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1. 发明授权

EP2962094B1 MULTI-POLE ION TRAP FOR MASS SPECTROMETRY 有权
公开(公告)号：EP2962094B1
公开(公告)日：2018-09-05
申请号：EP14756573.3
申请日：2014-02-25
申请人： The Rockefeller University
发明人： KRUTCHINSKY, Andrew, N. , SHERMAN, Vadim , COHEN, Herbert , CHAIT, Brian, T.
IPC分类号： G01N27/62 , G01N27/70 , G01T1/185 , H01J49/42 , H01J49/02 , H01J49/06 , H01J49/36
CPC分类号： H01J49/06 , H01J49/02 , H01J49/36 , H01J49/4225 , H01J49/424
摘要： An ion trap includes a containment region for containing ions, and a plurality of electrodes positioned on a regular polyhedral structure encompassing the containment region. An electrode is positioned on each vertex of the encompassing structure and at least one of the polygonal surfaces includes additional electrodes configured to form a plurality of quadrupoles on the surface. Alternating RF voltage is applied to the plurality of electrodes, so that directly neighboring electrodes are of equal amplitude and opposite polarity at any point in time. This configuration on the polyhedral structure forms a potential barrier for repelling the ions from each of the regular polygonal surfaces and containing them in the trap. Mass selective filters can be formed from the quadrupoles for parallel mass analysis in different m/z windows. Application of a small DC potential to a plate electrode outside the quadrupoles preferentially depletes single charged ions for enhanced signal-to-noise analysis.

2. 发明授权

EP2128791B1 Method of processing spectrometric data 有权
公开(公告)号：EP2128791B1
公开(公告)日：2018-08-01
申请号：EP08251890.3
申请日：2008-05-30
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Pfaff, Hans
IPC分类号： G06K9/00 , G01N33/68 , H01J49/00
CPC分类号： G06F19/703 , G06F17/10 , G06F17/11 , G06F19/12 , G06K9/00543 , H01J49/02
摘要： A method of characterising a sample from spectrometric data using calculation of spectral distance values is disclosed, for use in the field of mass spectrometry. Molecular formula assignment of peaks in mass spectral data is difficult and time-consuming, and the invention provides a computer implemented method of finding a most likely elemental composition of a measured spectral peak of interest. The method analyses isotopic peaks in a portion of the spectrum, using both their mass positions and intensities, to determine a spectral distance between those peaks and isotopic peaks of a candidate composition, finding peaks that match (140). A pattern spectral distance is determined (150) to provide a measure of the correspondence between a set of those peaks in the measured spectrum and peaks of each of a number of candidate compositions. The spectral fit is used to determine a most likely candidate composition (160).

3. 发明公开

EP2962094A2 MULTI-POLE ION TRAP FOR MASS SPECTROMETRY 有权
标题翻译：多极离子陷阱MASS
公开(公告)号：EP2962094A2
公开(公告)日：2016-01-06
申请号：EP14756573.3
申请日：2014-02-25
申请人： The Rockefeller University
发明人： KRUTCHINSKY, Andrew, N. , SHERMAN, Vadim , COHEN, Herbert , CHAIT, Brian, T.
IPC分类号： G01N27/62 , G01N27/70 , G01T1/185 , H01J49/42
CPC分类号： H01J49/06 , H01J49/02 , H01J49/36 , H01J49/4225 , H01J49/424
摘要： An ion trap includes a containment region for containing ions, and a plurality of electrodes positioned on a regular polyhedral structure encompassing the containment region. An electrode is positioned on each vertex of the encompassing structure and at least one of the polygonal surfaces includes additional electrodes configured to form a plurality of quadrupoles on the surface. Alternating RF voltage is applied to the plurality of electrodes, so that directly neighboring electrodes are of equal amplitude and opposite polarity at any point in time. This configuration on the polyhedral structure forms a potential barrier for repelling the ions from each of the regular polygonal surfaces and containing them in the trap. Mass selective filters can be formed from the quadrupoles for parallel mass analysis in different m/z windows. Application of a small DC potential to a plate electrode outside the quadrupoles preferentially depletes single charged ions for enhanced signal-to-noise analysis.

