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1. 发明授权

EP3671197B1 ION CONCENTRATION MEASUREMENT DEVICE 有权
公开(公告)号：EP3671197B1
公开(公告)日：2024-10-16
申请号：EP19764262.2
申请日：2019-02-04
IPC分类号： G01N27/28 , G01N27/416 , G01N33/487
CPC分类号： G01N27/4166 , G01N33/48792 , G01N27/00

2. 发明授权

EP3011322B1 SYMMETRICALLY ARRANGED SENSOR ELECTRODES IN AN OPHTHALMIC ELECTROCHEMICAL SENSOR 有权
标题翻译：对称排列的传感器电极在一个眼科电化学传感器
公开(公告)号：EP3011322B1
公开(公告)日：2018-03-28
申请号：EP14813015.6
申请日：2014-04-21
申请人： Verily Life Sciences LLC
发明人： ETZKORN, James , LIU, Zenghe
IPC分类号： A61B5/145
CPC分类号： A61B5/1486 , A61B3/101 , A61B5/0002 , A61B5/0004 , A61B5/002 , A61B5/14507 , A61B5/14532 , A61B5/14546 , A61B5/1477 , A61B5/6821 , A61B5/7264 , A61B2560/0214 , G01N27/30 , G01N27/3271 , G01N27/4166 , G02C7/04
摘要： An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have a first side edge and a second side edge. The reference electrode can be situated such that at least a portion of the first and second side edges of the working electrode are adjacent respective sections of the reference electrode.

3. 发明公开

EP3030890A4 USING KINETIC CYCLIC VOLTAMMETRY TO EVALUATE ANALYTE KINETICS AND CONCENTRATIONS 有权
标题翻译： USE ANALYTKINETIK和浓度的动力学伏安法评定的
公开(公告)号：EP3030890A4
公开(公告)日：2017-03-22
申请号：EP14834533
申请日：2014-08-11
申请人： MAYO FOUNDATION
发明人： LEE KENDALL H , JANG DONG-PYO
IPC分类号： G01N27/26 , A61B5/145 , A61B5/1473 , G06F19/00
CPC分类号： A61B5/4064 , A61B5/14539 , A61B5/14546 , A61B5/1473 , A61B5/6868 , G01N27/4166 , G01N27/49
摘要： Materials and methods for using kinetic cyclic voltammetry to measure analyte levels and assess analyte kinetics.

4. 发明公开

EP3011322A4 SYMMETRICALLY ARRANGED SENSOR ELECTRODES IN AN OPHTHALMIC ELECTROCHEMICAL SENSOR 有权
标题翻译：在EINEM OPHTHALMISCHEN ELEKTROCHEMISCHEN传感器中对称ANGEORDNETE SENSORELEKTRODEN
公开(公告)号：EP3011322A4
公开(公告)日：2017-01-25
申请号：EP14813015
申请日：2014-04-21
申请人： VERILY LIFE SCIENCES LLC
发明人： ETZKORN JAMES , LIU ZENGHE
IPC分类号： G01N27/26 , A61F2/14 , G01N27/416 , G02C7/04 , G08C17/00
CPC分类号： A61B5/1486 , A61B3/101 , A61B5/0002 , A61B5/0004 , A61B5/002 , A61B5/14507 , A61B5/14532 , A61B5/14546 , A61B5/1477 , A61B5/6821 , A61B5/7264 , A61B2560/0214 , G01N27/30 , G01N27/3271 , G01N27/4166 , G02C7/04
摘要： An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have a first side edge and a second side edge. The reference electrode can be situated such that at least a portion of the first and second side edges of the working electrode are adjacent respective sections of the reference electrode.
摘要翻译：眼睛安装的装置包括嵌入聚合物材料中的电化学传感器，该聚合材料构造成用于安装到眼睛的表面。电化学传感器包括工作电极，参比电极和选择性地与分析物反应以产生与可眼睛安装的装置暴露于的流体中的分析物的浓度相关的传感器测量的试剂。工作电极可以具有第一侧边缘和第二侧边缘。参考电极可以被定位成使得工作电极的第一和第二侧边缘的至少一部分与参考电极的相应部分相邻。

