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1. 发明授权

EP2906617B1 HYDROGEL PRODRUGS 有权转让
公开(公告)号：EP2906617B1
公开(公告)日：2018-03-14
申请号：EP13773790.4
申请日：2013-10-08
申请人： Ascendis Pharma A/S
发明人： RAU, Harald , VOIGT, Tobias , LAUFER, Burkhardt , BISEK, Nicola , HAHN, Franziska , KNAPPE, Thomas
IPC分类号： C08J3/24 , C08G83/00 , A61K47/10 , C08J3/075 , C08F2/32 , C08G65/32 , C08G65/332
CPC分类号： A61K47/60 , A61K31/4188 , A61K47/557 , A61K47/59 , A61K47/645 , A61K47/6845 , A61K47/6849 , A61K47/6903 , C08F2/22 , C08G65/332 , C08G65/3322 , C08G65/33337 , C08G65/33389 , C08G69/44 , C08G69/48 , C08G83/004 , C08G83/006 , C08G2210/00 , C08J3/075 , C08J2300/202 , C08J2371/02 , C08J2400/202 , C08J2471/02 , C08L2203/02
摘要： The present invention relates to a process for the preparation of a hydrogel and to a hydrogel obtainable by said process. The present invention further relates to a process for the preparation of a hydrogel-spacer conjugate, to a hydrogel-spacer conjugate obtainable by said process, to a process for the preparation of a carrier-linked prodrug and to carrier-linked prodrugs obtainable by said process, in particular to carrier-linked prodrugs that provide for a controlled or sustained release of a drug from a carrier. In addition, the invention relates to the use of the hydrogel for the preparation of a carrier-linked prodrug.

2. 发明公开

EP3000836A4 PHOTODEGRADABLE CROSSLINKING AGENT, PHOTODEGRADABLE GEL, CELL CULTURE DEVICE, CELL ARRANGEMENT/SEPARATION DEVICE, CELL ARRANGEMENT METHOD, CELL SEPARATION METHOD, METHOD OF FORMING TISSUE MATERIAL, AND TISSUE MATERIAL 失效
标题翻译：光降解网络资源，光降解GEL，细胞培养装置，ZELLANORDNUNGS- /分离器，ZELLA订购方法，细胞分离，产生的织物材料与组织材料的方法
公开(公告)号：EP3000836A4
公开(公告)日：2016-05-18
申请号：EP14801820
申请日：2014-05-13
申请人： NAT INST OF ADVANCED IND SCIEN
发明人： SUGIURA SHINJI , TAKAGI TOSHIYUKI , YANAGAWA FUMIKI , SUMARU KIMIO , KANAMORI TOSHIYUKI
IPC分类号： C08G65/333 , C08G63/12 , C08G69/26 , C08G81/00 , C12M1/00 , C12M3/04 , C12N1/00 , C12N5/00
CPC分类号： C08G65/33389 , C08G65/333 , C08G65/33337 , C08G69/40 , C08G81/00 , C12M23/20 , C12M23/30 , C12N5/0068 , C12N2537/10
摘要： The present invention provides a photodegradable cross-linking agent capable of manufacturing a photodegradable gel, which has appropriate moisture content and water solubility as a cell carrier and has strength that makes it possible to construct a complicated three-dimensional microstructure. The photodegradable cross-linking agent of the present invention includes a main chain 2 which is composed of branched polyethylene glycol having three or more branched chains and a photodegradable benzyl group 3 which is disposed on the terminus of the branched chains, in which the benzyl group has an active ester group 4, which is reactive with an amino group or a hydroxyl group, and one or more nitro groups in a benzene ring.
摘要翻译：本发明提供一种能够制造可光降解的凝胶，其具有适当的水分含量和水溶性作为细胞载体，并具有强度做使得有可能构建一个复杂的三维微结构的可光降解的交联剂。本发明的可光降解的交联剂包括由支链的聚乙二醇的具有三个或更多支链和其上的支链的末端设置在可光降解的苄基3所有，主链2中的所有，其中苄基具有活性酯基4，所有这与一个苯环在氨基或羟基基团，以及一个或多个硝基基团反应。

