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1. 发明授权

EP1865884B1 SKIN SUBSTITUTES WITH IMPROVED PURITY 有权
标题翻译： HAUTSUBSTITUTE MIT VERBESSERTER REINHEIT
公开(公告)号：EP1865884B1
公开(公告)日：2017-01-18
申请号：EP06738193.9
申请日：2006-03-15
申请人： Stratatech Corporation
发明人： ALLEN-HOFFMANN, Lynn , IVARIE, Cathy, Ann-Rasmussen , CENTANNI, John, M.
IPC分类号： A61F2/10 , C12N5/071
CPC分类号： A61F2/105 , C12N5/0629 , C12N5/0698 , C12N2502/094 , C12N2502/1323

2. 发明公开

EP3037051A3 APPARATUS FOR GRAFTING OF SKIN TISSUE 有权
标题翻译： VORRICHTUNG ZUM EINSETZEN VON HAUTGEWEBE
公开(公告)号：EP3037051A3
公开(公告)日：2016-10-12
申请号：EP16156038.8
申请日：2009-09-24
申请人： The General Hospital Corporation , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： Asrani, Falguni , Farinelli, William A. , Shah, Ajay , Lui, Vincent , Anderson, R. Rox
IPC分类号： A61B17/322 , A61F2/10 , A61B17/00
CPC分类号： A61B17/322 , A61B2017/00969 , A61B2017/3225 , A61F2/105
摘要： Methods and apparatus are provided for affecting an appearance of skin by harvesting small portions of tissue from a donor (first) site and applying them at a recipient (second) site. A plurality of micrografts can be formed from a piece of graft tis-sue and attached to a dressing material. The dressing material can then be expanded to increase a separation distance between the micrografts, and the dressing material having spaced-apart micrografts attached thereto can be applied to a prepared recipient site. An apparatus can be provided that expands the dressing material using a pressurized fluid. A further method can include providing a suspension of small portions of graft tissue in a solution. The solution can be injected into blisters formed at a recipient (second) site and the tissue portions allowed to attach and proliferate. A method and apparatus can also be provided for forming corre-sponding blisters at a donor site and at a recipient site. The raised (removed) portions of the blisters can be removed and attached to a dressing material, and the portions from the donor (first) site can be placed onto the exposed blister areas at the recipient site.
摘要翻译：提供了通过从供体（第一）部位收集少部分组织并将其施用于受体（第二）部位来影响皮肤外观的方法和装置。多个微移植物可以由一块移植物组织形成并附着到敷料材料上。然后可以将敷料材料膨胀以增加微移植物之间的间隔距离，并且具有与其连接的间隔开的微移植物的敷料材料可应用于制备的受体部位。可以提供一种使用加压流体使敷料材料膨胀的装置。另一种方法可以包括提供移植组织的小部分在溶液中的悬浮液。溶液可以注射到在受体（第二）部位形成的水疱中，组织部分允许附着和增殖。还可以提供一种方法和装置，用于在供体部位和受体部位形成相应的水泡。泡罩的隆起（去除）部分可以被去除并附着到敷料材料上，并且来自供体（第一）部位的部分可以放置在受体部位的暴露的水泡区域上。

3. 发明公开

EP3065791A1 METHOD OF PRINTING A TISSUE CONSTRUCT WITH EMBEDDED VASCULATURE 有权
标题翻译： VERFAHREN ZUM DRUCKEN EINES GEWEBEKONSTRUKTS MIT EINGEBETTETER VASKULATUR
公开(公告)号：EP3065791A1
公开(公告)日：2016-09-14
申请号：EP14859356.9
申请日：2014-11-04
申请人： President and Fellows of Harvard College
发明人： LEWIS, Jennifer , KOLESKY, David B. , SCOTT, Mark A. , HOMAN, Kimberly A. , TRUBY, Ryan L. , GLADMAN, Amelia Sydney
IPC分类号： A61L27/38
CPC分类号： A61L27/507 , A61F2/06 , A61F2/105 , A61F2240/002 , A61L27/222 , A61L27/225 , A61L27/3633 , A61L27/3808 , A61L27/3813 , A61L27/3826 , A61L2430/34 , B29C64/106 , B29C64/40 , B33Y10/00 , B33Y80/00 , C12M33/00
摘要： A printed tissue construct comprises one or more tissue patterns, where each tissue pattern comprises a plurality of viable cells of one or more predetermined cell types. A network of vascular channels interpenetrates the one or more tissue patterns. An extracellular matrix composition at least partially surrounds the one or more tissue patterns and the network of vascular channels.
摘要翻译：印刷的组织结构包括一个或多个组织图案，其中每个组织图案包括一个或多个预定细胞类型的多个活细胞。血管通道网络穿过一个或多个组织模式。细胞外基质组合物至少部分地围绕血管通道的一个或多个组织模式和网络。印刷具有嵌入脉管系统的组织构建体的方法包括在衬底上沉积一个或多个包含多个活细胞的细胞细丝，以形成一个或多个组织图案。一个或多个组织图案中的每一个包括一个或多个预定的细胞类型。一个或多个牺牲丝，每个包含短暂的油墨，沉积在基底上，以形成互穿一个或多个组织图案的血管图案。血管图案和一个或多个组织图案至少部分地被细胞外基质组合物包围。然后除去逸散性油墨以在细胞外基质组合物中产生血管通道，从而在组织构建体中形成互穿血管网络。