5. 发明公开

EP3090256A1 ANALYZER FOR MONITORING SALT CONTENT IN HIGH RESISTIVITY FLUIDS 有权转让
标题翻译： ANALYSEVORRICHTUNG ZURÜBERWACHUNGDES SALZGEHALTS在FLÜSSIGKEITENMIT HOHEM WIDERSTAND
公开(公告)号：EP3090256A1
公开(公告)日：2016-11-09
申请号：EP14824967.5
申请日：2014-12-02
申请人： Saudi Arabian Oil Company
发明人： ALEISA, Rashed Mohammad , AKMAL, Naim , ALAMRI, Taher Ali Atef
IPC分类号： G01N27/416 , G01N33/28
CPC分类号： G01N27/4166 , G01N27/06 , G01N27/38 , G01N33/22 , G01N33/28 , G01N33/2835
摘要： An electrochemical polymerization based salt content analyzer determines salt composition in a direct, fast, and serial manner. The salt content analyzer (100) includes three electrodes: a working electrode (202), a counter electrode (205) and a reference electrode (204). In operation, the current passing through the electrodes as a sweeping voltage is applied is analyzed to determine the salt content of the analyte. When a voltage is applied, an electro-polymerizable monomer forms a thin film on the working electrode (202). The working electrode (202) includes an access control mechanism (405) to only expose a fraction of the working length of the working electrode (202) to the outside environment at any given time. The access control mechanism (405) is advanced between tests to expose a fresh portion of the working electrode and conceal the portion with a thin film of electro-polymerized monomer. Thus, testing may be performed in a serial manner.
摘要翻译：一种基于电化学聚合的盐含量分析仪，其配置为以直接，快速和串联的方式测定盐组成。盐含量分析仪包括三个电极：工作电极，对电极和参比电极。在操作中，可以分析施加作为扫描电压通过电极的电流，以确定分析物的盐含量。当施加电压时，电可聚合单体在工作电极上形成薄膜。工作电极包括访问控制机构，用于仅在任何给定时间将工作电极的工作长度的一部分暴露于外部环境。访问控制机构在测试之间进行，以暴露工作电极的新鲜部分并且用电聚合单体的薄膜隐藏该部分。因此，可以以串行方式执行测试。

6. 发明公开

EP3078965A1 BIOSENSOR COMPRISING ELECTRODE FOR MEASURING HEMATOCRIT VALUE 有权
标题翻译： BIOSENSOR MIT ELEKTRODEN ZUR MESSUNG DESHÄMATOKRITWERTS
公开(公告)号：EP3078965A1
公开(公告)日：2016-10-12
申请号：EP16163918.2
申请日：2016-04-05
申请人： ARKRAY, Inc.
发明人： SAEDA, Megumi , KANEDA, Hisashi
IPC分类号： G01N27/327 , C12Q1/00
CPC分类号： G01N15/05 , C12Q1/006 , G01N27/028 , G01N27/3272 , G01N27/3273 , G01N27/3274 , G01N27/4166 , G01N2015/0065 , G01N2015/055
摘要： Provided is a method for measuring the concentration of a substance in a blood sample, the method comprising the steps of: supplying the blood sample to a biosensor comprising a hematocrit electrode for measuring a hematocrit value on the surface of which electrode an electrically conductive polymer is non-covalently attached to the electrode surface by physical adsorption, a working electrode, a counter electrode, and a reference electrode; measuring the value of a first current which flows when a voltage of 0 to 400 mV is applied to the working electrode, and calculating the concentration of the substance from the measured value of the first current; measuring the value of a second current which flows when a voltage of 100 to 300 mV is applied to the hematocrit electrode; and correcting the concentration of the substance with the value of the second current or the hematocrit value calculated from the value of the second current.
摘要翻译：提供了一种用于测量血液样品中物质浓度的方法，所述方法包括以下步骤：将血液样品供给到生物传感器，所述生物传感器包括用于测量导电聚合物的电极表面上的血细胞比容值的血细胞比容电极通过物理吸附非共价地附着到电极表面，工作电极，对电极和参比电极; 测量当对工作电极施加0至400mV的电压时流动的第一电流的值，并根据第一电流的测量值计算物质的浓度; 测量当对血细胞比容电极施加100至300mV的电压时流动的第二电流的值; 并根据第二电流的值计算的第二电流值或血细胞比容值修正物质的浓度。

