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1. 发明授权

EP2635840B1 SYSTEM FOR FORMING EMULSIONS 有权转让
标题翻译：用于形成乳剂的系统
公开(公告)号：EP2635840B1
公开(公告)日：2017-01-04
申请号：EP11838713.3
申请日：2011-11-01
申请人： Bio-Rad Laboratories, Inc.
发明人： HIDDESSEN, Amy L. , MASQUELIER, Donald A. , NESS, Kevin D. , HINDSON, Benjamin J. , MAKAREWICZ, Anthony J., Jr. , STEENBLOCK, Erin R.
IPC分类号： F17D1/16 , F03B11/02 , B01L3/00 , B01F13/00 , B01F3/08 , B01F13/10 , G01N1/38 , G01N35/10
CPC分类号： B01L3/502784 , B01F3/0807 , B01F13/0062 , B01F13/1022 , B01L3/502761 , B01L2200/0605 , B01L2200/0673 , B01L2300/0867 , B01L2400/0487 , G01N1/38 , G01N2035/1046 , Y10T137/0396 , Y10T137/8593

2. 发明授权

EP1429866B1 PROCEDE ET DISPOSITIF D'ISOLEMENT ET/OU DETERMINATION D'UN ANALYTE 有权
标题翻译：方法和装置分离和/或测定分析物
公开(公告)号：EP1429866B1
公开(公告)日：2009-06-03
申请号：EP02777429.8
申请日：2002-09-12
申请人： BIOMERIEUX , COMMISSARIAT A L'ENERGIE ATOMIQUE
发明人： GINOT, Frédéric , ACHARD, Jean-Luc , DRAZEK, Laurent , PHAM, Pascale
IPC分类号： B01L3/02 , G01N1/40
CPC分类号： B01L3/0244 , G01N1/40 , G01N2035/1046 , Y10T436/25 , Y10T436/2525
摘要： The invention concerns a method for isolating an analyte (1) from an initial sample containing same, on a reactive surface (9) in contact with all or part of the initial sample, characterized in that it comprises the following steps which consist in: 1) forming and/or maintaining a reaction volume entity (2), comprising an internal liquid medium (4), corresponding to all or part of the initial sample, the entity (2) including an interface (5) with an external medium (6), having with the latter a surface tension; 2) applying a temperature difference between at least two thermal points located: a) proximate to and/or b) on the surface and/or c) within said entity (2), said thermal points being respectively different, in terms of temperature and positioning; 3) fixing the analyte (1) on the reactive surface (9), positioned on the path of forced convection generated by the temperature difference.

3. 发明公开

EP1771244A1 MICROREACTEUR GOUTTE 审中-公开
标题翻译： DROP微反
公开(公告)号：EP1771244A1
公开(公告)日：2007-04-11
申请号：EP05790710.7
申请日：2005-07-05
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE , Centre National de la Recherche Scientifique
发明人： MARCHAND, Gilles , VINET, Françoise , DELAPIERRE, Guillaume , HASSINE, Fatima , GMOUH, Saïd , VAULTIER, Michel
IPC分类号： B01J19/00 , B01L3/00 , G01N27/447
CPC分类号： C07D221/18 , B01F13/0071 , B01F13/0076 , B01J14/00 , B01J19/0093 , B01L3/502792 , B01L2300/0816 , B01L2300/089 , B01L2400/0406 , B01L2400/0415 , B01L2400/0427 , B01L2400/0433 , B01L2400/0442 , B01L2400/0487 , C07C41/14 , C07C227/16 , C12P17/12 , G01N2035/1046
摘要： The invention relates to a drop microreactor, i.e. a microreactor comprised of a drop of a particular liquid, whereby this microreactor does not walls, and the interface of the particular liquid with the ambient medium and with the support onto which the drop is deposited define the boundaries of the microreactor. The microreactor is characterized in that it is comprised of a drop containing at least one ionic liquid. The invention also relates to methods for carrying out chemical or biochemical reactions and/or a mixture of the two while using said microreactor as well as to a lab-on-chip comprising a microreactor of the aforementioned type.

4. 发明公开

EP1735428A2 OPTOELECTRONIC TWEEZERS FOR MICROPARTICLE AND CELL MANIPULATION 审中-公开
标题翻译：光电镊子进行操纵细胞和微粒
公开(公告)号：EP1735428A2
公开(公告)日：2006-12-27
申请号：EP05745418.3
申请日：2005-04-12
申请人： The Regents of the University of California
发明人： WU, Ming-Chiang , CHIOU, Pei, Yu , OHTA, Aaron T.
IPC分类号： C12M3/04
CPC分类号： B03C5/026 , B01L3/502761 , B01L2400/0454 , G01N2035/1046
摘要： An optical image-driven light induced dielectrophoresis (DEP) apparatus and method are described which provide for the manipulation of particles or cells with a diameter on the order of 100 μm or less. The apparatus is referred to as optoelectric tweezers (OET) and provides a number of advantages over conventional optical tweezers, in particular the ability to perform operations in parallel and over a large area without damage to living cells. The OET device generally comprises a planar liquid-filled structure having one or more portions which are photoconductive to convert incoming light to a change in the electric field pattern. The light patterns are dynamically generated to provide a number of manipulation structures that can manipulate single particles and cells or groups of particles/cells. The OET preferably includes a microscopic imaging means to provide feedback for the optical manipulation, such as detecting position and characteristics wherein the light patterns are modulated accordingly.

