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1. 发明公开

EP2551262A4 GLUTAMATE DERIVATIVES OR SALTS THEREOF 审中-公开
标题翻译：谷氨酸衍生物或它们的盐
公开(公告)号：EP2551262A4
公开(公告)日：2014-01-15
申请号：EP11759645
申请日：2011-03-23
申请人： AJINOMOTO KK
发明人： SUGIKI MASAYUKI , OKAMATSU TORU
IPC分类号： C07C309/51 , A23L27/00 , A23L27/22 , A61K31/198 , A61K31/223 , A61P1/04 , A61P1/12 , A61P5/18 , A61P43/00
CPC分类号： C07C309/51 , C07C237/04 , C07F9/3834 , C07F9/4021
摘要： Compounds having an excellent CaSR agonist activity are in demand. The invention provides glutamate derivatives or salts thereof, pharmaceutical compositions comprising the glutamate derivatives, preventive or therapeutic agents for diarrhea, hyperparathyroidism or peptic ulcer.

2. 发明公开

EP2292670A2 Charge control agent, toner, image forming method, and image forming apparatus 审中-公开
标题翻译：电荷控制剂，调色剂，图像形成方法和图像形成装置
公开(公告)号：EP2292670A2
公开(公告)日：2011-03-09
申请号：EP10011818.1
申请日：2005-05-11
申请人： Canon Kabushiki Kaisha
发明人： Fukui, Tatsuki , Kenmoku, Takashi , Kusakari, Ako , Mihara, Chieko , Yano, Tetsuya , Fujimoto, Norikazu
IPC分类号： C08F20/58 , C08F246/00 , C08F212/08 , C08F220/14 , C08F8/34 , C08F8/14 , G03G9/097 , G03G13/20 , G03G15/08 , G03G15/20 , C08F220/06 , C07C231/02 , C07C233/09 , C07C303/26 , C07C309/15 , C07C309/51 , C07C309/69 , C07C309/76 , C08F220/58 , G03G9/087
CPC分类号： C08F8/34 , C07C309/15 , C07C309/51 , C07C309/69 , C07C309/76 , C08F8/14 , C08F212/08 , C08F220/58 , C08F2220/585 , G03G9/08726 , G03G9/097 , C08F220/14
摘要： A charge control agent for controlling a charged state of powder contains a polymer having a unit having a structure represented by the chemical formula (19):

wherein R represents -A 25 -SO 2 R 25 ; R 25 w, R 25x , and R 25y are selected from combinations described in the following item (i); and A 25 and R 25 are selected from combinations described in the following item (i-B);
(i) R 25w and R 25x each represent a hydrogen atom, and R 25y represents a CH 3 group or a hydrogen atom;
(i-B) A 25 represents a substituted or unsubstituted aromatic ring structure, or a substituted or unsubstituted heterocyclic structure; R 25 represents OH, a halogen atom, ONa, OK, or OR 25a where R 25a represents a substituted or unsubstituted aliphatic hydrocarbon structure, a substituted or unsubstituted aromatic ring structure, or a substituted or unsubstituted heterocyclic structure.
摘要翻译：用于控制粉末带电状态的电荷控制剂含有具有由化学式（19）表示的结构的单元的聚合物：其中R表示-A25-SO2R25; R25w，R25x和R25y从以下项目（i）中描述的组合中选择; A25和R25选自以下项目（i-B）中描述的组合; （i）R 25w和R 25x各自表示氢原子，并且R 25y表示CH 3基团或氢原子; （i-B）A 25表示取代或未取代的芳族环结构或取代或未取代的杂环结构; R 25表示OH，卤原子，ONa，OK或OR 25a，其中R 25a表示取代或未取代的脂族烃结构，取代或未取代的芳族环结构或取代或未取代的杂环结构。

