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1. 发明公开

EP3003394A4 OCTAPOD IRON OXIDE NANOPARTICLES AS HIGH-PERFORMANCE T2 CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING 有权
标题翻译： OCTAPOD - 铁氧化物纳米颗粒高性能T2-DYE磁共振成像
公开(公告)号：EP3003394A4
公开(公告)日：2017-01-25
申请号：EP13886302
申请日：2013-06-03
申请人： THE U S A AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES , UNIV XIAMEN
发明人： GAO JINHAO , CHEN XIAOYUAN , ZHAO ZENGHUAN
IPC分类号： A61K49/00 , C01G49/08
CPC分类号： A61K49/1833 , A61K49/06 , A61K49/08 , A61K49/1818 , A61K49/1851 , C01G49/08
摘要： Disclosed are nanoparticles comprising octapod iron oxide having eight trigonal bipyramidal arms and a method of preparing the same. The nanoparticles are prepared by heating a mixture of a ferric carboxylate, a carboxylic acid, a chloride salt, water, and a non-polar solvent, to a temperature above about 300° C. Also disclosed is a method of magnetic resonance imaging a tissue in a mammal, comprising use of the aforesaid nanoparticles.

2. 发明公开

EP1988928A1 MAGNETIC NANO-COMPOSITE FOR CONTRAST AGENT, INTELLIGENT CONTRAST AGENT, DRUG DELIVERY AGENT FOR SIMULTANEOUS DIAGNOSIS AND TREATMENT, AND SEPARATION AGENT FOR TARGET SUBSTANCE 审中-公开
标题翻译：纳米磁性复合体对造影剂，SMART造影剂的药物输送剂为目标物质同时诊断和治疗脱模剂
公开(公告)号：EP1988928A1
公开(公告)日：2008-11-12
申请号：EP07709086.8
申请日：2007-02-23
申请人： Atgen Co.Ltd.
发明人： HAM, Seung-Joo , SUH, Jin-Suck , HUH, Yong-Min , YOON, Ho-Geun , YANG, Jae-Moon
IPC分类号： A61K49/06
CPC分类号： G01N33/574 , A61K41/0052 , A61K47/593 , A61K47/60 , A61K47/6923 , A61K49/1806 , A61K49/1833 , A61K49/1836 , A61K49/1839 , A61K49/1851 , A61K49/1857 , A61K49/186 , A61K49/1875 , A61K49/1887 , B82Y5/00 , G01N33/5434 , G01N2446/80
摘要： The present invention relates to water soluble magnetic nanocomposite using an amphiphilic compound. Specifically, the present invention relates to water soluble magnetic nanocomposite which may be not only used as a contrast agent for magnetic resonance imaging (MRI), an intelligent contrast agent for diagnosing cancer characterized by binding a tissue-specific binder ingredient, a drug delivery system for simultaneous diagnosis and treatment by polymerizing or enveloping drugs and binding a tissue-specific binder ingredient, but also used for separating a target substance using magnetism, and a process for preparing the same.

3. 发明公开

EP3209335A1 AGENTS FOR USE IN THE DETECTION OF NUCLEASE ACTIVITY 审中-公开
标题翻译：用于检测核酸酶活性的试剂
公开(公告)号：EP3209335A1
公开(公告)日：2017-08-30
申请号：EP15784338.4
申请日：2015-10-20
申请人： Hernández Hincapié, Frank J.
发明人： HERNANDEZ, Luiza Iuliana
IPC分类号： A61K49/08 , A61K49/12 , A61K49/18 , C12Q1/04 , C12Q1/44
CPC分类号： A61K49/10 , A61K49/085 , A61K49/12 , A61K49/1851 , C12Q1/04 , C12Q1/44 , G01N33/57419 , G01N33/57438 , G01N2333/922
摘要： The present invention relates to the field of diagnostics and, more in particular, to MRI activatable contrast agents and compositions thereof for the detection of nuclease activity, wherein said nuclease activity is caused by microbial infection or by nuclease activity related to cancer, particularly colon cancer or pancreatic cancer. Activatable contrast agents for MRI have been developed, wherein the oligonucleotide is flanked by a paramagnetic and a superparamagnetic agent, and thus providing magnetic quenching. Moreover, the oligonucleotide has regions that confer resistance to mammalian endonucleases and sensitivity to microbial endonucleases. When the activatable contrast agent of the invention is in the presence of microbial nuclease activity or a tumour cell nuclease activity, the oligonucleotide is cleaved, agents are unquenched, and the signal derived from the activated contrast agent is detected by MRI.
摘要翻译：本发明涉及诊断领域，并且更具体地涉及用于检测核酸酶活性的MRI可活化造影剂及其组合物，其中所述核酸酶活性由微生物感染或与癌症有关的核酸酶活性引起，特别是结肠癌或胰腺癌。已经开发了用于MRI的可活化造影剂，其中寡核苷酸侧翼为顺磁性和超顺磁性剂，因此提供磁性猝灭。而且，寡核苷酸具有赋予哺乳动物内切核酸酶抗性和对微生物内切核酸酶敏感性的区域。当本发明的可活化造影剂存在微生物核酸酶活性或肿瘤细胞核酸酶活性时，寡核苷酸被切割，试剂未被猝灭，并且通过MRI检测来自活化造影剂的信号。