4. 发明授权

EP1810314B1 MASS SPECTROMETER 有权转让
标题翻译： MASSENSPEKTROMETER
公开(公告)号：EP1810314B1
公开(公告)日：2015-04-01
申请号：EP05800123.1
申请日：2005-11-03
申请人： Micromass UK Limited
发明人： BATEMAN, Robert Harold , GILES, Kevin , PRINGLE, Steven Derek , WILDGOOSE, Jason Lee
IPC分类号： G01N27/62 , H01J49/06
CPC分类号： G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/02 , H01J49/062 , H01J49/065 , H01J49/066 , H01J49/40 , H01J49/401 , H01J49/42
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator, an ion guide arranged downstream of the ion mobility spectrometer or separator and a mass analyser downstream of the ion guide. The ion guide comprises an ion funnel comprising a plurality of electrodes having apertures that become progressively smaller in size or area. An AC or RF voltage is applied to the electrodes of the ion guide to confine ions radially.
摘要翻译：公开了一种质谱仪，其包括离子迁移谱仪或分离器，布置在离子迁移谱仪或分离器下游的离子导向器和离子导向器下游的质量分析器。离子导向器包括一个离子漏斗，该离子漏斗包括多个电极，其具有在尺寸或面积上逐渐变小的孔。将AC或RF电压施加到离子导向器的电极以径向限制离子。

5. 发明公开

EP1958233A4 AUTOMATED ANALYSIS OF COMPLEX MATRICES USING MASS SPECTROMETER 有权转让
标题翻译：使用质谱仪复矩阵自动分析
公开(公告)号：EP1958233A4
公开(公告)日：2011-10-05
申请号：EP06828156
申请日：2006-12-07
申请人： DH TECHNOLOGIES DEV PTE LTD
发明人： KIESER BYRON
IPC分类号： H01J49/26 , H01J49/00 , H01J49/02
CPC分类号： H01J49/02 , H01J49/0031

6. 发明公开

EP2128791A3 Method of processing spectrometric data 有权
标题翻译：处理数据光谱的方法
公开(公告)号：EP2128791A3
公开(公告)日：2011-03-09
申请号：EP08251890.3
申请日：2008-05-30
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Pfaff, Hans
IPC分类号： G06K9/00 , G01N33/68 , H01J49/00
CPC分类号： G06F19/703 , G06F17/10 , G06F17/11 , G06F19/12 , G06K9/00543 , H01J49/02
摘要： A method of characterising a sample from spectrometric data using calculation of spectral distance values is disclosed, for use in the field of mass spectrometry. Molecular formula assignment of peaks in mass spectral data is difficult and time-consuming, and the invention provides a computer implemented method of finding a most likely elemental composition of a measured spectral peak of interest. The method analyses isotopic peaks in a portion of the spectrum, using both their mass positions and intensities, to determine a spectral distance between those peaks and isotopic peaks of a candidate composition, finding peaks that match (140). A pattern spectral distance is determined (150) to provide a measure of the correspondence between a set of those peaks in the measured spectrum and peaks of each of a number of candidate compositions. The spectral fit is used to determine a most likely candidate composition (160).

7. 发明公开

EP1764824A3 System and method for preparative mass spectrometry 审中-公开
标题翻译：系统和方法，用于制备质谱
公开(公告)号：EP1764824A3
公开(公告)日：2010-04-21
申请号：EP06254795.5
申请日：2006-09-14
申请人： Purdue Research Foundation
发明人： Blake, Thomas , Ouyang, Zheng , Cooks, Graham R.
IPC分类号： H01J49/02 , H01J49/04
CPC分类号： H01J49/02 , B82Y30/00 , H01J49/04 , Y10T436/25 , Y10T436/25375 , Y10T436/25875
摘要： A preparative mass spectrometer system includes an ionizer (11) which converts the mixture into gas phase ions of the molecules in the mixture (10), and a separator (12) which separates the ions according to their mass to charge ratio or mobility. The separator is a linear ion trap mass analyzer that accumulates the ions based on their mass to charge ratio. A surface (13) is in cooperative relationship with the separator so that the separated molecules are soft landed onto the surface at different locations (14) such that the collected molecules can be stored or further processed/analyzed.

