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1. 发明公开

EP3233820A1 NOUVEAUX ACÉTALS DE LA 1-(3,3-DIMÉTHYLCYCLOHEX-1-ÈNYL) ÉTHANONE, LEUR PROCÉDÉ DE PRÉPARATION AINSI QUE LEUR UTILISATION EN PARFUMERIE 有权转让
标题翻译： NOUVEAUXACÉTALSDE LA 1-（3,3-DIMÉTHYLCYCLOHEX-1-ÈNYL）ÉTHANONE，LEURPROCÉDÉDEPRÉPARATIONAINSI QUE LEUR UTILIZATION EN PARFUMERIE
公开(公告)号：EP3233820A1
公开(公告)日：2017-10-25
申请号：EP15828740.9
申请日：2015-12-14
申请人： V. Mane Fils
发明人： MURATORE, Agnès , MAHAIM, Cyril
IPC分类号： C07D317/12 , A61K8/49 , A61Q13/00 , C07D319/06 , C07D321/06
CPC分类号： C11B9/0076 , A61K8/4973 , A61Q13/00 , C07D317/12 , C07D319/06 , C07D321/06 , C11B9/0084
摘要： The invention relates to novel fragrant compounds having animalic or ambergris notes, without any woody characteristic. More specifically, the invention relates to novel acetal derivatives of 1-(3,3-dimethylcyclohex-1-enyl) ethanone of general formula I, to a method for the synthesis of said compounds and to the use thereof in perfumery.
摘要翻译：本发明涉及具有动物或龙涎香香味的新型香味化合物，没有任何木质特征。更具体地说，本发明涉及通式I的1-（3,3-二甲基环己-1-烯基）乙酮的新的缩醛衍生物，涉及合成所述化合物的方法及其在香料中的用途。

2. 发明公开

EP2304043A1 HIV PROTEASE INHIBITORS AND METHODS FOR USING 审中-公开
标题翻译： HIV蛋白酶抑制剂和使用方法
公开(公告)号：EP2304043A1
公开(公告)日：2011-04-06
申请号：EP09795121.4
申请日：2009-07-08
申请人： Purdue Research Foundation
发明人： GHOSH, Arun, K.
IPC分类号： C12P13/04 , C12P13/24
CPC分类号： C07D493/04 , C07D273/01 , C07D313/14 , C07D319/06 , C07D319/14 , C07D321/06 , C07D321/12 , C07D325/00 , C07D327/10 , C07D491/04 , C07D495/04
摘要： Compounds that inhibit proteolytic enzymes of Human Immunodeficiency Virus (HIV) are described. Preparation of the inhibitors, pharmaceutical compositions containing them, and uses of the compounds or compositions for the treatment of HIV infections are also described.

3. 发明授权

EP0984000B1 PROCESS FOR PRODUCING AMIDE DERIVATIVES AND INTERMEDIATE COMPOUNDS 失效
标题翻译：用于生产酰胺衍生物及其中间体
公开(公告)号：EP0984000B1
公开(公告)日：2008-12-03
申请号：EP96931297.4
申请日：1996-09-24
申请人： Japan Tobacco Inc. , Agouron Pharmaceuticals, Inc.
发明人： INABA, Takashi, Central Pharmaceutical Research , YAMADA, Yasuki, Central Pharmaceutical Research , SHANLEY, James , DEASON, Michael
IPC分类号： C07C323/25 , C07C319/20 , C07D321/06 , C07D493/04 , C07D303/36 , C07D317/28 , C07B53/00
CPC分类号： C07D317/28 , C07C319/20 , C07D319/20 , C07D321/06 , C07C323/25
摘要： A process for producing amide derivatives represented by general formula (XV) or enantiomers thereof, novel intermediate compounds useful for producing these compounds, etc., and a process for producing the same, wherein each symbol is as defined in the specification. Compared with the conventional processes, the above process can be very easily effected and enables an efficient production of the compounds (XV), i.e., those involving the compounds (XVI) having an HIV protease inhibitory effect in high yields. The novel intermediates are highly advantageous as intermediates for producing not only the above compounds (XVI) but also those which are useful as an X-ray contrast medium, etc.

