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1. 发明授权

EP3945358B1 OBLIQUE PLANE MICROSCOPE AND METHOD FOR OPERATING THE SAME 有权
公开(公告)号：EP3945358B1
公开(公告)日：2024-04-24
申请号：EP20188631.4
申请日：2020-07-30
IPC分类号： G02B21/00 , G02B21/14 , G02B21/36
CPC分类号： G02B21/14 , G02B21/006 , G02B21/367 , G02B21/0032

2. 发明公开

EP3351992A1 MICRO-SPECTROMETRY MEASUREMENT METHOD AND SYSTEM 有权
公开(公告)号：EP3351992A1
公开(公告)日：2018-07-25
申请号：EP17305076.6
申请日：2017-01-24
申请人： Horiba France SAS
发明人： Kokota, Alexandre , Shynkar, Vasyl , Marchessoux, Cédric
IPC分类号： G02B21/36 , G01J3/28 , G01J3/02 , G01J3/44 , G02B21/00 , G02B21/24 , G02B7/38
CPC分类号： G02B21/367 , G01J3/027 , G01J3/2823 , G01J3/44 , G02B7/38 , G02B21/006 , G02B21/244
摘要： The invention concerns an optical micro-spectrometry system comprising an optical microscope (10), a spectrometry system (50) and an optical system (14) adapted to direct an excitation light beam on the sample through said at least one microscope objective (11, 12) and to collect a Raman or PL light beam from a sample.
According to the invention, the optical micro-spectrometry system comprises an imaging system (16, 41) configured for acquiring a first image (71) and a second image (72) of the sample, by reflection or transmission of an illumination beam from a sample surface, the first image (71) having a large field of view and the second image (72) having a small field of view, a processing system (40) configured for determining an area in the first image (71) corresponding to the second image (72), a display system (44) configured for displaying the first image (71), the second image (72), and a third image (73) representing said area in overlay on the first image (71).

3. 发明公开

EP3327482A1 FLUORESCENCE IMAGE PRODUCING METHOD, FLUORESCENCE IMAGE PRODUCING APPARATUS, AND FLUORESCENCE IMAGE PRODUCING PROGRAM 审中-公开
公开(公告)号：EP3327482A1
公开(公告)日：2018-05-30
申请号：EP17206181.4
申请日：2010-08-06
申请人： Sony Corporation
发明人： Kishima, Koichiro , Yamamoto, Takashi
IPC分类号： G02B21/16 , G02B21/36 , G01N21/64 , G02B21/24 , G02B21/00 , G02B21/10
CPC分类号： A45D33/02 , G01J1/58 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G02B21/006 , G02B21/0076 , G02B21/10 , G02B21/16 , G02B21/244 , G02B21/367
摘要： Method and apparatus for producing an image associated with a biological sample is provided. The biological sample is focused on the biological sample based on fluorescence of a first fluorescent material and the image is captured based on fluorescence of the second fluorescent material. A computer readable memory device storing instructions to cause a data processing unit is also provided.

4. 发明公开

EP3293559A1 MICROSCOPE 无效
标题翻译：显微镜
公开(公告)号：EP3293559A1
公开(公告)日：2018-03-14
申请号：EP17186629.6
申请日：2017-08-17
申请人： Olympus Corporation
发明人： BRINKMAN, Brendan , SHIMADA, Yoshihiro
IPC分类号： G02B21/33 , G02B21/00 , G02B21/26
CPC分类号： G02B21/33 , G01N21/0303 , G01N21/6458 , G01N2021/0342 , G01N2021/0367 , G02B21/006 , G02B21/0088 , G02B21/086 , G02B21/16 , G02B21/22 , G02B21/26 , G02B21/34 , G02B21/361
摘要： Highly reliable observation is achieved by preventing a liquid immersion medium from running out while still reducing the amount and replenishment frequency of the liquid immersion medium with a simple and inexpensive structure. Provided is a microscope 1 including: a chamber 5 that stores a solution W2 in which a cuvette 3 accommodating a solution W1 together with a sample S is immersed and that has an index of refraction identical to that of the solution W1; an immersion objective lens 11 that is placed outside the chamber 5 and that collects light emitted from the sample S; a camera 31 that acquires an image of the light collected by the immersion objective lens 11; a targeting section 12 that moves the immersion objective lens 11 in a direction along a detection light axis P thereof; and a movable stage 7 that supports the cuvette 3 in the chamber 5 so as to be movable in at least a direction along the detection light axis P, wherein the cuvette 3 and the chamber 5 have a transparent section 3b and a transparent section 5b that can transmit light coming from the sample S, and the immersion objective lens 11 is placed so as to face the transparent section 3b of the cuvette 3 with the transparent section 5b of the chamber 5 interposed therebetween.
摘要翻译：通过防止液体浸渍介质用完，同时通过简单和廉价的结构仍然减少液体浸渍介质的量和补充频率来实现高度可靠的观察。本发明提供一种显微镜1，其包括：腔室5，其内部收纳有溶液W2，在该溶液W2中浸渍有与溶液W1一起浸渍有溶液W1的反应杯3，并具有与溶液W1相同的折射率; 浸没物镜11，其设置在腔室5的外侧并且收集从样品S发射的光; 摄像机31，其获取由浸渍物镜11收集的光的图像; 瞄准部12，其使浸渍用物镜11沿着其检测光轴P的方向移动; 以及可移动台7，该可移动台7将腔室5内的反应杯3支承为能够沿着检测光轴P的至少一个方向移动，其中，反应杯3和腔室5具有透明部3b和透明部5b 可以透过来自样品S的光，并且浸渍物镜11被放置为与腔室5的透明部分5b介于其间的反应杯3的透明部分3b相对。

