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1. 发明公开

EP2895883A1 ENERGY-SENSITIVE FAST NEUTRON IMAGING DETECTOR AND METHOD FOR ENERGY-SENSITIVE FAST NEUTRON DETECTION 有权
标题翻译：能量敏感的图像检测器，用于能量敏感检测快中子快中子和方法
公开(公告)号：EP2895883A1
公开(公告)日：2015-07-22
申请号：EP13750867.7
申请日：2013-08-13
申请人： Paul Scherrer Institut , Physikalisch-Technische Bundesanstalt (PTB)
发明人： CORTESI, Marco , DANGENDORF, Volker , PRASSER, Horst-Michael , ZBORAY, Robert
IPC分类号： G01T1/185 , G01T3/00
CPC分类号： G01T3/003 , G01T1/185 , G01T3/008
摘要： An energy-sensitive imaging detector for fast-neutrons includes: a) a series of energy-selective stacks (4 to 14 to 18) of radiator foils (6) which converts neutrons (n) into recoil protons (p, p1 to p3); said foils (6) are separated by gas-filled gaps (13) and are made of two layers fastened together: a hydrogen-rich layer, such as a polyethylene layer (10) for neutron-to-proton conversion, and a metal foil layer, such as an aluminum layer, defining a proton energy cut-off and limiting angle of proton emission; b) surrounding gas in the gas-filled gaps (13) in which energetic recoil protons emerging from the radiator foil release electrons; c) an electric field (E drift ) able to efficiently drift the electrons (20) through the gas-filled gaps (13); and d) an electron detector with a position sensitive readout (PSRO), based on Micro-Pattern Gaseous Detector (MPGD) technologies (like e.g. the THick Gaseous Electron Multipliers - THGEM) or other means of electron amplification in gas; the charge detector is equipped with a dedicated imaging data-acquisition system, which detect the drifted electrons thereby sensing the position of the original impinging neutrons.

2. 发明公开

EP3152525A1 VERFAHREN ZUR BESTIMMUNG DES VOLUMENFLUSSES EINES STRÖMENDEN MEDIUMS DURCH EINE MESSSTRECKE UND ZUGEORDNETE MESSEINRICHTUNG 审中-公开
标题翻译：程序对确定流动介质的体积流量BY米跑和相关设备
公开(公告)号：EP3152525A1
公开(公告)日：2017-04-12
申请号：EP15725992.0
申请日：2015-05-20
申请人： Physikalisch-Technische Bundesanstalt (PTB) , Diehl Metering GmbH
发明人： SOSNA, Christoph , HAMMERSCHMIDT, Ulf
IPC分类号： G01F1/684
CPC分类号： G01F1/7084 , G01F1/7044
摘要： Disclosed is a method for determining the volumetric flow rate of a fluid medium through a measuring section in a substantially gas-type independent manner, said method comprising the following steps: pulsed heating of the medium by means of a heating element; recording a first time at which a maximum temperature occurs at a first temperature sensor lying upstream or downstream from, and adjacent to, the heating element; recording a second time at which a maximum temperature occurs at a second temperature sensor lying downstream of the heating element, wherein the second temperature sensor is located further away from the heat source than the first temperature sensor; calculating a time difference between the first and the second time; and determining the volumetric flow rate on the basis of the time difference.
摘要翻译：一种用于确定性采矿方法通过在基本上气体类型无关的方式测定部的流体介质的体积流率，包括通过使用加热元件，检测在第一时间点进行加热以脉冲方式的介质在哪一个温度最大值出现在第一温度传感器，所述第一温度传感器被设置邻接上游或加热元件的下游，检测在时间将在哪个温度最大值出现在第二温度传感器的第二点，所述第二温度传感器被设置在下游的加热元件，所述第二温度传感器从比所述第一温度传感器的加热元件是furtheraway，并且在时间确定该第一和第二点之间的时间差。的体积流率被确定性开采在该时间差的依赖。因此提供了一种用于执行该方法的设备。

3. 发明公开

EP2833916A1 MAGNETIC NANOPARTICLES DISPERSION, ITS PREPARATION AND DIAGNOSTIC AND THERAPEUTIC USE 审中-公开
标题翻译：磁性纳米粒子分散，生产以及诊断和治疗用途
公开(公告)号：EP2833916A1
公开(公告)日：2015-02-11
申请号：EP13719039.3
申请日：2013-04-04
申请人： Charite - Universitätsmedizin Berlin , Physikalisch-Technische Bundesanstalt (PTB)
发明人： KRATZ, Harald , WAGNER, Susanne , SCHNORR, Jörg , TAUPITZ, Matthias , EBERT, Monika , EBERBECK, Dietmar
IPC分类号： A61K41/00 , A61K49/18
CPC分类号： A61K49/1851 , A61B5/0515 , A61B5/055 , A61B5/416 , A61B5/417 , A61B5/418 , A61K9/5161 , A61K41/0052
摘要： The present invention relates to magnetic particle dispersions comprising coated monocrystalline and/or polycrystalline single nanoparticles of iron oxides and nano-particulate aggregates (multi-core particles) thereof with improved nonlinear magnetization behavior and improved heating properties in alternating magnetic fields. When measured in a magnetic particle spectrometer (MPS) the particle dispersions show a pronounced overtone structure, especially in the higher harmonics, which surpasses all previously known particle systems many times over. Therefore, the dispersions are especially useful for applications such as MPI (magnetic particle imaging). In addition, the new particle dispersions are suitable for treatment of iron deficiency anemia and for applications in therapeutic hyperthermia, particularly passive partial-body hyperthermia or cell tracking and magnetic resonance imaging (MRI). Hence, the diagnostic and therapeutic use of the dispersions as well as pharmaceutical compositions of diagnostic or therapeutic interest comprising these dispersions are also objects of the present invention.