3. 发明授权

EP1682513B1 VERFAHREN ZUR HERSTELLUNG VON CYCLISCHEN N-SUBSTITUIERTEN ALPHA-IMINOCARBONS UREN 有权
标题翻译：用于生产环N-取代的α-IMINOCARBONS UREN
公开(公告)号：EP1682513B1
公开(公告)日：2011-01-12
申请号：EP04790788.6
申请日：2004-10-23
申请人： Sanofi-Aventis Deutschland GmbH
发明人： SCHUBERT, Gerrit
IPC分类号： C07D217/08 , C07C217/28 , C07C309/32
CPC分类号： C07D217/08 , C07C271/28 , C07C309/51 , C07C309/88 , C07D217/16
摘要： The invention relates to a method for producing cyclic, N-substituted alpha-iminocarboxylic acids of formula (I). According to said method, biphenyl-4-yl-carbamic acid esters are converted into 4'-carbamic acid ester-biphenyl-4-sulphonic acid salts, the sulphonic acid salts are then chlorinated to obtain the corresponding sulphonyl chlorides and the latter are reacted with silylated alpha-iminocarboxylic acids to form the compounds of formula (I).

4. 发明授权

EP1565429B1 DIARYL UREIDO DERIVATIVES AND THEIR MEDICAL USE 有权
标题翻译： DARYEN MEDIZINISCHE VERWENDUNG的DIARYLUREIDODERIVATE
公开(公告)号：EP1565429B1
公开(公告)日：2009-05-13
申请号：EP03770917.7
申请日：2003-11-10
申请人： NeuroSearch A/S
发明人： VALGEIRSSON, Jon , NIELSEN, Elsebet Ostergaard, c/o Neurosearch A/S , PETERS, Dan, c/o Neurosearch A/S
IPC分类号： C07C275/42 , C07C309/46 , C07D209/40 , C07D213/72 , C07D231/56 , C07D257/04 , C07D271/07 , C07D333/36 , A61K31/17 , A61K31/19 , A61K31/381 , A61K31/416 , A61K31/4245 , A61K31/44
CPC分类号： C07D213/75 , C07C275/42 , C07C309/51 , C07C2603/18 , C07D209/40 , C07D231/56 , C07D257/04 , C07D271/07 , C07D317/66 , C07D333/36
摘要： This invention relates to novel aryl ureido benzoic acid derivatives useful as selective and non-competitive antagonists of the ionotropic GluR5 receptor. Due to their biological activity, the aryl ureido derivatives of the invention are considered useful for treating diseases that are responsive to modulation of an aspartate or a glutamate receptor. Moreover the invention provides chemical compounds for use according to the invention, as well as pharmaceutical compositions comprising the chemical compounds, and methods of treating diseases or disorders or conditions responsive to modulation of an aspartate or a glutamate receptor.
摘要翻译：本发明涉及可用作离子型GluR5受体的选择性和非竞争性拮抗剂的新型芳基脲基苯甲酸衍生物。由于其生物活性，本发明的芳基脲基衍生物被认为可用于治疗对天冬氨酸或谷氨酸受体的调节有反应的疾病。此外，本发明提供了根据本发明使用的化合物，以及包含化合物的药物组合物，以及治疗对天冬氨酸或谷氨酸受体的调节作用的疾病或病症或病症的方法。

5. 发明公开

EP1628953A4 PROCESS FOR PREPARING REVERSE TRANSCRIPTASE INHIBITORS 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG VON INHIBITOREN DER REVERSEN TRANSKRIPTASE
公开(公告)号：EP1628953A4
公开(公告)日：2006-11-02
申请号：EP04758431
申请日：2004-03-26
申请人： SMITHKLINE BEECHAM CORP
发明人： MARTIN MICHAEL TOLAR
IPC分类号： C07C303/00 , C07C303/38 , C07C303/40 , C07C311/39 , C07C311/46 , C12N20060101
CPC分类号： C07C303/40 , C07C303/22 , C07C303/38 , C07C309/88 , C07C311/46 , C07C311/39 , C07C309/51
摘要： The present invention is directed to processes for the synthesis of intermediates useful in the preparation of non-nucleoside reverse transcriptase inhibitors.
摘要翻译：本发明涉及用于合成可用于制备非核苷逆转录酶抑制剂的中间体的方法。

