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1. 发明公开

EP3968022A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
公开(公告)号：EP3968022A1
公开(公告)日：2022-03-16
申请号：EP21186630.6
申请日：2015-10-20
申请人： Astute Medical, Inc.
发明人： ANDERBERG, Joseph , McPHERSON, Paul , GRAY, Jeff , NAKAMURA, Kevin , KAMPF, James Patrick , KWAN, Thomas
IPC分类号： G01N33/50
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of C-C motif chemokine 16, C-C motif chemokine 14, and Tyrosine-protein kinase receptor UFO as diagnostic and prognostic biomarker assays in renal injuries.

2. 发明公开

EP3783363A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
公开(公告)号：EP3783363A1
公开(公告)日：2021-02-24
申请号：EP20198819.3
申请日：2009-10-21
申请人： Astute Medical, Inc.
发明人： ANDERBERG, Joseph , GRAY, Jeff , McPHERSON, Paul , NAKAMURA, Kevin
IPC分类号： G01N33/68
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Tissue inhibitor of metalloproteinase 2, and optionally further one or more markers of Cytoplasmic aspartate aminotransferase, soluble Tumor necrosis factor receptor superfamily member 5, soluble CD40 Ligand, soluble C-X-C Motif chemokine 16, S100-A12, Eotaxin, soluble E-selectin, Fibronectin, Granulocyte colony-stimulating factor, Granulocyte-macrophage colony-stimulating factor, Heparin-binding growth factor 2 , soluble Hepatocyte growth factor receptor, Interleukin-1 receptor antagonist, Interleukin-1 beta, Interleukin-10, Interleukin-15, Interleukin-3, Myeloperoxidase, Nidogen-1, soluble Oxidized low-density lipoprotein receptor 1, Pappalysin-1, soluble P-selectin glycoprotein ligand 1, Antileukoproteinase, soluble Kit ligand, Tissue inhibitor of metalloproteinase 1, soluble Tumor necrosis factor, soluble Vascular cell adhesion molecule 1, and Vascular endothelial growth factor A as diagnostic and prognostic biomarkers in renal injuries.

3. 发明授权

EP3153863B1 METHODS AND USES FOR EVALUATION OF ACUTE RENAL FAILURE/ACUTE RENAL INJURY 有权
公开(公告)号：EP3153863B1
公开(公告)日：2020-04-01
申请号：EP16196505.8
申请日：2010-11-05
申请人： Astute Medical, Inc.
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James Patrick
IPC分类号： G01N33/68

4. 发明公开

EP3308166A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
公开(公告)号：EP3308166A1
公开(公告)日：2018-04-18
申请号：EP16808459.8
申请日：2016-06-10
申请人： Astute Medical, Inc.
发明人： ANDERBERG, Joseph , McPHERSON, Paul , GRAY, Jeff , NAKAMURA, Kevin , KAMPF, James, Patrick , KWAN, Thomas
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/4703 , G01N2333/70596 , G01N2333/96466 , G01N2800/347 , G01N2800/348
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of Follistatin-related protein 3, Basigin, Cathepsin B, and Tenascin as diagnostic and prognostic bio-marker assays in renal injuries.

5. 发明公开

EP3249402A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：肾损伤和肾功能衰竭的诊断和预后的方法和组合物
公开(公告)号：EP3249402A1
公开(公告)日：2017-11-29
申请号：EP17175396.5
申请日：2011-10-06
申请人： Astute Medical, Inc.
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James Patrick
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Follistatin, and optionally further one or more biomarkers selected from the group consisting of Beta-nerve growth factor, Interleukin-17A, Follitropin subunit beta, Collagenase 3, Vitamin D Binding Protein, Islet amyloid polypeptide, Insulin C-peptide, Complement Factor H, Gastric inhibitory polypeptide, Glucagon-like peptide 1, Glucagon, Involucrin, Type II cytoskeletal Keratin-1/Keratin-10, Type II cytoskeletal Keratin-6A/6B/6C, Osteocalcin, Lipopolysaccharide, Pancreatic prohormone, Peptide YY, Agouti-related protein, Ciliary neurotrophic factor, Appetite-regulating hormone, Transthyretin, Insulin receptor substrate 1, and NF-kappa-B inhibitor alpha as diagnostic and prognostic biomarker assays in renal injuries.
摘要翻译：本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。具体而言，本发明涉及使用检测Follistatin以及任选地进一步选自β神经生长因子，白细胞介素-17A，促卵泡素亚基β，胶原酶3，维生素D结合蛋白，胰岛淀粉样蛋白的组中的一种或多种生物标记的测定多肽，胰岛素C-肽，补体因子H，胃抑制性多肽，胰高血糖素样肽1，胰高血糖素，Involucrin，II型细胞骨架角蛋白-1 /角蛋白-10，II型细胞骨架角蛋白-6A / 6B / 6C，骨钙素，脂多糖，胰激肽原，肽YY，刺鼠相关蛋白，睫状神经营养因子，食欲调节激素，转甲状腺素蛋白，胰岛素受体底物1和NF-κB抑制剂α作为肾损伤诊断和预后生物标志物测定。

