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1. 发明公开

EP3256139A4 IRON OXIDE NANOPARTICLES AND METHODS OF USE THEREOF 审中-实审
公开(公告)号：EP3256139A4
公开(公告)日：2018-07-18
申请号：EP16750009
申请日：2016-02-12
申请人： UNIV PENNSYLVANIA
发明人： KOO HYUN , GAO LIZENG , CORMODE DAVID , NAHA PRATAP
IPC分类号： A61K9/51 , A01N59/16 , A01P1/00 , A61K33/26
CPC分类号： A61K8/19 , A01N59/16 , A61K8/0245 , A61K8/20 , A61K8/22 , A61K8/66 , A61K8/73 , A61K9/006 , A61K9/0063 , A61K9/14 , A61K9/5161 , A61K33/26 , A61K33/40 , A61K47/6923 , A61K2800/413 , A61K2800/624 , A61K2800/92 , A61Q11/00 , Y02A50/471 , Y02A50/473 , A61K2300/00 , A01N25/12 , A01N25/26 , A01N59/00 , A01N59/06 , A01N59/10 , A01N59/20 , A01N59/26
摘要： The presently disclosed subject matter relates to iron oxide nanoparticle compositions and formulations thereof for: (1) the treatment and elimination of biofilms; (2) the prevention of biofilm formation; (3) biofilm extracellular matrix degradation; (4) the inhibition of bacterial viability and growth within the biofilm; and (5) the prevention of tooth or apatitic demineralization. In particular, the presently disclosed subject matter provides a composition for the prevention and treatment of an oral disease (e.g., dental caries) that includes one or more iron oxide nanoparticles and hydrogen peroxide.

2. 发明授权

EP2730280B1 A menthane carboxamide for the treatment of skin inflammation 有权
标题翻译：薄荷甲酰胺用于治疗皮肤炎症
公开(公告)号：EP2730280B1
公开(公告)日：2018-05-09
申请号：EP12191877.5
申请日：2012-11-08
申请人： Symrise AG
发明人： Krammer, Gerhard , Siegel, Sven , Middendorf, Silke
IPC分类号： A61K31/167 , A61K31/196 , A61K45/06 , A61P11/00 , A61P17/00 , A61K8/42 , A61K9/00 , A61K9/68 , A61Q11/00
CPC分类号： A61K31/167 , A61K8/42 , A61K9/0056 , A61K9/0058 , A61K9/006 , A61K9/0063 , A61K9/0095 , A61K31/196 , A61K45/06 , A61Q11/00
摘要： Suggested is a pharmaceutical composition, comprising menthane carboxylic acid-N-(4-methoxy-phenyl)-amide.

3. 发明公开

EP3086785A4 IMPROVED LOCAL ANESTHETIC SOLUTION FOR DENTAL AND/OR CONTRAST MEDIA USE 审中-公开
标题翻译： VERBESSERTELÖSUNGFÜRLOKALANÄSTHESIEZURZAHNÄRZTLICHENVERWENDUNG UND / ODER KONTRASTMITTELVERWENDUNG
公开(公告)号：EP3086785A4
公开(公告)日：2017-08-30
申请号：EP15733133
申请日：2015-01-01
申请人： REAL TIME IMAGING TECH LLC
发明人： UZBELGER FELDMAN DANIEL
IPC分类号： A61K9/08 , A61K31/137 , A61K31/167 , A61K31/245 , A61K31/381 , A61K31/445 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/26 , A61P23/02
CPC分类号： A61K31/167 , A61B6/032 , A61B6/14 , A61B6/481 , A61B6/485 , A61K9/0019 , A61K9/0043 , A61K9/0063 , A61K9/08 , A61K31/137 , A61K31/245 , A61K31/381 , A61K31/445 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/26 , A61K49/04 , A61M5/14 , A61M5/178 , A61M11/00 , A61M2202/048 , A61M2210/0618 , A61M2210/0625 , A61K2300/00
摘要： An improved local anesthetic solution with diminished bitter taste includes an anesthetic agent, an anesthetic solution vehicle, and a bitterness suppressant. The bitterness suppressant includes one or more compounds selected from the group consisting of: a sugar selected from the group consisting of monosaccharide sugars, disaccharide sugars, polysaccharide sugars, and combinations of the any of the foregoing; sweet-tasting compounds; acids; amino acids; salts; miscellaneous suppressant substances; and combinations of any of the foregoing. The improved local anesthetic solution optionally includes one or more additional agents selected from the group consisting of: buffering agents; vasoconstrictors; preservative compounds; stabilizers; contrast media agents; and combinations of any of the foregoing.
摘要翻译：改善的苦味减弱的局部麻醉剂溶液包括麻醉剂，麻醉溶液载体和抑制苦味剂。苦味抑制剂包括选自以下的一种或多种化合物：选自单糖糖，二糖糖，多糖糖和前述任何的组合的糖; 甜味化合物; 酸; 氨基酸; 盐; 杂项抑制物质; 以及任何前述的组合。改良的局部麻醉剂溶液任选地包含一种或多种选自以下的另外的试剂：缓冲剂; 血管收缩剂; 防腐剂化合物; 稳定剂; 造影剂; 以及任何前述的组合。

