专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP2155663B1 SUBSTITUTED 2-[2-(PHENYL)ETHYLAMINO]ALKANEAMIDE DERIVATIVES AND THEIR USE AS SODIUM AND/OR CALCIUM CHANNEL MODULATORS 有权
标题翻译：取代的2- [2-（苯基）乙基氨基]烷烃酰胺衍生物及其作为钠和/或钙通道调节剂的用途
公开(公告)号：EP2155663B1
公开(公告)日：2017-11-29
申请号：EP08749449.8
申请日：2008-05-14
申请人： Newron Pharmaceuticals S.p.A.
发明人： MELLONI, Piero , RESTIVO, Alessandra , IZZO, Emanuela , FRANCISCONI, Simona , COLOMBO, Elena , SABIDO-DAVID, Cibele
IPC分类号： C07C237/06 , A61K31/165 , C07D295/182
CPC分类号： A61K31/381 , A61K31/137 , A61K31/165 , A61K31/40 , A61K31/4515 , A61K31/519 , A61K31/5513 , C07C237/06 , C07C237/08 , C07C237/20 , C07C317/28 , C07C321/26 , C07C323/25 , C07C327/42 , C07C327/44 , C07D207/16 , C07D295/182 , C07D333/20

2. 发明公开

EP3110799A4 HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL 无效
公开(公告)号：EP3110799A4
公开(公告)日：2017-10-11
申请号：EP15755760
申请日：2015-02-26
申请人： EPIRUS BIOPHARMACEUTICALS INC
发明人： PAJOUHESH HASSAN , HOLLAND RICHARD , ZHANG LINGYUN , PAJOUHESH HOSSEIN , MONTAGNE JASON , WHELAN BRENDAN
IPC分类号： C07D235/04 , A61K31/165 , A61K31/40 , A61K31/404 , A61K31/4166 , A61K31/4184 , A61K31/4458 , A61K31/4465 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/498 , A61K31/5375 , A61P25/02 , A61P25/06 , A61P25/08 , A61P29/00 , C07C237/08 , C07C237/14 , C07C237/20 , C07C237/24
CPC分类号： C07D403/12 , C07C235/08 , C07C237/04 , C07C237/06 , C07C237/08 , C07C237/12 , C07C237/14 , C07C237/20 , C07C237/24 , C07C2601/02 , C07C2601/14 , C07C2603/74 , C07D207/09 , C07D207/16 , C07D209/14 , C07D211/58 , C07D211/60 , C07D233/76 , C07D235/14 , C07D241/04 , C07D241/08 , C07D241/44 , C07D265/30 , C07D295/15 , C07D295/182 , C07D295/185 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06
摘要： The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns heterocyclic compounds (e.g., compounds according to any of Formulas (1)-(X) or Compounds (1)-(92) of Table 1) that are that are useful in treatment of conditions such as epilepsy, cancer, pain, migraine, Parkinson's Disease, mood disorders, schizophrenia, psychosis, tinnitus, amyotropic lateral sclerosis, glaucoma, ischaemia, spasticity disorders, obsessive compulsive disorder, restless leg syndrome and Tourette syndrome.

3. 发明公开

EP2442644A1 OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE 有权转让
标题翻译： OPSINBINDENDE配体和它们的组合物及其使用方法
公开(公告)号：EP2442644A1
公开(公告)日：2012-04-25
申请号：EP10789866.0
申请日：2010-06-16
申请人： Bikam Pharmaceuticals, Inc.
发明人： GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, Robert , BREWER, Mark, L. , QUACH, Tan , COTE, Jamie, B. , BERMAN, Judd
IPC分类号： A01N35/00 , A61K31/11
CPC分类号： C07D295/215 , C07B59/002 , C07B2200/05 , C07C233/10 , C07C275/14 , C07C2601/16 , C07D205/04 , C07D207/12 , C07D207/14 , C07D211/38 , C07D241/04 , C07D241/08 , C07D243/08 , C07D295/182 , C07D295/185 , C07D295/194 , C07D295/205 , C07D295/26 , C07D491/10 , C07D493/08
摘要： Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.

