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1. 发明公开

EP3154553A4 ENTERIC ELASTOMERS 有权
公开(公告)号：EP3154553A4
公开(公告)日：2018-03-28
申请号：EP15806483
申请日：2015-06-11
申请人： MASSACHUSETTS INSTITUTE OF TECH , THE BRIGHAM AND WOMENS HOSPITAL INC , TOKITAE LLC
发明人： ZHANG SHIYI , BELLINGER ANDREW , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , GLETTIG DEAN LIANG , WOOD LOWELL L JR , ECKHOFF PHILIP A
IPC分类号： A61M31/00 , A61K9/00 , A61M29/04
CPC分类号： A61K47/48776 , A61K9/0053 , A61K9/0065 , A61K9/48 , A61K31/357 , A61K31/65 , A61K31/7048 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/40 , A61K47/42 , A61K47/48176 , A61K47/58 , A61K47/6901 , A61M31/002 , C08G18/4277 , C08G18/73 , C08G63/08 , C08G83/006 , C08G2230/00 , C08L33/02 , C08L33/08 , C08L33/14 , C08L2203/02
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

2. 发明公开

EP2853553A1 METHOD FOR PREPARING CROSS-LINKED HYPERBRANCHED POLYAMIDOAMINE PARTICLES USING REVERSE PHASE SUSPENSION POLYMERIZATION AND PRECURSOR 审中-公开
标题翻译：用于生产交联化的超支化POLYAMIDOAMINTEILCHEN USING A反相悬浮聚合和其前体
公开(公告)号：EP2853553A1
公开(公告)日：2015-04-01
申请号：EP13794646.3
申请日：2013-03-12
申请人： Korea Advanced Institute Of Science And Technology
发明人： KIM, Sang Youl , EOM, Young Sik
IPC分类号： C08G73/02 , C08G69/48 , C08J3/12 , C02F1/28
CPC分类号： C08G73/028 , B01J20/264 , B01J20/267 , B01J20/3085 , C02F1/683 , C02F2101/20 , C08G83/006 , C08G2340/00 , Y10T428/2982
摘要： Disclosed herein is a method of preparing hyperbranched polyamidoamine particles, including: a) preparing a polyamidoamine precursor mixture from a multifunctional amine monomer and a multifunctional acrylamide monomer; and b) polymerizing the polyamidoamine precursor mixture into cross-linked hyperbranched polyamidoamine particles using reverse phase suspension polymerization. Also, hyperbranched polyamidoamine particles prepared by the method are provided, which can remove heavy metals in an aqueous solution without the need for an ultrafiltration apparatus.
摘要翻译：本发明公开了在制备超支化聚酰氨基胺颗粒，的方法，包括：a）从多官能胺单体和多官能丙烯酰胺单体制备前体混合物聚酰氨基胺; 和b）聚合该聚酰胺基胺前体混合物到使用反相悬浮聚合交联的超支化聚酰氨基胺颗粒。所以，超支化聚酰氨基胺提供通过该方法制备的颗粒，可以在wässrige溶液中除去重金属，而不需要上超滤装置。

3. 发明公开

EP2809709A1 BRANCHED POLYMERS 审中-公开
标题翻译：支化聚合物
公开(公告)号：EP2809709A1
公开(公告)日：2014-12-10
申请号：EP13743364.5
申请日：2013-02-01
申请人： Commonwealth Scientific & Industrial Research Organisation ( C.S.I.R.O. )
发明人： GUNATILLAKE, Pathiraja Arachchillage , HINTON, Tracey Michelle , THANG, San , TIZARD, Mark Leslie
IPC分类号： C08G83/00 , A61K48/00
CPC分类号： C08F293/005 , A61K47/58 , C08F2438/03 , C08G83/006 , C12N15/1131 , C12N15/87 , C12N2310/14 , C12N2310/351 , C12N2320/32
摘要： The present invention relates to branched polymer comprising a support moiety and at least three block co-polymer chains covalently coupled to and extending from the moiety, wherein: (i) each of the at least three block co-polymer chains comprise (a) a cationic polymer block that is covalently coupled to a hydrophilic polymer block, or (b) a cationic polymer block that is covalently coupled to a hydrophobic polymer block, said hydrophobic polymer block being covalently coupled to a hydrophilic polymer block; and (ii) at least one of said covalent couplings associated with each of said block co-polymer chains is biodegradable.

