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1. 发明公开

EP3321666A1 THERMAL CONTRAST ASSAY AND READER 有权
标题翻译：热对比测定和读数器
公开(公告)号：EP3321666A1
公开(公告)日：2018-05-16
申请号：EP17204410.9
申请日：2013-01-30
申请人： Regents of the University of Minnesota , The Governing Council of the University of Toronto
发明人： Bischof, John C. , Qin, Zhenpeng , Chan, Warren , Akkin, Taner
IPC分类号： G01N21/84 , G01N33/558
CPC分类号： G01N25/4806 , G01N21/8483 , G01N25/48 , G01N33/558 , G01N2021/8488 , Y02A50/58
摘要： Assays used in conjunction with a thermal contrast reader are disclosed. In the assay, the test strip includes materials that can develop a thermal response if a target analyte is present in a sample. The thermal contrast reader includes housing having an opening to receive the test strip at a test location, an energy source directed at the test location and a heat sensor directed at the test location. The heat sensor is configured to sense heating of the test strip upon activation of the heat source at the test location, if the target analyte is present in the sample. The heat sensor can provide sensor output using diagnostic circuitry coupled to the sensor output and configured to provide a diagnostic output. The diagnostic output can indicate the diagnostic condition of the patient as a function of the sensor output. The present disclosure also includes methods of detecting target analytes and kits comprising lateral flow assays and thermal contrast reader.
摘要翻译：公开了与热对比度读数器结合使用的测定法。在该测定中，测试条包括如果目标分析物存在于样品中则可以产生热响应的材料。热对比度读取器包括具有在测试位置接收测试条的开口的壳体，指向测试位置的能量源和指向测试位置的热传感器。如果目标分析物存在于样本中，则热传感器被配置为在测试位置激活热源时感测测试条的加热。热传感器可以使用耦合到传感器输出的诊断电路来提供传感器输出并且被配置为提供诊断输出。诊断输出可以根据传感器输出指示患者的诊断状况。本公开还包括检测目标分析物和试剂盒的方法，其包括横向流动分析和热对比读取器。

2. 发明公开

EP2839264A4 DEVICE FOR PERFORMING DIAGNOSTIC TEST AND METHODS FOR USE THEREOF 有权
标题翻译：进行诊断测试的装置及其使用方法
公开(公告)号：EP2839264A4
公开(公告)日：2015-09-16
申请号：EP13777614
申请日：2013-04-12
申请人： EHRENKRANZ JOEL R L
发明人： EHRENKRANZ JOEL R L
IPC分类号： G01N33/50
CPC分类号： G01N33/558 , G01N21/6428 , G01N21/78 , G01N21/8483 , G01N35/00029 , G01N2021/6439 , G01N2021/8488 , G01N2035/00108 , Y02A90/26
摘要： Assay cassettes and testing devices that can be used to provide rapid, accurate, affordable, laboratory-quality testing at the point of care. Such assay cassettes and testing devices are designed to provide rapid, quantitative test results in a point-of-care setting or the like. Likewise, such assay cassettes and testing devices may eliminate or replace expensive, centralized clinical testing equipment and technical personnel. Such testing device may include automated data reporting and decision support. Methods for performing point of care diagnostic tests are also disclosed.

3. 发明授权

EP1785730B1 System und Verfahren zur Untersuchung einer Probenflüssigkeit 失效转让
标题翻译：系统和Verfahren zur Untersuchung einerProbenflüssigkeit
公开(公告)号：EP1785730B1
公开(公告)日：2013-02-13
申请号：EP05024897.0
申请日：2005-11-15
申请人： F.Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： Krämer, Uwe, Dr. , List, Hans
IPC分类号： A61B5/145 , G01N21/84 , G01N35/00
CPC分类号： G01N21/55 , A61B5/14532 , A61B2562/0295 , G01N33/48764 , G01N35/00009 , G01N2021/8488 , G01N2035/00019 , Y10T436/110833 , Y10T436/112499 , Y10T436/12

4. 发明公开

EP2385363A3 Optical arrangement for assay reading device 审中-公开
标题翻译：用于化验读取装置的光学装置
公开(公告)号：EP2385363A3
公开(公告)日：2012-05-02
申请号：EP10184102.1
申请日：2004-05-25
申请人： Alere Switzerland GmbH
发明人： Phelan, Andrew
IPC分类号： G01N21/84 , G01N21/86 , G01N33/487 , G01N21/27 , G01N21/78
CPC分类号： G01N21/78 , G01N21/274 , G01N21/8483 , G01N2021/8488 , G01N2021/8494 , G01N2201/06106 , G01N2201/062
摘要： An assay result reading device for reading the result of an assay performed using a test strip, the device comprising: a light source or sources, said light source(s) emitting light incident upon at least two, spatially separated zones of the test strip; and a photodetector which detects light emanating from each of the two said zones; in a further aspect is disclosed an assay result reading device for reading the result of an assay performed using a test strip, the device comprising: at least one light source incident upon a zone of the test strip; and at least two photodetectors both of which are able to detect some of the light emanating from the zone of the test strip illuminated by the light source.

