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1. 发明授权

EP2760334B1 PATIENT MONITORING METHOD AND MONITORING DEVICE 有权转让
公开(公告)号：EP2760334B1
公开(公告)日：2018-11-21
申请号：EP12781401.0
申请日：2012-09-26
申请人： Guy's And St Thomas' Nhs Foundation Trust
发明人： HART, Nicholas , MOXHAM, John , FEDELE, Fiammetta
IPC分类号： A61B5/0488 , A61B5/08 , A61B5/0245 , A61B5/0452
CPC分类号： A61B5/0205 , A61B5/0245 , A61B5/04012 , A61B5/04017 , A61B5/0452 , A61B5/0472 , A61B5/0488 , A61B5/08 , A61B5/7203
摘要： A method of monitoring a patient includes measuring neural respiratory drive using a monitoring device (10), repeating the measurement either continuously or at regular time intervals, and comparing the measurements obtained in order to predict treatment failure and/clinical deterioration and/or re-admission. In embodiments of the invention, the neural respiratory drive is measured by obtaining a measure of the second intercostal space parasternal electromyogram. A monitoring device (10) includes a signal input (20), a processing unit (30), and a output unit (50), and is arranged to measure the neural respiratory drive, store the measured value and compare it to a previously measured value for the neural respiratory drive.

2. 发明公开

EP3364873A1 MULTI-VECTOR SENSING IN CARDIAC DEVICES USING A HYBRID APPROACH 有权
公开(公告)号：EP3364873A1
公开(公告)日：2018-08-29
申请号：EP16791181.7
申请日：2016-10-20
申请人： Cardiac Pacemakers, Inc.
发明人： BRISBEN, Amy Jean , ALLAVATAM, Venugopal , SIEJKO, Krzysztof Z. , MAHAJAN, Deepa , WIKA, Kevin G. , HERRMANN, Keith L. , HAHN, Stephen J.
IPC分类号： A61B5/0402 , A61B5/00 , A61B5/0456 , A61B5/0468 , A61B5/0452 , A61N1/39 , A61B5/04 , A61B5/042 , A61N1/362 , A61B5/0472 , A61B5/0245 , A61B5/024
CPC分类号： A61N1/36514 , A61B5/02416 , A61B5/0245 , A61B5/04011 , A61B5/04012 , A61B5/04017 , A61B5/0402 , A61B5/04028 , A61B5/042 , A61B5/0422 , A61B5/0452 , A61B5/04525 , A61B5/0456 , A61B5/0468 , A61B5/0472 , A61B5/686 , A61B5/6869 , A61B5/72 , A61B5/7203 , A61B5/7221 , A61N1/046 , A61N1/05 , A61N1/0563 , A61N1/3622 , A61N1/3625 , A61N1/3704 , A61N1/3925 , A61N1/3956 , A61N1/3987
摘要： New and alternative approaches to the monitoring of cardiac signal quality for external and/or implantable cardiac devices. In one example, signal quality is monitored continuously or in response to a triggering event or condition and, upon identification of a reduction in signal quality, a device may reconfigure its sensing state. In another example, one or more trends of signal quality are monitored by a device, either continuously or in response to a triggering event or condition, and sensing reconfiguration may be performed in response to identified trends and events. In yet another example, a device may use a looping data capture mode to track sensing data in multiple vectors while primarily relying on less than all sensing vectors to make decisions and, in response to a triggering event or condition, the looped data can be analyzed automatically, without waiting for additional data capture to reconfigure sensing upon identification of the triggering event or condition. In another example a device calculates a composite cardiac cycle by overlaying signal morphology for a number of cardiac cycles and analyzes the composite cardiac cycle to calculate signal quality metrics.

