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1. 发明授权

EP1636246B1 PRODUCTION OF 2 -DEOXYNUCLEOSIDES AND 2 -DEOXYNUCLEOSIDE PRECURSORS FROM 2-DEHYDRO-3-DEOXY-D-GLUCONATE 有权
标题翻译：制备2-脱氧核苷和2-DESOXYNUKLEOSIDVORSTUFEN由2-脱氢-3-脱氧-D-葡萄糖酸
公开(公告)号：EP1636246B1
公开(公告)日：2015-08-19
申请号：EP04740261.5
申请日：2004-06-24
申请人： Scientist of Fortune S.A. , Evologic S.A.
发明人： MARLIERE, Philippe , DÖRING, Volker , THIBAUT, Denis , KREIMEYER, Annett
IPC分类号： C07H7/027 , C07H1/00 , C12P7/42 , C12N9/88 , C12N1/20
CPC分类号： C07H1/00 , C07H7/027 , C12N9/88 , C12P7/24 , C12P7/42

2. 发明授权

EP3122886B1 ENZYMATIC PRODUCTION OF ACETYL PHOSPHATE FROM FORMALDEHYDE 有权转让
公开(公告)号：EP3122886B1
公开(公告)日：2020-11-11
申请号：EP15712086.6
申请日：2015-03-13
申请人： Scientist of Fortune S.A.
发明人： MARLIERE, Philippe
IPC分类号： C12P9/00

3. 发明公开

EP3149180A1 METHOD FOR THE ENZYMATIC PRODUCTION OF D-ERYTHROSE AND ACETYL PHOSPHATE 有权转让
标题翻译： VERFAHREN ZUR ENZYMATISCHEN HERSTELLUNG VON D-ERYTHROSEACETYL UND ACETYLPHOSPHAT
公开(公告)号：EP3149180A1
公开(公告)日：2017-04-05
申请号：EP15729352.3
申请日：2015-05-22
申请人： Scientist of Fortune S.A.
发明人： MARLIERE, Philippe
IPC分类号： C12P19/02 , C12P9/00 , C12P7/26
摘要： Described is a method for the production of D-erythrose and acetyl phosphate comprising the enzymatic conversion of D-fructose into D-erythrose and acetyl phosphate by making use of a phosphoketolase. The produced D-erythrose can further be converted into glycolaldehyde by a method for the production of glycolaldehyde comprising the enzymatic conversion of D-erythrose into glycolaldehyde by making use of an aldolase, wherein aldolase is a 2-deoxyribose-5-phosphate aldolase (EC 4.1.2.4) or a fructose-bisphosphate aldolase (EC 4.1.2.13). The produced glycolaldehyde can finally be converted into acetyl phosphate by the enzymatic conversion of the thus produced glycolaldehyde into acetyl phosphate by making use of a phosphoketolase or a sulfoacetaldehyde acetyltransferase.
摘要翻译：描述了D-呋喃糖和乙酰基磷酸酯的制备方法，其包括通过使用磷酸酮醇酶将D-果糖酶促转化成D-赤藓糖和乙酰基磷酸酯。所制备的D-赤藓糖可通过使用醛缩酶将D-赤藓糖酶转化为乙二醇的方法进一步转化为乙二醇，其中所述醛缩酶是2-脱氧核糖-5-磷酸醛缩酶（ EC 4.1.2.4）或果糖 - 二磷酸醛缩酶（EC 4.1.2.13）。通过利用磷酸酮糖苷酶或磺乙醛乙酰转移酶将由此制备的乙二醇转化成乙酰磷酸酯，可以最终将生成的乙二醇转化为乙酰磷酸酯。

