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    • 9. 发明公开
    • DENTAL CANALICULI SEALING AGENT AND METHOD FOR PRODUCING THE SAME
    • 用于密封牙小管和方法生产
    • EP2626058A1
    • 2013-08-14
    • EP11830599.4
    • 2011-09-30
    • KURARAY NORITAKE DENTAL INC.
    • HASHIMOTO, TadashiOSHITA, MizukoISHIHARA, Shumei
    • A61K6/033
    • A61K8/24A61K6/0017A61K6/033A61K6/0643A61K8/19A61K2800/59A61Q11/00
    • A dentinal tubule sealant comprises poorly-soluble calcium phosphate particles (A), a phosphorus-free calcium compound (B), and water (C), wherein the particles (A) are at least one member selected from the group consisting of dicalcium phosphate anhydrous [CaHPO 4 ] particles, α-tricalcium phosphate [α-Ca 3 (PO 4 ) 2 ] particles, β-tricalcium phosphate [β-Ca 3 (PO 4 ) 2 ] particles, amorphous calcium phosphate [Ca 3 (PO 4 ) 2 •nH 2 O] particles, calcium pyrophosphate [Ca 2 P 2 O 7 ] particles, calcium pyrophosphate dihydrate [Ca 2 P 2 O 7 •2H 2 O] particles, octacalcium phosphate pentahydrate [Ca 8 H 2 (PO 4 ) 6 •5H 2 O] particles, and dicalcium phosphate dihydrate [CaHPO 4 •2H 2 O] particles, and the dentinal tubule sealant contains 30 to 76% by weight of the particles (A), 0.001 to 4% by weight of the compound (B), and 23 to 69% by weight of the water (C). Thus, there is provided a dentinal tubule sealant capable of sealing dentinal tubules of an exposed dentin and also remineralizing the surrounding dentin after the sealing.
    • 牙小管密封剂包括难溶性磷酸钙粒子(A),无磷的钙化合物(B)和水(C),worin粒子(A)中的至少一个成员选自磷酸氢钙由......组成 无水[4使用CaHPO]颗粒,磷酸三钙±[±-Ca 3(PO 4)2]的颗粒,²磷酸三钙[²-CA 3(PO 4)2]的颗粒,无定形磷酸钙的[Ca 3(PO 4 )2€¢nH的2 O]粒子,焦磷酸钙的[Ca 2 P 2 O 7]颗粒,焦磷酸钙二水合物的[Ca 2 P 2 O 7€¢2H 2 O]粒子,磷酸八钙五水合物的[Ca 8 H 2(PO 4)6€¢5H 2 O]粒子,磷酸二钙二水合物[使用CaHPO 4€¢2H 2 O]粒子,和牙本质小管封闭剂含有30〜76%(重量)的颗粒(A),0.001至4% 重量的化合物(B),和23至69重量%的水(C)组成。 因此,提供了能够密封露出牙本质的牙本质小管并由此再矿化密封后周边牙本质的牙小管封闭剂。