3. 发明公开

EP3364871A1 SIGNAL QUALITY MONITORING FOR MULTIPLE SENSE VECTORS IN CARDIAC DEVICES 有权
公开(公告)号：EP3364871A1
公开(公告)日：2018-08-29
申请号：EP16790826.8
申请日：2016-10-20
申请人： Cardiac Pacemakers, Inc.
发明人： BRISBEN, Amy Jean , ALLAVATAM, Venugopal , SIEJKO, Krzysztof Z. , MAHAJAN, Deepa , WIKA, Kevin G. , HERRMANN, Keith L. , HAHN, Stephen J.
IPC分类号： A61B5/0402 , A61B5/00 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61N1/39 , A61B5/04 , A61B5/042 , A61B5/024 , A61B5/0245 , A61B5/0452 , A61B5/0472
CPC分类号： A61N1/36514 , A61B5/02416 , A61B5/0245 , A61B5/04011 , A61B5/04012 , A61B5/04017 , A61B5/0402 , A61B5/04028 , A61B5/042 , A61B5/0422 , A61B5/0452 , A61B5/04525 , A61B5/0456 , A61B5/0468 , A61B5/0472 , A61B5/686 , A61B5/6869 , A61B5/72 , A61B5/7203 , A61B5/7221 , A61N1/046 , A61N1/05 , A61N1/0563 , A61N1/3622 , A61N1/3625 , A61N1/3704 , A61N1/3925 , A61N1/3956 , A61N1/3987
摘要： New and alternative approaches to the monitoring of cardiac signal quality for external and/or implantable cardiac devices. In one example, signal quality is monitored continuously or in response to a triggering event or condition and, upon identification of a reduction in signal quality, a device may reconfigure its sensing state. In another example, one or more trends of signal quality are monitored by a device, either continuously or in response to a triggering event or condition, and sensing reconfiguration may be performed in response to identified trends and events. In yet another example, a device may use a looping data capture mode to track sensing data in multiple vectors while primarily relying on less than all sensing vectors to make decisions and, in response to a triggering event or condition, the looped data can be analyzed automatically, without waiting for additional data capture to reconfigure sensing upon identification of the triggering event or condition. In another example a device calculates a composite cardiac cycle by overlaying signal morphology for a number of cardiac cycles and analyzes the composite cardiac cycle to calculate signal quality metrics.

4. 发明公开

EP3346914A1 SYSTEM FOR ANALYZING ELECTROPHYSIOLOGICAL DATA AND METHOD FOR ANALYZING ELECTROPHYSIOLOGICAL DATA 有权转让
公开(公告)号：EP3346914A1
公开(公告)日：2018-07-18
申请号：EP16763726.3
申请日：2016-09-07
申请人： Ablacon Inc.
发明人： RUPPERSBERG, Peter
IPC分类号： A61B5/042 , A61B5/00 , A61B18/14 , A61B5/04 , A61B5/0402 , A61B5/044 , A61B18/00
CPC分类号： A61B5/0006 , A61B5/04011 , A61B5/04012 , A61B5/04017 , A61B5/04028 , A61B5/0422 , A61B5/044 , A61B5/6852 , A61B5/6858 , A61B5/742 , A61B18/1492 , A61B2018/00267 , A61B2018/00351 , A61B2018/00577 , A61B2018/1467 , A61B2090/065
摘要： Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart. In some embodiments, electrogram signals are acquired from inside a patient's heart, and subsequently normalized, adjusted and/or filtered, followed by generating a two-dimensional spatial map, grid or representation of the electrode positions, processing the amplitude-adjusted and filtered electrogram signals to generate a plurality of three-dimensional electrogram surfaces corresponding at least partially to the 2D map, one surface being generated for each or selected discrete times, and processing the plurality of three-dimensional electrogram surfaces through time to generate a velocity vector map corresponding at least partially to the 2D map. The resulting velocity vector map is configured to reveal the location of the source of the at least one cardiac rhythm disorder, which may be, by way of example, an active rotor in a patient's myocardium and atrium.

5. 发明公开

EP3295870A1 HANDHELD ELECTROCARDIOGRAPHIC MEASUREMENT DEVICE 审中-公开
标题翻译：手持式心电图测量装置
公开(公告)号：EP3295870A1
公开(公告)日：2018-03-21
申请号：EP16792533.8
申请日：2016-04-25
申请人： Murata Manufacturing Co., Ltd.
发明人： SHIMUTA, Toru
IPC分类号： A61B5/0402 , A61B5/02
CPC分类号： A61B5/0404 , A61B5/0205 , A61B5/02427 , A61B5/04017 , A61B5/0408 , A61B5/6826
摘要： A handheld electrocardiographic measurement device (1) includes a substantially spheroidal body part (10), a stopper portion (11) projecting along an axial direction of the body part (10) to restrict a position of a thumb of one hand by abutting on a side surface of the thumb when a user grips the body part (10) with the one hand, a platelike flange portion (18) projecting from a side surface of the body part (10) in a direction substantially orthogonal to a projecting direction of the stopper portion (11), a first electrocardiographic electrode (19A) disposed on a back side of the body part (10) to touch a finger of the one hand when the body part (10) is gripped with the one hand, and a second electrocardiographic electrode (19B) disposed on a surface of the flange portion (18) to touch a finger of the other hand when the flange portion (18) is pinched by the other hand.
摘要翻译：手持式心电图测量装置（1）包括基本上类球形的本体部分（10），沿着本体部分（10）的轴向方向突出的止动部分（11），用于通过邻接一个手的拇指来限制一只手的拇指的位置当用户用一只手抓住主体部分10时拇指的拇指侧表面沿着与主体部分10的突出方向基本正交的方向从主体部分10的侧表面突出的板状凸缘部分18，当用一只手握住身体部位（10）时，第一心电电极（19A）设置在身体部位（10）的后侧上以接触一只手的手指，第二心电电极当凸缘部分（18）被另一只手夹住时，心电图电极（19B）设置在凸缘部分（18）的表面上以接触另一只手的手指。

