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1. 发明公开

EP2570812A3 Droplet actuator devices and methods employing magnetic beads 有权转让
公开(公告)号：EP2570812A3
公开(公告)日：2013-12-11
申请号：EP12191032.7
申请日：2008-02-11
申请人： Advanced Liquid Logic, Inc.
发明人： Sista, Ramakrishna , Pamula, Vamsee K. , Srinivasan, Vijay , Eckhardt, Allen E. , Pollack, Michael G.
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/54326 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/502784 , B01L2200/025 , B01L2200/028 , B01L2200/0647 , B01L2200/0673 , B01L2200/141 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0427 , B01L2400/043 , C12M25/01 , C12M25/16 , G01N27/44717 , G01N27/44786 , G01N33/54386 , G01N35/0098 , G01N2035/1046
摘要： A method of assembling a droplet actuator assembly (1400) comprises: attaching to a mount structure (1410) a substrate (1434) including an electrode emitting an electric field (1438) affecting a droplet present in the droplet actuator assembly and a magnet assembly (1420) configured to accommodate a magnet (1428) emitting a magnetic field affecting a magnetically responsive bead present in the droplet actuator assembly. At least one of the substrate (1434) and the magnet assembly (1420) are removably attached to the mount structure (1410). Attaching the substrate (1434) may further comprise selecting the substrate from among a plurality of substrates (1434) configured to attach to the mount structure (1410) and including different electric field emission characteristics, and/or selecting the magnet assembly (1420) from among a plurality of magnetic assemblies (1420), each magnet assembly configured to attach to the mount structure (1410) and including different magnet properties.

2. 发明公开

EP2111554A2 DROPLET ACTUATOR DEVICES AND METHODS EMPLOYING MAGNETIC BEADS 有权
标题翻译：滴落执行器装置和使用磁珠的方法
公开(公告)号：EP2111554A2
公开(公告)日：2009-10-28
申请号：EP08729498.9
申请日：2008-02-11
申请人： Advanced Liquid Logic, Inc.
发明人： SISTA, Ramakrishna , PAMULA, Vamsee K. , POLLACK, Michael G. , SRINIVASAN, Vijay , ECKHARDT, Allen E.
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/54326 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/502784 , B01L2200/025 , B01L2200/028 , B01L2200/0647 , B01L2200/0673 , B01L2200/141 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0427 , B01L2400/043 , C12M25/01 , C12M25/16 , G01N27/44717 , G01N27/44786 , G01N33/54386 , G01N35/0098 , G01N2035/1046
摘要： A method of assembling a droplet actuator assembly (1400) comprises: attaching to a mount structure (1410) a substrate (1434) including an electrode emitting an electric field (1438) affecting a droplet present in the droplet actuator assembly and a magnet assembly (1420) configured to accommodate a magnet (1428) emitting a magnetic field affecting a magnetically responsive bead present in the droplet actuator assembly. At least one of the substrate (1434) and the magnet assembly (1420) are removably attached to the mount structure (1410). Attaching the substrate (1434) may further comprise selecting the substrate from among a plurality of substrates (1434) configured to attach to the mount structure (1410) and including different electric field emission characteristics, and/or selecting the magnet assembly (1420) from among a plurality of magnetic assemblies (1420), each magnet assembly configured to attach to the mount structure (1410) and including different magnet properties.
摘要翻译：提供与磁响应珠接触并具有减少量的物质的液滴的方法。该方法通常包括以下步骤：（a）提供液滴致动器（200），其包括：（i）包括电极（214）的衬底（210），所述电极布置成用于在表面上进行液滴操作; （ii）起始液滴（218/222），其包含：（1）一个或多个磁响应珠粒（220）; （2）物质的起始量; 和（3）起始量; （b）将所述一个或多个磁响应珠磁性固定在与目标液滴分离区相距一定距离的位置处，（224）; （c）进行包括液滴分割操作的一个或多个液滴操作，所述液滴分割操作被选择以分割组合的液滴以产生一组液滴，所述液滴集合包括：（i）包含基本上全部所述一个或多个磁响应珠并具有减少物质相对于起始浓度的量; 和（ii）基本上不含磁响应珠的液滴（222）。

