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1. 发明公开

EP4440623A1 COMBINATION THERAPY FOR CANCER TREATMENT 审中-公开
公开(公告)号：EP4440623A1
公开(公告)日：2024-10-09
申请号：EP22902337.9
申请日：2022-11-29
申请人： Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center
发明人： DUNCAN, James S.
IPC分类号： A61K47/64 , A61P35/00
CPC分类号： A61P35/00 , A61K47/55 , A61K45/06 , A61K31/517 , A61K31/166 , A61K31/519

2. 发明公开

EP3200792A2 POLY (ADP-RIBOSE) POLYMERASE 1 INHIBITORS STRUCTURALLY UNRELATED TO NAD 审中-公开
标题翻译： POLY（ADP-RIBOSE）聚合酶1抑制剂结构上与NAD无关
公开(公告)号：EP3200792A2
公开(公告)日：2017-08-09
申请号：EP15847892.5
申请日：2015-09-30
申请人： The Institute for Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center
发明人： TULIN, Alexei
IPC分类号： A61K31/4453 , A61P35/00 , C07D211/14
CPC分类号： C07D405/14 , A61P35/00 , C07D207/06 , C07D263/04 , C07D295/15 , C07D317/28 , C07D317/72 , C07D319/06 , C07D405/06 , C07D407/04
摘要： Compounds that are not related to NAD, and which target PARP1-histone H4 interaction are provided, as well as compositions of these compounds, and methods for specific inhibition of poly(ADP-ribose) polymerase 1 (PARP-1) using these compounds are provided. These PARP-1 inhibitors may be used to treat cancer in which PARP-1 activation or biologic activity plays a role, including prostate cancer, breast cancer, kidney cancer, ovarian cancer, lymphoma, leukemia, and glioblastoma, among others.
摘要翻译：提供了与NAD无关并且靶向PARP1-组蛋白H4相互作用的化合物，以及这些化合物的组合物以及使用这些化合物特异性抑制聚（ADP-核糖）聚合酶1（PARP-1）的方法是提供。这些PARP-1抑制剂可用于治疗其中PARP-1活化或生物活性起作用的癌症，包括前列腺癌，乳腺癌，肾癌，卵巢癌，淋巴瘤，白血病和成胶质细胞瘤等。

3. 发明授权

EP1021175B1 COMPOUNDS AND METHODS FOR THERAPEUTIC INTERVENTION IN PREVENTING DIABETIC COMPLICATIONS 失效
标题翻译：连接和方法对于治疗干预糖尿病并发症防治
公开(公告)号：EP1021175B1
公开(公告)日：2015-04-08
申请号：EP98904931.7
申请日：1998-02-05
申请人： FOX CHASE CANCER CENTER
发明人： BROWN, Truman, R. , KAPPLER, Francis , SZWERGOLD, Benjamin , LAL, Sundeep , SU, Bangying
IPC分类号： A61P5/48 , A61P9/00 , A61P27/12 , A61K31/13 , A61K31/197 , A61K31/198 , A61K31/275 , A61K31/5375 , C07H19/20
CPC分类号： A61K31/13 , A61K31/197 , A61K31/198 , A61K31/275 , A61K31/5375 , C07H19/20

4. 发明公开

EP2425850A8 Bispecific single chain FV antibody molecules and methods of use thereof 有权
标题翻译：双特异性单链Fv抗体分子及其使用方法
公开(公告)号：EP2425850A8
公开(公告)日：2012-04-25
申请号：EP11177829.6
申请日：2006-06-14
申请人： The Regents of The University of California , FOX CHASE CANCER CENTER
发明人： Adams, Gregory P. , Horak, Eva M. , Weiner, Louis M. , Marks, James D.
IPC分类号： A61K39/395 , C07K16/44 , C07K16/28
CPC分类号： A61K39/395 , A61K51/109 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/622 , G01N2333/71
摘要： Bispecific single chain antibody molecules are disclosed which may be used to advantage to treat various forms of cancer associated with the overexpression of members of the EGFR protein family.

5. 发明授权

EP1791958B1 YEAST/BACTERIAL TWO-HYBRID SYSTEM AND METHODS OF USE THEREOF 有权
标题翻译：酵母/细菌双杂交系统及其使用方法
公开(公告)号：EP1791958B1
公开(公告)日：2012-02-22
申请号：EP05806571.5
申请日：2005-08-31
申请人： FOX CHASE CANCER CENTER , THE GENERAL HOSPITAL CORPORATION
发明人： SEREBRIISKII, Ilya , GOLEMIS, Erica, A. , JOUNG, Keith, J.
IPC分类号： C12N15/63 , C07H21/04
CPC分类号： C12N15/72 , C12N15/1055 , C12N15/81
摘要： A combined yeast/bacterial two-hybrid system is disclosed.

