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    • 9. 发明公开
    • SYSTEM ZUR ENTFERNUNG VON PROINFLAMMATORISCHEN MEDIATOREN SOWIE VON GRANULOZYTEN UND MONOZYTEN AUS BLUT
    • EP3185926A1
    • 2017-07-05
    • EP15763840.4
    • 2015-08-25
    • 3M Innovative Properties Company
    • VON HARTEN, BodoKRIETER, DetlefLEMKE, Horst Dieter
    • A61M1/34A61M1/36B01D67/00
    • A61M1/3633A61M1/34A61M1/3406A61M1/341A61M1/3472A61M1/3679A61M1/3693A61M2202/0014A61M2202/0441A61M2202/0443A61M2202/0445B01D15/26B01D39/14B01D61/00B01D63/02B01D69/02B01D2325/20B01J20/28
    • The invention relates to a blood treatment system comprising at least one first device and at least one second device. The first device is a membrane filter for removing toxic mediators from blood, and the second device is suitable for removing granulocytes and monocytes from blood. The first device has a first blood-side flow path for conducting blood, and the second device has a second blood-side flow path. The first and second device are connected serially one behind the other such that the first blood-side flow path is fluidically connected to the second blood-side flow path. The membrane filter has a filter interior in the housing of the membrane filter and a semi-permeable membrane arranged in the filter interior, said membrane separating the filter interior into a retentate area and a permeate area. The housing has a blood inlet device and a blood outlet device, which are fluidically connected to the retentate area, and a permeate outlet for discharging permeate from the permeate area. The blood inlet device, the retentate area, and the blood outlet device form the first blood-side flow path. The membrane filter has a separating characteristic such that the filter coefficient for albumin, SK
      Alb , ranges from 0.015 to 0.35.
    • 本发明涉及包括至少一个第一装置和至少一个第二装置的血液处理系统。 第一种装置是用于去除血液中有毒介质的膜过滤器,第二种装置适用于从血液中去除粒细胞和单核细胞。 第一装置具有用于导血的第一血液侧流路,第二装置具有第二血液侧流路。 第一和第二装置串联连接,使得第一血液侧流动路径流体连接到第二血液侧流动路径。 膜过滤器在膜过滤器的壳体中具有过滤器内部,并且在过滤器内部具有半透膜,所述膜将过滤器内部分隔成滞留物区域和渗透物区域。 壳体具有与滞留区域流体连接的血液入口装置和血液出口装置以及用于从渗透区域排出渗透物的渗透物出口。 血液入口装置,滞留物区域和血液出口装置形成第一血液侧流动路径。 膜过滤器具有分离特性,使得白蛋白SKAlb的过滤系数范围为0.015至0.35。