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2. 发明公开

EP4331681A3 METHOD FOR DELIVERING ACTIVATORS TO CELLS 审中-实审
公开(公告)号：EP4331681A3
公开(公告)日：2024-05-22
申请号：EP24150035.4
申请日：2019-03-14
申请人： Kabushiki Kaisha Toshiba
发明人： ISHIHARA, Mitsuko , AKAHOSHI, Eiichi , NAITO, Katsuyuki , NOZAKI, Emi , SARUWATARI, Saeko
IPC分类号： A61P43/00
CPC分类号： A61K31/7088 , A61K31/7105 , A61K31/711 , A61K45/00 , A61K47/24 , A61K47/18 , A61K47/22 , A61K48/00 , A61P43/00 , C07C229/24 , C07D233/02 , C07D243/08 , C07D251/04 , C07D295/15 , C07D295/13 , C07D211/14 , C07D241/04 , A61K9/1272
摘要： The present embodiment provides a method for delivering activators to cells, wherein said activator containing lipid particles are brought into contact with the cells,
where a compound represented by the formula (1):

Q-CHR2 (1)

wherein
Q is represented by the following formula (1-Q):

RQ12N-(CRQ22)q1-NRQ1-(CRQ22)q2-* (1-Q)

wherein
each RQ1 is independently an alkyl,
each RQ2 is independently hydrogen or an alkyl,
any two of RQ1s and RQ2s may link together to form a nitrogen-containing alicyclic ring,
q1 is an integer of 1 to 4,
q2 is an integer of 0 to 4, and
the mark * indicates the position bonding to -CHR2; and
each R is independently an aliphatic group of C12 to C24;
wherein said R is represented by the following formula (1-R):

-LR1-C(=O)-O-LR2 (1-R)

where
LR1 is alkylene and
LR2 is represented by the following formula (1-R2):

-CH2-CH=CH-(CH2)r2-H (1-R2)

where r2 is an integer of 1 to 10.

4. 发明公开

EP3277083A1 ORGAN PRESERVATION COMPOSITION 审中-实审转让
标题翻译：器官保存组成
公开(公告)号：EP3277083A1
公开(公告)日：2018-02-07
申请号：EP16727247.5
申请日：2016-04-01
申请人： TX Innovations B.V.
发明人： DOORSCHODT, Benedict Marie
IPC分类号： A01N1/02
CPC分类号： A01N1/0226 , C01B25/30 , C01D7/00 , C07C229/08 , C07C229/24 , C07C237/10 , C07C309/14 , C07K5/0806 , C07K5/0819 , C08L71/08
摘要： An aqueous organ preservation solution includes taurine and L-alanine-L-glutamine and glutamic acid. The organ preservation composition can be stored in a solid state, for example in the form of small particles (e.g. a powder or micronized powder), and be dissolved in water, thereby instantly providing a ready-to-use organ preservation solution.

5. 发明授权

EP2847177B1 METHODS FOR MAKING OXETAN-3-YLMETHANAMINES 有权
标题翻译：制备OXETAN-3-YLMETHANAMINES的方法
公开(公告)号：EP2847177B1
公开(公告)日：2017-10-11
申请号：EP13724059.4
申请日：2013-05-01
申请人： Boehringer Ingelheim International GmbH
发明人： KAPADIA, Suresh, R. , REEVES, Jonathan, Timothy , ZENG, Xingzhong , ERIKSSON, Magnus Carl Arne
IPC分类号： C07D305/06 , C07C213/02 , C07C215/10 , C07C227/10 , C07C229/24
CPC分类号： C07D305/06 , C07C213/00 , C07C215/10 , C07C215/28 , C07C227/10 , C07C229/24 , C07C229/34

6. 发明公开

EP3214069A1 COMPOSITIONS PULVERULENTES D'UN COMPLEXE ENTRE UN ACIDE ET UN METAL ET LEUR PROCEDE DE PREPARATION 有权
标题翻译：酸和金属之间的络合物的强制组合物以及制备该组合物的方法
公开(公告)号：EP3214069A1
公开(公告)日：2017-09-06
申请号：EP17164032.9
申请日：2013-03-15
申请人： Innov'ia 3i
发明人： BUISSON, Pierre , HUET, Robert , FOURNIER, Sébastien , VENDEVILLE, Jean-Eudes
IPC分类号： C07C319/20 , C07C323/52 , C07C323/58 , C07C227/18 , C07C229/76 , B01J2/04 , C08L5/00 , A23K20/147 , A23K20/22 , A23K20/24 , A23K50/75
CPC分类号： C07C323/58 , A23K20/147 , A23K20/22 , A23K20/24 , A23K20/30 , A23K50/75 , B01J2/04 , C07C227/14 , C07C227/18 , C07C229/24 , C07C229/76 , C07C319/20 , C07C323/52 , C07F3/00 , C07F3/006 , C07F3/02 , C07F3/04 , C07F3/06 , C07F5/00 , C07F5/02 , C07F5/06 , C07F13/00 , C07F15/0086 , C07F15/02 , C07F15/04 , C07F15/06 , C08L5/00 , Y10T428/2982
摘要： La présente invention a pour objet des compositions pulvérulentes d'un complexe entre un acide et un métal et leur procédé de préparation.
摘要翻译：本发明涉及酸和金属之间的络合物的粉末组合物及其制备方法。

