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1. 发明公开

EP3279666A1 MEANS AND METHODS FOR DETERMINATION OF ISOTOPE LABELED AMINO ACIDS 无效
标题翻译：测定同位素标记的氨基酸的方法和方法
公开(公告)号：EP3279666A1
公开(公告)日：2018-02-07
申请号：EP16183106.0
申请日：2016-08-05
申请人： BASF Plant Science Company GmbH
发明人： The designation of the inventor has not yet been filed
IPC分类号： G01N33/68 , B01D59/26
CPC分类号： G01N33/6806 , B01D59/26 , B01D59/44 , B01D59/50 , G01N33/6848 , G01N33/6851 , G01N2560/00
摘要： The present invention relates to a method for extracting at least one isotope-labelled compound from a complex matrix sample comprising a) contacting said complex matrix sample with an extraction solvent comprising a water-miscible organic solvent and water, b) binding cationic isotope-labelled compounds to a solid adsorbent in the presence of an acid, c) collecting non-cationic isotope-labelled compounds not binding to said solid adsorbent and/or eluting said cationic isotope-labelled compounds from said solid sorbent, d) thereby extracting at least one isotope-labelled compound from said complex matrix sample. The present invention further relates to a method for determining at least one isotope-labelled compound comprised in a complex matrix sample, comprising the aforesaid steps and the further steps of separating cationic and/or non-cationic isotope-labelled compounds by chromatographic steps, and determining, cationic and/or non-cationic isotope-labelled compounds. Further, the present invention relates to kits and uses related to said methods.
摘要翻译：本发明涉及从复合基质样品中提取至少一种同位素标记的化合物的方法，其包括a）使所述复合基质样品与包含水混溶性有机溶剂和水的提取溶剂接触，b）结合阳离子同位素标记的化合物在酸存在下与固体吸附剂接触，c）收集不与所述固体吸附剂结合的非阳离子同位素标记化合物和/或从所述固体吸附剂洗脱所述阳离子同位素标记化合物，d）由此提取至少一种来自所述复杂基质样品的同位素标记的化合物。本发明进一步涉及用于确定包含在复合基质样品中的至少一种同位素标记化合物的方法，其包括上述步骤和通过色谱步骤分离阳离子和/或非阳离子同位素标记化合物的其他步骤，以及测定阳离子和/或非阳离子同位素标记的化合物。此外，本发明涉及与所述方法有关的试剂盒和用途。

2. 发明授权

EP2565646B1 DIAGNOSTIC MARKER FOR KIDNEY DISEASES AND USE THEREOF 有权
标题翻译：肾病的诊断标记及其应用
公开(公告)号：EP2565646B1
公开(公告)日：2017-10-18
申请号：EP11775009.1
申请日：2011-04-26
申请人： Sysmex Corporation , Human Metabolome Technologies, Inc.
发明人： SATO, Hajime , OHASHI, Yoshiaki , SASAKI, Kazunori , SUTO, Kouzou , OTOMO, Yasuhiro
IPC分类号： G01N33/50 , G01N33/48 , G01N33/68
CPC分类号： G01N27/62 , G01N33/6806 , G01N33/6893 , G01N2800/347