7. 发明公开

EP3029458A1 GAS SENSOR ELEMENT AND GAS SENSOR 有权
标题翻译： GASSENSORELEMENT UND GASSENSOR
公开(公告)号：EP3029458A1
公开(公告)日：2016-06-08
申请号：EP15197867.3
申请日：2015-12-03
申请人： NGK Insulators, Ltd.
发明人： SAKAKIBARA, Hironori , OZAWA, Shuichi , FUJITA, Hiroki , MAEDA, Shinsaku
IPC分类号： G01N27/407 , G01N27/406
CPC分类号： G01N27/419 , G01N27/4075 , G01N27/4077 , G01N27/409 , G01N27/4166
摘要： A sensor element 101 includes a sensor element main body 101a including an oxygen ion-conductive solid electrolyte layer (each of layers 1 to 6) and a porous protective layer 91 covering at least part of the sensor element main body 101a. Then, the porous protective layer 91 has the value of the number of interfaces in a unit thickness direction, which is the number of particle interfaces of constituent particles every 100 µm in the thickness direction, of 15 or more and 250 or less. Also, the porous protective layer 91 has the value of the ratio of the number of interfaces (= the number of interfaces in a unit surface direction/the number of interfaces in a unit thickness direction) of the number of interfaces in a unit surface direction, which is the number of particle interfaces of constituent particles every 100 µm in the surface direction perpendicular to the thickness direction, to the number of interfaces in a unit thickness direction of more than 0 and 0.7 or less. The value of the number of interfaces in a unit thickness direction is preferably 30 or more. The thickness of the porous protective layer 91 may be 500 µm or less.
摘要翻译：传感器元件101包括具有氧离子传导性固体电解质层（层1〜6）的传感器元件主体101a和覆盖传感器元件主体101a的至少一部分的多孔保护层91。然后，多孔保护层91具有在厚度方向上每100μm的构成粒子的粒子界面数为单位厚度方向的界面数为15以上且250以下的值。此外，多孔保护层91具有在单位面方向上的界面数量的界面数（=单位面方向的界面数/单位厚度方向的界面数）的比率的值是与垂直于厚度方向的面方向每100μm的构成粒子的粒子数相对于单位厚度方向的界面数多于0以上且0.7以下的数量。单位厚度方向的界面数优选为30以上。多孔保护层91的厚度可以为500μm以下。

8. 发明公开

EP2989440A2 OPIOID DETECTION BASED ON HIGH QUALITY GRAPHENE TRANSISTOR ARRAYS AND A SYNTHETIC MU RECEPTOR 审中-公开
标题翻译：阿片检测以质量为基础GRAPH晶体管阵列和合成MU受体
公开(公告)号：EP2989440A2
公开(公告)日：2016-03-02
申请号：EP14789098.2
申请日：2014-04-25
申请人： The Trustees Of The University Of Pennsylvania
发明人： JOHNSON, Alan, T. , XI, Jin , HAN, Ganghee , LERNER, Mitchell , SAVEN, Jeffery, G. , LIU, Renyu , MATSUNAGA, Felipe , PEREZ-AGUILAR, Jose, Manuel
IPC分类号： G01N21/00 , G01N33/566 , G01N21/75
CPC分类号： G01N27/3275 , C23C16/44 , G01N27/4145 , G01N27/4166 , G01N33/54373 , G01N33/9486 , G01N2333/726
摘要： The present invention provides methods for fabricating field-effect devices and sensor arrays. The field of the invention also pertains to methods of using the sensors individually, in combination, and in array fashion to detect molecules. The present invention also provides for products produced by the methods of the present invention and for apparatuses used to perform the methods of the present invention.

