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1. 发明公开

EP4365284A1 VIRUS RECOVERY METHOD 审中-公开
公开(公告)号：EP4365284A1
公开(公告)日：2024-05-08
申请号：EP22833318.3
申请日：2022-06-30
申请人： Asahi Kasei Medical Co., Ltd.
发明人： MIYAOKA, Rimi , TANIGUCHI, Hiroki , OKADA, Takashi
IPC分类号： C12N7/02 , B01D61/00 , B01D69/08 , C12N1/00 , C12N1/02
CPC分类号： C12N7/02 , B01D61/00 , B01D69/08 , C12N1/02 , C12N1/00
摘要： The purpose of the invention is to provide a virus recovery method including reducing viability of cells in a culture solution and filtering, through a hollow fiber membrane, the culture solution containing a virus produced by the cells to recover the virus. The hollow fiber membrane has a gradient structure in which an average pore size becomes smaller from an upstream side to a downstream side in a membrane thickness direction.

2. 发明公开

EP4361258A1 VIRUS SAMPLE CONCENTRATING METHOD 审中-公开
公开(公告)号：EP4361258A1
公开(公告)日：2024-05-01
申请号：EP22828024.4
申请日：2022-03-29
申请人： Shimadzu Corporation , Kyoto University
发明人： YASOJIMA, Makoto , TAKEMORI, Hiroaki , TOMONO, Takuya , DAIGO, Fumi , TANAKA, Hiroaki , IHARA, Masaru
IPC分类号： C12N7/02
CPC分类号： C12N7/02 , Y02A50/30
摘要： A liquid (30) containing a virus passes through a solid phase (10) made of a polymer having a hydrophobic group to cause the solid phase (10) to retain viruses (40), and then an organic solvent (70) causes the viruses (40) to be eluted from the solid phase (10). As a result, it is possible to rapidly concentrate a virus sample at a high concentration rate.

3. 发明公开

EP4351631A1 METHODS OF REGULATING ADENO-ASSOCIATED VIRUS PRODUCTION 审中-公开
公开(公告)号：EP4351631A1
公开(公告)日：2024-04-17
申请号：EP22821139.7
申请日：2022-06-10
申请人： Spark Therapeutics, Inc.
发明人： YAZICIOGLU, Mustafa , OZDEMIR, Ahmet, Yunus
IPC分类号： A61K38/44 , A61K38/52 , C12N7/02 , C12N7/04 , C12N9/02 , C12N9/90 , C12N15/864 , A61K38/16
CPC分类号： C07K14/005 , C12N2750/1412220130101 , C12N2750/1415220130101 , C12N2750/1414320130101 , C12N2710/1032220130101 , C12N9/003 , C07K2319/9520130101 , A61K38/00

4. 发明公开

EP4324907A1 METHOD FOR PRODUCING VIRUS PARTICLES 审中-公开
公开(公告)号：EP4324907A1
公开(公告)日：2024-02-21
申请号：EP22788196.8
申请日：2022-04-14
申请人： The University of Tokyo
发明人： OKADA, Takashi , WADA, Mikako
IPC分类号： C12M1/10 , C12N7/02
摘要： It is an object of the present invention to provide a method for producing a virus to obtain high-purity virus particles, said method being more efficient than conventional methods. Specifically, the present invention relates to a method for producing full-genome virus particles, comprising steps of purifying full-genome virus particles from a virus particle mixed solution containing empty virus particles, intermediate virus particles and the full-genome virus particles, wherein the method comprises: a step (a) of rotating a zonal rotator at a low speed and arranging the virus particle mixed solution, a liquid having a lower density than the full-genome virus particles (liquid L), and a liquid having a higher density than the liquid L (liquid H1) in this order from the rotation axis side of the rotor toward the outside; a step (b) of operating the zonal rotor after the step (a) at an ultracentrifugation mode, so as to separate the empty virus particles, the intermediate virus particles and the full-genome virus particles from one another; and a step (c) of removing the contents of the zonal rotor after the step (b), while fractionating the contents, so as to recover a fraction comprising the full-genome virus particles.