4. 发明公开

EP3031911A1 RECOMBINANT MICROORGANISM FOR THE PRODUCTION OF USEFUL METABOLITES 有权转让
标题翻译： REKOMBINANTER MIKROORGANISMUS ZUR HERSTELLUNGNÜTZLICHER代谢物
公开(公告)号：EP3031911A1
公开(公告)日：2016-06-15
申请号：EP15187136.5
申请日：2012-07-12
申请人： Scientist of Fortune S.A.
发明人： MARLIERE, Philippe
IPC分类号： C12N9/04 , C12N9/12 , C12N9/88 , C12P7/28 , C12N9/00
CPC分类号： C12P7/28 , C12N9/16 , C12N9/88 , C12N15/63 , C12P5/026 , C12P17/182 , C12P19/32 , C12Y301/03011 , C12Y401/02009 , C12Y401/02022 , Y02P20/52
摘要： Described are recombinant microorganisms characterized by having phosphoketolase activity, having a diminished or inactivated Embden-Meyerhof-Parnas pathway (EMPP) by inactivation of the gene(s) encoding phosphofructokinase or by reducing phosphofructokinase activity as compared to a non-modified microorganism and having a diminished or inactivated oxidative branch of the pentose phosphate pathway (PPP) by inactivation of the gene(s) encoding glucose-6-phosphate dehydrogenase or by reducing glucose-6-phosphate dehydrogenase activity as compared to a non-modified microorganism. These microorganisms can be used for the production of useful metabolites such as acetone, isobutene or propene.
摘要翻译：描述的是具有磷酸酮醇酯酶活性的重组微生物，其与非修饰的微生物相比，通过使编码磷酸果糖激酶的基因失活或减少磷酸果糖激酶活性而具有减弱或失活的Embden-Meyerhof-Parnas途径（EMPP）通过灭活编码葡萄糖-6-磷酸脱氢酶的基因或通过降低葡萄糖-6-磷酸脱氢酶活性与未修饰的微生物相比，戊糖磷酸途径（PPP）的减少或失活的氧化分支。这些微生物可用于生产有用的代谢物如丙酮，异丁烯或丙烯。

5. 发明公开

EP3019604A2 MEVALONATE DIPHOSPHATE DECARBOXYLASE VARIANTS 有权转让
标题翻译： MEVALONAT - 二磷酸 - 脱羧酶VARIANTEN
公开(公告)号：EP3019604A2
公开(公告)日：2016-05-18
申请号：EP14749728.3
申请日：2014-07-09
申请人： Global Bioenergies , Scientist of Fortune S.A.
发明人： MAZALEYRAT, Sabine , DELCOURT, Marc , ANISSIMOVA, Maria , MARLIERE, Philippe
IPC分类号： C12N9/90
摘要： Described are mevalonate diphosphate decarboxylase variants having improved activity in converting 3-phosphonoxyisovalerate into isobutene. Such variants can be employed in processes for biologically producing isobutene from 3-hydroxyisovalerate or from 3-hydroxy-3-methylbutyrate into isobutene, for biologically producing isoprenol from mevalonate or from mevalonate-3-phosphate or for biologically producing 1,3-butadiene from 3-hydroxypent-4-enoate or from 3-phosphonoxypent-4-enoate. Also described is an enzyme which is characterized in that it is capable of converting 3-phosphonoxyisovalerate into isobutene with a kcat of more than 0.1 s−1.
摘要翻译：描述了具有改善3-膦酰氧异戊酸转化成异丁烯的活性的甲羟戊酸二磷酸脱羧酶变体。这样的变体可以用于从3-羟基异戊酸酯或3-羟基-3-甲基丁酸生物异丁烯生产异丁烯的方法，用于从甲羟戊酸或甲羟戊酸-3-磷酸生物地生产异戊二烯或用于生物学生产1,3-丁二烯 3-羟基戊-4-烯酸酯或3-膦酰氧基-4-戊酸酯。还描述了一种酶，其特征在于其能够使用超过0.1s-1的kcat将3-膦酰氧异戊酸转化成异丁烯。