3. 发明授权

EP2863934B1 ADVANCED GLYCATION END PRODUCT ANALOGUES 有权
标题翻译：先进的糖化终端产品类似物
公开(公告)号：EP2863934B1
公开(公告)日：2017-08-16
申请号：EP13742478.4
申请日：2013-06-25
申请人： Phytoquest Limited
发明人： NASH, Robert James
IPC分类号： C12P13/04 , C12P13/10 , A61K36/81 , A61K36/87 , A61K36/19 , A61K36/23 , A61K36/28 , A61K36/38 , A61K36/66 , C07H7/02 , G01N30/06 , G01N30/72 , G01N33/68 , H01J49/00 , A61P3/10 , A61P9/10 , A61P17/06 , A61P25/26 , A61P25/24 , A61P25/28
CPC分类号： C07H7/02 , A61K36/19 , A61K36/23 , A61K36/28 , A61K36/38 , A61K36/66 , A61K36/81 , A61K36/87 , G01N30/06 , G01N30/7206 , G01N33/6806 , H01J49/0027
摘要： Disclosed are processes for the production of composition comprising one or more fructose amino acids, said process comprising the steps of: (a) providing plant material derived from a botanical source selected from plants of the families Solanaceae, Compositae, (Asteraceae), Guttiferae, Umbelliferae, Papaveraceae, Vitidaceae or Acanthaceae; (b) extracting one or more fructose amino acid(s) from said plant material; and optionally (c) detecting the presence and/or measuring the amount of said fructose amino acid(s) in the extract of step (b).
摘要翻译：公开了用于生产包含一种或多种果糖氨基酸的组合物的方法，所述方法包括以下步骤：（a）提供衍生自选自茄科，菊科（菊科）伞形科，罂粟科，Vitidaceae或Acanthaceae; （b）从所述植物材料中提取一种或多种果糖氨基酸; 和任选地（c）检测步骤（b）的提取物中存在和/或测量所述果糖氨基酸的量。

4. 发明公开

EP3190418A1 USE OF SM_SPHINGOMYELIN (D18:1, C16:0) AS A MARKER FOR HEART FAILURE 审中-公开
标题翻译：使用SM_SPHINGOMYELIN（D18：1，C16：0）作为心力衰竭的标记
公开(公告)号：EP3190418A1
公开(公告)日：2017-07-12
申请号：EP17152793.0
申请日：2012-07-27
申请人： metanomics GmbH , Ruprecht-Karls-Universität Heidelberg
发明人： Reszka, Regina , Fuhrmann, Jens , Kastler, Jürgen , Bethan, Bianca , Kluttig, Martin , Katus, Hugo , Frey, Norbert , Sigl geb. Wolf, Johanna , Weis, Tanja
IPC分类号： G01N33/68 , G01N30/72 , G01N30/86 , G01N33/50 , G01N33/62 , G01N33/74 , G01N33/92 , G01N30/30 , G01N30/88
CPC分类号： G01N33/6893 , G01N30/72 , G01N30/8668 , G01N33/50 , G01N33/62 , G01N33/6806 , G01N33/743 , G01N33/92 , G01N2030/3076 , G01N2030/8813 , G01N2405/04 , G01N2405/08 , G01N2560/00 , G01N2800/325 , G01N2800/56 , Y10T436/143333 , Y10T436/144444 , Y10T436/145555 , Y10T436/146666 , Y10T436/147777 , Y10T436/148888 , Y10T436/163333 , Y10T436/171538 , Y10T436/173845 , Y10T436/200833 , Y10T436/201666 , Y10T436/203332 , Y10T436/21
摘要： The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject and a method for monitoring progression or regression of heart failure in a subject. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.
摘要翻译：本发明涉及诊断方法领域。具体而言，本发明考虑了用于诊断受试者中的心力衰竭的方法以及用于监测受试者中心力衰竭的进展或衰退的方法。本发明还涉及用于执行上述方法的工具，诸如诊断装置。