4. 发明公开

EP2061449A1 SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES 审中-公开
标题翻译： SUBSTITUIERTE ACETYLEN-VERBINDUNGEN ZUR BEHANDLUNG VON ERKRANKUNGEN
公开(公告)号：EP2061449A1
公开(公告)日：2009-05-27
申请号：EP07785739.9
申请日：2007-08-16
申请人： LEO PHARMA A/S
发明人： LIANG, Xifu , HØYER, Thomas , FENSHOLDT, Jef , HAVEZ, Sophie Elisabeth , NØRREMARK, Bjarne
IPC分类号： A61K31/137 , A61K31/381 , A61K31/4045 , A61K31/357 , C07C211/30 , C07C215/24 , C07C215/28 , C07C229/30 , C07C255/58 , C07D209/20 , C07D231/38 , C07D317/58 , C07D333/58 , C07F7/08 , C07F7/18
CPC分类号： C07F7/0818 , C07B2200/07 , C07C211/29 , C07C211/30 , C07C211/49 , C07C215/24 , C07C215/28 , C07C215/30 , C07C215/50 , C07C215/54 , C07C217/46 , C07C217/58 , C07C217/62 , C07C229/30 , C07C229/34 , C07C229/38 , C07C233/36 , C07C233/38 , C07C233/62 , C07C235/10 , C07C235/60 , C07C237/16 , C07C255/30 , C07C255/58 , C07C271/20 , C07C275/24 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C311/05 , C07C311/18 , C07C311/29 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07D207/12 , C07D209/08 , C07D211/46 , C07D211/58 , C07D211/62 , C07D213/40 , C07D231/12 , C07D263/32 , C07D295/13 , C07D295/182 , C07D309/08 , C07D309/10 , C07D317/28 , C07D317/58 , C07D333/20 , C07D333/58 , C07F7/1852 , C07F7/1856
摘要： The invention relates to novel compounds according to formula Ia and Ib; (Formula Ia and Ib) wherein A represents substituted or unsubstituted C1-10heteroaryl, C6-14aryl or C6- 10heterocycloalkylaryl; R1 is C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6hydroxyalkyl, C1-6haloalkyl, C1-6amino, C3-6 cycloalkyl, or C1-6heterocycloalkyl, each of which are optionally substituted; X represents -CR3R4-(CR5R6)n-(CR7=CR8)m-(C6-14aryl)r-(C1-10heteroaryl)s-(CR9R10)p- (CR11 = CR12)q, R2 represents C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6hydroxyalkyl, C1-6haloalkyl, C1-6amino, C1-12alkylsilyl, C6-30alkylarylsilyl, C1-10heteroaryl, C6-14aryl, C1-10heterocycloalkyl, C1-10heterocycloalkenyl, C1-8cycloalkyl, C1-18cycloalkenyl, each of which is optionally substituted, or R2 represents hydrogen, carboxy, or hydroxy; or a pharmaceutically acceptable salt, solvate, or ester thereof; to processes for the preparation thereof, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, wherein said compounds being useful, e.g. in the treatment of diseases associated with disturbances of CaSR activity, such as hyperparathyroidism.
摘要翻译：本发明涉及根据式Ia和Ib的新化合物; （式Ia和Ib）其中A表示取代或未取代的C1-10杂芳基，C6-14芳基或C6-10杂环烷基芳基; R 1是C 1-6烷基，C 2-6烯基，C 2-6炔基，C 1-6羟基烷基，C 1-6卤代烷基，C 1-6氨基，C 3-6环烷基或C 1-6杂环烷基，其各自任选被取代; X表示-CR3R4-（CR5R6）n-（CR7 = CR8）m-（C6-14芳基）r-（C1-10杂芳基）s-（CR9R10）p-（CR11 = CR12）q，R2表示C1-6烷基，C2 6-烯基，C 2-6炔基，C 1-6羟烷基，C 1-6卤代烷基，C 1-6氨基，C 1-12烷基甲硅烷基，C 6-30烷基芳基甲硅烷基，C 1-10杂芳基，C 6-14芳基，C 1-10杂环烷基，C 1-10杂环烯基，C 1-8环烷基，，其各自任选被取代，或R 2表示氢，羧基或羟基; 或其药学上可接受的盐，溶剂化物或酯; 其制备方法，所述用于治疗的化合物，包含所述化合物的药物组合物，其中所述化合物是有用的。治疗与CaSR活动相关的疾病，如甲状旁腺功能亢进。