3. 发明公开

EP2832765A1 MULTI-ARM POLYETHYLENE GLYCOL DERIVATIVE, INTERMEDIATE THEREOF AND METHOD FOR PRODUCING SAME 有权
标题翻译：多臂聚乙二醇，中间体AND METHOD FOR ITS
公开(公告)号：EP2832765A1
公开(公告)日：2015-02-04
申请号：EP13768770.3
申请日：2013-03-28
申请人： NOF Corporation
发明人： YOSHIOKA Hiroki , HIRAI Midori , NAKATSUHARA Hitoshi , YAMAMOTO Yuji
IPC分类号： C08G65/329
CPC分类号： C08G65/2609 , C08G65/2696 , C08G65/329 , C08G65/3322 , C08G65/33306 , C08G65/33337 , C08G65/33368 , C08G65/33389 , C08G2650/30
摘要： Provided is a multi-arm polyethylene glycol derivative having a narrow molecular weight distribution. A multi-arm polyethylene glycol derivative represented by the formula (1):

wherein, L represents a group selected from a linear or branched alkylene, arylene, or cycloalkylene group having two or more carbon atoms and combinations thereof, which may have an ether bond in a chain; X represents a dehydroxylation residue of a linear sugar alcohol having 5 or 7 carbon atoms; m is the number of polyethylene glycol chains bonded to X and represents 4 or 6; n is the average addition molar number of oxyethylene groups and n represents an integer of 3 to 600; Y represents a single bond or an alkylene group which may have an ester bond, a urethane bond, an amide bond, an ether bond, a carbonate bond, a secondary amino group, a urea bond, a thioether bond or a thioester bond in a chain or at an end; and Z represents a chemically reactive functional group.

4. 发明授权

EP1732971B1 PROCESS FOR THE PREPARATION OF ACTIVATED POLYETHYLENE GLYCOLS 有权
标题翻译：用于生产活性炭的聚乙二醇
公开(公告)号：EP1732971B1
公开(公告)日：2012-11-14
申请号：EP05714584.9
申请日：2005-03-04
申请人： RBA Pharma Inc.
发明人： FAURE, Marie-Pierre , SHINGEL, Kirill
IPC分类号： C08G65/329 , C08G65/00 , C08G65/30
CPC分类号： C08G65/329 , C08G65/33389 , C08G65/3346 , C08L2203/02

5. 发明授权

EP0268849B1 Poly(aminoaromatic) compounds 失效
标题翻译：聚（氨基芳族）化合物
公开(公告)号：EP0268849B1
公开(公告)日：1993-10-20
申请号：EP87115677.4
申请日：1987-10-26
申请人： THE DOW CHEMICAL COMPANY
发明人： Durvasula, Visweswara R. , Stuber, Fred A.
IPC分类号： C08G65/32 , C08G18/50
CPC分类号： C08G65/322 , C08G18/5027 , C08G18/5072 , C08G18/52 , C08G65/33389 , C08G75/02

6. 发明公开

EP0268849A3 Poly(aminoaromatic) compounds 失效
标题翻译：多酚与芳香族胺的接枝
公开(公告)号：EP0268849A3
公开(公告)日：1989-12-13
申请号：EP87115677.4
申请日：1987-10-26
申请人： THE DOW CHEMICAL COMPANY
发明人： Durvasula, Visweswara R. , Stuber, Fred A.
IPC分类号： C08G65/32 , C08G18/50
CPC分类号： C08G65/322 , C08G18/5027 , C08G18/5072 , C08G18/52 , C08G65/33389 , C08G75/02
摘要： Disclosed is a class of poly(aminoaromatic) compounds (I) obtained by capping polymeric polyols or polythiols with aromatic amine groups wherein the latter groups are linked by -O- or -S- to the polyol (polythiol) residues. Also disclosed are the precursor poly(nitroaromatic) compounds (II) and process therefor from which the compounds (I) are derived. The polyamines are characterized by amine reactivities in respect of isocyanate polyaddition reactions which allows for polymer reaction rates that are intermediate of prior art related polyamine compounds. Accordingly, the compounds (I) find their prime utility in the formation of synthetic resins containing polyurea linkages.