3. 发明授权

EP2570812B1 METHOD OF ASSEMBLING A DROPLET ACTUATOR ASSEMBLY 有权转让
公开(公告)号：EP2570812B1
公开(公告)日：2018-07-18
申请号：EP12191032.7
申请日：2008-02-11
申请人： Advanced Liquid Logic, Inc.
发明人： Sista, Ramakrishna , Pamula, Vamsee K. , Srinivasan, Vijay , Eckhardt, Allen E. , Pollack, Michael G.
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/54326 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/502784 , B01L2200/025 , B01L2200/028 , B01L2200/0647 , B01L2200/0673 , B01L2200/141 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0427 , B01L2400/043 , C12M25/01 , C12M25/16 , G01N27/44717 , G01N27/44786 , G01N33/54386 , G01N35/0098 , G01N2035/1046
摘要： A method of assembling a droplet actuator assembly (1400) comprises: attaching to a mount structure (1410) a substrate (1434) including an electrode emitting an electric field (1438) affecting a droplet present in the droplet actuator assembly and a magnet assembly (1420) configured to accommodate a magnet (1428) emitting a magnetic field affecting a magnetically responsive bead present in the droplet actuator assembly. At least one of the substrate (1434) and the magnet assembly (1420) are removably attached to the mount structure (1410). Attaching the substrate (1434) may further comprise selecting the substrate from among a plurality of substrates (1434) configured to attach to the mount structure (1410) and including different electric field emission characteristics, and/or selecting the magnet assembly (1420) from among a plurality of magnetic assemblies (1420), each magnet assembly configured to attach to the mount structure (1410) and including different magnet properties.

4. 发明公开

EP2570811A3 Droplet actuator devices and methods employing magnetic beads 有权
标题翻译： Tröpfchenaktuatorvorrichtungen和方法用磁珠
公开(公告)号：EP2570811A3
公开(公告)日：2013-12-11
申请号：EP12191029.3
申请日：2008-02-11
申请人： Advanced Liquid Logic, Inc.
发明人： Sista, Ramakrishna , Pamula, Vamsee K. , Srinivasan, Vijay , Eckhardt, Allen E. , Pollack, Michael G.
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/54326 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/502784 , B01L2200/025 , B01L2200/028 , B01L2200/0647 , B01L2200/0673 , B01L2200/141 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0427 , B01L2400/043 , C12M25/01 , C12M25/16 , G01N27/44717 , G01N27/44786 , G01N33/54386 , G01N35/0098 , G01N2035/1046
摘要： A droplet actuator device (600) comprises: an array of electrodes (622) on a substrate (614) configured for conducting one or more droplet operations; a magnet (638) that exerts a magnetic field on a droplet (634) positioned on a first set of one or more of the electrodes (622); and a magnetic shield (642) that shields a droplet (634) positioned on a second set of one or more of the electrodes (622) from the magnetic field. A method of conducting a droplet operation using the device comprises: positioning a first droplet (634) comprising one or more magnetically responsive beads on one or more electrodes (622) from the first set, so that the beads are attracted by the magnetic field; positioning a second droplet comprising one or more magnetically responsive beads on one or more electrodes from the second set, so that the beads are not attracted by the magnetic field; and conducting a droplet operation on the first droplet and/or the second droplet.

5. 发明公开

EP2633330A1 MICROFLUIDIC PROCESSING OF TARGET SPECIES IN FERROFLUIDS 有权转让
标题翻译： MI EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN
公开(公告)号：EP2633330A1
公开(公告)日：2013-09-04
申请号：EP11836778.8
申请日：2011-06-07
申请人： Yale University, Inc.
发明人： KOSER, Hur
IPC分类号： G01N35/08 , G01N33/483 , G01N27/327 , G01N15/14 , B81B7/00
CPC分类号： B01D57/02 , B01L3/502753 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2400/0415 , B01L2400/043 , B03C1/0335 , B03C1/253 , B03C1/288 , B03C1/32 , B03C2201/18 , B03C2201/24 , B03C2201/26 , G01N15/1404 , G01N27/44786
摘要： Disclosed are systems, devices, methods, and other implementations, including a device to detect at least one target species in a sample, with the device including a microfluidic channel configured to receive the sample containing the at least one target species and a biocompatible ferrofluid in which the at least one target species is suspended, a detector to determine the at least one target species in the sample, and at least two of electrodes positioned proximate the microfluidic channel, the at least two electrodes configured to generate controllable magnetic forces in the sample containing the ferrofluid when a controllable at least one electrical current is applied to the at least two electrodes. The generated controllable magnetic forces causes the at least one target species to be directed towards the detector. Also disclosed are devices for separating target species in a ferrofluid, and for focusing target species suspended in a ferrofluid.
摘要翻译：公开了系统，装置，方法和其他实施方式，包括用于检测样品中的至少一种目标物种的装置，其中该装置包括微流体通道，该微流体通道被配置为接收含有至少一种靶物种的样品和生物相容性铁磁流体所述至少一种靶物种悬浮在其中，所述检测器用于确定所述样品中的至少一种目标物种，以及位于所述微流体通道附近的至少两个电极，所述至少两个电极被配置为在所述样品中产生可控的磁力当至少两个电极施加可控的至少一个电流时，所述铁磁流体包含所述铁磁流体。产生的可控磁力使得至少一个目标物种被引向检测器。还公开了用于分离铁磁流体中的目标物种和用于聚焦悬浮在铁磁流体中的目标物种的装置。