9. 发明公开

EP2851823A1 Data management unit for supporting health control 审中-公开
标题翻译：数据来源：UnterstützungderGesundheitsüberwachung
公开(公告)号：EP2851823A1
公开(公告)日：2015-03-25
申请号：EP13185396.2
申请日：2013-09-20
申请人： Sanofi-Aventis Deutschland GmbH
发明人： The designation of the inventor has not yet been filed
IPC分类号： G06F19/00
CPC分类号： G06F19/3437 , G01N27/4166 , G01N33/48792 , G06F19/00 , G16H40/63 , G16H50/50
摘要： The present invention refers to a data management unit for supporting health control and a corresponding medical device comprising
• a data storage (130) adapted to store a plurality of measurement values of a physiological parameter, for example the fasting blood glucose level, and for each measurement value an associated time stamp and
• a trend indicator (164), wherein the trend indicator is adapted to indicate different trend categories, for example an increasing trend, a steady trend and a decreasing trend, preferably as a respective visible sign (201,202) on a display (162) and/or as a respective audible signal by a loudspeaker,
• a processor (140) adapted to select a first group of measurement values and a second group of measurement values from the plurality of measurement values of the data storage (130) such that the associated time stamp of the measurement values of the first group encompasses a predefined first time interval and the associated time stamp of the measurement values of the second group encompasses a predefined second time interval, wherein the second time interval is more recent than the first time interval, wherein the processor is further adapted to calculate a first mean value as a median from the first group of measurement values and a second mean value from the second group of measurement values,

wherein the processor (140) interacts with the trend indicator (164) such that the trend indicator (164) indicate one of the different trend categories, for example the increasing trend, the steady trend or the decreasing trend, dependent on a result of a comparison of the second mean value to the first mean value. Additionally, the invention refers to a corresponding method and a computer program for indicating a trend, and to a corresponding computer program product.
摘要翻译：本发明涉及用于支持健康控制的数据管理单元和相应的医疗设备，包括适于存储生理参数的多个测量值的数据存储（130），例如空腹血糖水平，并且每个测量值相关联的时间戳和趋势指标（164），其中趋势指标适于指示不同的趋势类别，例如增加趋势，稳定趋势和下降趋势，优选地作为相应的可见信号（ 201202）和/或由扬声器作为相应的可听信号，处理器（140）适于从多个测量值中选择第一组测量值和第二组测量值所述数据存储器（130）使得所述第一组的所述测量值的关联时间戳包含预定义的第一时间间隔，并且所述相关联的时间戳第二组的测量值包括预定义的第二时间间隔，其中第二时间间隔比第一时间间隔更近，其中处理器还适于根据第一组测量值计算作为中值的第一平均值，以及来自第二组测量值的第二平均值，其中处理器（140）与趋势指示器（164）相互作用，使得趋势指示器（164）指示不同趋势类别之一，例如增加趋势，稳定趋势或下降趋势，取决于第二平均值与第一平均值的比较结果。此外，本发明涉及用于指示趋势的相应方法和计算机程序以及对应的计算机程序产品。

10. 发明公开

EP2768951A1 MODIFIED ARSENITE OXIDASE AND A BIOSENSOR FOR DETECTING ARSENITE 有权转让
标题翻译：改性ARSENITOXIDASE和生物传感器检测砷
公开(公告)号：EP2768951A1
公开(公告)日：2014-08-27
申请号：EP12781415.0
申请日：2012-10-19
申请人： The Bio Nano Centre Limited
发明人： CASS, Anthony Edward George , SANTINI, Joanne , JOHNSON, Christopher James
IPC分类号： C12N9/00 , C12Q1/00 , C12Q1/26
CPC分类号： C12Q1/005 , C12N9/0004 , C12Q1/26 , C12Y120/09001 , C12Y120/99001 , G01N27/327 , G01N27/4166 , G01N27/447 , G01N2333/902
摘要： The present invention provides an arsenite oxidase enzyme modified to prevent translocation by modification of a translocation signal sequence. A microorganism modified to express the heterologous arsenite oxidase enzyme is also provided by the invention, together with a device for detecting the presence of arsenite in a sample.

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