltage signal having at least one high power frequency component, and at least one low power frequency component, is applied to an ion trap. Each high power component has an amplitude sufficiently large to eject one or more selected ions from the trap, by resonantly exciting the ions. Each low power component has an amplitude sufficient to induce dissociation (or reaction) of one or more selected ions, but insufficient to resonate the ions for detection. The frequency (or band of frequencies) of each high and low power frequency component is selected to match a resonance frequency of ions having a desired mass-to-charge ratio. Each low power component is applied for the purpose of inducing dissociation or reaction of specific trapped ions, which may be parent, daughter, reagent, or product ions, and each high power component is applied to eject undesired products of each such dissociation or reaction process from the trap. In accordance with the invention, a supplemental voltage signal having appropriately selected high and low power frequency components is applied to a trap during an (MS)n or CI, or combined CI/(MS)n, mass spectrometry operation.

10. 发明公开

EP0579935A1 Quadrupole ion trap technique for ion isolation 失效
标题翻译： Verfahren zur selektiven Speicherung von Ionen in einer Quadrupolionenfalle。
公开(公告)号：EP0579935A1
公开(公告)日：1994-01-26
申请号：EP93108719.1
申请日：1993-05-29
申请人： VARIAN ASSOCIATES, INC.
发明人： Wells, Gregory J.
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/424 , H01J49/4285 , H01J49/429
摘要： A method for isolating an ion in a QIT (1) employing values from a mass axis calibration chart to establish the maximum DAC value to scan to in order to scan out m(p)-1 and less during ramp up of RF trapping field while applying a specifically selected fixed supplemental frequency applied during said calibration; and employing values from the calibration curve to establish the DAC value to scan out m(p)+1 and greater during ramping down of RF trapping field, while applying a previously determined fixed broadband spectrum to the QIT end caps (3, 3').
摘要翻译：一种用于分离QIT（1）中的离子的方法，其采用质量轴校准图表的值，以建立扫描到的最大DAC值，以便在RF捕获场的斜坡上升期间扫描m（p）-1和更小，同时在所述校准期间施加特定选择的固定补充频率; 并且使用来自校准曲线的值来建立DAC值，以在RF捕获场的下降期间扫描m（p）+1和更大，同时将先前确定的固定宽带频谱应用于QIT端帽（3,3'）。

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