4. 发明公开

EP2874663A1 NANOCONSTRUCTS WITH PHARMACOLOGICAL ACTIVITY 有权
标题翻译： NANOKONSTRUKTE MIT药剂师WIRKUNG
公开(公告)号：EP2874663A1
公开(公告)日：2015-05-27
申请号：EP13773359.8
申请日：2013-07-19
申请人： Università degli Studi di Milano - Bicocca , Universita' degli Studi di Milano
发明人： GRANUCCI, Francesca , PROSPERI, Davide , ZANONI, Ivan , CORSI, Fabio, Ruggero, Maria , COLOMBO, Miriam
IPC分类号： A61K47/48 , A61K49/18 , A61P29/00
CPC分类号： A61K9/5138 , A61K9/5115 , A61K38/1709 , A61K47/6935 , A61K49/1851 , C07K14/47
摘要： The present invention relates to methods and means of transport of active substances in the cell cytosol. In particular, the invention relates to means that make it possible to transport directly in the cytosol substances capable of interacting with protein systems, such as the family of nuclear factors of activated T-cells (NFATs) or nucleic acids localized in the cytosol. In particular, the invention relates to nanoconstructs useful in the treatment of inflammatory diseases, methods for their preparation, and compositions containing them.
摘要翻译：本发明涉及活性物质在细胞质溶胶中的运输方法和方法。特别地，本发明涉及使得可以直接在能够与蛋白质系统相互作用的细胞质物质例如活化的T细胞（NFAT）的核因子家族或定位于胞质溶胶中的核酸的物质转运。特别地，本发明涉及可用于治疗炎性疾病的纳米结构，其制备方法和含有它们的组合物。

5. 发明公开

EP2647389A1 Magnetic nanoparticle dispersion, its preparation and diagnostic and therapeutic use 审中-公开
标题翻译： Magnetische Nanopartikeldispersion，ihre Herstellung sowie diagnische und therapeutische Verwendung
公开(公告)号：EP2647389A1
公开(公告)日：2013-10-09
申请号：EP12163254.1
申请日：2012-04-04
申请人： Charité - Universitätsmedizin Berlin , Physikalisch-Technische Bundesanstalt (PTB)
发明人： Kratz, Harald , Wagner, Susanne , Schnorr, Jörg , Taupitz, Matthias , Ebert, Monika , Eberbeck, Dietmar
IPC分类号： A61K41/00 , A61K49/18
CPC分类号： A61K49/1851 , A61B5/0515 , A61B5/055 , A61B5/416 , A61B5/417 , A61B5/418 , A61K9/5161 , A61K41/0052
摘要： The present invention relates to magnetic particle dispersions comprising coated individual monocrystalline and/or polycrystalline nanoparticles of iron oxides and nanoparticulate aggregates (multi-core particles) thereof with improved nonlinear magnetization behavior and improved heating properties in alternating magnetic fields. When measured in a magnetic particle spectrometer (MPS) the particle dispersions show a pronounced overtone structure, especially in the higher harmonics, which surpasses all previously known particle systems many times over. Therefore, the dispersions are especially useful for applications such as MPI (magnetic particle imaging). In addition, the new particle dispersions are suitable for applications in therapeutic hyperthermia, particularly passive partial-body hyperthermia or cell tracking and magnetic resonance imaging (MRI). Hence, the diagnostic and therapeutic use of the dispersions as well as pharmaceutical compositions of diagnostic or therapeutic interest comprising these dispersions are also objects of the present invention.
摘要翻译：本发明涉及包含铁氧化物和纳米颗粒聚集体（多芯颗粒）的涂覆的单个单晶和/或多晶纳米颗粒的磁性颗粒分散体，其具有改进的非线性磁化行为和交替磁场中改进的加热性能。当在磁性粒子光谱仪（MPS）中测量时，颗粒分散体显示明显的泛音结构，特别是在高次谐波中，超过所有先前已知的粒子系统多次。因此，分散体对于诸如MPI（磁性颗粒成像）的应用尤其有用。此外，新的颗粒分散体适用于治疗性高热，特别是被动部分身体高热或细胞跟踪和磁共振成像（MRI）。因此，分散体的诊断和治疗用途以及包含这些分散体的诊断或治疗感兴趣的药物组合物也是本发明的目的。