5. 发明公开

EP2282204A1 Early determination of assay results 有权转让
标题翻译： FRÜHERKENNUNGVON测定结果
公开(公告)号：EP2282204A1
公开(公告)日：2011-02-09
申请号：EP10183291.3
申请日：2004-05-25
申请人： Alere Switzerland GmbH
发明人： Sharrock, Stephen Paul , Phelan, Andrew
IPC分类号： G01N33/487 , G01N21/86 , G01N33/543 , G01N33/76
CPC分类号： G01N21/274 , G01N21/4738 , G01N21/78 , G01N21/8483 , G01N31/22 , G01N2021/8488 , G01N2021/8494 , G01N2201/06106 , G01N2201/062
摘要： Disclosed is a device for determining the result of an assay, comprising:
a computation circuit, responsive to an analyte signal representing the amount of an analyte or the rate of accumulation of an analyte, wherein said circuit is capable of comparing the analyte signal to a first threshold and comparing the analyte signal to a second threshold, the second threshold being less than the first threshold, characterised in that:
an output signal is generated if the analyte signal exceeds the first threshold and wherein an output signal is generated if the analyte signal is less than the second threshold, the output signal being indicative of a first result if the analyte signal exceeds the first threshold, and the output signal being indicative of a second result if the analyte signal is less than the second threshold;
and wherein the assay is terminated if the analyte signal exceeds the first threshold; and the assay is terminated if the signal is less than the second threshold.
摘要翻译：公开了一种用于确定测定结果的装置，包括：响应于表示分析物的量的分析物信号或分析物的累积速率的计算电路，其中所述电路能够将分析物信号与第一阈值并将分析物信号与第二阈值进行比较，所述第二阈值小于所述第一阈值，其特征在于：如果所述分析物信号超过所述第一阈值，则生成输出信号，并且如果所述分析物信号如果所述分析物信号超过所述第一阈值，则所述输出信号指示第一结果，并且如果所述分析物信号小于所述第二阈值，则所述输出信号指示第二结果; 并且其中如果所述分析物信号超过所述第一阈值，则所述测定终止; 如果信号小于第二阈值，则终止测定。

6. 发明公开

EP1970698A3 Method For Reading Test Strips 有权
标题翻译： Verfahren zum Ablesen von Teststreifen
公开(公告)号：EP1970698A3
公开(公告)日：2010-09-29
申请号：EP08152478.7
申请日：2008-03-07
申请人： Rohm and Haas Company
发明人： Gregory, Walter Jay , Stapelkamp, William Harrison
IPC分类号： G01N21/86 , A61B5/00 , G01N33/487 , G06T7/00 , G06T7/40 , G01N21/27 , G01J3/46
CPC分类号： G01N21/8483 , G01N21/27 , G01N2021/177 , G01N2021/5923 , G01N2021/593 , G01N2021/8488 , G01N2035/00108 , G06T7/90 , G06T2207/10024
摘要： There is provided a method for identifying the color intensities of red lines on a white test strip, comprising the steps of
(A) attaching said white test strip to a card that is larger and darker than said white test strip,
(B) scanning said card with said attached white test strip,
(C) creating a digital image of said card, wherein each pixel in said digital image has a Red value, a Green value, and a Blue value,
(D) using said digital image to calculate a color intensity for each red line on said white test strip.
摘要翻译：提供了一种用于识别白色测试条上的红线的颜色强度的方法，包括以下步骤：（A）将所述白色测试条附着到比所述白色测试条更大和更暗的卡上;（B）扫描所述白色测试条（C）创建所述卡的数字图像，其中所述数字图像中的每个像素具有红色值，绿色值和蓝色值，（D）使用所述数字图像来计算一个所述白色测试条上每条红线的颜色强度。

7. 发明公开

EP1709429A1 A HANDHELD DEVICE WITH A DISPOSABLE ELEMENT FOR CHEMICAL ANALYSIS OF MULTIPLE ANALYTES 审中-公开
标题翻译：伸手阻止终端设备一次性元在多次分析物的化学分析
公开(公告)号：EP1709429A1
公开(公告)日：2006-10-11
申请号：EP05704927.2
申请日：2005-01-04
申请人： GENERAL ELECTRIC COMPANY
发明人： XIAO, Caibin , BOYETTE, Scott, M. , POTYRAILO, Radislav, A.
IPC分类号： G01N21/55 , G01N21/25 , G01N21/27 , G01N21/31 , G01N33/543
CPC分类号： G01N21/7703 , G01N21/253 , G01N21/272 , G01N21/274 , G01N21/314 , G01N21/552 , G01N21/8483 , G01N2021/7783 , G01N2021/8488 , G01N2201/0221 , G01N2201/0245 , G01N2201/0461 , G01N2201/122
摘要： A portable system and method for measuring the concentration of multiple chemical or biological substances where an onsite analysis of such substances is needed. The new and original handheld sensor system uses a disposable optical test element and a spectroscopic detector that measures the test element response to specific analytes through a change in light absorbance, luminescence, and other forms of light-based response. In this way, reflection light intensities indicative of the test element response can be used to measure the concentration of the target analytes. The sensor system is also capable of being interfaced to an information processing unit or computer so that analytical data can be manipulated or stored electronically.

