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1. 发明公开

EP3392335A1 METHOD FOR CULTURING ADHERENT CELLS 无效
公开(公告)号：EP3392335A1
公开(公告)日：2018-10-24
申请号：EP16875595.7
申请日：2016-12-12
申请人： Zeon Corporation
发明人： KUSABIRAKI, Kazuki , ICHIMURA, Naoya
IPC分类号： C12N5/071
CPC分类号： C12N5/0068 , C12N2509/00 , C12N2533/30
摘要： The invention is a method for culturing adherent cells, culturing the adherent cells in a liquid medium in an alicyclic structure-containing polymer culture vessel, releasing the cells from the culture vessel by liquid flow without adding a protease, and suspending the cultured cells in a liquid medium. The cells can be easily released by a small force such as pipetting because the cells adhere loosely to the alicyclic structure-containing polymer culture vessel.

2. 发明公开

EP3378930A1 SCAFFOLD FOR THE GROWTH OF TISSUE IN VIVO 有权
公开(公告)号：EP3378930A1
公开(公告)日：2018-09-26
申请号：EP18169764.0
申请日：2010-12-15
申请人： VivaBioCell SpA
发明人： CURCIO, FRANCESCO
IPC分类号： C12M3/00 , C12N5/00
CPC分类号： C12N5/0062 , A61K9/00 , A61K35/32 , A61L27/18 , A61L27/50 , A61L27/56 , A61L2300/64 , B33Y10/00 , B33Y50/02 , C12M21/08 , C12M23/02 , C12M25/14 , C12N2533/30 , C12N2535/00 , C12N2537/00
摘要： A continuous device for culturing mammalian cells in a three-dimensional structure for the transplantation or implantation in vivo is described. The culturing device comprises (a) a scaffold formed by a matrix of interconnected growth surfaces spaced at regular intervals and (b) a fluid distribution means at the inlet and the exit of the growth areas. The device is particularly useful for culturing bone cells for dental implants or bone reconstruction.

4. 发明授权

EP2828377B1 METHOD FOR MANUFACTURING A THREE-DIMENSIONAL BIOMIMETIC SCAFFOLD AND USES THEREOF 有权
公开(公告)号：EP2828377B1
公开(公告)日：2018-08-22
申请号：EP13702949.2
申请日：2013-01-25
申请人： Queen Mary University of London
发明人： MATA CHAVARRÍA, Alvaro , AGUILAR, Juan Pablo
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , A61L27/3633 , B03C5/005 , C12N2533/30 , C12N2533/50 , C12N2533/76 , C12N2535/10 , C12N2537/00 , C25D13/00 , G01N27/447 , G01N27/453
摘要： The present invention relates to a method for manufacturing a three-dimensional (3D) biomimetic scaffold that exploits the use of electrical fields and electrical insulating materials to pattern previously polymerized hydrogels with different molecules and/or macromolecular entities. The invention also relates to the 3D-biomimetic scaffolds obtained and to the uses and applications thereof.

5. 发明公开

EP3344754A1 METHOD FOR INDUCING DIFFERENTIATION OF STEM CELLS 审中-公开
公开(公告)号：EP3344754A1
公开(公告)日：2018-07-11
申请号：EP16760503.9
申请日：2016-09-05
申请人： Stichting Katholieke Universiteit
发明人： FEITZ, Wouter Franciscus Joannes , OOSTERWIJK, Egbert , MIHAILA, Silvia Maria , ROWAN, Alan Edward
IPC分类号： C12N5/00 , C08G65/325 , C12N5/077 , C12N5/0775 , C08G65/333
CPC分类号： C12N5/0663 , C08L71/02 , C12N5/0062 , C12N2506/1346 , C12N2513/00 , C12N2527/00 , C12N2533/30 , C12N2533/32 , C12N2533/40
摘要： A cell culture including a cell culturing medium for growing stem cells, a three-dimensional (3D) cell growth matrix and stem cells, wherein the cell culture has a critical stress σc of 2-30 Pa, wherein the critical stress is a stress which marks an onset of strain stiffening and wherein the cell culture has a storage modulus G′ measured at 37° C. of 50-1000 Pa.