4. 发明授权

EP0983999B8 PROCESS FOR PRODUCING AMIDE DERIVATIVES AND INTERMEDIATES 失效
标题翻译：生产酰胺衍生物和中间体的方法
公开(公告)号：EP0983999B8
公开(公告)日：2005-06-08
申请号：EP96931296.6
申请日：1996-09-24
申请人： Japan Tobacco Inc. , Agouron Pharmaceuticals, Inc.
发明人： INABA, Takashi, Central Pharmaceutical Research , YAMADA, Yasuki, Central Pharmaceutical Research
IPC分类号： C07C323/25 , C07C319/14 , C07D321/06 , C07D493/04 , C07D263/14 , C07D413/04 , C07B53/00
CPC分类号： C07D413/04 , C07C319/14 , C07D217/26 , C07D263/14 , C07D321/06 , C07C323/25 , C07C323/42
摘要： A process for producing amide derivatives represented by general formula [XV] or enantiomers thereof, novel intermediate compounds useful for producing these compounds, etc., and a process for producing the same, wherein each symbol is as defined in the specification. Compared with the conventional processes, the above process can be very easily effected and enables an efficient production of the compounds [XV], i.e., those involving the compounds [XVI] having an HIV protease inhibitory effect in high yields. The n ovel intermediates are highly advantageous as intermediates for producing not only the above compounds [XVI] but also those which are useful as an X-ray contrast medium, etc.
摘要翻译：生产通式[ⅩⅤ]所代表的酰胺衍生物或其对映异构体的方法，用于生产这些化合物的新的中间体化合物及其生产方法，其中每个符号如说明书中所定义。与常规方法相比，上述方法可以非常容易地进行，并且能够有效地生产化合物[ⅩⅤ]，即涉及具有HIV蛋白酶抑制作用的化合物[ⅩⅥ]的高产率。作为用于制造上述化合物[XVI]的中间体，以及作为X射线造影剂等有用的中间体，非常有利。

5. 发明公开

EP0984000A4 PROCESS FOR PRODUCING AMIDE DERIVATIVES AND INTERMEDIATE COMPOUNDS 失效
标题翻译：用于生产酰胺衍生物及其中间体
公开(公告)号：EP0984000A4
公开(公告)日：2004-08-11
申请号：EP96931297
申请日：1996-09-24
申请人： JAPAN TOBACCO INC , AGOURON PHARMA
发明人： INABA TAKASHI , YAMADA YASUKI , SHANLEY JAMES , DEASON MICHAEL
IPC分类号： C07C319/20 , C07C323/25 , C07D317/28 , C07D319/20 , C07D321/06 , C07B53/00 , C07D303/36 , C07D493/04 , C07M7/00
CPC分类号： C07D317/28 , C07C319/20 , C07D319/20 , C07D321/06 , C07C323/25
摘要： A process for producing amide derivatives represented by general formula (XV) or enantiomers thereof, novel intermediate compounds useful for producing these compounds, etc., and a process for producing the same, wherein each symbol is as defined in the specification. Compared with the conventional processes, the above process can be very easily effected and enables an efficient production of the compounds (XV), i.e., those involving the compounds (XVI) having an HIV protease inhibitory effect in high yields. The novel intermediates are highly advantageous as intermediates for producing not only the above compounds (XVI) but also those which are useful as an X-ray contrast medium, etc.

6. 发明授权

EP0930312B1 Production method of optically active amino alcohols 有权
标题翻译：一种制备光学活性的氨基醇处理
公开(公告)号：EP0930312B1
公开(公告)日：2003-01-02
申请号：EP99100704.8
申请日：1999-01-15
申请人： JAPAN TOBACCO INC. , AGOURON PHARMACEUTICALS, INC.
发明人： Inaba, Takashi Cent. Pharm.Res.Inst.Jap.Tob. Inc. , Sagawa, Shoichi Cent. Pharm.Res.Inst.Jap.Tob.Inc. , Abe, Hiroyuki Cent. Pharm.Res.Inst.Jap.Tob.Inc.
IPC分类号： C07D321/06 , C07D317/28
CPC分类号： C07D321/06 , C07D317/28