4. 发明授权

EP2337507B1 METHOD AND APPARATUS FOR GRAFTING OF SKIN TISSUE 有权
标题翻译：方法和设备，用于插入皮肤组织
公开(公告)号：EP2337507B1
公开(公告)日：2016-04-13
申请号：EP09816842.0
申请日：2009-09-24
申请人： The General Hospital Corporation , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： ASRANI, Falguni , FARINELLI, William A. , SHAH, Ajay , LIU, Vincent , ANDERSON, R. Rox
IPC分类号： A61B17/322 , A61F2/10 , A61B17/00
CPC分类号： A61B17/322 , A61B2017/00969 , A61B2017/3225 , A61F2/105

5. 发明公开

EP2957288A1 CELL SUSPENSION PREPARATION DEVICE 审中-公开
标题翻译： ZELLSUSPENSIONHERSTELLUNGSVORRICHTUNG
公开(公告)号：EP2957288A1
公开(公告)日：2015-12-23
申请号：EP15159890.1
申请日：2002-02-07
申请人： Avita Medical Ltd
发明人： Stoner, Marie , Wood, Fiona
IPC分类号： A61K35/36
CPC分类号： A61F2/105 , A61K35/36 , A61M37/00 , A61M2202/09 , A61M2205/7545 , C12M45/02 , C12M45/06 , C12M45/09 , C12M45/22 , C12M47/02 , C12N5/0629 , C12N2500/98 , C12N2500/99 , C12N2509/00
摘要： The present invention provides a unique method and or device suitable for producing a transplantable cellular suspension of living tissue suitable for grafting to a patient. In applying the method and or in using the device donor tissue is harvested, subjected to a cell dissociation treatment, cells suitable for grafting back to a patient are collected and dispersed in a solution that is suitable for immediate dispersion over the recipient graft site.
摘要翻译：本发明提供了适用于生产适合于移植给患者的活组织的可移植细胞悬浮液的独特方法和/或装置。在应用该方法和/或使用该装置时，收获组织，进行细胞解离处理，将适合于移植回患者的细胞收集并分散在适于在接受者移植部位立即分散的溶液中。

6. 发明授权

EP2343079B1 CELL SUSPENSION PREPARATION DEVICE 有权
标题翻译： DEVICE细胞悬液生产
公开(公告)号：EP2343079B1
公开(公告)日：2015-03-25
申请号：EP10184235.9
申请日：2002-02-07
申请人： Avita Medical Ltd
发明人： Stoner, Marie , Wood, Fiona
IPC分类号： C12M3/06
CPC分类号： C12M45/09 , A61F2/105 , A61K35/36 , C12N2509/00
摘要： The present invention provides a unique method and or device suitable for producing a transplantable cellular suspension of living tissue suitable for grafting to a patient. In applying the method and or in using the device donor tissue is harvested, subjected to a cell dissociation treatment, cells suitable for grafting back to a patient are collected and dispersed in a solution that is suitable for immediate dispersion over the recipient graft site.