6. 发明授权

EP2671570B1 MAGNETIC NANOPARTICLE, HAVING A CURIE TEMPERATURE WHICH IS WITHIN BIOCOMPATIBLE TEMPERATURE RANGE, AND METHOD FOR PREPARING SAME 有权转让
公开(公告)号：EP2671570B1
公开(公告)日：2018-05-30
申请号：EP12741665.9
申请日：2012-01-31
申请人： Korea University Research and Business Foundation
发明人： KIM, Young Keun , WU, Jun Hua , MIN, Ji Hyun , LEE, Ji-Sung , JUNG, Jae-Ho
IPC分类号： A61K9/16 , A61K47/50 , A61K47/02 , A61K49/08 , A61K49/18 , C01G45/12 , G01N33/58
CPC分类号： G01N27/72 , A61K49/1827 , A61K49/1851 , A61K49/1866 , A61K49/1875 , C01G45/12 , C01P2002/72 , C01P2002/85 , C01P2004/04 , C01P2004/62 , C01P2004/64 , C01P2006/42 , G01N33/587
摘要： The present invention relates to a magnetic nanoparticle having a Curie temperature which is within a biocompatible temperature range, a method for preparing same, and a nanocomposite and a target substance detection composition comprising the magnetic nanoparticle. As the magnetic nanoparticle of the present invention has a Curie temperature within the temperature range of 0 degrees centigrade to 41 degrees centigrade, the ferromagnetic and paramagnetic properties of the magnetic nanoparticle may be controlled within a biocompatible temperature range at a temperature at which a biological control agent is not destroyed, and the temperature of the magnetic nanoparticle is adjusted to control the magnetic properties thereof such that the properties of the magnetic nanoparticle may be used only when ferromagnetic properties are required, such as in the case of signal amplification in detecting, separating, and delivering biological control agents. Accordingly, the magnetic nanoparticle of the present invention can minimize adverse effects of ferromagnetic properties thereof, and can be used in the effective detection and separation of biological control agents.

7. 发明授权

EP2874663B1 NANOCONSTRUCTS WITH PHARMACOLOGICAL ACTIVITY 有权
标题翻译：纳米药物的药理活性
公开(公告)号：EP2874663B1
公开(公告)日：2018-01-10
申请号：EP13773359.8
申请日：2013-07-19
申请人： Università degli Studi di Milano - Bicocca , Universita' degli Studi di Milano
发明人： GRANUCCI, Francesca , PROSPERI, Davide , ZANONI, Ivan , CORSI, Fabio, Ruggero, Maria , COLOMBO, Miriam
IPC分类号： A61K47/50 , A61K49/18 , A61P29/00
CPC分类号： A61K9/5138 , A61K9/5115 , A61K38/1709 , A61K47/6935 , A61K49/1851 , C07K14/47
摘要： The present invention relates to methods and means of transport of active substances in the cell cytosol. In particular, the invention relates to means that make it possible to transport directly in the cytosol substances capable of interacting with protein systems, such as the family of nuclear factors of activated T-cells (NFATs) or nucleic acids localized in the cytosol. In particular, the invention relates to nanoconstructs useful in the treatment of inflammatory diseases, methods for their preparation, and compositions containing them.