7. 发明公开

EP0930312A1 Production method of optically active amino alcohols 有权
标题翻译：维生素Zur Herstellung von optisch aktiven Aminoalkoholen
公开(公告)号：EP0930312A1
公开(公告)日：1999-07-21
申请号：EP99100704.8
申请日：1999-01-15
申请人： Japan Tobacco Inc. , AGOURON PHARMACEUTICALS, INC.
发明人： Inaba, Takashi Cent. Pharm.Res.Inst.Jap.Tob. Inc. , Sagawa, Shoichi Cent. Pharm.Res.Inst.Jap.Tob.Inc. , Abe, Hiroyuki Cent. Pharm.Res.Inst.Jap.Tob.Inc.
IPC分类号： C07D321/06 , C07D317/28
CPC分类号： C07D321/06 , C07D317/28
摘要： A method for producing an optically active amino alcohol compound of the formula [3], an enantiomer thereof or a salt thereof, comprising reacting a mesoepoxide compound of the formula [1] with a compound of the formula [2] in the presence of a mixed catalyst comprising a Lewis acid and a proton donor:
wherein R 1 , R 2 and R 3 are each H, an optionally substituted lower alkyl, and the like, or R 1 and R 1 or R 2 and R 3 may form an optionally substituted ring; and R 4 and R 5 are each H, an optionally substituted lower alkyl, and the like, or R 4 and R 5 may form an optionally substituted ring together with the adjacent N, or an imide group or azide group together with the adjacent N, and R 6 is H or a silyl group. The present invention enables stereoselective production of a desired intermediate compound, which is an HIV protease inhibitor, extremely efficiently as compared to conventional methods. The method of the present invention is a very useful method which can be used not only for the production of said intermediate compound but also for the production of various other compounds.
摘要翻译：一种制备式Ä3的光学活性氨基醇化合物，其对映异构体或其盐的方法，包括使式Ä1a的中间环氧化物化合物与式Ä2a化合物在含有路易斯酸的混合催化剂存在下反应和一个质子供体：其中R 1，R 2和R 3各自为H，任选取代的低级烷基等，或者R 1和R 1或R“ 2>和R 3可以形成任选取代的环; R 4和R 5各自为H，任选取代的低级烷基等，或者R 4和R 5可以与相邻的N或酰亚胺基一起形成任选取代的环或叠氮基与相邻的N一起，R 6为H或甲硅烷基。与常规方法相比，本发明能够非常有效地立体选择性地制备作为HIV蛋白酶抑制剂的所需中间体化合物。本发明的方法是一种非常有用的方法，其不仅可以用于所述中间体化合物的制备，而且可用于制备各种其它化合物。

8. 发明授权

EP0668274B1 Sulfonamidodioxepanes with hypoglycemic activity, methods of preparation, intermediates and salts thereof 失效
标题翻译：与降血糖特性Sulfonamidodioxepane，其制备方法，及其中间体和它的盐的方法
公开(公告)号：EP0668274B1
公开(公告)日：1998-08-26
申请号：EP95102353.0
申请日：1995-02-20
申请人： PLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija, dionicko drustvo
发明人： Dumic, Miljenko , Filic, Darko , Vinkovic, Mladen , Jamnicky, Blanka
IPC分类号： C07D321/06 , A61K31/18
CPC分类号： C07D321/06

9. 发明公开

EP0668274A1 Sulfonamidodioxepanes with hypoglycermic activity, methods of preparation, intermediates and salts thereof 失效
标题翻译： Sulfonamidodioxepane与降血糖特性，其制备方法，及其中间体和它的盐的方法。
公开(公告)号：EP0668274A1
公开(公告)日：1995-08-23
申请号：EP95102353.0
申请日：1995-02-20
申请人： PLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija dionicko drustvo
发明人： Dumic, Miljenko , Filic, Darko , Vinkovic, Mladen , Jamnicky, Blanka
IPC分类号： C07D321/06 , A61K31/18
CPC分类号： C07D321/06
摘要： Novel O-substituted or O-unsubstituted 6-sulfonamido-1,3-dioxepane-5-ols having hypoglycemic activity are obtained from 6-amino-1,3-dioxepane-5-ol, tetrahydro-6H-[1,3]-dioxepino[5,6-d]oxazole, 5,6-epoxy-1,3-dioxepane or N-sulfonyl-tetrahydro-1 H,4H-[1,3]-dioxepino[5,6-b]azirine as starting materials.
摘要翻译：新颖O形substituiertem奥德unsubstituiertem O-6亚磺酰氨基-1,3-二氧杂环庚烷-5-醇具有降血糖活性是从6-氨基-1,3-二氧杂环庚烷-5-醇，四氢-6H- [1,3]获得 -dioxepino [5,6-d]恶唑，5,6-环氧-1,3-二氧杂环庚烷或N-磺酰基 - 四氢-1H，4H- [1,3] -dioxepino [5,6-b] azirines如启动材料。

10. 发明授权

EP0589359B1 Verfahren zur Herstellung von Ketenacetalen 失效
标题翻译：制备烯酮缩醛。
公开(公告)号：EP0589359B1
公开(公告)日：1995-06-28
申请号：EP93114921.5
申请日：1993-09-16
申请人： Wacker-Chemie GmbH
发明人： Fleischmann, Gerald, Dr. , Eck, Herbert, Dr. , Petersen, Hermann , Pflaum, Siegfried, Dr.
IPC分类号： C07C43/303 , C07C41/48 , C07D321/06
CPC分类号： C07D321/06 , C07C41/50 , C07C43/303

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