6. 发明公开

EP1546673A4 NOVEL GREEN AND ORANGE FLUORESCENT LABELS AND THEIR USES 审中-公开
标题翻译：奥古斯丁绿色荧光灯
公开(公告)号：EP1546673A4
公开(公告)日：2006-08-09
申请号：EP03754878
申请日：2003-09-23
申请人： CHROMAGEN INC
发明人： BHATT RAM , CONRAD MICHAEL J , BENCHEIKH AZZOUZ , XIONG YIFENG
IPC分类号： G01N1/00 , C07C309/50 , C07C309/51 , C07C311/29 , C07C331/20 , C07D207/44 , C07D207/452 , C07D207/46 , G01N33/533
CPC分类号： C07D207/46 , C07C309/50 , C07C309/51 , C07C311/29 , C07C331/20 , C07C2603/50 , C07D207/452 , G01N33/533 , Y10S436/80
摘要： The present invention provides novel fluorescent compounds and covalent attachment chemistries which facilitate the use of these compounds as labels for ultrasensitive and quantitative fluorescent detection of low levels of biomolecules. In a preferred embodiment, the fluorescent labels of this invention are novel derivatives of the hydroxy-pyrene trisulphonic and disulphonic acids which may be used in any assay in which radioisotopes, colored dyes or other fluorescent molecules are currently used. Thus, for example, any assay using labeled antibodies, proteins, oligonucleotides or lipids, including fluorescent cell sorting, fluorescence microscopy (including dark-field microscopy), fluorescence polarization assays, ligand, receptor binding assays, receptor activation assays and diagnostic assays can benefit from use of the compounds disclosed herein.
摘要翻译：本发明提供了新颖的荧光化合物和共价附着化学物质，其有利于这些化合物用作低水平生物分子的超敏感和定量荧光检测的标签。在优选的实施方案中，本发明的荧光标记是羟基芘三磺酸和二磺酸的新衍生物，其可用于目前使用放射性同位素，着色染料或其它荧光分子的任何测定中。因此，例如，使用标记的抗体，蛋白质，寡核苷酸或脂质（包括荧光细胞分选，荧光显微术（包括暗视野显微镜），荧光偏振测定，配体，受体结合测定，受体活化测定和诊断测定）使用本文公开的化合物。

7. 发明授权

EP1315695B1 BENZENE TRICARBOXYLIC ACID AMIDES AS INSULIN RECEPTOR ACTIVATORS 有权
标题翻译： BENZOLTRICARBONSÄUREAMIDE作为活化剂胰岛素受体
公开(公告)号：EP1315695B1
公开(公告)日：2005-07-13
申请号：EP01968657.5
申请日：2001-09-06
申请人： TELIK, INC.
发明人： Robinson, Louise , Cairns, Nicholas , Manchem, Prasad V. V. S. V. , Chow, Steven R.
IPC分类号： C07C235/84 , C07C309/28 , C07C231/02 , C07C231/12 , C07C303/22 , A61K31/185 , G01N33/50
CPC分类号： G01N33/5005 , C07C233/81 , C07C309/51 , G01N33/566 , G01N2333/912 , G01N2800/042
摘要： The present invention relates to trimesic acid amides, pharmaceutical compositions comprising said compounds, uses of said compounds and compositions, and processes for their preparation. Specifically, this invention relates to means to enhance insulin-dependent glucose uptake. More specifically, the invention concerns compounds and pharmaceutical compositions that active the insulin receptor kinase, which leads to an increased sensitivity to insulin and an increase in glucose uptake, as well as processes for preparation of the compounds. As such, the invention also concerns methods or uses of the compounds for the treatment of animals with hyperglycemia, especially for the treatment of type 2 diabetes.

8. 发明公开

EP1440190A2 VERFAHREN ZUR BEHANDLUNG VON LÖSUNGSMITTELGESPONNENEN CELLULOSISCHEN FASERN 有权
标题翻译：了治疗溶剂编织纤维素纤维
公开(公告)号：EP1440190A2
公开(公告)日：2004-07-28
申请号：EP02778982.5
申请日：2002-10-30
申请人： LENZING AKTIENGESELLSCHAFT
发明人： RENFREW, Andrew Hunter Morris
IPC分类号： D01F11/00
CPC分类号： C07C309/51 , D01F2/00 , D01F11/02 , D06M13/41
摘要： The invention relates to a method for treating solvent-spun cellulose fibers during which the fibers are brought into contact with a textile auxiliary in an alkaline medium. The inventive method is characterized in that a compound of general formula (I) or a salt thereof is used as the textile auxiliary, whereby: R1 is a binding link selected from the group consisting of a linear or branched chain with 1 to 4 C atoms and phenyl; R2 and R3 are identical or different from one another and are selected from the group consisting of (CH2)m-CH=CH2 with m ranging from 0 to 2, and; R4 represents an ionic group and/or a group that can be ionized in the alkaline medium.