8. 发明公开

EP3003394A1 OCTAPOD IRON OXIDE NANOPARTICLES AS HIGH-PERFORMANCE T2 CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING 有权
标题翻译： OCTAPOD-异山梨醇 - 纳米脂肪酸ALHHOCHLEISTUNGSFÄHIGET2-KONTRASTMITTEL ZUR MAGNETISCHEN RESONANZABBILDUNG
公开(公告)号：EP3003394A1
公开(公告)日：2016-04-13
申请号：EP13886302.2
申请日：2013-06-03
申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services , Xiamen University
发明人： GAO, Jinhao , CHEN, Xiaoyuan , ZHAO, Zenghuan
IPC分类号： A61K49/00
CPC分类号： A61K49/1833 , A61K49/06 , A61K49/08 , A61K49/1818 , A61K49/1851 , C01G49/08
摘要： Disclosed are nanoparticles comprising octapod iron oxide having eight trigonal bipyramidal arms and a method of preparing the same. The nanoparticles are prepared by heating a mixture of a ferric carboxylate, a carboxylic acid, a chloride salt, water, and a non-polar solvent, to a temperature above about 300° C. Also disclosed is a method of magnetic resonance imaging a tissue in a mammal, comprising use of the aforesaid nanoparticles.
摘要翻译：公开了包含具有八个三角双锥体臂的八脚氧化铁的纳米颗粒及其制备方法。通过将羧酸铁，羧酸，氯化物盐，水和非极性溶剂的混合物加热到高于约300℃的温度来制备纳米颗粒。还公开了一种磁共振成像组织在哺乳动物中，包括使用上述纳米颗粒。

9. 发明公开

EP1798504A1 Method of making dried particles 审中-公开
标题翻译： Verfahren zur Herstellung von getrockneter Partikel。
公开(公告)号：EP1798504A1
公开(公告)日：2007-06-20
申请号：EP05112378.4
申请日：2005-12-19
申请人： Koninklijke Philips Electronics N.V.
发明人： The designation of the inventor has not yet been filed
IPC分类号： F26B5/06 , A61K9/19
CPC分类号： A61K9/1676 , A61K9/1682 , A61K49/0002 , A61K49/1818 , A61K49/1851 , B82Y5/00 , F26B5/065
摘要： A method is provided that prepares resuspendable particles of a compound. The particles are prepared by drying a liquid that comprises the compound. The particles are dried in such a way that they do not aggregate on redispersion. The particles that are thus obtained are especially suitable for use in biosensors, as contrast agent or as part of a pharmaceutical composition.
摘要翻译：提供了制备化合物的可再悬浮颗粒的方法。通过干燥包含该化合物的液体来制备颗粒。颗粒被干燥，使得它们在再分散时不聚集。由此获得的颗粒特别适用于生物传感器，作为造影剂或作为药物组合物的一部分。

10. 发明授权

EP3003394B1 OCTAPOD IRON OXIDE NANOPARTICLES AS HIGH-PERFORMANCE T2 CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING 有权
公开(公告)号：EP3003394B1
公开(公告)日：2018-05-23
申请号：EP13886302.2
申请日：2013-06-03
申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services , Xiamen University
发明人： GAO, Jinhao , CHEN, Xiaoyuan , ZHAO, Zenghuan
IPC分类号： A61K49/00 , C01G49/08
CPC分类号： A61K49/1833 , A61K49/06 , A61K49/08 , A61K49/1818 , A61K49/1851 , C01G49/08
摘要： Disclosed are nanoparticles comprising octapod iron oxide having eight trigonal bipyramidal arms and a method of preparing the same. The nanoparticles are prepared by heating a mixture of a ferric carboxylate, a carboxylic acid, a chloride salt, water, and a non-polar solvent, to a temperature above about 300° C. Also disclosed is a method of magnetic resonance imaging a tissue in a mammal, comprising use of the aforesaid nanoparticles.

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