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1. 发明公开

EP3374779A1 APPARATUS AND METHODS FOR SPATIAL ENCODING OF FFL-BASED MPI DEVICES 有权
公开(公告)号：EP3374779A1
公开(公告)日：2018-09-19
申请号：EP16865075.2
申请日：2016-11-11
申请人： University of Massachusetts
发明人： TONYUSHKIN, Alexey
IPC分类号： G01R33/381 , G01R33/38 , G01R33/10 , G01R33/02 , A61B5/055 , A61B5/05
CPC分类号： G01R33/1276 , A61B5/02007 , A61B5/0515 , A61B5/418 , A61B5/4312 , A61B2576/00 , G01R33/10
摘要： Selection-focus coils de-signed for 3D FFL-based MPI may allow for spatial encoding without additional shift coils and provide relatively large FOV and field gradient with very flat FFL. Additionally, a single-sided FFL-based device which is capable of 3D imaging is disclosed. With sufficient current amplitudes, FFL could encode the whole volume of a small animal or penetrate deep into human organs such as the vascular system or lymph nodes. An MPI device based on the proposed selection scheme could be a compact and robust alternative to the state-of-the-art FFP (FFL)-based MPI scanners.

2. 发明授权

EP2790574B1 REMOVAL OF BACKGROUND IN MPI 失效转让
标题翻译：在MPI中删除背景
公开(公告)号：EP2790574B1
公开(公告)日：2018-03-21
申请号：EP12823097.6
申请日：2012-12-14
申请人： Koninklijke Philips N.V. , Philips Deutschland GmbH
发明人： RAHMER, Jürgen Erwin , GLEICH, Bernhard , WEIZENECKER, Jürgen
IPC分类号： A61B5/05 , A61B5/00 , G01R33/12
CPC分类号： G01N27/72 , A61B5/0515 , A61B5/7203 , A61B2576/00 , G01R33/1276 , G06T7/0012
摘要： An apparatus (100) detects magnetic particles in a field of view (28). The apparatus includes selection and focus magnetic field coil pairs (12, 14), drive pairs (16), and detection coils (148). A computer is configured to receive background signals with the detection coils, controls current supplied to the drive coil pair to shift the field of view in space, and reconstruct detection signals from the detection coils into an image of the field of view (28). The computer selects one or more frequency components of the detection signals and/or weighted by use of a frequency component specific signal quality factor obtained from the background signal measurements. Only the selected and/or weighted frequency components are used for reconstruction of the image.

3. 发明授权

EP1886278B1 METHOD OF DETERMINING A SPATIAL DISTRIBUTION OF MAGNETIC PARTICLES 失效转让
标题翻译：确定磁性粒子空间分布的方法
公开(公告)号：EP1886278B1
公开(公告)日：2018-02-21
申请号：EP05826735.2
申请日：2005-12-05
申请人： Philips Intellectual Property & Standards GmbH , Koninklijke Philips N.V.
发明人： NIELSEN, Tim, Philips Int. Prop. & Stand. GmbH , GLEICH, Bernhard, Philips Int. Prop. & Stand. GmbH , WEIZENECKER, Jürgen, Philips Int. Prop & Stand. GmbH
IPC分类号： G06T11/00
CPC分类号： A61B5/05 , A61B5/0515 , A61B5/7257
摘要： The invention relates to a method of determining a spatial distribution of magnetic particles in an examination area, in which a magnetic field is generated which has a first part-region having a relatively low magnetic field strength and a second part-region having a relatively high magnetic field strength. The position of the two part-regions is changed, as a result of which the magnetization in the examination area changes, and real measured values which depend on the change in magnetization are recorded. A dependence distribution which depends on a spatial distribution of magnetic particles is then determined such that a sum which comprises as summands a) the difference of the real measured values from fictitious measured values which are determined by applying a transfer function to the dependence distribution, and b) the product of a regularization parameter and of a regularization value which is determined by applying the regularization functional to the dependence distribution, is minimized. Finally, the spatial distribution of magnetic particles is determined by means of the determined dependence distribution.

