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1. 发明授权

EP1636246B1 PRODUCTION OF 2 -DEOXYNUCLEOSIDES AND 2 -DEOXYNUCLEOSIDE PRECURSORS FROM 2-DEHYDRO-3-DEOXY-D-GLUCONATE 有权
标题翻译：制备2-脱氧核苷和2-DESOXYNUKLEOSIDVORSTUFEN由2-脱氢-3-脱氧-D-葡萄糖酸
公开(公告)号：EP1636246B1
公开(公告)日：2015-08-19
申请号：EP04740261.5
申请日：2004-06-24
申请人： Scientist of Fortune S.A. , Evologic S.A.
发明人： MARLIERE, Philippe , DÖRING, Volker , THIBAUT, Denis , KREIMEYER, Annett
IPC分类号： C07H7/027 , C07H1/00 , C12P7/42 , C12N9/88 , C12N1/20
CPC分类号： C07H1/00 , C07H7/027 , C12N9/88 , C12P7/24 , C12P7/42

2. 发明授权

EP2119444B1 THERAPEUTIC AGENT FOR PAIN DISEASE 有权
标题翻译：治疗剂镇痛
公开(公告)号：EP2119444B1
公开(公告)日：2015-07-08
申请号：EP08704491.3
申请日：2008-02-06
申请人： Nippon Zoki Pharmaceutical Co., Ltd.
发明人： NAKAZAWA, Yoshitaka
IPC分类号： A61K31/7012 , A61P25/04 , C07H7/027
CPC分类号： A61K31/7012 , C07H7/027

3. 发明授权

EP1405858B1 PROCESS FOR PRODUCING SUGAR CHAIN ASPARAGINE DERIVATIVE 有权
标题翻译：用于生产天冬酰胺的糖链
公开(公告)号：EP1405858B1
公开(公告)日：2013-01-02
申请号：EP02743643.5
申请日：2002-06-19
申请人： Glytech, Inc. , Kajihara, Yasuhiro
发明人： KAJIHARA, Yasuhiro , SASAKI, Ken
IPC分类号： C07H13/10 , C07H15/12 , C07H5/06 , C07H7/027 , C08B37/00 , C12P13/04 , C12P19/04
CPC分类号： C07H13/10 , C07H5/06 , C07H7/027 , C07H15/12 , C12P13/04 , C12P19/04 , C12P19/28 , Y02P20/55

4. 发明公开

EP2280018A1 METHOD FOR EXTRACTING SIALIC ACID-CONTAINING COMPOUND FROM PLANT 审中-公开
标题翻译：从植物中提取含唾酸酸的化合物的方法
公开(公告)号：EP2280018A1
公开(公告)日：2011-02-02
申请号：EP09735204.1
申请日：2009-01-22
申请人： Incorporated Administrative Agency, National Agriculture and Food Research Organization
发明人： KAWASE, Shin-ichiro
IPC分类号： C07H7/027 , C07H1/08
CPC分类号： C07H1/08 , A61K36/48 , A61K36/899 , C07H7/027
摘要： It is an object of the present invention to provide an extraction method for a sialic acid-containing compound from a natural raw material, which has no risk of contamination with pathogens affecting animals, can achieve mass production, and does not require the use of an organic solvent harmful to the environment and human body. Provided is an extraction method for a water-soluble sialic acid-containing compound, the method comprising: crudely extracting a water-soluble component with water, polyol, or water containing either an acid or an alkali or polyol from a plant body or a processed product of the plant body, in particular, seeds of cereal or seeds of bean; and separating and recovering the water-soluble sialic acid-containing compound from the resultant crude extract solution with a column packed with a serotonin affinity support.
摘要翻译：本发明的一个目的是提供一种从天然原料中提取含唾液酸的化合物的提取方法，该提取方法不会影响动物病原体的污染风险，可以实现大规模生产，并且不需要使用对环境和人体有害的有机溶剂。本发明提供一种水溶性含唾液酸化合物的提取方法，该方法包括：从植物体中粗提取含有酸，碱或多元醇的水，多元醇或水的水溶性成分，植物体的产品，特别是谷类的种子或豆的种子; 用填充有血清素亲和载体的柱从所得的粗提物溶液中分离并回收水溶性含唾液酸的化合物。

5. 发明公开

EP2119444A4 THERAPEUTIC AGENT FOR PAIN DISEASE 有权
标题翻译：治疗剂镇痛
公开(公告)号：EP2119444A4
公开(公告)日：2010-06-09
申请号：EP08704491
申请日：2008-02-06
申请人： NIPPON ZOKI PHARMACEUTICAL CO
发明人： NAKAZAWA YOSHITAKA
IPC分类号： A61K31/7012 , A61P25/04 , C07H7/027
CPC分类号： A61K31/7012 , C07H7/027

6. 发明公开

EP1405858A4 PROCESS FOR PRODUCING SUGAR CHAIN ASPARAGINE DERIVATIVE 有权
标题翻译：用于生产天冬酰胺的糖链
公开(公告)号：EP1405858A4
公开(公告)日：2009-11-25
申请号：EP02743643
申请日：2002-06-19
申请人： OTSUKA CHEMICAL CO LTD , KAJIHARA YASUHIRO
发明人： KAJIHARA YASUHIRO , SASAKI KEN
IPC分类号： C07H13/10 , C12P19/26 , C07H5/06 , C07H7/027 , C07H15/12 , C07K7/06 , C08B37/00 , C12P13/04 , C12P19/04 , C12P19/28
CPC分类号： C07H13/10 , C07H5/06 , C07H7/027 , C07H15/12 , C12P13/04 , C12P19/04 , C12P19/28 , Y02P20/55