7. 发明授权

EP2879716B1 STRAIN-PROMOTED CROSSLINKING OF PEG-BASED HYDROGELS VIA COPPER-FREE CYCLOADDITION 有权
标题翻译：基于PEG的水凝胶通过无铜循环应变促进交联
公开(公告)号：EP2879716B1
公开(公告)日：2017-05-17
申请号：EP13825218.4
申请日：2013-07-31
申请人： The University of Akron
发明人： WEISS, Robert A. , BECKER, Matthew
IPC分类号： A61K47/34 , C08L89/00 , C08L71/02 , C08L71/00 , C08G65/333 , C08G65/325 , A61K9/06
CPC分类号： C08L71/00 , A61K9/06 , A61K47/34 , C08G65/325 , C08G65/33389 , C08L71/02 , C08L89/00 , C08L2205/02
摘要： The present invention is directed to a covalently crosslinked hydrogel comprising the strain-promoted reaction product of an 8-member cycloalkyne functionalized polyalkylene glycol and a multi-arm glycerol exytholate triazide and methods for making them. Because the precursor materials can be manipulated without causing crosslinking, provided the strain threshold is not reached, these hydrogels permit mechanical control over when (and where) cross linking occurs and are easier to use than prior strain-activated or temperature-activated systems. These novel hydrogels do not require a catalyst to cross link, thus avoiding the biocompatibility problems common to many catalysts. Nor is the crosslinking process affected by the presence of catalysts or other substances, which have interfered with crosslinking in known strain induced hydrogels. Because of their crosslinking reaction kinetics, these novel hydrogels can encapsulate and transport highly sensitive cells and other biological additives and have no known toxic byproducts.
摘要翻译：本发明涉及一种共价交联的水凝胶及其制备方法，所述共价交联的水凝胶包含八元环炔烃官能化聚亚烷基二醇和多臂甘油三乙醇胺三嗪的菌株促进反应产物。由于可以在不引起交联的情况下操纵前体材料，只要没有达到应变阈值，这些水凝胶允许机械控制何时（和哪里）发生交联并且比之前的应变激活或温度激活系统更容易使用。这些新颖的水凝胶不需要催化剂交联，从而避免了许多催化剂常见的生物相容性问题。交联过程也不受存在催化剂或其他物质影响，这些物质干扰了已知应变诱导水凝胶中的交联。由于它们的交联反应动力学，这些新颖的水凝胶可以包封和运输高度敏感的细胞和其他生物添加剂，并且没有已知的有毒副产物。

8. 发明公开

EP3000836A1 PHOTODEGRADABLE CROSSLINKING AGENT, PHOTODEGRADABLE GEL, CELL CULTURE DEVICE, CELL ARRANGEMENT/SEPARATION DEVICE, CELL ARRANGEMENT METHOD, CELL SEPARATION METHOD, METHOD OF FORMING TISSUE MATERIAL, AND TISSUE MATERIAL 失效
标题翻译：光降解网络资源，光降解GEL，细胞培养装置，ZELLANORDNUNGS- /分离器，ZELLA订购方法，细胞分离，产生的织物材料与组织材料的方法
公开(公告)号：EP3000836A1
公开(公告)日：2016-03-30
申请号：EP14801820.3
申请日：2014-05-13
申请人： National Institute of Advanced Industrial Science and Technology
发明人： SUGIURA Shinji , TAKAGI Toshiyuki , YANAGAWA Fumiki , SUMARU Kimio , KANAMORI Toshiyuki
IPC分类号： C08G65/333 , C08G63/12 , C08G69/26 , C08G81/00 , C12M1/00 , C12M3/04 , C12N1/00 , C12N5/00
CPC分类号： C08G65/33389 , C08G65/333 , C08G65/33337 , C08G69/40 , C08G81/00 , C12M23/20 , C12M23/30 , C12N5/0068 , C12N2537/10
摘要： The present invention provides a photodegradable cross-linking agent capable of manufacturing a photodegradable gel, which has appropriate moisture content and water solubility as a cell carrier and has strength that makes it possible to construct a complicated three-dimensional microstructure. The photodegradable cross-linking agent of the present invention includes a main chain 2 which is composed of branched polyethylene glycol having three or more branched chains and a photodegradable benzyl group 3 which is disposed on the terminus of the branched chains, in which the benzyl group has an active ester group 4, which is reactive with an amino group or a hydroxyl group, and one or more nitro groups in a benzene ring.