6. 发明公开

EP3214165A4 FIBER STRUCTURE FOR USE AS CELL SCAFFOLD MATERIAL 审中-公开
公开(公告)号：EP3214165A4
公开(公告)日：2018-07-04
申请号：EP15855508
申请日：2015-10-30
申请人： TORAY INDUSTRIES
发明人： KADOWAKI KOJI , KUGA CHISA , FUJITA MASAKI , TANAHASHI KAZUHIRO , YAMADA SATOSHI , KANEKO TAKAYUKI , TSUCHIKURA HIROSHI
IPC分类号： C12M3/00 , A61L17/10 , A61L17/12 , A61L27/00 , D01F6/62 , D03D1/00
CPC分类号： C12N5/0068 , A61L17/105 , A61L17/12 , A61L27/00 , A61L27/18 , A61L27/50 , C12M3/00 , C12N2533/30 , D01F6/62 , D03D1/00 , D03D15/0088
摘要： The present invention aims to provide a fiber structure which can be used as a cell scaffold material showing improvement in both the cellular adhesiveness and the cell growth capacity, which improvement was achieved by controlling the fiber orientation in the multifilament and the average fiber diameter, which are physical properties. The present invention provides a fiber structure which can be used as a cell scaffold material, which fiber structure comprises a multifilament formed by bundling monofilaments having an average fiber diameter of 1 to 15 µm, wherein each of the monofilaments satisfies the condition of the following Formula 1: (Y/X)×100‰¥50 ... Formula 1 [wherein in Formula 1, X represents the number of monofilaments for which the average crossing angle is investigated, and Y represents the number of monofilaments having an average crossing angle of not more than 25° in X].

7. 发明授权

EP3009447B1 PRODUCTION OF ERYTHROPOIESIS STIMULATING PROTEIN USING METAL IONS 有权
公开(公告)号：EP3009447B1
公开(公告)日：2018-06-06
申请号：EP15191348.0
申请日：2010-07-23
申请人： Dr. Reddy's Laboratories, Ltd. , Dr. Reddy's Laboratories Inc.
发明人： PANKHANIA, Ashvin , REDDY, Degalahal, Ganesh , KAMARAJU, Mamata
IPC分类号： C07K14/505 , C12P21/00 , C12N5/00
CPC分类号： C07K14/505 , C12N5/0018 , C12N2500/74 , C12N2500/76 , C12N2501/33 , C12N2533/30 , C12P21/005
摘要： The present invention provides methods of increasing the levels of low pl isoforms of expressing erythropoiesis stimulating protein in media containing metal ions, to improve product quality.

8. 发明公开

EP3320342A1 NOUVEAUX HYDROGELS DE STRUCTURE SILYLÉE ET PROCÉDÉ D'OBTENTION 有权
标题翻译：新型硅烷化结构水凝胶及其获得方法
公开(公告)号：EP3320342A1
公开(公告)日：2018-05-16
申请号：EP16736458.7
申请日：2016-07-07
申请人： Université de Montpellier , Centre National de la Recherche Scientifique (C.N.R.S.)
发明人： MARTINEZ, Jean , MEHDI, Ahmad , SUBRA, Gilles , JEBORS, Said , ECHALIER, Cécile
IPC分类号： G01N33/543 , A61L27/52 , C07F7/18
CPC分类号： A61L27/52 , A61L26/0066 , A61L26/008 , A61L27/18 , A61L27/22 , A61L27/54 , A61L2300/404 , A61L2400/06 , C07F7/087 , C07F7/1804 , C07K1/1077 , C07K5/06095 , C07K5/0823 , C07K7/06 , C08G65/336 , C12N5/0668 , C12N2533/30 , C12N2533/50 , G01N33/5436 , C08L89/00 , C08L89/06 , C08L5/08
摘要： The present invention relates to hydrogels prepared using silylated organic molecules (such as silylated biomolecules), a method for obtaining same, and uses thereof.