7. 发明公开

EP1697297A1 VERFAHREN ZUR HERSTELLUNG VON 2-KETO-L-GULONSÄUREESTERN 审中-公开
标题翻译：用于生产2-酮基-L-古洛糖酯
公开(公告)号：EP1697297A1
公开(公告)日：2006-09-06
申请号：EP04803718.8
申请日：2004-12-10
申请人： BASF Aktiengesellschaft
发明人： DOMSCHKE, Thomas , MERGER, Martin , HAESE, Frank , RESCH, Peter , FAUST, Tillmann
IPC分类号： C07C67/08 , C07H7/02 , C07H7/027
CPC分类号： C07C67/08 , C07H7/02 , C07H7/027 , C07C69/716
摘要： The invention relates to a method for the production of 2-keto-L-gulonic acid-C1-C10-alkyl esters by esterification of 2-keto-L-gulonic acid hydrate with an anhydrous C1-C10-alkyl alcohol in the presence of an acid homogeneous catalyst in a reaction cascade consisting of at least two reactors, wherein one of said reactors is a tube reactor, without removing the water produced during esterification from the reaction chamber.

8. 发明授权

EP1562965B1 VERFAHREN ZUR HERSTELLUNG VON 2-KETO-L-GULONSÄURE-C-4 C-10 /sb -ALKYLESTERN 有权
标题翻译： PROCESS FOR 2-酮基-L-古洛糖酸C-4 C-10 / SB - 烷基的制备
公开(公告)号：EP1562965B1
公开(公告)日：2006-04-05
申请号：EP03789016.7
申请日：2003-11-07
申请人： BASF Aktiengesellschaft
发明人： DOMSCHKE, Thomas , MERGER, Martin , GROSSMANN, Georg , FAUST, Tillmann
IPC分类号： C07H7/027
CPC分类号： C07H7/027 , Y02P20/127
摘要： The invention relates to a method for producing 2-keto-L-gulonic acid-C4-C10 alkyl ester by esterifying 2-keto-L-gulonic acid (KGS) with an unsaturated, branched or unbranched C4-C10 alcohol. The inventive method is characterized by the fact that an aqueous KGS solution is reacted with a C4-C10 alcohol up to an esterification degree of 20 to 70 percent in a pre-esterification process carried out under acidic catalysis conditions; and the obtained product is dehydrogenated with an unsaturated, branched or unbranched C4-C10 alcohol in a continuous rectification device, whereby the esterification reaction continues, n-butanol preferably being used as the alkyl alcohol. In a preferred embodiment, the aqueous KGS solution is concentrated up to or beyond the limit of solubility prior to the esterification process, preferably by catalyzing a homogeneous or heterogeneous catalyst, especially sulfonic acid, at temperatures of 50 to 120 °C. In another embodiment, the produced KGS ester is reacted in one or several additional steps so as to obtain L-ascorbic acid.

9. 发明公开

EP1405858A8 PROCESS FOR PRODUCING SUGAR CHAIN ASPARAGINE DERIVATIVE 有权
标题翻译：生产糖链天门冬酰胺衍生物的方法
公开(公告)号：EP1405858A8
公开(公告)日：2004-11-10
申请号：EP02743643.5
申请日：2002-06-19
申请人： Otsuka Chemical Co., Ltd. , Kajihara, Yasuhiro
发明人： KAJIHARA, Yasuhiro , SASAKI, Ken
IPC分类号： C07H15/12 , C07H5/06 , C07H7/027 , C08B37/00 , C12P13/04 , C12P19/04
CPC分类号： C07H13/10 , C07H5/06 , C07H7/027 , C07H15/12 , C12P13/04 , C12P19/04 , C12P19/28 , Y02P20/55
摘要： The present invention provides a process for preparing a sugar chain asparagine derivative. According to the process, various isolated sugar chain asparagine derivatives useful in the field of the development of pharmaceuticals and the like can be conveniently obtained in a large amount as compared to that of the prior art. The present invention also provides a process for preparing a sugar chain asparagine and a process for preparing a sugar chain via a step for preparing a sugar chain asparagine derivative. The present invention further provides a novel sugar chain asparagine derivative, a sugar chain asparagine and a sugar chain.
摘要翻译：本发明提供了制备糖链天冬酰胺衍生物的方法。根据该方法，与现有技术相比，可以方便地获得用于药物开发领域等的各种分离的糖链天冬酰胺衍生物。本发明还提供了制备糖链天冬酰胺的方法和通过制备糖链天冬酰胺衍生物的步骤制备糖链的方法。本发明进一步提供了新型糖链天冬酰胺衍生物，糖链天冬酰胺和糖链。

10. 发明授权

EP0867446B1 Process for the production of 2-keto-D-gluconic acid 失效
标题翻译：一种生产2-酮基-D-葡糖酸处理
公开(公告)号：EP0867446B1
公开(公告)日：2004-01-21
申请号：EP98302208.8
申请日：1998-03-24
申请人： CERESTAR HOLDING B.V.
发明人： Elseviers, Myriam , Lemmens, Hilde Odile Jozefine , Coomans, Sonie Marianne Jeannine , Röper, Harald Wilhelm Walter
IPC分类号： C07H7/027
CPC分类号： C07H7/027

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