9. 发明公开

EP0910358A1 PHENYL DERIVATIVES USEFUL AS BLOCKERS OF CHLORIDE CHANNELS 失效
标题翻译：苯基衍生物氯化物通道阻滞剂
公开(公告)号：EP0910358A1
公开(公告)日：1999-04-28
申请号：EP97924020.0
申请日：1997-05-26
申请人： NEUROSEARCH A/S
发明人： CHRISTOPHERSEN, Palle , PEDERSEN, Ove
IPC分类号： A61K31 , A61P1 , A61P7 , A61P9 , A61P27 , A61P29 , A61P37 , C07C233 , C07C271 , C07C275 , C07C309 , C07C311 , C07C335
CPC分类号： C07C233/55 , A61K31/155 , A61K31/17 , C07C271/58 , C07C275/40 , C07C309/51 , C07C311/08 , C07C311/21 , C07C311/47 , C07C311/60 , C07C335/22
摘要： The present invention relates to a method for the treatment of a disorder or disease of a living animal body, including a human, which disorder or disease is responsive to the blockade of chloride channels, comprising administering to a living animal body in need thereof a therapeutically effective amount of a compound having formula (I) or a pharmaceutically acceptable salt thereof wherein R?2, R3, R4 and R5¿ are each independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, amino, and aryl, aralkyl, arylamino, aryloxy, aryl-CO-, or heteroaryl, wherein the aryl or heteroaryl group may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro and amino; or R?3 and R4 or R4 and R5¿ together form a fused 4 to 7 membered carbocyclic ring which may be unsaturated, or partially or fully saturated while the other substituents R?2, R3, R4 and R5¿ is as defined above; Y is -CO-, -CS-, -SO¿2?-, or -C(=N-R?8¿)-, wherein R8 is hydrogen, alkyl, or cyano; X is -NH-, -CH¿2?-NH-, -SO2-NH-, or -CH2-; Z is -NR?6¿-, -O-, -CH=CH-, -N=CH-, -CH=N-, or -NR6-CH2-, wherein R6 is hydrogen, or alkyl; R?11, R12, R13, R14 and R15¿ are each independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, amino, and aryl, aralkyl, arylamino, aryloxy, aryl-CO-, or heteroaryl, wherein the aryl or heteroaryl group may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro and amino; or one of R?11 and R12, R12 and R13, R13 and R14 or R14 and R15¿ together form a fused 4 to 7 membered carbocyclic ring which may be unsaturated, or partially or fully saturated while the other substituents R?11, R12, R13, R14 and R15¿ is as defined above.

10. 发明授权

EP0467185B1 Oligomers, their uses and formulations 失效转让
标题翻译：低聚物，它们的用途和配方
公开(公告)号：EP0467185B1
公开(公告)日：1998-10-21
申请号：EP91111315.7
申请日：1991-07-08
申请人： THE DOW CHEMICAL COMPANY , MERRELL PHARMACEUTICALS INC.
发明人： Cardin, Alan D. , Jackson, Richard L. , Mullins, Michael J.
IPC分类号： C08G71/02 , C08G64/08 , C08G63/688 , C08G69/32 , C07C309/51 , C07C309/42 , A61K31/795 , A61K31/74
CPC分类号： A61K31/185 , A61K31/785 , A61K31/795 , C07C309/42 , C07C309/51 , C08G63/19 , C08G63/6884 , C08G63/6924 , C08G64/06 , C08G64/081 , C08G64/083 , C08G69/26 , C08G69/32 , C08G71/02 , Y10S514/885

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