4. 发明公开

EP3213294A1 ERMITTLUNG LOKALER GÜTEMASSE AUS EINEM VOLUMENBILDDATENSATZ 有权
标题翻译： ERMITTLUNG LOKALERGÜTEMASSEAUS EINEM VOLUMENBILDDATENSATZ
公开(公告)号：EP3213294A1
公开(公告)日：2017-09-06
申请号：EP15813259.7
申请日：2015-10-29
申请人： Volume Graphics GmbH , Physikalisch-Technische Bundesanstalt (PTB)
发明人： BARTSCHER, Markus , GÜNTHER, Thomas , POLIWODA, Christoph , REINHART, Christof
IPC分类号： G06T7/00
CPC分类号： G06T7/0006 , G06T2207/10072 , G06T2207/10136 , G06T2207/30164
摘要： The invention relates to a method and a device for processing a volumetric image record. The method comprises the following steps: carrying out a non-optical image scanning method on an object to be analysed and generating a volumetric image record and extracting the object contour from the volumetric image record in order to determine the position of the object surface; defining an object surface point and a surrounding area for said object surface point and analysing the grey tones within the surrounding area; calculating a quality value, which reflects the localised quality of the surface, for the object surface point on the basis of the grey-tone analysis. The device comprises equipment for carrying out a non-optical image scanning method on an object to be analysed and for generating a volumetric image record and comprises a processing device which is programmed to extract an object contour from the volumetric image record in order to determine the position of the object surface, said processing unit, in addition, being programmed to define at least one trajectory or a surrounding area for an object surface point, to analyse the grey-tone progression along the at least one trajectory or to analyse the grey tones within the surrounding area, and to calculate a quality value for the object surface point in order to represent a localised quality of the surface.
摘要翻译：本发明涉及一种用于处理体积图像记录的方法和设备。该方法包括以下步骤：对待分析对象进行非光学图像扫描方法，并生成体积图像记录并从体积图像记录中提取对象轮廓以确定对象表面的位置; 为所述物体表面点定义物体表面点和周围区域并分析周围区域内的灰度色调; 基于灰度分析计算物体表面点的质量值，该质量值反映表面的局部质量。该设备包括用于在要分析的对象上执行非光学图像扫描方法并且用于生成体积图像记录的设备，并且包括处理设备，该处理设备被编程为从体积图像记录中提取对象轮廓以便确定所述处理单元另外被编程为定义物体表面点的至少一个轨迹或周围区域，以分析沿着所述至少一个轨迹的灰度级进展或分析灰度色调在周围区域内，并计算物体表面点的质量值，以表示表面的局部质量。

5. 发明公开

EP2647389A1 Magnetic nanoparticle dispersion, its preparation and diagnostic and therapeutic use 审中-公开
标题翻译： Magnetische Nanopartikeldispersion，ihre Herstellung sowie diagnische und therapeutische Verwendung
公开(公告)号：EP2647389A1
公开(公告)日：2013-10-09
申请号：EP12163254.1
申请日：2012-04-04
申请人： Charité - Universitätsmedizin Berlin , Physikalisch-Technische Bundesanstalt (PTB)
发明人： Kratz, Harald , Wagner, Susanne , Schnorr, Jörg , Taupitz, Matthias , Ebert, Monika , Eberbeck, Dietmar
IPC分类号： A61K41/00 , A61K49/18
CPC分类号： A61K49/1851 , A61B5/0515 , A61B5/055 , A61B5/416 , A61B5/417 , A61B5/418 , A61K9/5161 , A61K41/0052
摘要： The present invention relates to magnetic particle dispersions comprising coated individual monocrystalline and/or polycrystalline nanoparticles of iron oxides and nanoparticulate aggregates (multi-core particles) thereof with improved nonlinear magnetization behavior and improved heating properties in alternating magnetic fields. When measured in a magnetic particle spectrometer (MPS) the particle dispersions show a pronounced overtone structure, especially in the higher harmonics, which surpasses all previously known particle systems many times over. Therefore, the dispersions are especially useful for applications such as MPI (magnetic particle imaging). In addition, the new particle dispersions are suitable for applications in therapeutic hyperthermia, particularly passive partial-body hyperthermia or cell tracking and magnetic resonance imaging (MRI). Hence, the diagnostic and therapeutic use of the dispersions as well as pharmaceutical compositions of diagnostic or therapeutic interest comprising these dispersions are also objects of the present invention.
摘要翻译：本发明涉及包含铁氧化物和纳米颗粒聚集体（多芯颗粒）的涂覆的单个单晶和/或多晶纳米颗粒的磁性颗粒分散体，其具有改进的非线性磁化行为和交替磁场中改进的加热性能。当在磁性粒子光谱仪（MPS）中测量时，颗粒分散体显示明显的泛音结构，特别是在高次谐波中，超过所有先前已知的粒子系统多次。因此，分散体对于诸如MPI（磁性颗粒成像）的应用尤其有用。此外，新的颗粒分散体适用于治疗性高热，特别是被动部分身体高热或细胞跟踪和磁共振成像（MRI）。因此，分散体的诊断和治疗用途以及包含这些分散体的诊断或治疗感兴趣的药物组合物也是本发明的目的。

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