5. 发明授权

EP1386657B1 Dispositif d'injection et de mélange de micro-gouttes liquides 有权转让
标题翻译：注射和混合液体微滴的装置
公开(公告)号：EP1386657B1
公开(公告)日：2006-01-04
申请号：EP03354066.7
申请日：2003-07-17
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE
发明人： Fouillet, Yves , Achard, Jean-Luc Immeuble "Le Brasilia" , Fuchs, Olivier
IPC分类号： B01F13/00
CPC分类号： B01F13/0071 , B01F15/0216 , B01F15/0241 , B01F2215/0037 , B01L3/0244 , B01L3/0262 , B01L3/5088 , B01L2300/0812 , B01L2400/027 , G01N2021/8564 , G01N2035/1046 , Y10T436/2575

6. 发明公开

EP1401577A1 A SYSTEM AND METHOD FOR HIGH THROUGHPUT PROCESSING OF DROPLETS 审中-公开
标题翻译：系统和方法DROP高通量处理
公开(公告)号：EP1401577A1
公开(公告)日：2004-03-31
申请号：EP02728784.6
申请日：2002-04-17
申请人： BioTrove, Inc.
发明人： HESS, Robert , BRENAN, Colin , LINTON, John , OZBAL, Can , GREEN, Donald , HUNTER, Ian
IPC分类号： B01L3/00 , B01L3/02 , B01J19/00 , B01F13/00
CPC分类号： G01N30/466 , B01F5/0085 , B01F13/0059 , B01J19/0046 , B01J2219/0036 , B01J2219/00387 , B01J2219/00414 , B01J2219/00418 , B01J2219/00479 , B01J2219/00495 , B01J2219/00515 , B01J2219/00518 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00657 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/0072 , B01L3/0262 , B01L3/0268 , B01L3/505 , B01L3/5085 , B01L2300/0812 , B01L2300/0845 , C40B60/14 , G01N30/24 , G01N30/7233 , G01N30/7266 , G01N30/84 , G01N35/00009 , G01N2030/628 , G01N2030/8417 , G01N2035/1037 , G01N2035/1046 , Y10T436/2575 , G01N30/18
摘要： A method for high throughput processing of a plurality of droplets. The droplets are dispensed onto a moving surface (1) and delayed in a delay line (11) in which the droplets hang from the moving surface for at least a specified minimum period of time. A laminate (6) may be spooled onto the moving surface (1) and each droplet may be dispensed onto the laminate (6). At least one operation is performed on each droplet from the group of operations consisting of mixing, diluting, concentration, heating, cooling, humidifying, filtering, and analyzing. The laminate (6) may then, in certain embodiments, be spooled off the moving surface (1), processed, and reused.

7. 发明公开

EP1376846A1 Dispositif de déplacement de petits volumes de liquide le long d'un micro-catenaire par des forces électrostatiques 有权
标题翻译： Vorrichtung zum Austragen kleiner VolumenFlüssigkeiteiner Mikrokettenlinie entlang
公开(公告)号：EP1376846A1
公开(公告)日：2004-01-02
申请号：EP03101771.8
申请日：2003-06-17
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE
发明人： FOUILLET, Yves , CHARLES, Raymond , CONSTANTIN, Olivier , JEANSON, Hubert
IPC分类号： H02N11/00 , F04B19/00
CPC分类号： H02N11/006 , B01L3/502792 , B01L2300/0845 , B01L2300/089 , B01L2300/1827 , B01L2400/0415 , F04B17/00 , F04B19/006 , G01N2035/1046
摘要： L'invention concerne un dispositif de déplacement d'au moins un petit volume de liquide (5) sous l'effet d'une commande électrique, comprenant un substrat (1) pourvu de premiers moyens électriquement conducteurs (2), le dispositif comprenant également des deuxièmes moyens électriquement conducteurs (3) disposés en vis-à-vis des premiers moyens électriquement conducteurs (2), les premiers moyens électriquement conducteurs et les deuxièmes moyens électriquement conducteurs pouvant être reliés à des moyens d'alimentation électrique pour permettre l'application de forces électrostatiques au petit volume de liquide (5). Les deuxièmes moyens électriquement conducteurs comprennent au moins un fil conducteur (3) disposé parallèlement au substrat et à une distance déterminée du substrat pour permettre le déplacement du petit volume de liquide (5) le long dudit fil conducteur (3) sous l'effet des forces électrostatiques appliquées.
摘要翻译：液滴操作方法在电气控制下具有小的液体体积（5）。存在具有电导体（2）的基板（1）。对液体体积施加静电力。电导体是与衬底平行的线（3），与基底设定距离，允许施加静电力的小体积液体沿着导线移动。