5. 发明公开

EP4317402A1 FILTRATION MEMBER, CONCENTRATION APPARATUS, AND CONCENTRATION METHOD 审中-公开
公开(公告)号：EP4317402A1
公开(公告)日：2024-02-07
申请号：EP22774671.6
申请日：2022-01-31
申请人： Yokogawa Electric Corporation
发明人： INOUE, Kentaro , TAGUCHI, Tomoyuki , KATAYAMA, Hiroyuki , MATSUI, Yasuhiro
IPC分类号： C12M1/12 , B01D35/06 , C12N7/02
摘要： A filtration member 110 including pores having a pore diameter through which microorganisms may pass and configured to have a positive charge or a negative charge upon application of a voltage.

6. 发明公开

EP4206329A1 METHOD FOR PURIFYING USEFUL SUBSTANCE 审中-实审
公开(公告)号：EP4206329A1
公开(公告)日：2023-07-05
申请号：EP21861155.6
申请日：2021-08-03
申请人： KANEKA CORPORATION
发明人： KONOIKE, Fuminori , KISHI, Kenta , MINAKUCHI, Kazunobu , MURATA, Dai , NISHIHACHIJO, Masakatsu
IPC分类号： C12P21/08 , B01J20/04 , C07K1/14 , C07K14/005 , C07K16/00 , C12N7/02
摘要： The objective of the present invention is to provide a method for purifying a useful substance with effectively suppressing the occurrence of precipitate after an impurity is adsorbed to be removed on the specific adsorbent from a useful substance-containing liquid. The method for purifying a useful substance from a useful substance-containing liquid according to the first present invention is characterized in comprising the steps of contacting the useful substance-containing liquid with a hardly-soluble magnesium compound, removing the hardly-soluble magnesium compound from the useful substance-containing liquid contacted with the hardly-soluble magnesium compound to obtain a treated liquid, and adjusting pH of the treated liquid to 8.0 or less. The method for purifying a useful substance from a useful substance-containing liquid according to the second present invention is characterized in comprising the steps of contacting the useful substance-containing liquid with a hardly-soluble magnesium compound, and contacting the useful substance-containing liquid with an aluminum compound.

7. 发明公开

EP4171657A1 METHODS FOR THE REMOVAL OF FREE FACTOR VIII FROM PREPARATIONS OF LENTIVIRAL VECTORS MODIFIED TO EXPRESS SAID PROTEIN 审中-公开
公开(公告)号：EP4171657A1
公开(公告)日：2023-05-03
申请号：EP21749390.7
申请日：2021-06-24
申请人： Bioverativ Therapeutics Inc. , Fondazione Telethon , Ospedale San Raffaele S.r.l.
发明人： ISMAIL, Ayman , LIU, Tongyao , MAYANI, Mukesh
IPC分类号： A61K48/00 , C12N7/02 , C12N15/86 , C12N15/867

8. 发明公开

EP4114422A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF INTRACELLULAR BACTERIAL INFECTIONS 审中-实审
公开(公告)号：EP4114422A1
公开(公告)日：2023-01-11
申请号：EP21763712.3
申请日：2021-03-08
申请人： Endolytix Technology, Inc.
发明人： HOLDER, Jason , MAGNANT, Gary P.
IPC分类号： A61K35/76 , A61P31/04 , C12N7/00 , C12N7/02 , C12Q1/70

9. 发明公开

EP4100546A1 SYSTEM AND METHOD FOR PROCESSING VIRUS PREPARATIONS TO REDUCE HETEROGENEITY 审中-公开
公开(公告)号：EP4100546A1
公开(公告)日：2022-12-14
申请号：EP21751374.6
申请日：2021-02-03
申请人： The Trustees of Indiana University
发明人： JARROLD, Martin F. , CLEMMER, David E. , DRAPER, Benjamin E. , BARNES, Lauren F.
IPC分类号： C12Q1/6872 , A61K35/76 , C12N7/02

10. 发明公开

EP4097239A2 METHODS AND SYSTEMS FOR PRODUCING AAV PARTICLES 审中-公开
公开(公告)号：EP4097239A2
公开(公告)日：2022-12-07
申请号：EP21710085.8
申请日：2021-01-28
申请人： Voyager Therapeutics, Inc.
发明人： MATHUR, Krishanu , HENDRICKS, Andrade , LUTHER, Matthew , CARDINAL, Jacob J. , HURWIT, Daniel S. , KARPES, Lori B. , MORRISON, Christopher J.
IPC分类号： C12N15/86 , C12N15/864 , C12N15/866 , C12N7/02 , A61K48/00

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