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1. 发明公开

EP2570812A3 Droplet actuator devices and methods employing magnetic beads 有权转让
公开(公告)号：EP2570812A3
公开(公告)日：2013-12-11
申请号：EP12191032.7
申请日：2008-02-11
申请人： Advanced Liquid Logic, Inc.
发明人： Sista, Ramakrishna , Pamula, Vamsee K. , Srinivasan, Vijay , Eckhardt, Allen E. , Pollack, Michael G.
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/54326 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/502784 , B01L2200/025 , B01L2200/028 , B01L2200/0647 , B01L2200/0673 , B01L2200/141 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0427 , B01L2400/043 , C12M25/01 , C12M25/16 , G01N27/44717 , G01N27/44786 , G01N33/54386 , G01N35/0098 , G01N2035/1046
摘要： A method of assembling a droplet actuator assembly (1400) comprises: attaching to a mount structure (1410) a substrate (1434) including an electrode emitting an electric field (1438) affecting a droplet present in the droplet actuator assembly and a magnet assembly (1420) configured to accommodate a magnet (1428) emitting a magnetic field affecting a magnetically responsive bead present in the droplet actuator assembly. At least one of the substrate (1434) and the magnet assembly (1420) are removably attached to the mount structure (1410). Attaching the substrate (1434) may further comprise selecting the substrate from among a plurality of substrates (1434) configured to attach to the mount structure (1410) and including different electric field emission characteristics, and/or selecting the magnet assembly (1420) from among a plurality of magnetic assemblies (1420), each magnet assembly configured to attach to the mount structure (1410) and including different magnet properties.

2. 发明公开

EP2111554A2 DROPLET ACTUATOR DEVICES AND METHODS EMPLOYING MAGNETIC BEADS 有权
标题翻译：滴落执行器装置和使用磁珠的方法
公开(公告)号：EP2111554A2
公开(公告)日：2009-10-28
申请号：EP08729498.9
申请日：2008-02-11
申请人： Advanced Liquid Logic, Inc.
发明人： SISTA, Ramakrishna , PAMULA, Vamsee K. , POLLACK, Michael G. , SRINIVASAN, Vijay , ECKHARDT, Allen E.
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/54326 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/502784 , B01L2200/025 , B01L2200/028 , B01L2200/0647 , B01L2200/0673 , B01L2200/141 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0427 , B01L2400/043 , C12M25/01 , C12M25/16 , G01N27/44717 , G01N27/44786 , G01N33/54386 , G01N35/0098 , G01N2035/1046
摘要： A method of assembling a droplet actuator assembly (1400) comprises: attaching to a mount structure (1410) a substrate (1434) including an electrode emitting an electric field (1438) affecting a droplet present in the droplet actuator assembly and a magnet assembly (1420) configured to accommodate a magnet (1428) emitting a magnetic field affecting a magnetically responsive bead present in the droplet actuator assembly. At least one of the substrate (1434) and the magnet assembly (1420) are removably attached to the mount structure (1410). Attaching the substrate (1434) may further comprise selecting the substrate from among a plurality of substrates (1434) configured to attach to the mount structure (1410) and including different electric field emission characteristics, and/or selecting the magnet assembly (1420) from among a plurality of magnetic assemblies (1420), each magnet assembly configured to attach to the mount structure (1410) and including different magnet properties.
摘要翻译：提供与磁响应珠接触并具有减少量的物质的液滴的方法。该方法通常包括以下步骤：（a）提供液滴致动器（200），其包括：（i）包括电极（214）的衬底（210），所述电极布置成用于在表面上进行液滴操作; （ii）起始液滴（218/222），其包含：（1）一个或多个磁响应珠粒（220）; （2）物质的起始量; 和（3）起始量; （b）将所述一个或多个磁响应珠磁性固定在与目标液滴分离区相距一定距离的位置处，（224）; （c）进行包括液滴分割操作的一个或多个液滴操作，所述液滴分割操作被选择以分割组合的液滴以产生一组液滴，所述液滴集合包括：（i）包含基本上全部所述一个或多个磁响应珠并具有减少物质相对于起始浓度的量; 和（ii）基本上不含磁响应珠的液滴（222）。