5. 发明公开

EP3211367A1 DISPOSITIF MICROSCOPE CONFOCAL CHROMATIQUE 有权转让
标题翻译：显微镜共焦色度装置
公开(公告)号：EP3211367A1
公开(公告)日：2017-08-30
申请号：EP17166752.0
申请日：2010-02-23
申请人： Unity Semiconductor
发明人： GASTALDO, Philippe
IPC分类号： G01B11/22 , G01N21/95 , G01N21/956 , G02B21/00
CPC分类号： G01N21/9501 , G01N21/9503 , G02B21/0016 , G02B21/006 , G02B21/0064 , H01L22/12
摘要： Un microscope confocal chromatique (7) pourvu d'une voie d'éclairage (10) et d'une voie d'analyse (20), la voie d'éclairage (10) comprenant une source lumineuse polychromatique (11), une fente (12) et un objectif (15) à fort chromatisme axial, la voie d'analyse (20) comprenant ledit objectif, une fente de filtrage chromatique (22) et un capteur d'intensité lumineuse (24) dans cet ordre, la fente de la voie d'analyse assurant un filtrage spatial des longueurs d'onde non focalisées sur la surface de l'objet (30).
摘要翻译：一种具有照明路径（10）和分析路径（20）的彩色共焦显微镜（7），照明路径（10）包括多色光源（11），狭缝所述分析通道（20）依次包括所述透镜，滤色器槽（22）和光强度传感器（24），所述透镜（15）具有高轴向色度的透镜该分析通道在物体（30）的表面上提供未聚焦波长的空间滤波。

6. 发明授权

EP2401574B1 DISPOSITIF ET PROCÉDÉ D'INSPECTION DE PLAQUETTES SEMI-CONDUCTRICES 有权转让
标题翻译： DISPOSITIF ETPROCÉDÉD'INSPECTION DE PLAQUETTES SEMI-CONDUCTRICES
公开(公告)号：EP2401574B1
公开(公告)日：2017-06-07
申请号：EP10708249.7
申请日：2010-02-23
申请人： Unity Semiconductor
发明人： GASTALDO, Philippe
IPC分类号： G01B11/22 , G01N21/95 , G01N21/956 , G02B21/00
CPC分类号： G01N21/9501 , G01N21/9503 , G02B21/0016 , G02B21/006 , G02B21/0064 , H01L22/12

7. 发明公开

EP3097443A1 OPTICAL IMAGING DEVICES AND VARIABLE-FOCUS LENS ELEMENTS, AND METHODS FOR USING THEM 审中-公开
标题翻译：光学成像装置和使及其使用变焦和方法镜片
公开(公告)号：EP3097443A1
公开(公告)日：2016-11-30
申请号：EP15740974.9
申请日：2015-01-22
申请人： The Regents of the University of Colorado, a body corporate
发明人： GOPINATH, Juliet, T. , GIBSON, Emily, A. , BRIGHT, Victor, M. , WEIR, Richard , RESTREPO, Diego
IPC分类号： G02B3/14
CPC分类号： G02B23/243 , G02B3/14 , G02B6/06 , G02B21/0032 , G02B21/006 , G02B21/0076 , G02B23/2446 , G02B23/2469 , G02B23/26 , G02B26/005 , H04N5/2256 , H04N2005/2255
摘要： The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.
摘要翻译：本发明涉及光学成像装置和在生物和医学成像应用中是有用的方法。在一个实施方式中，在光学成像装置包括具有第一端和第二端，脉冲的红外辐射被光学耦合到所述柔性光导的第一端的源极的输出端的柔性光导; 透镜组件附接到并光学耦合到所述柔性光导的第二端，所述透镜组件包括一个可变焦距透镜元件，具有可调焦距的可变焦距透镜元件; 以及耦合到所述柔性的引导光的光检测器，以从朝向柔性光导的所述第一端的第二端检测辐射传播。的光学成像装置和方法可在两个共焦和多光子技术一起使用。