4. 发明公开

EP3044252A1 BIOINERT ARTICLE AND ITS USE 有权
标题翻译：生物学家GEGENSTAND在塞恩安汶
公开(公告)号：EP3044252A1
公开(公告)日：2016-07-20
申请号：EP14780780.4
申请日：2014-09-08
申请人： Freie Universität Berlin
发明人： HAAG, Rainer , WEINHART, Marie , WEI, Qiang , BECHERER, Tobias , GRUNWALD, Ingo
IPC分类号： C08J7/04 , C08G83/00 , A61L27/34 , C12M1/22 , C09D201/00
CPC分类号： C09D5/1693 , A61F2/0077 , A61F2002/009 , A61L27/34 , A61L2420/08 , C08G83/006 , C08J7/042 , C08J2300/202 , C08L101/005 , C09D171/00 , C09D201/005 , C09D201/06 , C12M23/20 , C08L101/02
摘要： An article, comprising a substrate and a polymer film attached to the substrate is provided, the polymer film comprising a first layer of a first polymer functionalized by a first functionalization compound covalently bound to said first polymer and bearing at least one catecholic group being present on a surface of the first layer. The polymer film is a layered film, a top layer of which is formed by the first layer, the layered film comprising at least one further layer of at least one further polymer functionalized by a further functionalization compound covalently bound to said further polymer and bearing at least one catecholic group being present on a surface of the at least one further layer, wherein an average ratio of catecholic groups per polymer molecule is equal to or less than 1 in case of the first polymer and greater than 1 in case of the further polymer.
摘要翻译：提供了一种包括基材和连接到基底上的聚合物膜的制品，所述聚合物膜包含第一聚合物层，所述第一聚合物膜由第一官能化化合物官能化，所述第一官能化化合物与所述第一聚合物共价结合，并且至少存在一个儿茶酚基，第一层的表面。聚合物膜是层状膜，其顶层由第一层形成，层状膜包含至少一个另外的另外的另一层的另外的聚合物，所述至少一个另外的聚合物被另外的官能化化合物官能化，所述另外的官能化化合物与所述另外的聚合物共价结合并承载在至少一个儿茶酚基存在于所述至少一个另外的层的表面上，其中在第一聚合物的情况下，每个聚合物分子的儿茶酚基的平均比例等于或小于1，在另外的聚合物的情况下大于1 。

5. 发明公开

EP2904035A1 POLYMER SYNTHESIS 审中-公开
标题翻译： POLYMERSYNTHESE
公开(公告)号：EP2904035A1
公开(公告)日：2015-08-12
申请号：EP13771543.9
申请日：2013-10-04
申请人： National University of Ireland Galway
发明人： WANG, Wenxin , AIED, Ahmed , PANDIT, Abhay
IPC分类号： C08G83/00 , C08J3/075 , C08J3/24 , C08F16/24 , C08F16/26 , C08F16/28 , C08F16/30 , A61K47/48 , C08F220/38
CPC分类号： C12N15/907 , A61K48/00 , C08F220/38 , C08F222/1006 , C08F226/02 , C08F236/20 , C08G83/005 , C08G83/006 , C08J3/075 , C08J3/246 , C08J2300/202 , C08F220/14 , C08F220/34
摘要： A polymer for transfecting a nucleic acid into a cell, the polymer comprising a plurality of polymeric branches, wherein at least one branch comprises at least one disulfide group and at least one vinyl group, which may an unsubstituted vinyl or a functionalized vinyl group.

6. 发明公开

EP2653480A4 METHOD FOR PRODUCING REFINED POLYROTAXANE 有权转让
标题翻译：用于生产纯化聚轮烷
公开(公告)号：EP2653480A4
公开(公告)日：2014-07-09
申请号：EP11848894
申请日：2011-12-05
申请人： SUMITOMO SEIKA CHEMICALS , ADVANCED SOFTMATERIALS INC
发明人： YAMASAKI TOMOAKI , OKAZAKI SHINYA , OKAZAKI HIROKI , HAMAMOTO SHIGEKI , ZHAO CHANGMING
IPC分类号： C08B37/16 , C08G65/06 , C08G83/00 , C08J3/14 , C08J3/16
CPC分类号： C08G83/007 , C08B37/0015 , C08G83/006 , C08L71/02 , C08L5/16

7. 发明公开

EP2734593A1 AN AQUEOUS DISPERSIBLE POLYMER COMPOSITION 无效
标题翻译：水性分散聚合物组合物
公开(公告)号：EP2734593A1
公开(公告)日：2014-05-28
申请号：EP12814606.5
申请日：2012-07-18
申请人： Nipsea Technologies Pte Ltd.
发明人： WANG, Shaofeng , LI, Jingqiu , YE, Xiaoqun , SUNDARARAJAN, G. , DOU, Zeling , SEOW, Swee How
IPC分类号： C09D175/00 , C09D167/02 , C09D5/00 , C08F293/00 , C08G63/12 , C08L75/00 , C08L67/02
CPC分类号： C09D175/04 , C08G18/10 , C08G18/6705 , C08G18/706 , C08G18/73 , C08G18/758 , C08G83/006 , C08L101/005 , C09D5/02 , C09D167/00 , C09D175/14 , C09D201/005 , Y10T428/31551 , C08G18/6659 , C08L75/04 , C08L67/00 , C08L75/14
摘要： The present disclosure relates to an aqueous dispersible polymer composition comprising: (a) at least one of:(i) a dendritic polymer in admixture with a hydrophilic functionalizing agent; and (ii) a hydrophilic functionalized dendrimer; and (b) a non-dendritic polymer capable of forming bonds with said dendritic polymer to thereby form a dendrimer-non-dendrimer (DND) polymer hybrid that is dispersible in the aqueous phase, methods of forming the same and uses thereof.
摘要翻译：本发明涉及一种水分散性聚合物组合物，其包含：（a）至少一种：（i）与亲水性官能化剂混合的树枝状聚合物; 和（ii）亲水官能化树枝状聚合物; 和（b）能够与所述树枝状聚合物形成键的非树枝状聚合物，从而形成可分散于水相中的树枝状聚合物 - 非树枝状聚合物（DND）聚合物杂化物，其形成方法及其用途。