6. 发明公开

EP3017051A2 METHOD FOR THE ENZYMATIC PRODUCTION OF 3-BUTEN-2-ONE 有权转让
标题翻译： VERFAHREN ZUR ENZYMATISCHEN HERSTELLUNG VON 3-BUTEN-2-ON
公开(公告)号：EP3017051A2
公开(公告)日：2016-05-11
申请号：EP14745092.8
申请日：2014-07-02
申请人： Scientist of Fortune S.A. , Global Bioenergies SA
发明人： MARLIERE, Philippe , ANISSIMOVA, Maria , ALLARD, Mathieu
IPC分类号： C12P5/02 , C12P7/26 , C12P7/16 , C12N1/00
CPC分类号： C12P7/16 , C12N1/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/88 , C12N15/52 , C12N15/70 , C12P5/026 , C12P7/04 , C12P7/26 , C12P19/32 , C12Y101/01001 , C12Y101/0103 , C12Y101/01034 , C12Y101/01184 , C12Y102/0105 , C12Y103/08001 , C12Y402/01017 , C12Y402/01018 , C12Y402/01055 , C12Y402/01059 , C12Y402/01074 , C12Y402/01116 , C12Y402/01127 , Y02E50/10
摘要： Described is a method for the production of 3-buten-2-one comprising the enzymatic conversion of 4-hydroxy-2-butanone into 3-buten-2-one by making use of an enzyme catalyzing 4-hydroxy-2-butanone dehydration, wherein said enzyme catalyzing 4-hydroxy-2-butanone dehydration is (a) a 3-hydroxypropiony-CoA dehydratase (EC 4.2.1.116), (b) a 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55), (c) an enoyl-CoA hydratase (EC 4.2.1.17), (d) a 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59), (e) a crotonyl-[acyl-carrier-protein] hydratase (EC 4.2.1.58), (f) a 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.60), (g) a 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61), (h) a long-chain-enoyl-CoA hydratase (EC 4.2.1.74), or (i) a 3-methylglutaconyl-CoA hydratase (EC 4.2.1.18). The produced 3-buten-2-one can be further converted into 3-buten-2-ol and finally into 1,3-butadiene.
摘要翻译：描述了制备3-丁烯-2-酮的方法，其包括通过使用催化4-羟基-2-丁酮脱水的酶将4-羟基-2-丁酮酶促转化成3-丁烯-2-酮其中所述催化4-羟基-2-丁酮脱水的酶是（a）3-羟基丙酰辅酶A脱水酶（EC 4.2.1.116），（b）3-羟基丁酰辅酶A脱水酶（EC 4.2.1.55），（c ）烯酰辅酶A水合酶（EC 4.2.1.17），（d）3-羟基辛酰 - [酰基 - 载体 - 蛋白]脱水酶（EC 4.2.1.59），（e）巴豆酰基 - [酰基 - 载体 - 蛋白]水合酶（EC 4.2.1.58），（f）3-羟基癸酰基 - [酰基载体蛋白]脱水酶（EC 4.2.1.60），（g）3-羟基棕榈酰 - [酰基载体蛋白]脱水酶（EC 4.2。 1.61），（h）长链烯酰辅酶A水合酶（EC 4.2.1.74），或（i）3-甲基谷丙酰辅酶A水合酶（EC 4.2.1.18）。生成的3-丁烯-2-酮可进一步转化为3-丁烯-2-醇，最后进一步转化为1,3-丁二烯。

7. 发明公开

EP3692022A1 CELLULAR TRANSPORT SYSTEM FOR TRANSFERRING A SULFONIC ACID CONSTRUCT CARRYING A CARGO INTO THE CYTOPLASM OF A CELL 审中-公开
公开(公告)号：EP3692022A1
公开(公告)日：2020-08-12
申请号：EP18782409.9
申请日：2018-10-02
申请人： Scientist of Fortune S.A.
发明人： KÜNZL, Tilmann , PANKE, Sven , MARLIERE, Philippe
IPC分类号： C07D239/47 , C07C309/07 , C07H5/06 , C07D471/04 , C12N9/78

8. 发明授权

EP3347479B1 ENZYMATIC PRODUCTION OF AN ACYL PHOSPHATE FROM A 2-HYDROXYALDEHYDE 有权
公开(公告)号：EP3347479B1
公开(公告)日：2019-11-06
申请号：EP16777914.9
申请日：2016-09-08
申请人： Scientist of Fortune S.A.
发明人： MARLIERE, Philippe
IPC分类号： C12P7/62 , C12P9/00

9. 发明公开

EP3433370A1 METHOD FOR PRODUCING ISOBUTENE FROM 3-METHYLCROTONYL-COA 有权
公开(公告)号：EP3433370A1
公开(公告)日：2019-01-30
申请号：EP17717632.8
申请日：2017-03-22
申请人： Global Bioenergies , Scientist of Fortune S.A.
发明人： ALLARD, Mathieu , MARLIERE, Philippe
IPC分类号： C12P5/02

10. 发明授权

EP2912184B1 PRODUCTION OF ALKENES FROM 3-HYDROXY-1-CARBOXYLIC ACIDS VIA 3-SULFONYLOXY-1-CARBOXYLIC ACIDS 有权
标题翻译：的3-羟基-1-羧酸VIA 3-磺酰氧基-1-羧酸烯烃的制备
公开(公告)号：EP2912184B1
公开(公告)日：2017-01-18
申请号：EP13798587.5
申请日：2013-10-24
申请人： Scientist of Fortune S.A. , Global Bioenergies
发明人： MARLIERE, Philippe , ANISSIMOVA, Maria , ALLARD, Mathieu
IPC分类号： C12P5/02 , C12N9/10
CPC分类号： C12P5/026 , C12N9/13

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