基本信息:
- 专利标题： HAIR FOLLICLE NEOGENESIS
- 专利标题（中）：毛囊新生
- 申请号：EP11796538.4 申请日：2011-06-17
- 公开(公告)号：EP2582791A2 公开(公告)日：2013-04-24
- 发明人： THANGAPAZHAM, Rajesh , DARLING, Thomas, N. , LI, Shaowei
- 申请人： The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- 申请人地址： 1401 Rockville Pike Suite 600 Rockville, MD 20852 US
- 专利权人： The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- 当前专利权人： THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMEN
- 当前专利权人地址： THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMEN
- 代理机构： Dörries, Hans Ulrich
- 优先权： US344258P 20100618
- 国际公布： WO2011160055 20111222
- 主分类号： C12N5/071
- IPC分类号： C12N5/071 ; C12N5/077 ; A61K35/36 ; A61F2/10 ; C12Q1/68
摘要：
This invention provides a skin substitute comprising epithelial cells and modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells, and methods for using the same. This invention also provides a method for transplanting cells capable of inducing hair follicles, comprising subdermally or intradermally delivering to a patient modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells.
公开/授权文献:
- EP2582791B8 HAIR FOLLICLE NEOGENESIS 公开/授权日：2018-05-23