8. 发明授权

EP1060025B1 SYSTEM FOR PERFORMING ASSAYS ON A LEVITATED DROPLET 有权
标题翻译： DEVICE试样分析一个浮动滴
公开(公告)号：EP1060025B1
公开(公告)日：2003-10-29
申请号：EP99906407.4
申请日：1999-03-04
申请人： Ortho-McNeil Pharmaceutical, Inc. , Lund University
发明人： LAURELL, Thomas , NILSSON, Johan , SANTESSON, Sabina , NILSSON, Staffan , ZIVIN, Robert , THURMOND, Robin , PATEL, Lekha
IPC分类号： B01L11/00 , B01L3/02
CPC分类号： B01L99/00 , B01L3/0268 , B01L2200/0626 , G01N2035/00237 , G01N2035/00336 , G01N2035/1046 , G10K15/00
摘要： The present invention relates to a system for performing small volume assays and the uses of the system. The system comprises a levitator for suspending a droplet, a dispenser for delivering a substance to the surface of the suspended droplet and a detector system for detecting changes in the droplet.

9. 发明公开

EP0364203A1 A liquid drop forming device 失效
标题翻译： Vorrichtung zum Hervorbringen einesFlüssigkeitstropfens。
公开(公告)号：EP0364203A1
公开(公告)日：1990-04-18
申请号：EP89310330.9
申请日：1989-10-10
申请人： PHYBER HOLDINGS LIMITED
发明人： McMillan, Norman, Dr.
IPC分类号： G01N21/17 , B01L3/02
CPC分类号： G01N21/43 , B01L3/0241 , G01N11/04 , G01N13/02 , G01N21/17 , G01N2013/0241 , G01N2021/035 , G01N2021/1738 , G01N2021/8564 , G01N2035/1046 , G01N2201/08
摘要： A liquid drop forming device (10) for a liquid drop analyser (1) has a body member (21) with a conical drop supporting surface (22). Ducts (25) are provided in the body member (21) for delivery of discrete quantities of a sample liquid from a syringe (26) to the drop supporting surface (22) to form a pendant drop (27) at the drop supporting surface (22). Radiation guides (2, 3) are mounted on the body member (21) and comprise optical fibres forming a delivery guide (2) to deliver a radiation signal from the analyser (1) to the drop (27) and a receiver guide (3) to collect radiation from the drop (27) and return an output signal to a detector circuit (28) of the analyser (1).
Means may be provided to apply a stimulus such as vibrations to the drop (27).
摘要翻译：一种用于液滴分析仪（1）的液滴形成装置（10）具有带有圆锥形液滴支撑表面（22）的主体部件（21）。管道（25）设置在主体构件（21）中，用于将离散量的样品液体从注射器（26）输送到液滴支撑表面（22），以在液滴支撑表面（...）处形成悬垂液滴（27） 22）。辐射引导件（2,3）安装在主体部件（21）上并且包括形成输送引导件（2）的光纤，以将来自分析器（1）的辐射信号传送到液滴（27）和接收器引导件（3））以从所述液滴（27）收集辐射并将输出信号返回到所述分析器（1）的检测器电路（28）。可以提供装置以将诸如振动的刺激施加到液滴（27）。

10. 发明公开

EP0286419A2 Method and apparatus for analysing liquid properties 失效
标题翻译：用于测量液体的性质的方法和装置。
公开(公告)号：EP0286419A2
公开(公告)日：1988-10-12
申请号：EP88303147.8
申请日：1988-04-08
申请人： McMillan, Norman
发明人： McMillan, Norman
IPC分类号： G01N21/17 , G01N21/43 , G01N21/64
CPC分类号： B01L3/0241 , G01N11/02 , G01N13/02 , G01N21/1702 , G01N21/255 , G01N21/431 , G01N2013/0241 , G01N2021/035 , G01N2021/1738 , G01N2021/174 , G01N2021/8564 , G01N2035/1046 , G01N2201/08
摘要： An apparatus for measuring a property of a liquid comprises at least one guide (10) for electromagnetic radiation, means (20) for directing electromagnetic radiation into the guide, means (16) for providing at least one drop of liquid (15) in contact with the guide at a position where radiation from the guide can enter the drop, and means (22) for deriving a signal which is a function of the interaction of the radiation with the liquid of the drop.
摘要翻译：用于测量液体的性质的装置包括至少一个引导件（10），用于将电磁辐射的装置（20），用于将电磁辐射到导向装置（16），用于提供在接触的液体（15）的至少一个降用的位置处从导向辐射可以进入降（22）导向的装置，以及用于导出一个信号的所有这与下降的液体的辐射的相互作用的功能。

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