3. 发明公开

EP3300802A1 MICROFLUIDIC DEVICE 有权转让
公开(公告)号：EP3300802A1
公开(公告)日：2018-04-04
申请号：EP17193403.7
申请日：2017-09-27
申请人： Sharp Life Science (EU) Limited
发明人： KOSAKA, Tomohiro , KITOH, Kenichi , HARA, Takeshi , KADONO, Shinya , YASUO, Fumitoshi , DAIO, Manabu , TERANISHI, Tomoko , LI, Hao
IPC分类号： B01L3/00
CPC分类号： B01L3/502746 , B01L3/502715 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L2200/06 , B01L2300/0654 , B01L2300/0887 , B01L2300/165 , B01L2300/168 , B01L2400/0427 , G01N27/44786 , G01N27/44791
摘要： Provided is a microfluidic device that, as compared with a conventional microfluidic device, (i) is smoother in surface of a water-repellent layer provided above a segment electrode and (ii) makes it easier for microfluid provided in the surface of the water-repellent layer to slide. A microfluidic device (1) includes: an array substrate (10) including a plurality of electrodes (14); and a counter substrate (40) including at least one electrode (42), the array substrate (10) and the counter substrate (40) having therebetween an internal space (50) in which to cause an electroconductive droplet (51) to move across the plurality of electrodes (14), and the plurality of electrodes (14) being provided on a first flattening resin layer (13) and each being a light-blocking metal electrode.
摘要翻译：本发明提供一种微流体装置，其与现有的微流体装置相比，（i）在设于分段电极的上方的防水层的表面更平滑，并且（ii）更容易设置于防水层的表面，驱避层滑动。微流体装置（1）包括：包括多个电极（14）的阵列基板（10）; 和具有至少一个电极（42）的对向基板（40），所述阵列基板（10）和所述对向基板（40）之间具有内部空间（50），在所述内部空间中使导电性液滴（51）所述多个电极（14）和所述多个电极（14）设置在第一平坦化树脂层（13）上，并且每个电极均是阻光金属电极。

4. 发明授权

EP1328803B1 SYSTEMS AND METHODS FOR CELL SUBPOPULATION ANALYSIS 有权
标题翻译：系统和方法的单元部分群体分析
公开(公告)号：EP1328803B1
公开(公告)日：2005-09-07
申请号：EP01948448.4
申请日：2001-06-14
申请人： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： GASCOYNE, Peter, R., C. , BECKER, Frederick, F. , VYKOUKAL, Jody
IPC分类号： G01N30/00 , B03C5/02
CPC分类号： B03C5/026 , B03C5/028 , G01N15/1056 , G01N27/44786 , G01N30/0005 , G01N2015/0288 , G01N2015/1006 , G01N2015/1081

5. 发明公开

EP1279953A3 Verfahren und Vorrichtung zur Probentrennung 审中-公开
标题翻译：方法和装置用于样品分离
公开(公告)号：EP1279953A3
公开(公告)日：2004-12-29
申请号：EP02014850.8
申请日：2002-07-03
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
发明人： Hagedorn, Rolf, Dr. , Zimmermann, Heiko, Dr.
IPC分类号： G01N27/447
CPC分类号： G01N27/44786 , G01N27/44773
摘要： Es werden Verfahren und Vorrichtungen zur Probentrennung beschrieben, bei denen eine Flüssigkeit, die eine Probe mit mindestens einem Typ elektrisch geladener oder magnetischer Partikel enthält, entlang einer Trennstrecke (11) eine Strömung mit einer bestimmten Strömungsrichtung bildet und elektrischen oder magnetischen Feldern ausgesetzt wird, die in mindestens einem Separationsabschnitt (13, 14) der Trennstrecke Komponenten enthalten, die zur Strömungsrichtung gleichgerichtet sind, und in mindestens einem Anreicherungsabschnitt (15, 16) der Trennstrecke Komponenten enthalten, die zur Strömungsrichtung entgegengerichtet sind, so dass die Partikel entlang der Trennstrecke eine effektive Wanderungsgeschwindigkeit besitzen, die von der Position der Partikel in der Trennstrecke und der jeweiligen Ladung oder Magnetisierung der Partikel abhängt.