6. 发明授权

EP3052019B1 SYSTEM AND METHOD FOR MYOCARDIAL PERFUSION PATHOLOGY CHARACTERIZATION 有权
标题翻译：用于心肌灌注病理学表征的系统和方法
公开(公告)号：EP3052019B1
公开(公告)日：2018-03-07
申请号：EP14780477.7
申请日：2014-10-01
申请人： Koninklijke Philips N.V. , Kings College London
发明人： BREEUWER, Marcel , CHIRIBIRI, Amedeo , NAGEL, Eike
IPC分类号： A61B5/055 , G01R33/563 , A61B5/026 , A61B6/03 , A61B6/00 , A61B8/06 , A61B8/08 , G06T7/00 , G01R33/56
CPC分类号： A61B5/055 , A61B5/0044 , A61B5/026 , A61B5/04017 , A61B5/0402 , A61B6/032 , A61B6/037 , A61B6/481 , A61B6/503 , A61B6/507 , A61B8/06 , A61B8/0883 , A61B8/481 , G01R33/5608 , G01R33/56366 , G06T7/0016 , G06T2207/10076 , G06T2207/30048 , G06T2207/30104
摘要： A method of characterizing myocardial perfusion pathology by analyzing a plurality of medical images of at least a portion of the heart of a subject of interest (20), acquired in a consecutive manner by a medical imaging modality (10), the method comprising steps of: sampling intensities of selected myocardial image positions from the plurality of medical images and assigning an index representing an order of acquisition to the respective sampled intensities of the myocardial image positions to obtain intensity curves (60); and—calculating an index number (64, 66) indicative of a spatio-temporal perfusion inhomogeneity or perfusion dephasing among at least a subset of myocardial segments of the plurality of myocardial segments, based on the obtained intensity curves (60); a system (52) for myocardial perfusion pathology characterization by analyzing a plurality of medical images by carrying out such method; a medical imaging modality (10) comprising such system (52); a software module (48) for carrying out such method.

7. 发明公开

EP3259025A1 APPARATUS FOR ATRIAL ARRHYTHMIA EPISODE DETECTION 有权
公开(公告)号：EP3259025A1
公开(公告)日：2017-12-27
申请号：EP16708295.7
申请日：2016-02-18
申请人： Medtronic, Inc.
发明人： SARKAR, Shantanu , HANSEN, Daniel L. , NEITZELL, Grant A. , REILAND, Jerry D. , WYSZYNSKI, Ryan
IPC分类号： A61N1/365 , A61B5/04
CPC分类号： A61B5/046 , A61B5/04 , A61B5/04012 , A61B5/04014 , A61B5/04017 , A61B5/0452 , A61B5/0456 , A61B5/0464 , A61B5/686 , A61N1/3624 , A61N1/36507 , A61N1/36592 , A61N1/395 , A61N1/3987
摘要： A method and implantable medical device for determining an atrial arrhythmia event that includes sensing a cardiac signal, determining an atrial arrhythmia score for identifying the arrhythmia event in response to the sensed cardiac signal, determining a sensing window in response to the sensed cardiac signal, the sensing window having a first portion and a second portion, determining signal characteristics of the sensed cardiac signal within the first portion and within the second portion, determining whether the sensed cardiac signal within the first portion and within the second portion corresponds to a P-wave in response to the determined signal characteristics, determining whether a signal to noise ratio of the sensed cardiac signal within the first portion and the second portion of the sensing window is satisfied, determining whether to update the arrhythmia score in response to the determined P-wave and the determined signal to noise ratio, and determining whether to delivery an arrhythmia therapy in response to the updated arrhythmia score.