5. 发明公开

EP1951700A2 NOVEL PROCESSES FOR THE PREPARATION OF PIPERAZINYL AND DIAZAPANYL BENZAMIDE DERIVATIVES 审中-公开
标题翻译：新方法哌嗪和DIAZAPANYLBENZAMIDDERIVATEN生产
公开(公告)号：EP1951700A2
公开(公告)日：2008-08-06
申请号：EP06826786.3
申请日：2006-10-26
申请人： Janssen Pharmaceutica NV
发明人： MANI, Neelakandha S. , PANDIT, Chennagiri R. , REYES, Mayra B. , XIAO, Tong , PALMER, David C.
IPC分类号： C07D295/18 , C07D211/14 , C07D207/06
CPC分类号： C07D295/192 , C07D207/06 , C07D211/14 , C07D295/182 , C07D413/04
摘要： The present invention is directed to novel processes for the preparation of substituted piperazinyl and diazepanyl benzamides, useful for the treatment of disorders and conditions mediated by the histamine receptor.

6. 发明授权

EP0649420B1 PROCESS FOR THE PREPARATION OF 3,3-DIARYL ACRYLIC ACID AMIDES 失效
标题翻译：制备3,3-二芳基丙烯酸酰胺的方法
公开(公告)号：EP0649420B1
公开(公告)日：1997-05-02
申请号：EP93915866.3
申请日：1993-07-08
申请人： SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.
发明人： CURTZE, Jürgen , HAERTEL, Bodo
IPC分类号： C07D295/18 , A01N43/84 , C07C231/12 , A01N37/18
CPC分类号： C07D295/182 , C07C231/12
摘要： The invention provides a process for the preparation of 3,3-diaryl acrylic acid amides of general formula (I) in which A, B and Q are as defined in the specification, by condensing a compound of formula (II) with a compound of the formula CH3-CO-Q in which Q has the meaning given above, in a solvent in the presence of an alkali metal hydroxide, characterised in that the solvent is selected from alkanes, cycloalkanes or mixtures thereof.
摘要翻译：本发明提供了制备通式（I）的3,3-二芳基丙烯酸酰胺的方法，其中A，B和Q如说明书中所定义，通过式（II）的化合物与其中Q具有上述含义的式CH 3 -CO-Q在溶剂中在碱金属氢氧化物存在下反应，其特征在于溶剂选自烷烃，环烷烃或其混合物。

7. 发明公开

EP0639177A1 VERFAHREN ZUR HERSTELLUNG VON HYDROXYALKANCARBONSÄUREAMIDEN 失效
标题翻译： VERFAHREN ZUR HERSTELLUNG VONHYDROXYALKANCARBONSÄULAMIDEN
公开(公告)号：EP0639177A1
公开(公告)日：1995-02-22
申请号：EP93911742.0
申请日：1993-05-05
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHOLZ, Stefan , HARRE, Michael , VIDIC, Hans-Jörg , NEEF, Günter , KIRSCH, Gerald
IPC分类号： C07C231 , C07C235 , C07D295
CPC分类号： C07D295/182 , C07C231/02
摘要： The description relates to a process for producing hydroxyalkane carboxylic acid amides of the general formula (I), in which n is a whole number from 1 to 20 and R1 and R2 are alkyl groups with a maximum of 8 carbon atoms or together represent an alkylene group with 4 to 8 carbon atoms, possibly interrupted by an oxygen or a nitrogen atom, from hydroxyalkane carboxylic acids of the general formula (II): HO-CnH2n-COOH, in which n has the significance given above and amines of the general formula (III), in which R1 and R2 have the significance given above, characterized in that the hydroxylalkane carboxylic acid is heated with reflux in a one-pot reaction with 10 to 30 mol acetyl chloride per mol acid, the superfluous acetyl chloride is distilled off after acetylisation, the residue is heated with reflux with 1.5 to 5 mol thionyl chloride per mol acid, after the formation of acid chloride the thionyl chloride is distilled off, the residue is dissolved in a dialkyl ether with 4 to 8 carbon atoms, the solution obtained is added proportionately to an aqueous solution of the amine cooled to 0 to 10 °C and, after amide formation, the acetal group is separated off by treatment with aqueous sodium hydroxide solution at a reaction temperature of 10 to 30 °C.
摘要翻译：描述涉及通式（I）的羟基链烷羧酸酰胺的制备方法，其中n是1至20的整数，并且R 1和R 2是具有最多8个碳原子的烷基或共同表示亚烷基（II）的羟基烷烃羧酸与可能被氧或氮原子间隔的具有4至8个碳原子的基团：HO-C n H 2n -COOH，其中n具有上面给出的含义，以及通式（III）的化合物，其中R1和R2具有上面给出的含义，其特征在于羟基链烷羧酸在回流条件下与每摩尔10-30摩尔乙酰氯在一锅反应中加热，蒸除多余的乙酰氯在乙酰化之后，将残余物与每摩尔1.5-5摩尔亚硫酰氯加热回流，形成酰氯之后，蒸出亚硫酰氯，将残余物溶于含有4-8碳的二烷基醚 n原子时，将所得溶液按比例加入冷却至0-10℃的胺水溶液中，酰胺形成后，在10-30℃的反应温度下用氢氧化钠水溶液处理分离出缩醛基 C。