6. 发明公开

EP2570812A2 Droplet actuator devices and methods employing magnetic beads 有权转让
标题翻译：液滴致动器装置和采用磁珠的方法
公开(公告)号：EP2570812A2
公开(公告)日：2013-03-20
申请号：EP12191032.7
申请日：2008-02-11
申请人： Advanced Liquid Logic, Inc.
发明人： Sista, Ramakrishna , Pamula, Vamsee K. , Srinivasan, Vijay , Eckhardt, Allen E. , Pollack, Michael G.
IPC分类号： G01N33/543 , B01L3/00 , C12M1/12
CPC分类号： G01N33/54326 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/502784 , B01L2200/025 , B01L2200/028 , B01L2200/0647 , B01L2200/0673 , B01L2200/141 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0427 , B01L2400/043 , C12M25/01 , C12M25/16 , G01N27/44717 , G01N27/44786 , G01N33/54386 , G01N35/0098 , G01N2035/1046
摘要： A method of assembling a droplet actuator assembly (1400) comprises: attaching to a mount structure (1410) a substrate (1434) including an electrode emitting an electric field (1438) affecting a droplet present in the droplet actuator assembly and a magnet assembly (1420) configured to accommodate a magnet (1428) emitting a magnetic field affecting a magnetically responsive bead present in the droplet actuator assembly. At least one of the substrate (1434) and the magnet assembly (1420) are removably attached to the mount structure (1410). Attaching the substrate (1434) may further comprise selecting the substrate from among a plurality of substrates (1434) configured to attach to the mount structure (1410) and including different electric field emission characteristics, and/or selecting the magnet assembly (1420) from among a plurality of magnetic assemblies (1420), each magnet assembly configured to attach to the mount structure (1410) and including different magnet properties.
摘要翻译：一种组装液滴致动器组件（1400）的方法包括：将包括发射影响存在于液滴致动器组件中的液滴的电场（1438）的电极的衬底（1434）附接到安装结构（1410）;以及磁体组件 1420），其被配置为容纳发射影响存在于所述液滴致动器组件中的磁响应珠的磁场的磁体（1428）。衬底（1434）和磁体组件（1420）中的至少一个可移除地附接到安装结构（1410）。附接衬底（1434）可以进一步包括从被配置为附接到安装结构（1410）并包括不同电场发射特性的多个衬底（1434）中选择衬底，和/或从磁体组件（1420）选择在多个磁性组件（1420）中，每个磁体组件被配置成附接到安装结构（1410）并且包括不同的磁体属性。