8. 发明公开

EP1484611A3 Flow sensing for determination of assay results 有权转让
标题翻译：流量测量测定法测定结果
公开(公告)号：EP1484611A3
公开(公告)日：2006-08-23
申请号：EP04253077.4
申请日：2004-05-25
申请人： Inverness Medical Switzerland GmbH
发明人： Sharrock, Stephen Paul UNIPATH LTD
IPC分类号： G01N33/00 , G01N21/86 , G01N33/543 , G01N33/76
CPC分类号： G01N21/8483 , G01N21/274 , G01N21/78 , G01N2021/8488 , G01N2021/8494 , G01N2201/06106 , G01N2201/062
摘要： An assay result reading device for reading the result of an assay performed using a liquid transport carrier may include at least one light source capable of emitting light incident upon at least one of two or more spatially separated zones of the carrier, a photodetector so positioned as to be capable of detecting light emanating from each of the two said zones and generating signals representing the presence or absence of a fluid sample in the respective zone, and a computation circuit. The computation circuit may be responsive to the signals to calculate a flow rate for a fluid flowing along the carrier, compare the calculated flow rate to upper and lower limits, and reject the assay result if the calculated flow rate is outside the upper and lower limits.

9. 发明授权

EP0731951B1 OPTICAL SPECIMEN ANALYSIS SYSTEM AND METHOD 有权
标题翻译：光测试分析系统和方法
公开(公告)号：EP0731951B1
公开(公告)日：2000-07-05
申请号：EP94909763.8
申请日：1994-02-24
申请人： E-Y LABORATORIES, INC.
发明人： CHU, Albert, E. , TAO, Lian
IPC分类号： G06K9/00 , G01N15/14 , G01N33/52
CPC分类号： G01N21/8483 , G01N15/1468 , G01N15/1475 , G01N2021/177 , G01N2021/5919 , G01N2021/5923 , G01N2021/593 , G01N2021/5934 , G01N2021/8488 , G06F19/00 , G06T7/90 , G06T2207/10024 , G06T2207/30004
摘要： A method and system for automatically analyzing the presence of an analyte in a liquid specimen of biological origin are described. The liquid specimen is added to a testing substrate that has a receptor immobilized on a portion of its surface. If analyte is present in the specimen, it will specifically bind to the receptor. A labeled reagent is added to the testing substrate which will bind to the analyte, if present, and generate a color on the testing substrate. The testing substrate is then illuminated and, using electronic equipment, a digital image of its surface is acquired and automatically scanned to locate an area that has the highest color density, which corresponds to the presence of labeled reagent. A measurement of color density, corresponding to pixels per unit area, is generated. An area peripheral to the area of highest color density, which represents background density, is also located and a measured. The presence or absence of analyte in the liquid sample is determined by adjusting the measurement of labeled reagent with the background density measurement in accordance with a predefined mathematical function. In some cases, the result of the test will be interpreted as a binary, positive/negative result according to whether the measurement taken is above or below a given threshold. In other cases, a continuous range of values may be generated from different samples that correspond to the concentration of the analyte present in each tested sample.

10. 发明公开

EP0731951A1 OPTICAL SPECIMEN ANALYSIS SYSTEM AND METHOD 有权
标题翻译：光测试分析系统和方法
公开(公告)号：EP0731951A1
公开(公告)日：1996-09-18
申请号：EP94909763.0
申请日：1994-02-24
申请人： E-Y LABORATORIES, INC.
发明人： CHU, Albert, E. , TAO, Lian
IPC分类号： G01N21 , G06T7 , G01N15
CPC分类号： G01N21/8483 , G01N15/1468 , G01N15/1475 , G01N2021/177 , G01N2021/5919 , G01N2021/5923 , G01N2021/593 , G01N2021/5934 , G01N2021/8488 , G06F19/00 , G06T7/90 , G06T2207/10024 , G06T2207/30004
摘要： A method and system for automatically analyzing the presence of an analyte in a liquid specimen of biological origin are described. The liquid specimen is added to a testing substrate that has a receptor immobilized on a portion of its surface. If analyte is present in the specimen, it will specifically bind to the receptor. A labeled reagent is added to the testing substrate which will bind to the analyte, if present, and generate a color on the testing substrate. The testing substrate is then illuminated and, using electronic equipment, a digital image of its surface is acquired and automatically scanned to locate an area that has the highest color density, which corresponds to the presence of labeled reagent. A measurement of color density, corresponding to pixels per unit area, is generated. An area peripheral to the area of highest color density, which represents background density, is also located and a measured. The presence or absence of analyte in the liquid sample is determined by adjusting the measurement of labeled reagent with the background density measurement in accordance with a predefined mathematical function. In some cases, the result of the test will be interpreted as a binary, positive/negative result according to whether the measurement taken is above or below a given threshold. In other cases, a continuous range of values may be generated from different samples that correspond to the concentration of the analyte present in each tested sample.

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