7. 发明公开

EP2740443A1 PREPARATION OF FIBRIN GEL FOR USE AS IMPLANT SYSTEM 审中-公开
标题翻译： HERSTELLUNG VON FIBRINGEL ZUR VERWENDUNG ALS IMPLANTATSYSTEM
公开(公告)号：EP2740443A1
公开(公告)日：2014-06-11
申请号：EP12819721.7
申请日：2012-08-03
申请人： Instituto Para el Desarrollo Biotecnológico y la Innovación S.A.
发明人： WEINSTEIN OPPENHEIMER, Caroline Ruth , BROWN GONZÁLEZ, Donald Irving , FUENTES CHANDÍA, Miguel Ángel , CERIANI FERNÁNDEZ, Ricardo Andrés , ALBORNOZ MÁRQUEZ, Fernando Antonio , ACEVEDO GUTIÉRREZ, Cristian Andrés
IPC分类号： A61F2/10 , A61L27/60
CPC分类号： A61K35/16 , A61F2/10 , A61F2/105 , A61L27/225 , A61L27/3616 , A61L27/3683 , A61L27/3804 , A61L27/52 , A61L27/60 , F04C2270/0421
摘要： The present invention aims to generate a fibrin gel for cell proliferation and transport using the patient's own blood or compatible blood. The gel-preparation process consists in taking a quantity of blood from the patient, using sodium citrate as anticoagulant, separating off the citrated plasma by centrifugation, and resuspending the cells to be transported in the plasma. CaCl 2 is added to the resulting suspension to form the gel (either as an isolated coagulate or within a porous chitosan, gelatin or hyaluronic acid matrix), and the gel is cultured in an incubator to promote cell growth. The invention will be of use in cell growth for the purposes of implantation in cutaneous, cartilaginous, gingival and bone lesions, inter alia, and in the field of tissue engineering.
摘要翻译：本发明的目的在于使用患者自己的血液或相容的血液产生用于细胞增殖和转运的纤维蛋白凝胶。凝胶制备过程包括使用柠檬酸钠作为抗凝血剂从患者中取出一定数量的血液，通过离心分离柠檬酸盐血浆，并将待转运的细胞重新悬浮在血浆中。将CaCl 2加入到所得悬浮液中以形成凝胶（作为分离的凝结物或在多孔壳聚糖，明胶或透明质酸基质内），并将凝胶在培养箱中培养以促进细胞生长。本发明将在细胞生长中用于植入皮肤，软骨，牙龈和骨损伤，尤其是在组织工程领域中的目的。

8. 发明公开

EP2543396A4 ARTIFICIAL SKIN 有权
标题翻译：人造皮肤
公开(公告)号：EP2543396A4
公开(公告)日：2013-08-14
申请号：EP11750413
申请日：2011-01-19
申请人： SHISEIDO CO LTD
发明人： IRIYAMA SHUNSUKE , UMISHIO KENICHI , TSUNENAGA MAKOTO , INOMATA SHINJI , ADACHI EIJIRO
IPC分类号： A61L27/00
CPC分类号： A61K31/4406 , A61F2/105 , A61K8/4926 , A61K8/4946 , A61K8/64 , A61K31/4184 , A61K38/005 , A61K38/07 , A61K2800/782 , A61L27/362 , A61L27/3804 , A61L27/3813 , A61L27/3886 , A61L27/60 , A61Q19/08
摘要： The present invention relates to a method for producing artificial skin, comprising: adding a matrix metalloproteinase inhibitor and a heparanase inhibitor to an artificial skin formation culture medium comprising human epidermal keratinocytes and human dermal fibroblasts, culturing the cells in the artificial skin formation culture medium, and forming artificial skin.

9. 发明授权

EP2409651B1 Biological graft transferring instrument 有权
标题翻译：仪器用于生物植入物的传输
公开(公告)号：EP2409651B1
公开(公告)日：2013-05-08
申请号：EP11172068.6
申请日：2011-06-30
申请人： Terumo Kabushiki Kaisha
发明人： Nozaki, Yusuke
IPC分类号： A61B17/00 , A61F2/24 , A61F13/00 , A61K9/00 , A61M37/00 , C12M3/04
CPC分类号： A61M37/00 , A61B17/00 , A61B2017/00969 , A61F2/0063 , A61F2/105 , A61F2/24 , A61F13/00 , A61F2002/0072 , A61K9/00 , A61M37/0069 , A61M2202/09

10. 发明公开

EP2582791A2 HAIR FOLLICLE NEOGENESIS 有权转让
标题翻译：毛囊新生
公开(公告)号：EP2582791A2
公开(公告)日：2013-04-24
申请号：EP11796538.4
申请日：2011-06-17
申请人： The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
发明人： THANGAPAZHAM, Rajesh , DARLING, Thomas, N. , LI, Shaowei
IPC分类号： C12N5/071 , C12N5/077 , A61K35/36 , A61F2/10 , C12Q1/68
CPC分类号： A61L27/3886 , A61F2/105 , A61K35/36 , A61L27/24 , A61L27/3813 , A61L27/3834 , A61L27/60 , A61L2430/18 , C12N5/0627 , C12N5/0698 , C12N2501/04 , C12N2501/998 , C12N2502/092 , C12N2502/094 , C12N2502/1323 , C12N2502/30 , C12N2510/00 , C12N2533/78
摘要： This invention provides a skin substitute comprising epithelial cells and modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells, and methods for using the same. This invention also provides a method for transplanting cells capable of inducing hair follicles, comprising subdermally or intradermally delivering to a patient modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells.

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