8. 发明公开

EP2542613A1 DERIVATIZED HYPERBRANCHED POLYGLYCEROLS 审中-公开
标题翻译： DERIVATISIERTE HYPERVERZWEIGTE POLYGLYCEROLE
公开(公告)号：EP2542613A1
公开(公告)日：2013-01-09
申请号：EP11750116.3
申请日：2011-03-01
申请人： The University of British Columbia , Centre For Drug Research And Development
发明人： BURT, Helen , BROOKS, Donald , KIZHAKKEDATHU, Jayachandran , LIGGINS, Richard , GUAN, Dechi , YE, Lu , MUGABE, Clement , SO, Alan , GLEAVE, Martin , JACKSON, John, K. , KAINTHAN, Rajesh, Kumar
IPC分类号： C08G65/329 , A61K47/34 , A61K47/48 , C08G65/22
CPC分类号： A61K47/10 , A61K9/0034 , A61K9/006 , A61K9/5146 , A61K31/337 , A61K31/407 , A61K33/24 , A61K47/34 , A61K47/60 , C08G65/33306 , C08G65/33337 , C08G65/34 , C08G65/48 , C08G83/005 , C08G83/006 , C08G2650/54
摘要： Herein are provided derivatized hyperbranched polyglycerols ("dHPGs"). The dHPG comprises a core comprising a hyperbranched polyglycerol derivatized with C
1 C
20 alkyl chains and a shell comprising at least one hydrophilic substituent bound to hydroxyl groups of the core, wherein the hyperbranched polyglycerol comprises from about 1 to about 200 moles of the at least one hydrophilic substituent. The dHPGs are for use as agents for the delivery of a drug or other biologically active moiety to the urinary tract, the digestive tract, the airways, the vaginal cavity and cervix and the peritoneal cavity to treat indications such as cancer, which may be useful in the treatment of or the manufacture of a medicament, in the preparation, of a pharmaceutical composition for the treatment of cancer, as a pre-treatment or co- treatment to improve drug uptake in a tissue. Furthermore, there are provided methods of making dHPGs.

9. 发明公开

EP2471592A1 GAS SEPARATION MEMBRANE 审中-公开
标题翻译： GASTRENNUNGSMEMBRAN
公开(公告)号：EP2471592A1
公开(公告)日：2012-07-04
申请号：EP10811957.9
申请日：2010-08-26
申请人： Ibiden Co., Ltd. , National University Corporation Kyoto Institute of Technology
发明人： SUZUKI, Tomoyuki , YAMADA, Yasuharu
IPC分类号： B01D71/64 , B01D71/02 , C08G73/10 , C08J7/00
CPC分类号： B01D71/64 , B01D53/228 , B01D67/0079 , B01D67/0088 , B01D71/027 , B01D2323/08 , C08G73/1067 , C08G83/006 , C08L79/08 , Y02C20/20 , Y02P20/152
摘要： A gas separation membrane is provided which has both excellent gas permeability and gas separation characteristics, particularly permeability of carbon dioxide (CO 2 ) and separation characteristics of carbon dioxide and methane (CH 4 ), at such a high level that has not hitherto been achieved. The gas separation membrane was obtained by heat treating a membrane composed of a hyperbranched polyimide-based material in a non-oxidizing atmosphere.
摘要翻译：提供了一种气体分离膜，其具有优异的气体渗透性和气体分离特性，特别是二氧化碳（CO 2）的渗透性和二氧化碳和甲烷（CH 4）的分离特性，在迄今尚未达到的高水平。通过在非氧化性气氛中对由超支化聚酰亚胺系材料构成的膜进行热处理，得到气体分离膜。

10. 发明公开

EP3154622A4 SELF-ASSEMBLED RESIDENCE DEVICES AND RELATED METHODS 有权
公开(公告)号：EP3154622A4
公开(公告)日：2018-01-17
申请号：EP15805932
申请日：2015-06-11
申请人： MASSACHUSETTS INSTITUTE OF TECH , THE BRIGHAM AND WOMEN'S HOSPITAL INC
发明人： BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY , LIN JIAQI , DICICCIO ANGELA , GLETTIG DEAN LIANG , WOOD LOWELL L JR , ECKHOFF PHILIP A
IPC分类号： A61M31/00 , A61K9/00 , A61M29/04
CPC分类号： A61K47/48776 , A61K9/0053 , A61K9/0065 , A61K9/48 , A61K31/357 , A61K31/65 , A61K31/7048 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/40 , A61K47/42 , A61K47/48176 , A61K47/58 , A61K47/6901 , A61M31/002 , C08G18/4277 , C08G18/73 , C08G63/08 , C08G83/006 , C08G2230/00 , C08L33/02 , C08L33/08 , C08L33/14 , C08L2203/02
摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

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