9. 发明公开

EP2832765A4 MULTI-ARM POLYETHYLENE GLYCOL DERIVATIVE, INTERMEDIATE THEREOF AND METHOD FOR PRODUCING SAME 有权
标题翻译： MEHRARMIGES POLYETHYLINGLYCOLDERIVAT，ZWISCHENPRODUKT UND VERFAHREN ZU DESSEN HERSTELLUNG
公开(公告)号：EP2832765A4
公开(公告)日：2016-01-06
申请号：EP13768770
申请日：2013-03-28
申请人： NOF CORP
发明人： YOSHIOKA HIROKI , HIRAI MIDORI , NAKATSUHARA HITOSHI , YAMAMOTO YUJI
IPC分类号： C08G65/329 , C08G65/26 , C08G65/332 , C08G65/333
CPC分类号： C08G65/2609 , C08G65/2696 , C08G65/329 , C08G65/3322 , C08G65/33306 , C08G65/33337 , C08G65/33368 , C08G65/33389 , C08G2650/30
摘要： Provided is a multi-arm polyethylene glycol derivative having a narrow molecular weight distribution. A multi-arm polyethylene glycol derivative represented by the formula (1): wherein, L represents a group selected from a linear or branched alkylene, arylene, or cycloalkylene group having two or more carbon atoms and combinations thereof, which may have an ether bond in a chain; X represents a dehydroxylation residue of a linear sugar alcohol having 5 or 7 carbon atoms; m is the number of polyethylene glycol chains bonded to X and represents 4 or 6; n is the average addition molar number of oxyethylene groups and n represents an integer of 3 to 600; Y represents a single bond or an alkylene group which may have an ester bond, a urethane bond, an amide bond, an ether bond, a carbonate bond, a secondary amino group, a urea bond, a thioether bond or a thioester bond in a chain or at an end; and Z represents a chemically reactive functional group.
摘要翻译：提供具有窄分子量分布的多臂聚乙二醇衍生物。由式（1）表示的多臂聚乙二醇衍生物：其中，L表示可以具有醚键的选自具有两个以上碳原子的直链或支链亚烷基，亚芳基或亚环烷基的基团及其组合在一条链上 X表示具有5或7个碳原子的直链糖醇的脱羟基残基; m是与X键合的聚乙二醇链的数目，代表4或6; n是氧乙烯基的平均加成摩尔数，n表示3〜600的整数。 Y表示可以具有酯键，氨基甲酸酯键，酰胺键，醚键，碳酸键，仲氨基，脲键，硫醚键或硫酯键的单键或亚烷基链或结束; Z表示化学反应性官能团。

10. 发明公开

EP2906617A1 HYDROGEL PRODRUGS 有权转让
标题翻译：水凝胶的前体药物
公开(公告)号：EP2906617A1
公开(公告)日：2015-08-19
申请号：EP13773790.4
申请日：2013-10-08
申请人： Ascendis Pharma A/S
发明人： RAU, Harald , VOIGT, Tobias , LAUFER, Burkhardt , BISEK, Nicola , HAHN, Franziska , KNAPPE, Thomas
IPC分类号： C08J3/24 , C08G83/00 , A61K47/10 , A61K47/48 , C08J3/075 , C08F2/32 , C08G65/32 , C08G65/332
CPC分类号： A61K47/60 , A61K31/4188 , A61K47/557 , A61K47/59 , A61K47/645 , A61K47/6845 , A61K47/6849 , A61K47/6903 , C08F2/22 , C08G65/332 , C08G65/3322 , C08G65/33337 , C08G65/33389 , C08G69/44 , C08G69/48 , C08G83/004 , C08G83/006 , C08G2210/00 , C08J3/075 , C08J2300/202 , C08J2371/02 , C08J2400/202 , C08J2471/02 , C08L2203/02
摘要： The present invention relates to a process for the preparation of a hydrogel and to a hydrogel obtainable by said process. The present invention further relates to a process for the preparation of a hydrogel-spacer conjugate, to a hydrogel-spacer conjugate obtainable by said process, to a process for the preparation of a carrier-linked prodrug and to carrier-linked prodrugs obtainable by said process, in particular to carrier-linked prodrugs that provide for a controlled or sustained release of a drug from a carrier. In addition, the invention relates to the use of the hydrogel for the preparation of a carrier-linked prodrug.
摘要翻译：本发明涉及一种制备水凝胶和通过所述方法获得的水凝胶的方法。本发明还涉及一种制备水凝胶 - 间隔物缀合物的方法，可通过所述方法获得的水凝胶 - 间隔缀合物，制备载体连接的前体药物的方法和载体连接的前药，其可由所述方法，特别是提供从载体控制或持续释放药物的载体连接的前药。此外，本发明涉及水凝胶用于制备载体连接的前药的用途。

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