8. 发明授权

EP0343743B1 Improved preparation of 3,3-diphenylacrylic acid amides 失效
标题翻译：改进了3,3-二苯基丙烯酸酰胺的制备
公开(公告)号：EP0343743B1
公开(公告)日：1994-04-06
申请号：EP89201309.5
申请日：1989-05-22
申请人： SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.
发明人： Curtze, Jürgen , Krummel, Günter
IPC分类号： C07D295/18 , A01N37/18 , C07C231/00 , C07C233/65 , C07C235/46 , C07C237/30
CPC分类号： C07D295/182 , C07C231/12

9. 发明公开

EP0197657A3 A novel process for preparing amides from nitriles and amines 失效
标题翻译：用于制备来自尼日利亚和美洲的氨基酸的新方法
公开(公告)号：EP0197657A3
公开(公告)日：1988-01-07
申请号：EP86301647
申请日：1986-03-07
申请人： OSAKA UNIVERSITY
发明人： Murahashi, Shunichi , Naota, Takeshi
IPC分类号： C07C102/08 , C07D295/18 , C08G69/08
CPC分类号： C07D295/182 , C08G69/02
摘要： Organic amides, including polyamides are efficiently prepared by the direct reaction of an organinitrile and an amine in the presence of water and a reaction catalyst. The catalysts employed are compounds containing one or more of the following metals Ru-, Rh-, Zn-, Ni-, Mo-, Cu-, Co-, Ti-, Cr-, Zr-, Os-, Pd-, Se-, Fe-, Pb-, Hg-, V-, Cd-, Ir- and Pt-. Preferred catalysts are ruthenium complexes and zinc chloride.

10. 发明公开

EP0197657A2 A novel process for preparing amides from nitriles and amines 失效
标题翻译： Verfahren zur Herstellung von Amiden aus Nitrilen und Aminen。
公开(公告)号：EP0197657A2
公开(公告)日：1986-10-15
申请号：EP86301647.3
申请日：1986-03-07
申请人： OSAKA UNIVERSITY
发明人： Murahashi, Shunichi , Naota, Takeshi
IPC分类号： C07C231/06 , C07D295/18 , C08G69/08
CPC分类号： C07D295/182 , C08G69/02
摘要： Organic amides, including polyamides are efficiently prepared by the direct reaction of an organinitrile and an amine in the presence of water and a reaction catalyst. The catalysts employed are compounds containing one or more of the following metals Ru-, Rh-, Zn-, Ni-, Mo-, Cu-, Co-, Ti-, Cr-, Zr-, Os-, Pd-, Se-, Fe-, Pb-, Hg-, V-, Cd-, Ir- and Pt-. Preferred catalysts are ruthenium complexes and zinc chloride.
摘要翻译：有机酰胺，包括聚酰胺通过有机腈和胺在水和反应催化剂的存在下直接反应而有效制备。所使用的催化剂是含有一种或多种以下金属的化合物：Ru-，Rh-，Zn-，Ni-，Mo-，Cu-，Co-，Ti-，Cr-，Zr-，Os-，Pd-，Se - ，Fe-，Pb-，Hg-，V-，Cd-，Ir-和Pt-。优选的催化剂是钌络合物和氯化锌。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式