4. 发明授权

EP3073912B1 VERFAHREN ZUM MAGNETIC PARTICLE IMAGING MIT UNBESCHRÄNKTEM AXIALEN FIELD OF VIEW 有权
标题翻译：具有无限制轴向视场的磁性粒子成像方法
公开(公告)号：EP3073912B1
公开(公告)日：2018-01-31
申请号：EP13802304.9
申请日：2013-11-29
申请人： Universität zu Lübeck
发明人： BUZUG, Thorsten , KAETHNER, Christian , AHLBORG, Mandy , BRINGOUT, Gael , WEBER, Matthias
IPC分类号： A61B5/05
CPC分类号： G01R33/1276 , A61B5/0515 , G01R33/307 , G01R33/38

5. 发明授权

EP1615554B1 METHOD AND ARRANGEMENT FOR INFLUENCING MAGNETIC PARTICLES AND DETECTING INTERFERING MATERIAL 失效转让
标题翻译：磁性粒子影响及检测干扰物质的方法和装置
公开(公告)号：EP1615554B1
公开(公告)日：2017-12-20
申请号：EP04725750.6
申请日：2004-04-05
申请人： Philips Intellectual Property & Standards GmbH , Koninklijke Philips N.V.
发明人： GLEICH, Bernhard , WEIZENECKER, Jürgen
IPC分类号： A61B5/05 , A61N2/02 , A61N1/40
CPC分类号： A61N2/02 , A61B5/0515 , A61N1/406

6. 发明授权

EP2425268B1 ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES AND FOR MAGNETIC RESONANCE IMAGING 失效转让
标题翻译：影响和/或检测磁性颗粒和磁共振成像的装置和方法
公开(公告)号：EP2425268B1
公开(公告)日：2017-08-02
申请号：EP10717844.4
申请日：2010-04-23
申请人： Koninklijke Philips N.V. , Philips Intellectual Property & Standards GmbH
发明人： GLEICH, Bernhard
IPC分类号： G01R33/381 , G01R33/3875 , G01R33/44 , A61B5/05 , A61B5/00 , G01R33/48
CPC分类号： A61B5/0515 , A61B5/0035 , A61B5/05 , G01R33/381 , G01R33/3875 , G01R33/445 , G01R33/4808

7. 发明公开

EP3139832A1 METHOD AND APPARATUS FOR NONLINEAR SUSCEPTIBILITY MAGNITUDE IMAGING OF MAGNETIC NANOPARTICLES 审中-公开
标题翻译：方法和装置非线性SUSZEPTIBILITÄTSAUSMASSBILDGEBUNG磁性纳米粒子
公开(公告)号：EP3139832A1
公开(公告)日：2017-03-15
申请号：EP15789380.1
申请日：2015-05-06
申请人： The Trustees Of Dartmouth College
发明人： DIAMOND, Solomon G. , FICKO, Bradley W.
IPC分类号： A61B5/055 , A61N2/04
CPC分类号： G01R33/1276 , A61B5/0515 , A61N1/403
摘要： A magnetic nanoparticle imaging system has driving coils driven at multiple frequencies, the driving coils positioned to provide magnetic fields and field gradients to an imaging zone, and a static bias field magnet positioned to provide a static magnetic field and/or field gradient to the imaging zone. Magnetic sensors are positioned to sense magnetic fields from the imaging zone, and a signal processor processes signals from the sensors to find at least signal magnitude and phase at harmonics and/or intermodulation products of the multiple frequencies. In embodiments, the signal processing apparatus also determines signal magnitudes and phase of at least second and third harmonics of the first frequency, and maps location of nanoparticles in the imaging zone based upon the magnitudes of harmonics and magnitudes of the intermodulation products.
摘要翻译：磁性纳米颗粒成像系统具有驱动线圈在多个频率驱动时，驱动线圈位于成像区，以提供磁场和磁场梯度来，并定位以提供一静磁场和/或磁场梯度来成像的静态偏置磁场用磁铁区。磁传感器被定位为感测从所述成像区的磁场，和一个信号处理器处理来自传感器的信号，以找到在多个频率中的谐波和/或互调产物至少信号幅度和相位。在实施例中，信号处理装置如此bestimmt信号幅度和所述第一频率的至少第二和第三谐波的相位，并且在基于所述的互调产物的高次谐波和幅度的幅度的成像区的纳米颗粒的地图位置。

8. 发明公开

EP2996597A4 APPARATUS AND METHOD FOR SPATIALLY SELECTIVE INTERVENTIONAL NEUROPARTICLES 审中-公开
标题翻译： VORRICHTUNG UND VERFAHRENFÜRRÄUMLICHSELEKTIVE INTERVENTIONELLE NEUROPARTIKEL
公开(公告)号：EP2996597A4
公开(公告)日：2017-03-01
申请号：EP14768227
申请日：2014-03-21
申请人： WEINBERG MEDICAL PHYSICS LLC
发明人： WEINBERG IRVING N
IPC分类号： G01R33/00 , A61B5/00 , A61B5/05 , A61B5/06 , A61N2/00 , A61N5/06 , B82Y15/00
CPC分类号： A61N2/006 , A61B5/0515 , A61B5/062 , A61B5/40 , A61B2562/0285 , A61N5/0622 , A61N2005/0643