4. 发明公开

EP3119420A2 DELIVERY SYSTEM COMPRISING A PROTEOLYTIC ENZYME OR EFFECTOR THEREOF FOR USE IN A METHOD FOR ORAL TREATMENT AND USES THEREOF 有权
标题翻译：与口服治疗蛋白水解酶或效应及其用于使用的工艺，电源系统及其应用
公开(公告)号：EP3119420A2
公开(公告)日：2017-01-25
申请号：EP15731730.6
申请日：2015-03-19
申请人： Technion Research & Development Foundation Ltd.
发明人： SCHROEDER, Avraham D. , ZINGER, Assaf Yosef , HERMAN, Avishay
IPC分类号： A61K38/48
CPC分类号： A61K38/4886 , A61C7/00 , A61C19/063 , A61K9/0063 , A61K9/127 , C12Y304/24007
摘要： The present disclosure provides a delivery system comprising (i) a physiologically acceptable carrier and (ii) a proteolytic enzyme or effector thereof for use in a method for relaxing fibers within a subject's oral cavity. In some embodiments, the relaxation is for use in tooth manipulation (particularly repositioning). In some embodiments, the method involves the use of the proteolytic enzyme or effector thereof at a concentration effective to cause relaxation of fibers between the tooth's alveolar bone and gingiva while maintaining integrity of the fibers surrounding the tooth. Also disclosed herein are methods for fiber relaxation and/or repositioning of tooth making use of the proteolytic enzyme or effector thereof.
摘要翻译：本发明提供了一种输送系统，包括（i）生理学上可接受的载体和（ii）的蛋白水解酶或效应物，其用在受试者的口腔内放松纤维的方法。在一些实施方案中，松弛是用于牙齿操作（特别是重新定位）使用。在一些实施方案中，该方法涉及使用蛋白水解酶或效应的其在有效地使所述牙齿的牙槽骨和牙龈之间纤维的松弛，同时保持牙齿周围的纤维的完整性的浓度。所以光盘中游离缺失是纤维松弛和/或齿利用所述蛋白水解酶或效应物的重新定位的方法。

5. 发明公开

EP3068450A1 ZAHNPROTHESE ALS DARREICHUNGSFORM ZUR BEHANDLUNG CHRONISCHER ERKRANKUNGEN 有权转让
公开(公告)号：EP3068450A1
公开(公告)日：2016-09-21
申请号：EP14799992.4
申请日：2014-11-11
申请人： Heraeus Kulzer GmbH
发明人： RUPPERT, Klaus
IPC分类号： A61L27/54 , A61K9/00 , A61K6/00 , A61M31/00
CPC分类号： A61L27/54 , A61C5/50 , A61C8/00 , A61C8/005 , A61C19/063 , A61K6/0067 , A61K6/0073 , A61K9/0063 , A61K31/137 , A61K31/444 , A61K38/28 , A61K45/06 , A61K47/02 , A61K47/32 , A61P3/10 , A61P25/16 , A61P25/24 , A61P25/28 , A61P31/04 , A61K6/0023 , C08L33/08 , C08L33/10 , A61K6/0029
摘要： The present invention relates to a three-dimensional long-term active substance depot (Fig. 1a-k) which in particular is prepared on an individual basis, with a fissure surface and/or cutting edge individual to the patient, as a replica of at least part of a tooth, in particular of an individual molar of the patient, comprising at least one dental material and at least one active substance with a content that is sufficient for a continuous therapeutically effective dose over a period of at least one week, in particular sufficient to ensure a therapeutically active concentration of active substance in the blood of the patient over a prolonged period of several weeks. The invention likewise relates to a pharmaceutically active dental composition and to a pharmaceutically active dental material obtainable therefrom for producing the three-dimensional active substance depot, a method for producing the three-dimensional long-term active substance depot, its use for transmucosal active substance release and for treating chronic diseases. The invention therefore also relates to a method for long-term administration of at least one active substance for transmucosal active substance release for treating chronic diseases such as dementia, diabetes, Alzheimer's disease, Parkinson's disease, depression, cardiovascular disease, osteoporosis, arthritis, gout and rheumatism.
摘要翻译：本发明涉及三维长期活性物质储库（图1a-k），其特别是单独制备具有患者个体的裂隙表面和/或切割边缘的复制品牙齿的至少一部分，特别是患者的单独摩擦的至少一部分包括至少一种牙科材料和至少一种活性物质，其含量足以在至少一周的时间内持续治疗有效剂量，特别足以确保在数周内延长的患者血液中活性物质的治疗活性浓度。本发明同样涉及一种药学活性牙科用组合物及其可从其获得的用于制备三维活性物质贮库的药物活性牙科用材料，三维长效活性物质贮库的制造方法，其用于经粘膜活性物质释放和治疗慢性疾病。因此，本发明还涉及用于长期施用至少一种用于经粘膜活性物质释放的活性物质用于治疗慢性疾病如痴呆，糖尿病，阿尔茨海默病，帕金森病，抑郁症，心血管疾病，骨质疏松症，关节炎，痛风的治疗方法和风湿病。