6. 发明公开

EP3218724A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：肾损伤和肾功能衰竭的诊断和预后的方法和组合物
公开(公告)号：EP3218724A1
公开(公告)日：2017-09-20
申请号：EP15859966.2
申请日：2015-11-11
申请人： Astute Medical, Inc.
发明人： ANDERBERG, Joseph , MCPHERSON, Paul , GRAY, Jeff , NAKAMURA, Kevin , KAMPF, James Patrick
IPC分类号： G01N33/68
CPC分类号： G01N33/6869 , G01N33/6893 , G01N2333/4704 , G01N2333/7155 , G01N2800/347 , G01N2800/52
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Interleukin-18-binding protein as diagnostic and prognostic biomarker assays in renal injuries.
摘要翻译：本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。特别地，本发明涉及使用检测白细胞介素-18结合蛋白作为肾损伤中诊断和预后生物标志物测定的测定。

7. 发明公开

EP3153863A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：方法和组合物诊断和预后判断肾功能衰竭和肾损害
公开(公告)号：EP3153863A1
公开(公告)日：2017-04-12
申请号：EP16196505.8
申请日：2010-11-05
申请人： Astute Medical, Inc.
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James Patrick
IPC分类号： G01N33/68
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect soluble Transmembrane glycoprotein NMB, and optionally further a kidney injury marker of C-C motif chemokine 23, Brain-derived neurotrophic factor, Cathepsin S, Transforming growth factor beta-2, Urokinase-type plasminogen activator, Angiopoietin-2, Matrilysin, Carcinoembryonic antigen-related cell adhesion molecule 1, Creatine kinase MB, Insulin, Immunoglobulin M, Immunoglobulin E, Macrophage migration inhibitory factor, Galectin-3, Transforming growth factor beta-3, Heparan sulfate, soluble Cadherin-3, Complement C5, Platelet factor 4, Platelet basic protein, and Stromelysin-2 as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及一种用于在患有或疑似患有肾损伤的受试者监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及一种使用经配置以检测可溶性跨膜糖蛋白NMB一个一种或多种测定，并且任选地进一步肾损伤标记物CC基序趋化因子23，脑源性神经营养因子，组织蛋白酶S的，转化生长因子β-2，尿激酶型纤维蛋白溶酶原活化剂，血管生成素-2，基质溶素，癌胚抗原相关细胞粘附分子1，肌酸激酶MB，胰岛素，免疫球蛋白男，免疫球蛋白E，巨噬细胞迁移抑制因子，半乳糖凝集素-3，转化生长因子β-3，类肝素硫酸盐，可溶性钙粘蛋白3，补体C5，血小板因子4，血小板碱性蛋白，和溶基质蛋白酶-2在肾损伤作为诊断和预后标志物。

9. 发明公开

EP2820146A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：肾损伤和肾功能衰竭的诊断和预后的方法和组合物
公开(公告)号：EP2820146A1
公开(公告)日：2015-01-07
申请号：EP13755796.3
申请日：2013-02-27
申请人： Astute Medical, Inc.
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
IPC分类号： C12Q1/00 , G01N33/50 , G01N33/53
CPC分类号： G01N33/6893 , A61M1/1601 , A61M2202/0413 , A61M2205/75 , G01N2800/347 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of SPARC, Follistatin-related protein 1, Tumor necrosis factor receptor superfamily member 21, Growth arrest-specific protein 1, MHC class I polypeptide-related sequence A, Syndecan-1, and WNTl-inducible-signaling pathway protein 1 as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。具体而言，本发明涉及使用一种或多种配置成检测选自SPARC，Follistatin相关蛋白1，肿瘤坏死因子受体超家族成员21，生长停滞特异性蛋白1，MHC I类多肽相关序列A，Syndecan-1和WNT1诱导型信号传导通路蛋白1作为肾损伤中的诊断和预后生物标志物。

10. 发明公开

EP2721404A1 DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：诊断和肾功能衰竭和肾脏病变预后
公开(公告)号：EP2721404A1
公开(公告)日：2014-04-23
申请号：EP12802159.9
申请日：2012-06-20
申请人： Astute Medical, Inc.
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
IPC分类号： G01N33/00 , G01N33/48 , G01N33/53
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/52
摘要： Methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury are disclosed. In particular, the assays detect each of C-X-C motif chemokines -1, -2, and -3 as diagnostic and prognostic biomarkers in renal injuries.

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