6. 发明公开

EP1898692A2 ALTERNATE MORPHEEINS OF ALLOSTERIC PROTEINS AS A TARGET FOR THE DEVELOPMENT OF BIOACTIVE MOLECULES 审中-公开
标题翻译：作为生物活性分子开发目标的异构蛋白质异构体
公开(公告)号：EP1898692A2
公开(公告)日：2008-03-19
申请号：EP06773249.5
申请日：2006-06-15
申请人： FOX CHASE CANCER CENTER
发明人： JAFFE, Eileen, K.
IPC分类号： A01H1/00 , A61K38/42 , A61K31/192 , C12N9/10
CPC分类号： C12N9/10 , A61K31/00 , A61K31/04 , A61K31/192 , C12N9/0006 , C12N9/1077
摘要： A composition having an agent adapted to affect a multimeric protein by binding to a binding site thereof and thereby affecting an equilibrium of units, the multimeric protein has an assembly having a plurality of said units, each of the units has a first complementary surface and a second complementary surface and the first complementary surface of one unit is associated with the second complementary surface of another unit, provided that the assembly is at least one of different quaternary isoforms and on a condition that in the multimeric protein (1) a structure of each of the units determines a structure of the different quaternary isoforms, (2) the units are in the equilibrium and (3) the structure of the different quaternary isoforms influences a function of the multimeric protein, wherein said multimeric protein is Pseudomonas aeruginosa GDP-Mannose dehydrogenase, Bacillus subtilis HPr, kinase/phosphatase, mammalian CoA transferase, purine nucleoside phosphorylase, or peroxiredoxins.
摘要翻译：一种组合物，其具有适合通过结合其结合位点影响多聚体蛋白并由此影响单位平衡的试剂，所述多聚体蛋白具有含有多个所述单位的组件，每个单位具有第一互补表面和第二互补表面并且一个单元的第一互补表面与另一个单元的第二互补表面相关联，条件是该组件是至少一种不同的四元同等型，并且在多聚蛋白质（1）中每个单元的结构（2）单元处于平衡状态，以及（3）不同季化异构体的结构影响多聚体蛋白质的功能，其中所述多聚体蛋白质是铜绿假单胞菌（Pseudomonas aeruginosa）GDP-Mannose 枯草芽孢杆菌HPr，激酶/磷酸酶，哺乳动物CoA转移酶，嘌呤核苷磷酸化酶或过氧化物酶昕。

7. 发明公开

EP1791958A2 YEAST/BACTERIAL TWO-HYBRID SYSTEM AND METHODS OF USE THEREOF 有权
标题翻译：酵母/细菌双杂交系统及其使用方法
公开(公告)号：EP1791958A2
公开(公告)日：2007-06-06
申请号：EP05806571.5
申请日：2005-08-31
申请人： FOX CHASE CANCER CENTER , THE GENERAL HOSPITAL CORPORATION
发明人： SEREBRIISKII, Ilya , GOLEMIS, Erica, A. , JOUNG, Keith, J.
IPC分类号： C12N15/63 , C07H21/04
CPC分类号： C12N15/72 , C12N15/1055 , C12N15/81
摘要： A combined yeast/bacterial two-hybrid system is disclosed.

8. 发明公开

EP1148878A1 1,4,8,11-TETRAAZACYCLOTETRADECANE DERIVATIVES AS RADIODIGANOSTIC AGENTS AND THEIR USE IN DETERMINING HYPOXIA AND RADIORESISTANCE OF TUMORS 审中-公开
标题翻译：随着无线电诊断1,4,8,11四CYCLOTETRADECANE衍生物及其使用缺氧和抗辐射肿瘤的决心
公开(公告)号：EP1148878A1
公开(公告)日：2001-10-31
申请号：EP00908353.6
申请日：2000-01-26
申请人： FOX CHASE CANCER CENTER
发明人： CHAPMAN, Donald J. , SCHNEIDER, Richard F. , ENGELHARDT, Edward L.
IPC分类号： A61K31/415 , C07D257/02 , C07F13/00
CPC分类号： C07D403/14 , A61K49/0002 , A61K51/0497 , C07B59/002 , C07D403/04 , C07F13/005
摘要： 1,4,8,11-Tetraazacyclotetradecane which is chemically linked to from one to four nitroimidazol groups provides an effective radiodiagnostic agent for determining tissue hypoxia and radioresistance of tumor tissue.

9. 发明公开

EP1140147A2 hCG THERAPY FOR THE TREATMENT OF BREAST CANCER 有权
标题翻译： hCG的治疗转移性乳腺癌的治疗
公开(公告)号：EP1140147A2
公开(公告)日：2001-10-10
申请号：EP99967331.2
申请日：1999-12-15
申请人： FOX CHASE CANCER CENTER , Applied Research Systems ARS Holding N.V.
发明人： RUSSO, Irma, H. , RUSSO, Jose , DELUCA, Giampiero , JANSSENS, Jaak, Ph.
IPC分类号： A61K38/24 , A61P35/00
CPC分类号： A61K38/24 , A61K2300/00
摘要： This invention relates to the field of cancer therapy. More particularly, the invention relates to the treatment of mammary tumor, clinically manifest mammary tumor (breast cancer) and metastatic mammary tumor by administration of human Chorionic Gonadotropin (hCG). The treatment preferably comprises the administration of hCG in conjunction with an antiestrogen and/or a Type I Interferon.

10. 发明公开

EP1009230A1 NOVEL GENE ENCODING A DNA REPAIR ENDONUCLEASE AND METHODS OF USE THEREOF 失效
标题翻译： NEW GEN，对的DNA修复核酸内切酶码及使用方法
公开(公告)号：EP1009230A1
公开(公告)日：2000-06-21
申请号：EP98939122.2
申请日：1998-07-28
申请人： FOX CHASE CANCER CENTER
发明人： BELLACOSA, Alfonso
IPC分类号： A01K67/00 , A61K38/46 , A61K39/395 , C07H21/00 , C07K16/18 , C07K16/40 , C12N9/16 , C12N15/12 , C12N15/55 , C12N15/63 , C12Q1/68
CPC分类号： C07H21/04 , A01K2217/05 , A61K38/00 , C12N9/22 , C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , G01N2333/988
摘要： An isolated nucleic acid molecule encoding a human endonuclease, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids, proteins and antibodies thereto may be used to advantage in genetic or cancer screening assays. MED1, which recognizes and cleaves DNA, may also be used for the diagnostic detection of mutations and genetic variants.

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