9. 发明公开

EP3073912A1 VERFAHREN ZUM MAGNETIC PARTICLE IMAGING MIT UNBESCHRÄNKTEM AXIALEN FIELD OF VIEW 有权
标题翻译： VERFAHREN ZUM磁性颗粒成像麻醉剂UNBESCHRÄNKTEMAXIALEN视野
公开(公告)号：EP3073912A1
公开(公告)日：2016-10-05
申请号：EP13802304.9
申请日：2013-11-29
申请人： Universität zu Lübeck
发明人： BUZUG, Thorsten , KAETHNER, Christian , GRÜTTNER, Mandy , BRINGOUT, Gael , WEBER, Matthias
IPC分类号： A61B5/05
CPC分类号： G01R33/1276 , A61B5/0515 , G01R33/307 , G01R33/38
摘要： The invention relates to a method and an MPIS scanner for tomographic imaging of an object with magnetic particles distributed in the interior of the object, comprising the steps of generating a selection magnetic field with a predetermined magnetic field gradient in at least one field-free point (FFP) in a predetermined scanning plane, generating a time-dependent, periodic excitation magnetic field with a predetermined maximum frequency, repeatedly displacing the at least one FFP along a predetermined closed trajectory with a predetermined repetition time in the scanning plane, moving the object through the scanning plane along a predetermined advance direction with a predetermined advance speed, detecting the change in the magnetization state of the magnetic particles at the points in the object interior through which the at least one FFP passes, reconstructing the local particle concentrations at the points through which the at least one FFP passes in respect of an object coordinate system, interpolating the reconstructed particle concentration to the points in the object interior not passed through by at least one FFP, generating a display of the particle concentration distribution in the object interior, characterized by interpolating the particle concentrations reconstructed at path section end points of path sections along the advance direction to path section intermediate points taking into account the advance speed.
摘要翻译：本发明涉及一种用于对物体进行断层成像的方法和MPIS扫描仪，所述物体具有分布在物体内部的磁性粒子，包括以下步骤：在至少一个无场点中产生具有预定磁场梯度的选择磁场（FFP）在预定扫描平面中，产生具有预定最大频率的时间相关的周期性激励磁场，沿着预定的闭合轨迹重复地移动至少一个FFP，并以扫描平面中的预定重复时间移动物体以预定的提前速度沿着预定的前进方向通过扫描平面，检测在至少一个FFP通过的物体内部的点处磁性颗粒的磁化状态的变化，重建在点处的局部颗粒浓度所述至少一个FFP通过其相对于对象坐标通过将重构的粒子浓度内插到未被至少一个FFP通过的物体内部的点，产生物体内部的粒子浓度分布的显示，其特征在于内插在路径路段部分终点处重建的粒子浓度考虑到提前速度，沿前进方向的路段部分中间点。

10. 发明公开

EP2919647A1 NEUROPHYSIOLOGICAL DATA ANALYSIS USING SPATIOTEMPORAL PARCELLATION 有权
标题翻译：分析NEURO生理数据利用空间 - 时间瓜分
公开(公告)号：EP2919647A1
公开(公告)日：2015-09-23
申请号：EP13855226.0
申请日：2013-11-13
申请人： Elminda Ltd.
发明人： GEVA, Amir B. , STERN, Yaki , RECHES, Amit
IPC分类号： A61B5/0484 , A61B5/048 , G06K9/00 , A61B5/055 , G06F19/00
CPC分类号： A61B5/048 , A61B5/0042 , A61B5/0484 , A61B5/0515 , A61B5/0522 , A61B5/055 , A61B5/165 , A61B5/4064 , A61B5/4076 , A61B5/4836 , A61B5/7246 , A61B5/7267 , A61B5/7275 , A61B5/7282 , A61N1/36135 , G06F17/30598 , G06F19/00 , G06T11/206 , G06T2207/30016 , G16H50/50
摘要： A method of analyzing neurophysiological data recorded from a subject is disclosed. The method comprises identifying activity-related features in the data, and parceling the data according to the activity-related features to define a plurality of capsules, each representing a spatiotemporal activity region in the brain. The method further comprises comparing at least some of the defined capsules to at least one reference capsule, and estimating a brain function of the subject based on the comparison.

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