6. 发明公开

EP2948126A1 ASSEMBLY OF MICELLE AGGREGATES OF SURFACTANT MICELLES AND SILVER NANOPARTICLES AND USE AS ANTIBACTERIAL AGENT 审中-公开
标题翻译：作者MIZELLENAGGREGATEN OFF和表面活性剂胶束安排的银纳米粒子和它们作为抗菌剂
公开(公告)号：EP2948126A1
公开(公告)日：2015-12-02
申请号：EP14743761.0
申请日：2014-01-24
申请人： Otago Innovation Limited
发明人： MELEDANDRI, Carla Joy , SCHWASS, Donald Royden
IPC分类号： A61K6/00 , A61K33/38 , A61P31/04
CPC分类号： A61K33/38 , A61C19/06 , A61K9/0063 , A61K9/1075 , A61K9/14 , A61K47/20 , A61N1/205 , A61N1/30 , Y02A50/473
摘要： An assembly of micelle aggregates, wherein each aggregate comprises micelles of an anionic surfactant and nano-sized particles of metallic silver. A product comprising such assemblies for use in treating or preventing bacterial infections.

7. 发明公开

EP2923577A1 ANTIMICROBIAL COMPOSITION 审中-公开
标题翻译：抗菌组合物
公开(公告)号：EP2923577A1
公开(公告)日：2015-09-30
申请号：EP13854691.6
申请日：2013-11-08
申请人： Eco Friendly Institute Limited , Trife.Inc.
发明人： NAGATOSHI Kohei
IPC分类号： A01N63/02 , A01N65/34 , A61K8/64 , A61K8/97 , A61Q11/00
CPC分类号： A61K38/164 , A01N65/00 , A61K8/64 , A61K8/97 , A61K9/0063 , A61K36/736 , A61Q11/00 , A01N43/90 , A01N63/02 , A01N65/34
摘要： The present invention provides a highly safe antibacterial composition showing antibacterial activity against both Gram-positive bacteria and Gram-negative bacteria, of which flavor is not impaired. The antibacterial composition of the present invention contains nisin, and one or two or more kinds of plant-derived ingredients selected from the group consisting of juice, extract, and distillate of a Rosaceae plant, and a mixture of these. It is preferred that the Rosaceae plant is a plant belonging to the genus Prunus , it is more preferred that the plant belonging to the genus Prunus is Prunus mume , and it is particularly preferred that the plant-derived ingredient is Prunus mume fruit juice. The antibacterial composition of the present invention is useful especially as a composition for oral cavity.
摘要翻译：本发明提供一种高度安全的抗菌组合物，其显示出对革兰氏阳性菌和革兰氏阴性菌的抗菌活性，其风味不受损害。本发明的抗菌组合物含有乳链菌肽以及选自由蔷薇科植物的汁液，提取物和馏出物组成的组中的1种或2种以上的植物来源成分及它们的混合物。优选蔷薇科植物是属于梅属的植物，更优选属于梅属的植物是梅属，并且特别优选的是源自植物的成分是梅属梅果汁。本发明的抗菌组合物特别用作口腔用组合物。