5. 发明公开

EP3171173A1 METHOD OF DIAGNOSIS OF A THORACIC AORTIC ANEURYSM 审中-公开
标题翻译：胸部动脉瘤的诊断方法
公开(公告)号：EP3171173A1
公开(公告)日：2017-05-24
申请号：EP15195509.3
申请日：2015-11-19
申请人： Medizinische Universität Innsbruck
发明人： Dumfarth, Julia , Grimm, Michael , Bernhard, David , Doppler, Christian
IPC分类号： G01N33/68 , G01N33/92
CPC分类号： G01N33/6806 , G01N33/92 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/329
摘要： Method for diagnosing a thoracic aortic aneurysm comprising the steps of
a) quantifying a metabolite level based on at least one metabolite in a sample from a subject,
b) comparing the metabolite level in the sample with a reference value, wherein the reference value is obtained by quantifying the metabolite level determined in step a) in a sample from at least one healthy control subject, and
c) determining if there is a difference of the metabolite level to the reference value, wherein a difference between the metabolite level and the reference value indicates a higher risk of prevalence of a thoracic aortic aneurysms in the subject.
摘要翻译：用于诊断胸主动脉瘤的方法包括以下步骤：a）基于来自受试者的样品中的至少一种代谢物对代谢物水平进行定量，b）将样品中的代谢物水平与参考值进行比较，其中获得参考值通过对来自至少一个健康对照受试者的样品中的步骤a）中确定的代谢物水平进行定量，和c）确定代谢物水平与参考值是否存在差异，其中代谢物水平与参考值之间的差异表明受试者中胸主动脉瘤患病风险较高。

7. 发明公开

EP3076991A2 NUTRITIVE POLYPEPTIDES AND FORMULATIONS THEREOF, AND METHODS OF PRODUCTION AND USE THEREOF 无效
标题翻译： NUTRITIOUS多肽及其制剂及方法进行生产及其用途
公开(公告)号：EP3076991A2
公开(公告)日：2016-10-12
申请号：EP14792624.0
申请日：2014-09-25
申请人： Axcella Health Inc.
发明人： HAMILL, Michael, J. , HEARD, Kathryn , BERRY, David, A. , VON MALTZAHN, Geoffrey , SILVER, Nathaniel, W. , SAMAYOA, Phillip , RAHMAN, Shaila , KRAMARCZYK, John, F. , BOGHIGIAN, Brett, Adam , YOUNG, David, M. , BASU, Subhayu , CHEN, Ying-Ja , DOHERTY, Michael
IPC分类号： A61K38/38
CPC分类号： A61K38/1709 , A23L2/66 , A23L33/17 , A23L33/175 , A23L33/18 , A23L33/195 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K9/0053 , A61K9/0075 , A61K9/0095 , A61K9/146 , A61K9/2054 , A61K9/2866 , A61K38/00 , A61K38/10 , A61K38/16 , A61K38/164 , A61K38/168 , A61K38/17 , A61K38/1703 , A61K38/1767 , A61K38/38 , A61K38/45 , A61K45/06 , C12Y207/04003 , G01N33/6803 , G01N33/6806 , G01N33/6848 , G01N2500/00 , G06F19/18
摘要： Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
摘要翻译：中提供营养多肽。所以提供了包含编码多肽，重组微生物确实使所述多肽，用于表达所述多肽的载体，使用重组微生物制造的多肽的方法，组合物和式蒸发散也包括多肽，核酸以及使用所述多肽的方法的各种其他实施例中组合物和配方重刑。

8. 发明公开

EP2836833A1 PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 审中-公开
标题翻译：产前试验过程在唐氏综合征和三体18
公开(公告)号：EP2836833A1
公开(公告)日：2015-02-18
申请号：EP13775727.4
申请日：2013-04-12
申请人： Wayne State University , Nicolaides, Kypros
发明人： NICOLAIDES, Kypros , BAHADO-SINGH, Ray
IPC分类号： G01N33/53 , G01N33/50 , G01N33/48
CPC分类号： G01N33/70 , G01N33/492 , G01N33/50 , G01N33/6806 , G01N33/6812 , G01N2570/00 , G01N2800/387 , G16H50/30 , Y10T436/147777 , Y10T436/173845 , Y10T436/201666 , Y10T436/203332
摘要： The present invention is directed to methods for predicting a pregnant woman's risk of carrying a fetus with Down syndrome (Trisomy 21) or Trisomy 18. The methods are based on measuring one or more metabolites obtained from a pregnant woman's bodily fluid, such as blood or urine, and found to be predictive of Trisomy 21 or Trisomy 18.

