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1. 发明公开

EP4032583A1 SYSTEMS, AND DEVICES FOR TREATING TINNITUS WITH VNS PAIRING 审中-公开
公开(公告)号：EP4032583A1
公开(公告)日：2022-07-27
申请号：EP21214444.8
申请日：2012-10-12
申请人： Microtransponder, Inc. , The Board of Regents,The University of Texas System
发明人： KILGARD, Michael P. , ENGINEER, Navzer , PIERCE, David Michael , RENNAKER, Robert L.
IPC分类号： A61N1/372 , A61N1/36 , A61B5/11
摘要： A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits.

2. 发明公开

EP3593856A1 SYSTEM FOR PAIRING VAGUS NERVE STIMULATION WITH MOTOR THERAPY IN STROKE PATIENTS 有权
公开(公告)号：EP3593856A1
公开(公告)日：2020-01-15
申请号：EP19192580.9
申请日：2012-10-12
申请人： Microtransponder, Inc. , The Board of Regents,The University of Texas System
发明人： KILGARD, Michael P. , ENGINEER, Navzer , PIERCE, David Michael , RENNAKER, Robert L.
IPC分类号： A61N1/372
摘要： A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits.

3. 发明授权

EP1350095B1 METHOD AND APPARATUS FOR COMBINED MAGNETOPHORETIC AND DIELECTROPHORETIC MANIPULATION OF ANALYTE MIXTURES 有权
标题翻译：方法和设备分析物混合物结合，磁致介电电泳处理
公开(公告)号：EP1350095B1
公开(公告)日：2015-12-09
申请号：EP01950328.3
申请日：2001-06-14
申请人： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： GASCOYNE, Peter, R., C. , BECKER, Frederick, F. , VYKOUKAL, Jody
IPC分类号： G01N27/447 , B03C1/00 , B03C1/01 , B03C1/24 , B03C5/02 , G01N30/00
CPC分类号： B03C1/01 , B03C1/00 , B03C1/24 , B03C5/026 , B03C5/028 , G01N30/0005 , G01N2030/0015 , G01N2030/0065

4. 发明授权

EP2266537B1 Compositions for treating cancer 有权
标题翻译：组合物治疗癌症
公开(公告)号：EP2266537B1
公开(公告)日：2014-09-03
申请号：EP10011105.3
申请日：2000-03-31
申请人： Hana Biosciences, Inc. , The Board of Regents,The University of Texas System
发明人： Burge, Clive, T., R. , Goldie, James, H. , Webb, Murray, S. , Logan, Patricia, M. , Sarris, Andreas, H. , Cabanillas, Fernando , Mayer, Lawrence, D.
IPC分类号： A61K9/127 , A61P35/00 , A61K31/475 , A61K31/704
CPC分类号： A61K31/704 , A61K9/1272 , A61K31/475

5. 发明授权

EP1678199B1 METHODS AND COMPOSITIONS FOR MYCOPLASMA PNEUMONIAE EXOTOXINS 有权
标题翻译：方法和组合物肺炎支原体Exotoxine
公开(公告)号：EP1678199B1
公开(公告)日：2013-03-20
申请号：EP04809886.7
申请日：2004-10-01
申请人： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： BASEMAN, Joel, Barry , KANNAN, Thirumalai, Rengasamy
IPC分类号： C07K1/00 , C07K2/00 , A61K38/00 , A61K39/02 , A61K39/38 , G01N33/53
CPC分类号： A61K49/0008 , A61K39/00 , A61K2039/505 , A61K2039/53 , A61K2039/6037 , C07K14/30 , G01N33/56933 , G01N33/5695 , G01N2500/02 , Y10S530/825

6. 发明公开

EP2366712A2 A tumor suppressor designated TS10Q23.3 失效
标题翻译： TS10Q23.3Tumorunterdrückung
公开(公告)号：EP2366712A2
公开(公告)日：2011-09-21
申请号：EP10180064.7
申请日：1998-01-08
申请人： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： Steck, Peter , Pershouse, Mark A. , Jasser, Samar A. , Yung, W. K. Alfred , Tavtigian, Sean V.
IPC分类号： C07K14/47 , C12N9/16
CPC分类号： C12N9/16 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K14/4703 , C12N2799/021
摘要： A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated that a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.
摘要翻译：染色体10（10q23.3）的特定区域已经被一系列研究所牵连，其中包含参与胶质瘤的肿瘤抑制基因以及许多其他人类癌症。鉴定出该区域内的一个基因，该基因的相应编码区代表一种新的47kD蛋白。该产品的结构域与蛋白酪氨酸磷酸酶的保守催化结构域完全一致，表明在磷酸化事件中可能发挥功能作用。序列分析表明，在用于定义10q23.3区域的肿瘤细胞系中，该基因的许多外显子缺失，导致该基因作为肿瘤抑制基因的分类。进一步的分析已经证明在胶质瘤和前列腺癌细胞中基因中存在许多突变。还公开了用于诊断和治疗与该肿瘤抑制因子相关的癌症的方法，称为TS10q23.3。