6. 发明授权

EP0941142B1 PROCEDE ET DISPOSITIF DE SEPARATION DE PARTICULES OU MOLECULES PAR MIGRATION A TRAVERS UN FERROFLUIDE 失效
标题翻译：程序和装置，通过偏移ON铁磁流体粒子或分子的分离
公开(公告)号：EP0941142B1
公开(公告)日：2003-07-09
申请号：EP97948951.5
申请日：1997-11-28
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人： MAYER, Pascal , BIBETTE, Jérôme , VIOVY, Jean-Louis
IPC分类号： B03C1/32 , G01N27/447 , B01D57/02
CPC分类号： B03C1/32 , B01D57/02 , G01N27/44786
摘要： The invention concerns a method for separating particles or molecules whereby these particles or molecules are introduced in a separating medium and a moving force is applied to them in said medium. The method is characterised in that the separating medium is a ferrofluid, i.e. a colloidal suspension of magnetic particles and a magnetic field is applied to this ferrofluid generating therein at least an alternation of a zone rich in magnetic particles and a zone poor in magnetic particles, part at least of the region of the ferrofluid in which this alternation is generated is passed through by the particles or molecules to be separated during their migration.

7. 发明公开

EP1279953A2 Verfahren und Vorrichtung zur Probentrennung 审中-公开
公开(公告)号：EP1279953A2
公开(公告)日：2003-01-29
申请号：EP02014850.8
申请日：2002-07-03
申请人： FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
发明人： Hagedorn, Rolf, Dr. , Zimmermann, Heiko, Dr.
IPC分类号： G01N27/447
CPC分类号： G01N27/44786 , G01N27/44773
摘要： Es werden Verfahren und Vorrichtungen zur Probentrennung beschrieben, bei denen eine Flüssigkeit, die eine Probe mit mindestens einem Typ elektrisch geladener oder magnetischer Partikel enthält, entlang einer Trennstrecke (11) eine Strömung mit einer bestimmten Strömungsrichtung bildet und elektrischen oder magnetischen Feldern ausgesetzt wird, die in mindestens einem Separationsabschnitt (13, 14) der Trennstrecke Komponenten enthalten, die zur Strömungsrichtung gleichgerichtet sind, und in mindestens einem Anreicherungsabschnitt (15, 16) der Trennstrecke Komponenten enthalten, die zur Strömungsrichtung entgegengerichtet sind, so dass die Partikel entlang der Trennstrecke eine effektive Wanderungsgeschwindigkeit besitzen, die von der Position der Partikel in der Trennstrecke und der jeweiligen Ladung oder Magnetisierung der Partikel abhängt.
摘要翻译： 10A用于样品分离的方法包括沿着分离路径（11）使含有一个或多个带电粒子或磁性粒子的流体通过，以形成具有指定方向的流动，并且使用与流动对准的电场或磁场，以将组分分离分离路径（11）的分离区（13,14）。至少一个浓缩级（15,16）与流动逆流包含在分离路径中。颗粒具有有效的迁移速度，其取决于颗粒在分离路径中的位置和颗粒的主要电荷或磁化。包括用于分离装置（10）的独立权利要求，特别是用于电泳，电渗或磁性样品分离，具有分离路径（11），待分离的颗粒混合物的溶液或悬浮液的流动沿着该分离路径形成在指定的流动方向。场发生器（20）产生电场或磁场，其中场强分量相对于分离路径（11）单独的流动方向逐级对准。优选的方法：分离路径（11）沿着其长度具有不同的横截面，以便改变流速，即分离区域中较高的流速和浓缩区域中较低的流速（ S）。控制分离区域中的磁场或电场至少在浓度区域中产生0的粒子迁移速度。