8. 发明公开

EP2763665A4 ANTIMICROBIAL COMPOSITIONS AND METHODS EMPLOYING SAME 有权转让
标题翻译：抗菌组合物和申请流程。
公开(公告)号：EP2763665A4
公开(公告)日：2015-09-23
申请号：EP12838205
申请日：2012-10-08
申请人： NEXT SCIENCE LLC
发明人： MYNTTI MATTHEW F
IPC分类号： A61K9/06 , A01N25/30 , A61K9/70 , A61L26/00 , A61P17/02 , A61P31/04
CPC分类号： A61K31/194 , A01N25/02 , A01N25/08 , A01N37/36 , A01N59/26 , A01N61/00 , A61K8/19 , A61K8/365 , A61K8/39 , A61K8/41 , A61K8/416 , A61K8/44 , A61K8/463 , A61K8/466 , A61K8/4926 , A61K8/4973 , A61K8/55 , A61K8/602 , A61K8/86 , A61K9/0014 , A61K9/0063 , A61K9/06 , A61K9/08 , A61K31/14 , A61K31/19 , A61K33/00 , A61K33/02 , A61K33/04 , A61K33/20 , A61K33/24 , A61K33/32 , A61K33/42 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/34 , A61L26/0066 , A61L2300/404 , A61Q11/00 , A61Q17/005 , A01N2300/00 , A01N25/30 , A01N59/00
摘要： An aqueous composition with a higher-than-neutral pH includes a significant amount of one or more surfactants and large amounts of osmotically active solutes. This composition, as well as an acidic counterpart and solid materials, can be used in a variety of applications such as wound care, oral care, medical equipment reprocessing, healthcare acquired infection and implant treatment.

9. 发明公开

EP2906179A1 TOPICAL UBIQUINOL ORAL SUPPLEMENT COMPOSITIONS WITH AMORPHOUS CALCIUM PHOSPHATE 审中-公开
标题翻译：无定形磷酸钙TOPICAL泛醇食品补充组合物
公开(公告)号：EP2906179A1
公开(公告)日：2015-08-19
申请号：EP13845393.1
申请日：2013-10-11
申请人： Premier Dental Products Company
发明人： MCHALE, William A. , BROWN, Dale G.
IPC分类号： A61K8/02 , A61K9/00 , A61P1/02 , A61P29/00
CPC分类号： A61K31/09 , A61K8/345 , A61K8/891 , A61K9/0014 , A61K9/006 , A61K9/0063 , A61K31/122 , A61K33/42 , A61K47/10 , A61P1/02 , A61Q11/00 , A61K2300/00
摘要： Topical, UBIQUINOL, adjunctive, supplement compositions, containing amorphous calcium phosphate fluoride (ACPF), useful in: reducing oxidative stress, relieving oral discomfort and dry mouth, and remineralizing hydroxyapatite; comprising: UBIQUINOL in an aqueous-free emulsion that also contains: a stabilizing composition for UBIQUINOL, spilanthes extract, a trans-oral mucosal, absorption facilitator and ACPF; wherein: the emulsion forms a mucoadhesive gel in the presence of saliva that undergoes gradual saliva dissolution effecting passive diffusion of the UBIQUINOL supplement and the spilanthes extract into the oral mucosa, and remineralizing of tooth surfaces with ACPF; resulting in: adjunctively increasing UBIQUINOL levels, reducing oxidative stress, regulating immune response, relieving oral discomfort and dry mouth, and remineralizing tooth surfaces.

10. 发明公开

EP2887929A2 COMPOUNDS FOR PREVENTING, REDUCING AND/OR ALLEVIATING ITCHY SKIN CONDITION(S) 审中-公开
标题翻译：化合物的预防，减少和/或减轻发痒（S）的皮肤
公开(公告)号：EP2887929A2
公开(公告)日：2015-07-01
申请号：EP12750387.8
申请日：2012-08-23
申请人： Symrise AG
发明人： SCHMAUS, Gerhard , KROHN, Michael , SOMBROEK, Dirk , HAUSTEDT, Lars Ole , KLUGE, Grit , KOCH, Oskar , KÖHLER, Antje
IPC分类号： A61K31/12 , A61K8/35 , A61Q19/00 , A61P17/04
CPC分类号： A61K31/12 , A23G4/12 , A61K8/35 , A61K9/0014 , A61K9/0063 , A61K9/06 , A61K9/1075 , A61K9/2018 , A61K45/06 , A61K47/00 , A61K2800/10 , A61K2800/75 , A61Q5/00 , A61Q5/002 , A61Q5/004 , A61Q5/006 , A61Q5/02 , A61Q5/04 , A61Q5/10 , A61Q5/12 , A61Q11/00 , A61Q13/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/007 , A61Q19/02 , A61Q19/04 , A61K2300/00
摘要： The present invention primarily relates to the use of one or more specific compounds and/or one or more respective salt(s) thereof for preventing, reducing or alleviating itchy skin condition(s), and/or as PAR-2 antagonist. Furthermore, the present invention relates to compositions (products or, respectively, formulations), in particular for topical administration, preferably cosmetic or pharmaceutical compositions, in particular for preventing, reducing or alleviating one or more itchy skin conditions and/or for providing a PAR-2 antagonistic effect, comprising or consisting of an effect amount of such compound(s) and/or salt(s) and one or more cosmetically and/or pharmaceutically acceptable carriers.

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