8. 发明公开

EP2168141A2 MASS SPECTROMETER 有权转让
标题翻译：质谱分析仪
公开(公告)号：EP2168141A2
公开(公告)日：2010-03-31
申请号：EP08775941.1
申请日：2008-07-14
申请人： Micromass UK Limited
发明人： GREEN, Martin , KENNY, Daniel, James , LANGRIDGE, David , WILDGOOSE, Jason, Lee
IPC分类号： H01J49/42
CPC分类号： H01J49/4205 , H01J49/02 , H01J49/4225
摘要： A mass spectrometer is disclosed comprising a segmented quadrupole rod set ion trap for trapping ions in axial DC potential wells wherein a potential field is created at the exit of the ion trap which decreases with increasing radius in one radial direction. Ions within the ion trap are mass selectively excited in a radial direction. Ions which have been excited in the radial direction experience a potential field which no longer confines the ions axially within the ion trap but which instead acts to extract the ions and hence causes the ions to be ejected axially from the ion trap.
摘要翻译：公开了一种包括四极杆组离子阱（2,3）的质谱仪，其中在离子阱（4,5）的出口处产生势能场，其在一个径向方向上随半径增加而减小。离子阱（2,3）内的离子在径向方向上被质量选择性地激发。已经在径向激发的离子经历势场，该势场不再将离子轴向限制在离子阱内，而是用于提取离子并因此导致离子从离子阱（2,3）轴向射出，。

9. 发明公开

EP2128791A2 Method of processing spectrometric data 有权
标题翻译：韦尔法罕zur Verarbeitung spektrometrischer Daten
公开(公告)号：EP2128791A2
公开(公告)日：2009-12-02
申请号：EP08251890.3
申请日：2008-05-30
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Pfaff, Hans
IPC分类号： G06K9/00 , G01N33/68 , H01J49/00
CPC分类号： G06F19/703 , G06F17/10 , G06F17/11 , G06F19/12 , G06K9/00543 , H01J49/02
摘要： A method of characterising a sample from spectrometric data using calculation of spectral distance values is disclosed, for use in the field of mass spectrometry. Molecular formula assignment of peaks in mass spectral data is difficult and time-consuming, and the invention provides a computer implemented method of finding a most likely elemental composition of a measured spectral peak of interest. The method analyses isotopic peaks in a portion of the spectrum, using both their mass positions and intensities, to determine a spectral distance between those peaks and isotopic peaks of a candidate composition, finding peaks that match (140). A pattern spectral distance is determined (150) to provide a measure of the correspondence between a set of those peaks in the measured spectrum and peaks of each of a number of candidate compositions. The spectral fit is used to determine a most likely candidate composition (160).
摘要翻译：公开了使用光谱测量数据的光谱测量数据表征样品的方法，用于质谱领域。质谱数据中峰的分子式分配是困难和耗时的，并且本发明提供了一种计算机实现的方法，其找到所测量的感兴趣峰的最可能的元素组成。该方法使用它们的质量位置和强度来分析光谱的一部分中的同位素峰，以确定候选组合物的那些峰和同位素峰之间的光谱距离，找到与（140）匹配的峰。确定图案光谱距离（150）以提供测量光谱中的那些峰的集合与多个候选组合中的每一个的峰值之间的对应关系的度量。频谱拟合用于确定最可能的候选组合（160）。

10. 发明公开

EP2024064A2 ION DETECTION AND PARAMETER ESTIMATION FOR N-DIMENSIONAL DATA 有权转让
标题翻译：离子检测与参数平衡液相色谱 - IONMOBILITÄTSSPEKTROMETRIE - 海量数据
公开(公告)号：EP2024064A2
公开(公告)日：2009-02-18
申请号：EP07784158.3
申请日：2007-05-25
申请人： Waters Investments Limited
发明人： GORENSTEIN, Marc, V. , LI, Guo-zhong
IPC分类号： B01D59/44
CPC分类号： H01J49/26 , G06F19/703 , G06F19/707 , G06K9/00496 , G06K9/00523 , H01J49/0036 , H01J49/02
摘要： Methods and apparatus for LC/IMS/MS analysis involve obtaining noisy raw data from a sample, convolving the data with an artifact-reducing filter, and locating, in retention-time, ion mobility, and mass-to-charge-ratio dimensions, one or more ion peaks of the convolved data.

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