8. 发明公开

EP3084502A1 MEHRFARBEN-SCANNING-MIKROSKOP 有权
标题翻译：更多的色彩扫描显微镜
公开(公告)号：EP3084502A1
公开(公告)日：2016-10-26
申请号：EP14827438.4
申请日：2014-12-19
申请人： Carl Zeiss Microscopy GmbH
发明人： BATHE, Wolfgang
IPC分类号： G02B21/00
CPC分类号： G02B21/0076 , G02B21/0032 , G02B21/006 , G02B21/0064 , G02B21/008 , G02B21/18
摘要： The invention relates to a multi-color scanning microscope comprising at least one first light source for emitting a first excitation beam comprising first excitation light having a first wavelength and a second light source for emitting a second excitation beam comprising second excitation light having a second wavelength, which differs from the first wavelength, comprising coupling-in means for coupling the first excitation beam and/or the second excitation beam into an excitation beam path, comprising optical means for guiding the first excitation beam and the second excitation beam to a sample and for guiding detection light emitted by the sample in a detection beam path to a detection unit, wherein the optical means comprise at least the following components: at least one first main color splitter for separating the first excitation light and/or the second excitation light, on the one hand, from the detection light emitted by the sample, on the other hand, a scanner for scanning the sample with at least the first excitation light and the second excitation light, a microscope objective for focusing the first excitation light and the second excitation light onto or into the sample and for guiding the detection light emitted by the sample in the direction of the detection unit, and comprising the detector unit for detecting the detection light emitted by the sample. The microscope is characterized in that the coupling-in means and at least parts of the optical means are designed and arranged in such a way that the first excitation beam having the first wavelength is guided onto a first sample location and the second excitation beam having the second wavelength is guided onto a second sample location, which differs from the first sample location, and in that the detector unit comprises a first detector for detecting the light emitted by the first sample location and a second detector for detecting the light emitted by the second sample location.

9. 发明公开

EP2990855A1 DEVICE FOR A MICROSCOPE STAGE 审中-公开
标题翻译： VORRICHTUNGFÜREINENMIKROSKOPSTÄNDER
公开(公告)号：EP2990855A1
公开(公告)日：2016-03-02
申请号：EP15186091.3
申请日：2010-10-18
申请人： Ventana Medical Systems, Inc.
发明人： Loney, Gregory C. , Stark, Glenn , Todd, Chris , Sabata, Bikash
IPC分类号： G02B27/02 , G02B17/08 , G02B21/00 , G02B21/24
CPC分类号： G02B21/0036 , G01N1/312 , G01N35/0099 , G01N2035/00049 , G01N2035/00138 , G01N2035/0441 , G01N2035/0462 , G01N2035/0493 , G02B21/002 , G02B21/006 , G02B21/245 , G02B21/26 , G02B21/361
摘要： The application refers to a device for a microscope stage, comprising: a moving stage block; and a base block that guides the moving stage block, wherein the base block includes a first block being substantially flat; and a second block having a triangular shape. The first block and the second block guide the moving stage block in a translational direction. (Fig. 1)
摘要翻译：本申请涉及一种用于显微镜载物台的装置，包括：移动载物台; 以及引导所述移动台块的基块，其中所述基块包括基本上平坦的第一块; 和具有三角形形状的第二块。第一块和第二块在平移方向上引导移动台块。（图。1）

10. 发明公开

EP2870498A4 STRUCTURED ILLUMINATION MICROSCOPY APPARATUS AND METHOD 审中-公开
标题翻译：结构化光镜和方法
公开(公告)号：EP2870498A4
公开(公告)日：2016-03-02
申请号：EP13812818
申请日：2013-07-05
申请人： HARRIS MARTIN RUSSELL
发明人： HARRIS MARTIN RUSSELL
IPC分类号： G02B21/08 , B82Y10/00 , B82Y20/00 , B82Y35/00 , G02B21/16 , G02B21/36 , G02B23/24 , G02B23/26 , G02B27/58 , G03F7/20
CPC分类号： G02B21/0032 , B82Y10/00 , B82Y20/00 , B82Y35/00 , G01Q60/18 , G01Q60/22 , G02B1/002 , G02B3/0037 , G02B6/04 , G02B21/006 , G02B21/08 , G02B21/16 , G02B21/26 , G02B21/367 , G02B23/2461 , G02B23/2469 , G02B23/26 , G02B27/58
摘要： A microscope or endoscope, comprising a light condenser (such as an objective lens), and an array of micro-lenses (such as supported on a transparent plate), wherein the micro-lenses are arranged spatially to correspond in enlarged form to respective sub-resolution objects or point observational fields on or within a specimen that are separated from one another by an optically resolvable distance and to receive light from the sub-resolution objects or point observational fields, and each of the micro-lenses is arranged to converge light from the respective corresponding sub-resolution object or point observational field to a diffraction limited spot at an image plane.

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