9. 发明授权

EP1840207B1 METHOD OF CULTURING CELLS UNDER REGULATION IN THE EXTENSION DIRECTION 有权
标题翻译：在扩张方向调节细胞的方法
公开(公告)号：EP1840207B1
公开(公告)日：2018-05-02
申请号：EP06711533.7
申请日：2006-01-11
申请人： Kuraray Co., Ltd., , Nishio, Ryosuke
发明人： NISHIO, Ryosuke , NISHI, Taiji , FUKUDA, Motohiro , KIRITA, Yasuzo , KANAI, Seiichi , KITANI, Takenori
IPC分类号： C12N5/077 , C12M1/32 , C12M3/04
CPC分类号： C12M25/06 , C12M23/12 , C12N5/0657 , C12N2533/30 , C12N2535/00
摘要： [PROBLEMS] Relating to a bioassay method with the use of cultured cells and cell culture for a therapeutic purpose in the case of determining the efficacy of a drug or the like or examining the toxicity thereof, it is intended to provide a method of culturing cells under regulation in the extension direction and a cell culture plate. [MEANS FOR SOLVING PROBLEMS] A cell culture plate having a plural number of side walls (1) and a plural number of space structures (3) for providing cultured cells which are formed by the side walls (1), wherein the side walls (1) are provided with openings (2) so that the space structures (3) are linked together. By using this cell culture plate, a method of culturing cells under regulation in the extension direction can be provided.

10. 发明公开

EP3301121A1 A THERMORESPONSIVE POLYMER AND ITS USE IN A CELL CULTURE SUPPORT 审中-公开
标题翻译：一种热敏性聚合物及其在细胞培养支持中的应用
公开(公告)号：EP3301121A1
公开(公告)日：2018-04-04
申请号：EP16191842.0
申请日：2016-09-30
申请人： Freie Universität Berlin
发明人： DR. WEINHART, Heidemarie , STÖBENER, Daniel
IPC分类号： C08G65/26 , C08G65/331 , C08G65/332 , C08G65/22
CPC分类号： C08G65/331 , C08G65/22 , C08G65/2639 , C08G65/2654 , C08G65/3326 , C08G2650/16 , C08L2203/02 , C12N2533/30 , C12N2539/10
摘要： The present invention relates to a thermoresponsive polymer comprising a linear polyether chain of the general formulae (I) Nu-[CH 2 -CR 1 R 2 O] m -[CH 2 -CR 3 R 4 O] m -[CH 2 -CR 5 R 6 O] o -[CH 2 -CR 7 R 8 O] p -H; wherein R 1 , R 3 , R 5 and R 7 are in each case H or a C 1 -C 10 alkyl side chain, wherein R 1 , R 3 , R 5 and R 7 may be the same or different; R 2 and R 4 are in each case a side chain comprising at least one thermoresponsive moiety, wherein R 2 and R 4 may be the same or different; R 6 and R 8 are in each case H, a moiety containing at least one C=C double bond or a photo-crosslinkable moiety selected from a group of aromatic and heteroaromatic compounds, wherein R 6 and R 8 may the same or different, wherein at least one of R 6 and R 8 has to be a photo-crosslinkable moiety, Nu is nucleophilic moiety selected from a group comprising halogen or alkoxy; m, n are in each case or in sum 10-5000, preferably 10-1000, more preferably 100-500; o, p are in each case 1-20 or in sum 2-20, preferably 3-15, more preferably 5-10. The invention also relates to a cell substrate support comprising the polymer.
摘要翻译：（I）Nu- [CH 2 -CR 1 R 2 O] m - [CH 2 -CR 3 R 4 O] m - [CH 2 -CR 5 R 6 O] o - [CH 2 -CR 7 R 8 O] p -H的线性聚醚链的热响应性聚合物; 其中R1，R3，R5和R7各自为H或C1-C10烷基侧链，其中R1，R3，R5和R7可以相同或不同; R2和R4各自为包含至少一个热响应部分的侧链，其中R2和R4可以相同或不同; R6和R8各自为H，含有至少一个C = C双键的部分或选自芳族和杂芳族化合物组的光交联部分，其中R6和R8可以相同或不同，其中至少一个 R6和R8必须是可光交联部分，Nu是选自卤素或烷氧基的亲核部分; m，n分别总计为10-5000，优选10-1000，更优选100-500; o，p分别为1-20或总计2-20，优选3-15，更优选5-10。本发明还涉及包含该聚合物的细胞基质支持物。

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