7. 发明公开

EP3300802A1 MICROFLUIDIC DEVICE 有权转让
公开(公告)号：EP3300802A1
公开(公告)日：2018-04-04
申请号：EP17193403.7
申请日：2017-09-27
申请人： Sharp Life Science (EU) Limited
发明人： KOSAKA, Tomohiro , KITOH, Kenichi , HARA, Takeshi , KADONO, Shinya , YASUO, Fumitoshi , DAIO, Manabu , TERANISHI, Tomoko , LI, Hao
IPC分类号： B01L3/00
CPC分类号： B01L3/502746 , B01L3/502715 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L2200/06 , B01L2300/0654 , B01L2300/0887 , B01L2300/165 , B01L2300/168 , B01L2400/0427 , G01N27/44786 , G01N27/44791
摘要： Provided is a microfluidic device that, as compared with a conventional microfluidic device, (i) is smoother in surface of a water-repellent layer provided above a segment electrode and (ii) makes it easier for microfluid provided in the surface of the water-repellent layer to slide. A microfluidic device (1) includes: an array substrate (10) including a plurality of electrodes (14); and a counter substrate (40) including at least one electrode (42), the array substrate (10) and the counter substrate (40) having therebetween an internal space (50) in which to cause an electroconductive droplet (51) to move across the plurality of electrodes (14), and the plurality of electrodes (14) being provided on a first flattening resin layer (13) and each being a light-blocking metal electrode.
摘要翻译：本发明提供一种微流体装置，其与现有的微流体装置相比，（i）在设于分段电极的上方的防水层的表面更平滑，并且（ii）更容易设置于防水层的表面，驱避层滑动。微流体装置（1）包括：包括多个电极（14）的阵列基板（10）; 和具有至少一个电极（42）的对向基板（40），所述阵列基板（10）和所述对向基板（40）之间具有内部空间（50），在所述内部空间中使导电性液滴（51）所述多个电极（14）和所述多个电极（14）设置在第一平坦化树脂层（13）上，并且每个电极均是阻光金属电极。

8. 发明授权

EP1328803B1 SYSTEMS AND METHODS FOR CELL SUBPOPULATION ANALYSIS 有权
标题翻译：系统和方法的单元部分群体分析
公开(公告)号：EP1328803B1
公开(公告)日：2005-09-07
申请号：EP01948448.4
申请日：2001-06-14
申请人： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： GASCOYNE, Peter, R., C. , BECKER, Frederick, F. , VYKOUKAL, Jody
IPC分类号： G01N30/00 , B03C5/02
CPC分类号： B03C5/026 , B03C5/028 , G01N15/1056 , G01N27/44786 , G01N30/0005 , G01N2015/0288 , G01N2015/1006 , G01N2015/1081

9. 发明公开

EP1279953A3 Verfahren und Vorrichtung zur Probentrennung 审中-公开
标题翻译：方法和装置用于样品分离
公开(公告)号：EP1279953A3
公开(公告)日：2004-12-29
申请号：EP02014850.8
申请日：2002-07-03
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
发明人： Hagedorn, Rolf, Dr. , Zimmermann, Heiko, Dr.
IPC分类号： G01N27/447
CPC分类号： G01N27/44786 , G01N27/44773
摘要： Es werden Verfahren und Vorrichtungen zur Probentrennung beschrieben, bei denen eine Flüssigkeit, die eine Probe mit mindestens einem Typ elektrisch geladener oder magnetischer Partikel enthält, entlang einer Trennstrecke (11) eine Strömung mit einer bestimmten Strömungsrichtung bildet und elektrischen oder magnetischen Feldern ausgesetzt wird, die in mindestens einem Separationsabschnitt (13, 14) der Trennstrecke Komponenten enthalten, die zur Strömungsrichtung gleichgerichtet sind, und in mindestens einem Anreicherungsabschnitt (15, 16) der Trennstrecke Komponenten enthalten, die zur Strömungsrichtung entgegengerichtet sind, so dass die Partikel entlang der Trennstrecke eine effektive Wanderungsgeschwindigkeit besitzen, die von der Position der Partikel in der Trennstrecke und der jeweiligen Ladung oder Magnetisierung der Partikel abhängt.

10. 发明授权

EP0941142B1 PROCEDE ET DISPOSITIF DE SEPARATION DE PARTICULES OU MOLECULES PAR MIGRATION A TRAVERS UN FERROFLUIDE 失效
标题翻译：程序和装置，通过偏移ON铁磁流体粒子或分子的分离
公开(公告)号：EP0941142B1
公开(公告)日：2003-07-09
申请号：EP97948951.5
申请日：1997-11-28
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人： MAYER, Pascal , BIBETTE, Jérôme , VIOVY, Jean-Louis
IPC分类号： B03C1/32 , G01N27/447 , B01D57/02
CPC分类号： B03C1/32 , B01D57/02 , G01N27/44786
摘要： The invention concerns a method for separating particles or molecules whereby these particles or molecules are introduced in a separating medium and a moving force is applied to them in said medium. The method is characterised in that the separating medium is a ferrofluid, i.e. a colloidal suspension of magnetic particles and a magnetic field is applied to this ferrofluid generating therein at least an alternation of a zone rich in magnetic particles and a zone poor in magnetic particles, part at least of the region of the ferrofluid in which this alternation is generated is passed through by the particles or molecules to be separated during their migration.

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