7. 发明公开

EP2230314A1 Method of sensing an analyte 审中-公开
标题翻译： Verfahren zum Nachweis eines分析
公开(公告)号：EP2230314A1
公开(公告)日：2010-09-22
申请号：EP08161330.9
申请日：2001-01-31
申请人： The Board of Regents,The University of Texas System
发明人： McDevitt, John, T. , Anslyn, Eric, V. , Shear, Jason, B. , Neikirk, Dean, P.
IPC分类号： C12Q1/34 , C12Q1/37 , G01N33/543
CPC分类号： G01N21/6452 , B01J2219/005 , B01J2219/00576 , B01J2219/00648 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01L3/0289 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2200/027 , B01L2200/0657 , B01L2200/0668 , B01L2200/12 , B01L2300/0636 , B01L2400/0415 , B01L2400/049 , B01L2400/0633 , B01L2400/0638 , C07B2200/11 , C12Q1/34 , C12Q1/37 , C40B40/00 , G01N21/253 , G01N21/6428 , G01N21/6454 , G01N21/6458 , G01N21/6486 , G01N21/77 , G01N33/54313 , G01N33/54366 , G01N33/54373 , G01N2001/021 , G01N2021/6417 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2021/6482 , G01N2035/00158 , G01N2035/00564 , G01N2201/062 , G01N2201/0627 , G06F19/00 , Y02A90/26 , Y10S977/924 , Y10T436/2575
摘要： A method of sensing an analyte in a fluid comprises: passing a fluid over a sensor array, the sensor array comprising at least one particle positioned within a cavity of a supporting member, wherein the particle comprises a polymeric resin and a receptor coupled to the polymeric resin; monitoring a spectroscopic change of the particles as the fluid is passed over the sensor array, wherein the spectroscopic change is caused by the interaction of the analyte with the particle.
The receptor can be an enzyme substrate and the analyte an enzyme such as protease, nuclease or glycosidase.
摘要翻译：感测流体中的分析物的方法包括：将流体传递到传感器阵列上，所述传感器阵列包括位于支撑构件的空腔内的至少一个颗粒，其中所述颗粒包含聚合物树脂和与聚合物偶联的受体树脂; 当流体通过传感器阵列时监测颗粒的光谱变化，其中光谱变化由分析物与颗粒的相互作用引起。受体可以是酶底物，分析物可以是酶如蛋白酶，核酸酶或糖苷酶。

8. 发明公开

EP2220506A2 BIOMARKERS FOR THE DETECTION OF EARLY STAGE OVARIAN CANCER 有权转让
标题翻译：生物标志物对卵巢癌在早期的检测
公开(公告)号：EP2220506A2
公开(公告)日：2010-08-25
申请号：EP08843957.5
申请日：2008-10-29
申请人： Vermillion, Inc. , The Board of Regents,The University of Texas System
发明人： FUNG, Eric, Thomas , CLARKE, Charlotte , BAST, Robert , COOMBES, Kevin
IPC分类号： G01N33/574 , G01N33/68 , G01N33/53 , G01N33/48 , G01N33/50
CPC分类号： G01N33/57449 , G01N33/6848 , G01N2800/56
摘要： The present invention provides methods and compositions for detecting early stage ovarian cancer in a patient. Also, methods for evaluating the ovarian cancer state of a patient are described herein. These methods involve the detection, analysis, and classification of biomarkers in biological samples.

9. 发明授权

EP1169021B1 COMPOSITIONS AND METHODS FOR TREATING LYMPHOMA 有权
标题翻译：组合物以及用于治疗淋巴瘤方法
公开(公告)号：EP1169021B1
公开(公告)日：2009-09-16
申请号：EP00920004.9
申请日：2000-03-31
申请人： Hana Biosciences, Inc. , THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： SARRIS, Andreas, H. Hygeia Hospital & Harvard , CABANILLAS, Fernando , LOGAN, Patricia, M. BioLoma Consulting Inc. , BURGE, Clive, T., R. , GOLDIE, James, H. , WEBB, Murray, S. , Mayer D. Lawrence
IPC分类号： A61K9/127 , A61P35/00 , A61K31/475
CPC分类号： A61K31/704 , A61K9/1272 , A61K31/475
摘要： This invention provides methods for treating neoplasias in a mammal. In particular, the invention provides methods for treating various types of lymphomas, including relapsed forms of non-Hodgkin's Lymphoma. These methods involve the administration of liposome-encapsulated vinca alkaloids, e.g., vincristine, to a mammal with a lymphoma.

10. 发明公开

EP1985285A3 Compositions and methods for treating lymphoma 审中-公开
标题翻译：组合物和方法用于治疗淋巴瘤
公开(公告)号：EP1985285A3
公开(公告)日：2009-08-12
申请号：EP08003804.5
申请日：2000-03-31
申请人： Hana Biosciences, Inc. , THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： Burge, Clive T. R. , Goldie, James H. , Webb, Murray S. , Logan, Patricia M BioLoma Consulting Inc. , Sarris, Andreas H Hygeia Hospital & Harvard Medical International , Cabanillas, Fernando , Mayer, Lawrence D.
IPC分类号： A61K9/127 , A61P35/00 , A61K31/475
CPC分类号： A61K31/704 , A61K9/1272 , A61K31/475
摘要： This invention provides methods for treating neoplasias in a mammal. In particular, the invention provides methods for treating various types of lymphomas, including relapsed forms of non-Hodgkin's Lymphoma. These methods involve the administration of liposome-encapsulated vinca alkaloids, e.g., vincristine, to a mammal with a lymphoma.

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