8. 发明公开

EP3259022A1 APPARATUS FOR IDENTIFYING SICK SINUS SYNDROME IN AN IMPLANTABLE CARDIAC MONITORING DEVICE 有权
标题翻译：用于识别植入式心脏监测设备中的SICK SINUS综合征的装置
公开(公告)号：EP3259022A1
公开(公告)日：2017-12-27
申请号：EP16705702.5
申请日：2016-02-12
申请人： Medtronic, Inc.
发明人： SARKAR, Shantanu
IPC分类号： A61N1/365 , A61B5/04
CPC分类号： A61B5/046 , A61B5/04 , A61B5/04012 , A61B5/04014 , A61B5/04017 , A61B5/0422 , A61B5/0452 , A61B5/0456 , A61B5/0464 , A61B5/686 , A61N1/3624 , A61N1/36507 , A61N1/36592 , A61N1/395 , A61N1/3987
摘要： A cardiac monitoring device for determining the occurrence of a sick sinus syndrome condition of a patient that includes a plurality of electrodes to sense a cardiac signal, a sensing module electrically coupled to the plurality of electrodes having circuitry positioned therein to receive the sensed cardiac signal, and a processor coupled to the sensing module and configured to determine an RR interval variability during an RR interval variability session in response to the sensed cardiac signal, determine whether a P-wave occurs during the RR interval variability session, determine whether a sick sinus indicator is satisfied in response to a P-wave occurring, increment a sick sinus count in response to the sick sinus indicator being satisfied, determine whether a sick sinus burden is satisfied in response to the sick sinus count being incremented, and determine the occurrence of sick sinus syndrome in response to the sick sinus burden being satisfied.

9. 发明公开

EP3259021A1 APPARATUS FOR ATRIAL ARRHYTHMIA EPISODE DETECTION 有权
公开(公告)号：EP3259021A1
公开(公告)日：2017-12-27
申请号：EP16708299.9
申请日：2016-02-18
申请人： Medtronic, Inc.
发明人： SARKAR, Shantanu , HANSEN, Daniel L. , NEITZELL, Grant A.
IPC分类号： A61N1/362 , A61B5/04
CPC分类号： A61B5/046 , A61B5/04 , A61B5/04012 , A61B5/04014 , A61B5/04017 , A61B5/0452 , A61B5/0456 , A61B5/0464 , A61B5/686 , A61N1/3624 , A61N1/36507 , A61N1/36592 , A61N1/395 , A61N1/3987
摘要： A method and implantable medical device for determining an atrial arrhythmia event that includes sensing a cardiac signal, determining an atrial arrhythmia score for identifying the arrhythmia event in response to the sensed cardiac signal, determining a sensing window in response to the sensed cardiac signal, the sensing window having a first portion and a second portion, determining signal characteristics of the sensed cardiac signal within the first portion and within the second portion, determining whether the sensed cardiac signal within the first portion and within the second portion corresponds to a P-wave in response to the determined signal characteristics, determining whether a signal to noise ratio of the sensed cardiac signal within the first portion and the second portion of the sensing window is satisfied, determining whether to update the arrhythmia score in response to the determined P-wave and the determined signal to noise ratio, and determining whether to delivery an arrhythmia therapy in response to the updated arrhythmia score.

10. 发明公开

EP3212074A4 SYSTEMS AND METHODS FOR ABLATING TISSUE 有权
公开(公告)号：EP3212074A4
公开(公告)日：2017-11-08
申请号：EP14905089
申请日：2014-10-30
申请人： KARDIUM INC
发明人： WEINKAM DANIEL R , REINDERS DANIEL M , HARRINGTON DARRELL A , GOERTZEN DOUGLAS W , WEBER MICHAEL H
IPC分类号： A61B5/042 , A61B5/00 , A61B5/04 , A61B5/044 , A61B5/0456 , A61B18/12 , A61N1/08 , A61N1/36
CPC分类号： A61B18/1492 , A61B5/04017 , A61B5/042 , A61B5/0422 , A61B5/044 , A61B5/0452 , A61B5/0456 , A61B5/4848 , A61B5/6853 , A61B5/6858 , A61B5/7275 , A61B5/7285 , A61B5/743 , A61B5/7445 , A61B18/12 , A61B18/16 , A61B2018/0022 , A61B2018/00267 , A61B2018/00577 , A61B2018/00642 , A61B2018/00839 , A61B2018/00988 , A61B2505/05 , A61N1/056 , A61N1/08 , A61N1/36
摘要： Intra-cardiac voltage data display systems display a plurality of data sets derived at least from intra-cardiac voltage data sampled by an electrode. In some embodiments, at least some of the data sets are derived from a portion of the intra-cardiac voltage data that excludes an excludable portion of the intra-cardiac voltage data having a relationship with an occurrence of a particular cardiac event to facilitate identification of the existence of a transmural lesion in tissue adjacent the electrode. In some embodiments, the particular cardiac event is the occurrence of an R wave in the cardiac cycle, and the excludable portion is a V wave in the cardiac cycle.

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