专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP4083107A1 METHOD FOR PURIFYING BRANCHED POLYETHYLENE GLYCOL 审中-实审
公开(公告)号：EP4083107A1
公开(公告)日：2022-11-02
申请号：EP20904842.0
申请日：2020-12-21
申请人： NOF Corporation
发明人： HIRAI Midori , TAKEUCHI Kyu
IPC分类号： C08G65/30
摘要： A method for purifying a branched polyethylene glycol, the method comprising adding, to a branched polyethylene glycol compound represented by the following formula [1] and having a weight average molecular weight of 40000 or more:

(Z is a residue obtained by removing, from a compound having 3 to 5 active hydrogen groups, the active hydrogen groups; Y 1 and Y 2 each independently represent an alkylene group having 1 to 12 carbon atoms; A represents a protecting group for an active group selected from the group consisting of a hydroxyl group, a carboxyl group, an amino group, and a thiol group; Polymer represents a polyethylene glycol chain; 1 is 0 or 1; m is 0 or 1; and a and b are integers satisfying 1 ≤ a ≤ 3, 2 ≤ b ≤ 4, and 3 ≤ a + b ≤ 5),
at least one solid acid selected from the group consisting of magnesium silicate, aluminum silicate, and aluminum magnesium silicate and having a specific surface area of 50 to 250 m 2 /g in the presence of an aprotic organic solvent to obtain a mixture; stirring the mixture; and subsequently separating the solid acid.

2. 发明公开

EP2832765A1 MULTI-ARM POLYETHYLENE GLYCOL DERIVATIVE, INTERMEDIATE THEREOF AND METHOD FOR PRODUCING SAME 有权
标题翻译：多臂聚乙二醇，中间体AND METHOD FOR ITS
公开(公告)号：EP2832765A1
公开(公告)日：2015-02-04
申请号：EP13768770.3
申请日：2013-03-28
申请人： NOF Corporation
发明人： YOSHIOKA Hiroki , HIRAI Midori , NAKATSUHARA Hitoshi , YAMAMOTO Yuji
IPC分类号： C08G65/329
CPC分类号： C08G65/2609 , C08G65/2696 , C08G65/329 , C08G65/3322 , C08G65/33306 , C08G65/33337 , C08G65/33368 , C08G65/33389 , C08G2650/30
摘要： Provided is a multi-arm polyethylene glycol derivative having a narrow molecular weight distribution. A multi-arm polyethylene glycol derivative represented by the formula (1):

wherein, L represents a group selected from a linear or branched alkylene, arylene, or cycloalkylene group having two or more carbon atoms and combinations thereof, which may have an ether bond in a chain; X represents a dehydroxylation residue of a linear sugar alcohol having 5 or 7 carbon atoms; m is the number of polyethylene glycol chains bonded to X and represents 4 or 6; n is the average addition molar number of oxyethylene groups and n represents an integer of 3 to 600; Y represents a single bond or an alkylene group which may have an ester bond, a urethane bond, an amide bond, an ether bond, a carbonate bond, a secondary amino group, a urea bond, a thioether bond or a thioester bond in a chain or at an end; and Z represents a chemically reactive functional group.

3. 发明公开

EP4083108A1 REFINEMENT METHOD FOR POLYETHYLENE GLYCOL COMPOUND 审中-实审
公开(公告)号：EP4083108A1
公开(公告)日：2022-11-02
申请号：EP20906848.5
申请日：2020-12-21
申请人： NOF Corporation
发明人： KAWAHARA Ryo , SATO Atsushi , HIRAI Midori , TAKEUCHI Kyu
IPC分类号： C08G65/30
摘要： A method for purifying a polyethylene glycol compound represented by the formula [1], comprising the following steps (A) and (B):
Step (A): a step of dissolving the compound represented by the formula [1] in an organic solvent having a Hildebrand solubility parameter of 8 to 10 (cal/cm 3 ) 1/2 to obtain a solution,
Step (B): a step of mixing the solution with 0.1 to 1 part by mass of an adsorbent made from a hydrotalcite having a specific surface area of 50 to 200 m 2 /g with respect to 1 part by mass of the compound of the formula [1] to prepare a slurry,

(in the formula [1], Z is a residue obtained by removing, from a compound having 2 to 5 active hydrogen groups, the active hydrogen groups; A is an amino group; Y 1 and Y 2 are each independently an ether bond, an amide bond, an ester bond, a urethane bond, a carbonate bond, a secondary amino group, a thioether bond, a disulfide bond, a thioester bond, or an alkylene group containing these; Polymer represents a polyethylene glycol chain; X represents a hydrocarbon group having 1 to 7 carbon atoms, an acetal group having 3 to 9 carbon atoms, a hydroxyl group, a protecting group of a hydroxyl group, a carboxyl group, a protecting group of a carboxyl group, a thiol group, a protecting group of a thiol group, a cyano group, or an alkylene group containing these; 1 and m respectively satisfy l = 1 or 0, and m = 1 or 0; and a and b are integers satisfying 0 ≤ a ≤ 4, 0 ≤ b ≤ 4, and 1 ≤ a + b ≤ 4).