7. 发明授权

EP3004048B1 VERFAHREN ZUR HERSTELLUNG VON AMINOSÄUREN 有权
标题翻译：用于生产氨基
公开(公告)号：EP3004048B1
公开(公告)日：2017-03-08
申请号：EP14725973.3
申请日：2014-05-14
申请人： BASF SE
发明人： GRÜNANGER, Christian , BOU CHEDID, Roland , BIEL, Markus, Christian , MELDER, Johann-Peter
IPC分类号： C07C227/08
CPC分类号： C07C227/08 , C07C229/24 , C07C229/22 , C07C229/08

8. 发明公开

EP3127896A1 METHOD FOR PREPARING IMINODISUCCINATE CHELATING AGENT 有权转让
标题翻译：制备亚胺基琥珀酸螯合剂的方法
公开(公告)号：EP3127896A1
公开(公告)日：2017-02-08
申请号：EP15772328.9
申请日：2015-02-28
申请人： Hebei Think-Do Environment Co.,Ltd.
发明人： LI, Wenxi , XING, Zhenping
IPC分类号： C07C229/24 , C07C227/18
CPC分类号： C07C227/18 , C07C229/24
摘要： A method for preparing an iminodisuccinate chelating agent, wherein a reaction comprising raw material A, raw material B, an alkali metal hydroxide, and water is carried out under ambient pressure, and at a pH in the range of 6-12 and a reaction temperature ranging from 65°C to a boiling reflux temperature, and the mixed liquid obtained after the reaction is a mixture containing the iminodisuccinate chelating agent. The raw material A is a compound capable of obtaining a maleate through alkaline hydrolysis; and the raw material B is a compound capable of obtaining an aspartic acid through alkaline hydrolysis. With mild reaction conditions, a short reaction time and a high reaction yield, the preparation method is able to shorten the production process, improve the production efficiency, and reduce the production cost, and it is truly a preparation method which is highly efficient, environmentally friendly, and extremely suitable for industrial scale production.
摘要翻译：制备亚氨基二琥珀酸盐螯合剂的方法，其中包括原料A，原料B，碱金属氢氧化物和水的反应在环境压力下进行，并且在6-12的pH和反应温度在65℃至沸腾回流温度范围内，并且反应后获得的混合液体是含有亚氨基二琥珀酸盐螯合剂的混合物。原料A是能够通过碱水解获得马来酸盐的化合物，原料B是能够通过碱水解获得天冬氨酸的化合物。该方法反应条件温和，反应时间短，反应收率高，能够缩短生产工艺，提高生产效率，降低生产成本，是一种真正高效，环保的制备方法友好，非常适合工业规模生产。

9. 发明授权

EP2944959B1 HEMOGLOBIN STABILIZING STORAGE SOLUTION 失效
标题翻译：血红蛋白稳定化存储解决方案
公开(公告)号：EP2944959B1
公开(公告)日：2016-11-30
申请号：EP15174423.2
申请日：2008-10-06
申请人： Eiken Chemical Co., Ltd.
发明人： SUGO, Shin
IPC分类号： G01N33/531 , G01N1/28 , G01N33/48 , G01N33/72 , C07C229/00
CPC分类号： G01N33/721 , C07C229/24 , G01N33/80 , Y10T436/108331

10. 发明公开

EP3083553A1 POLYESTER POLYQUATERNARY AMMONIUM COMPOUND COLLECTORS FOR REVERSE FROTH FLOTATION OF SILICATES FROM NONSULFIDIC ORES 有权
标题翻译：聚季聚酯铵化合物收藏家含磷酸盐的矿石和含铁硅酸盐矿物反向泡沫浮选
公开(公告)号：EP3083553A1
公开(公告)日：2016-10-26
申请号：EP14811922.5
申请日：2014-12-15
申请人： Akzo Nobel Chemicals International B.V.
发明人： SMOLKO-SCHVARZMAYR, Natalija , KLINGBERG, Anders
IPC分类号： C07C219/06 , C11D1/62 , C07D219/06
CPC分类号： C08G63/916 , B03D1/011 , B03D1/016 , B03D1/02 , B03D1/021 , B03D2201/02 , B03D2201/06 , B03D2203/06 , C07C229/24 , C07C229/26 , C07D219/06
摘要： The present invention relates to a compound obtainable by the condensation of a polyol having 3-4 hydroxyl groups, adicarboxylic acid or a derivative thereof, an alkanolamine anda fatty acid, followed by reaction with an alkylating agent. This compound is useful as a collector in a process for the reverse froth flotation of non-sulfidic ores containing silicate as impurities, especially phosphate ores.
摘要翻译：本发明通过具有3-4个羟基基团，adicarboxylic酸或其衍生物，链烷醇胺和脂肪酸的多元醇的缩合，随后反应与烷基化剂，以涉及一种化合物可获得的。该化合物是如在过程的收集器，用于非硫化矿含硅酸盐作为杂质，爱尤其磷酸盐矿石的反向泡沫浮选是有用的。

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