9. 发明公开

EP2336763A1 Method for analysis of compounds with amino group and analytical reagent thereof 审中-公开
标题翻译：对于含有氨基和分析试剂为此物质分析方法。
公开(公告)号：EP2336763A1
公开(公告)日：2011-06-22
申请号：EP10012964.2
申请日：2003-02-13
申请人： Ajinomoto Co., Inc.
发明人： Miyano, Hiroshi , Yahashi, Akihisa , Shimbo, Kazutaka , Nakazawa, Masakazu , Hirayama, Kazuo
IPC分类号： G01N27/62 , G01N33/68 , G01N30/72
CPC分类号： G01N33/58 , C07D207/46 , G01N33/6803 , G01N33/6806 , G01N33/6848 , G01N2458/15 , G01N2560/00 , Y10T436/13 , Y10T436/14 , Y10T436/145555 , Y10T436/24
摘要： There is provided a method for the analysis of a compound with amino group such as amino acid and peptide contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimidyl carbamate iodide to enhance the selectivity whereby it is analyzed easily and conveniently with a high sensitivity. Particularly by means of mass spectrometry such as MS/MS method, the aimed compound is able to be quantitatively analyzed. There are further provided a labeling reagent for mass spectrometry used therefor and a novel compound which is able to be used for the labeling reagent.
摘要翻译：提供了一种用于具有氨基的化合物进行分析的方法：如包含在样品和方便的方式以高灵敏度在氨基酸和肽。含与氨基的化合物的样品中与氨基的化合物被标记有特定氨基甲酸酯化合物：如对 - 三甲基铵anilyl-N-羟基氨基甲酸叔丁酯碘化物，以增强选择性由此将其以高灵敏度容易和方便地进行分析。特别是，通过质谱分析法的方式：如MS / MS方法，目的化合物是能够定量分析。这里还提供了用于其用于质谱测试的标记试剂和一种新的化合物的所有其能够被用于标记试剂。

10. 发明公开

EP2172775A1 METHOD OF EVALUATING VISCERAL FAT ACCUMULATION 审中-公开
标题翻译： VERFAHREN ZUR BEWERTUNG DER ANREICHERUNG VON VISZERALFETT
公开(公告)号：EP2172775A1
公开(公告)日：2010-04-07
申请号：EP08765835.7
申请日：2008-06-25
申请人： Ajinomoto Co., Inc.
发明人： TANAKA, Takayuki , ANDO, Toshihiko , YAMAMOTO, Hiroshi , YAMAKADO, Minoru
IPC分类号： G01N33/68
CPC分类号： G01N33/6806 , G01N2800/02 , G01N2800/04 , G01N2800/50 , G06F19/3418 , G16H10/40
摘要： Provided are a method of evaluating visceral fat accumulation, a visceral fat accumulation-evaluating apparatus, a visceral fat accumulation-evaluating method, a visceral fat accumulation-evaluating system, a visceral fat accumulation-evaluating program, a recording medium, and the like, which are capable of evaluating a visceral fat accumulation condition accurately by utilizing concentrations of amino acids in blood. According to the method of evaluating visceral fat accumulation of the present invention, amino acid concentration data on concentration values of amino acids in blood collected from a subject to be evaluated is measured, and a visceral fat accumulation condition in the subject is evaluated based on the measured amino acid concentration data of the subject.
摘要翻译：提供了评价内脏脂肪蓄积的方法，内脏脂肪蓄积评价装置，内脏脂肪蓄积评价方法，内脏脂肪蓄积评价系统，内脏脂肪蓄积评价程序，记录介质等，其能够通过利用血液中氨基酸的浓度来准确地评估内脏脂肪蓄积条件。根据本发明的内脏脂肪蓄积的评价方法，测定从被评价对象收集的血液中的氨基酸的浓度值的氨基酸浓度数据，并根据对象的内脏脂肪蓄积条件测量受试者的氨基酸浓度数据。

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