4. 发明授权

EP2980115B1 PURIFICATION METHOD FOR POLYETHYLENE GLYCOL HAVING A SINGLE AMINO GROUP 有权
公开(公告)号：EP2980115B1
公开(公告)日：2019-03-06
申请号：EP14772579.0
申请日：2014-03-24
申请人： NOF Corporation
发明人： YOSHIOKA Hiroki , KIMURA Shingo , HIRAI Midori
IPC分类号： C08G65/30 , C08G65/333

5. 发明授权

EP2832765B1 MULTI-ARM POLYETHYLENE GLYCOL DERIVATIVE, INTERMEDIATE THEREOF AND METHOD FOR PRODUCING SAME 有权
标题翻译：多臂聚乙二醇，中间体AND METHOD FOR ITS
公开(公告)号：EP2832765B1
公开(公告)日：2017-02-15
申请号：EP13768770.3
申请日：2013-03-28
申请人： NOF Corporation
发明人： YOSHIOKA Hiroki , HIRAI Midori , NAKATSUHARA Hitoshi , YAMAMOTO Yuji
IPC分类号： C08G65/329 , C08G65/333 , C08G65/26 , C08G65/332
CPC分类号： C08G65/2609 , C08G65/2696 , C08G65/329 , C08G65/3322 , C08G65/33306 , C08G65/33337 , C08G65/33368 , C08G65/33389 , C08G2650/30
摘要： Provided is a multi-arm polyethylene glycol derivative having a narrow molecular weight distribution. A multi-arm polyethylene glycol derivative represented by the formula (1): wherein, L represents a group selected from a linear or branched alkylene, arylene, or cycloalkylene group having two or more carbon atoms and combinations thereof, which may have an ether bond in a chain; X represents a dehydroxylation residue of a linear sugar alcohol having 5 or 7 carbon atoms; m is the number of polyethylene glycol chains bonded to X and represents 4 or 6; n is the average addition molar number of oxyethylene groups and n represents an integer of 3 to 600; Y represents a single bond or an alkylene group which may have an ester bond, a urethane bond, an amide bond, an ether bond, a carbonate bond, a secondary amino group, a urea bond, a thioether bond or a thioester bond in a chain or at an end; and Z represents a chemically reactive functional group.

6. 发明公开

EP2980115A1 PURIFICATION METHOD FOR POLYETHYLENE GLYCOL HAVING A SINGLE AMINO GROUP 有权
标题翻译：具有单个氨基的聚乙二醇的纯化方法
公开(公告)号：EP2980115A1
公开(公告)日：2016-02-03
申请号：EP14772579.0
申请日：2014-03-24
申请人： NOF Corporation
发明人： YOSHIOKA Hiroki , KIMURA Shingo , HIRAI Midori
IPC分类号： C08G65/30
CPC分类号： C08G65/34 , C08G65/30 , C08G65/333
摘要： Provided is an industrially practicable purification method which affords a polyethylene glycol compound having one amino group with good efficiency and purity and does not discharge any waste such as any adsorbent and any ion-exchange resin.
An aqueous solution of the polyethylene glycol is prepared, the aqueous solution having a pH of 1 to 5. This aqueous solution and a mixed organic solvent are mixed together at 10°C or higher and 55°C or lower, causing layer separation into an organic layer and an aqueous layer. The ratio of an organic solvent I is 25 to 65% by mass and the ratio of an organic solvent II is 75 to 35% by mass in the mixed organic solvent. The organic solvent I is selected from an aromatic hydrocarbon-based solvent having a total carbon number of 8 or less and an ester compound solvent containing no hetero atom and having a total carbon number of 5 or less, the organic solvent II is a halogenated hydrocarbon-based solvent, and a mixing ratio Y of the organic solvent I to the organic solvent II (organic solvent I/organic solvent II), temperature T (°C), and molecular weight M of the polyethylene glycol compound satisfy the following relationship. 1.9 × 10 - 6 ⁢ M + 0.09 ≦ Y - 0.015 ⁢ T ≦ - 1.4 × 10 - 6 ⁢ M + 0.44
摘要翻译：本发明提供一种工业实用的纯化方法，其以高效率和纯度提供具有一个氨基的聚乙二醇化合物，并且不会排出任何吸附剂和任何离子交换树脂等废物。制备聚乙二醇的水溶液，该水溶液的pH为1至5.将该水溶液和混合的有机溶剂在10℃以上且55℃以下混合在一起，引起层分离成有机层和水层。在混合有机溶剂中，有机溶剂I的比例为25〜65质量％，有机溶剂II的比例为75〜35质量％。有机溶剂I选自总碳数为8以下的芳香族烃系溶剂和不含杂原子且总碳数为5以下的酯化合物溶剂，有机溶剂II为卤代烃有机溶剂I与有机溶剂II（有机溶剂I /有机溶剂II）的混合比例Y，温度T（℃）和聚乙二醇化合物的分子量M满足以下关系。 1.9×10-6⁢M+ 0.09≦Y型0.015⁢T≦-1.4×10-6⁢M+ 0.44

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式