8. 发明公开

EP0941142A1 PROCEDE ET DISPOSITIF DE SEPARATION DE PARTICULES OU MOLECULES PAR MIGRATION A TRAVERS UN FERROFLUIDE 失效
标题翻译：程序和装置，通过偏移ON铁磁流体粒子或分子的分离
公开(公告)号：EP0941142A1
公开(公告)日：1999-09-15
申请号：EP97948951.0
申请日：1997-11-28
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人： MAYER, Pascal , BIBETTE, Jérôme , VIOVY, Jean-Louis
IPC分类号： B01D57 , B03C1 , B03C5 , C12N15 , G01N27
CPC分类号： B03C1/32 , B01D57/02 , G01N27/44786
摘要： The invention concerns a method for separating particles or molecules whereby these particles or molecules are introduced in a separating medium and a moving force is applied to them in said medium. The method is characterised in that the separating medium is a ferrofluid, i.e. a colloidal suspension of magnetic particles and a magnetic field is applied to this ferrofluid generating therein at least an alternation of a zone rich in magnetic particles and a zone poor in magnetic particles, part at least of the region of the ferrofluid in which this alternation is generated is passed through by the particles or molecules to be separated during their migration.

9. 发明公开

EP3209410A4 SYSTEMS AND METHODS FOR SAMPLE PREPARATION, PROCESSING AND ANALYSIS 审中-公开
公开(公告)号：EP3209410A4
公开(公告)日：2018-05-02
申请号：EP15851818
申请日：2015-10-21
申请人： INTEGENX INC
发明人： KINDWALL ALEXANDER , PARK CHUNGSOO CHARLES , ILKOV FEDOR , JOVANOVICH STEVAN , KING DAVID , LITTLEHALE TRISTAN ROBERT , NILSON DAVID GRANT , PITTARO RICK , SCHUEREN ROBERT A , VANGBO MATTIAS , WUNDERLE PHILIP JUSTUS
IPC分类号： B01D59/42 , C25B11/02 , G01N27/447 , G01N27/49
CPC分类号： G01N27/44791 , B01L3/502715 , B01L7/52 , B01L2200/04 , B01L2200/10 , B01L2200/16 , B01L2300/0681 , B01L2300/0867 , B01L2300/1822 , B01L2300/1827 , B01L2400/0421 , G01N27/44704 , G01N27/44743 , G01N27/44786 , G01N27/453
摘要： The present disclosure provides systems and methods for sample preparation, processing and analysis. Also provided in the present disclosure is a fully-integrated electrophoresis cartridge which has a small footprint and configured to removably engage with the system.

10. 发明授权

EP2111554B1 DROPLET ACTUATOR DEVICES AND METHODS EMPLOYING MAGNETIC BEADS 有权
标题翻译：滴落执行器装置和使用磁珠的方法
公开(公告)号：EP2111554B1
公开(公告)日：2013-05-08
申请号：EP08729498.9
申请日：2008-02-11
申请人： Advanced Liquid Logic, Inc.
发明人： SISTA, Ramakrishna , PAMULA, Vamsee K. , POLLACK, Michael G. , SRINIVASAN, Vijay , ECKHARDT, Allen E.
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/54326 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/502784 , B01L2200/025 , B01L2200/028 , B01L2200/0647 , B01L2200/0673 , B01L2200/141 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0427 , B01L2400/043 , C12M25/01 , C12M25/16 , G01N27/44717 , G01N27/44786 , G01N33/54386 , G01N35/0098 , G01N2035/1046
摘要： A method of assembling a droplet actuator assembly (1400) comprises: attaching to a mount structure (1410) a substrate (1434) including an electrode emitting an electric field (1438) affecting a droplet present in the droplet actuator assembly and a magnet assembly (1420) configured to accommodate a magnet (1428) emitting a magnetic field affecting a magnetically responsive bead present in the droplet actuator assembly. At least one of the substrate (1434) and the magnet assembly (1420) are removably attached to the mount structure (1410). Attaching the substrate (1434) may further comprise selecting the substrate from among a plurality of substrates (1434) configured to attach to the mount structure (1410) and including different electric field emission characteristics, and/or selecting the magnet assembly (1420) from among a plurality of magnetic assemblies (1420), each magnet assembly configured to attach to the mount structure (1410) and including different magnet properties.

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