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1. 发明公开

EP0984284A3 Apparatus for use in automated analyzer 失效
标题翻译：在自动分析装置中使用的设备
公开(公告)号：EP0984284A3
公开(公告)日：2000-05-31
申请号：EP99203974.3
申请日：1992-02-21
申请人： Ciba Corning Diagnostics Corp.
发明人： Carey, Glen A. , Lewis, Scott C. , Mann, Raymond A. , Whitesel, Mary Beth , Polaniec, James P. , Woyansky, George J. , Pabst, Stefan R. , Klingshirn, Frank C.
IPC分类号： G01N35/02 , G01N21/76 , B01L3/00
CPC分类号： B01L3/508 , B01L2300/0854 , G01N21/76 , G01N35/0098 , G01N35/021 , G01N35/025 , G01N35/1002 , G01N35/1065 , G01N2035/00386 , G01N2035/00396 , G01N2035/00524 , G01N2035/00752 , G01N2035/0441 , G01N2035/0443 , G01N2035/0465 , G01N2035/0484 , G01N2035/0486 , G01N2035/1025 , Y10S215/01 , Y10S215/03 , Y10S215/08 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： Inter alia, an apparatus for selectively dispensing reagent into first and second vertical reagent dispense axes, for use in an automated analyzer to assay a test sample, the said analyzer having an event conveyor for conveying a plurality of cuvettes along an event path which includes a vertical sample dispense axis, the said first vertical reagent dispense axis which is spaced from and downstream of the said sample dispense axis and the said second vertical reagent dispense axis which is spaced from and downstream of the said first reagent axis, the said apparatus being characterised in that it comprises: (a) a reagent transport and selection means for supporting a plurality of first reagent containers which contain labeled reagent and a plurality of second reagent containers which contain solid phase reagent, and for selectively positioning any one of the said first reagent containers at one of a first vertical reagent aspirating axis and a second vertical reagent aspirating axis, and for selectively positioning any one of the said second reagent containers at one of a third vertical reagent aspirating axis and a fourth vertical reagent aspirating axis; (b) a first reagent probe transport means for supporting a first reagent aspirating and dispense probe for selective vertical movement between an upper position and a lower aspirating and dispense position and for selective horizontal movement between the said first reagent dispense axis and either of the said first and third reagent dispense axes; (c) a second reagent probe transport means for supporting a second reagent aspirating and dispensing probe for selective vertical movement between an upper position and a lower aspirating and dispense position and for selective horizontal movement between the said second reagent dispense axis and either of the said second and fourth dispense axes; and (d) control means including a central processing unit operatively connected to the said reagent transport and selection means, the said first reagent probe transport means and the said second reagent transport means for selectively positioning a predetermined first reagent container at either of the said first and second reagent aspirating axes and a predetermined second reagent container at either of the said third and fourth reagent aspirating axes, for selectively positioning the said first reagent probe for aspirating reagent from a selected first reagent container at the said first reagent aspirating axis or a selected second reagent container at the said third reagent aspirating axis, or from both of the said selected first and second selected reagent containers and for dispensing aspirated reagent into a cuvette at the said first reagent dispense axis, and, for selectively positioning the said second reagent probe for aspirating reagent from a selected first reagent container at the said second reagent aspirating axis or a selected second reagent container at the said fourth reagent aspirating axis, or from both of the said selected first and second reagent containers and for dispensing aspirated reagent into a cuvette at the said second reagent dispense axis is disclosed.

2. 发明授权

EP0572217B1 Rapid, improved immunoassays via the use of novel immune complex transfer techniques 失效
标题翻译：使用新的免疫复合转印技术快速，提高免疫
公开(公告)号：EP0572217B1
公开(公告)日：1999-07-28
申请号：EP93304042.0
申请日：1993-05-25
申请人： Ciba Corning Diagnostics Corp.
发明人： Piran, Uri , Riordan, William J. , Silbert-Shostek, Deborah R.
IPC分类号： G01N33/543 , G01N33/58
CPC分类号： G01N33/54306 , G01N33/54333 , Y10S435/961 , Y10S435/968 , Y10S435/971 , Y10S436/829

3. 发明授权

EP0519623B1 Multiple surface evanescent wave sensor system 失效
标题翻译：传感器系统具有多个表面倏逝波
公开(公告)号：EP0519623B1
公开(公告)日：1998-08-12
申请号：EP92305122.1
申请日：1992-06-04
申请人： Ciba Corning Diagnostics Corp.
发明人： Slovacek, Rudolf E. , Love, Walter F. , Cook, Thomas A. , Schulkind, Richard L. , Walczak, Irene M.
IPC分类号： G01N21/64 , G01N33/533 , G02B6/02
CPC分类号： G01N21/7703 , G01N21/648 , Y10S435/808 , Y10S436/805 , Y10S436/807

4. 发明公开

EP0829451A1 Fluid delivery system 失效
标题翻译：液体输送系统
公开(公告)号：EP0829451A1
公开(公告)日：1998-03-18
申请号：EP97203232.0
申请日：1994-07-21
申请人： Ciba Corning Diagnostics Corp.
发明人： Venooker, Ronald J. , Scavitto, John a. , Karkantis, Peter N. , Healey, David T. , Travers, Richard L.
IPC分类号： B67D5/02
CPC分类号： B67D7/0277 , B01L3/565 , B67D7/0294 , G01N35/1002
摘要： A fluid delivery system for aspirating liquid from a bottle (40) and conveying the liquid to a manifold fitting (55) of an analyzing instrument, said bottle having an interior space which contains a quantity of liquid and an opening to said interior space, said manifold fitting (55) having a cavity, an opening to the cavity, an access surface within said cavity and a fluid port in said access surface for operatively connecting the cavity to a source of sub-atmospheric pressure, said fluid delivery system comprising:

(a) coupling means (54) having a first end which is operatively connected to said opening of said bottle, and a second end which has a connector fitting (130) which is complimentary with said manifold fitting (55), said connector fitting having an end surface (129) and an opening in said end surface, said coupling means having a liquid passageway (138) which is operatively connected to the opening of said bottle and which extends from said first end to the opening in said end surface;
(b) connecting means for releasably connecting said connector fitting to said manifold fitting so that said end surface (129) abuts said access surface and said liquid passageway (138) is aligned with said fluid port for operatively connecting said fluid port to the opening of said bottle; and
(c) sealing means for forming a seal between said end surface and said access surface around said fluid port is disclosed.

5. 发明公开

EP0753748A3 Sample transport system 失效
标题翻译：样品输送
公开(公告)号：EP0753748A3
公开(公告)日：1998-01-07
申请号：EP96305159.4
申请日：1996-07-12
申请人： Ciba Corning Diagnostics Corp.
发明人： Lapeus, David J. , Ballash, Michael A.
IPC分类号： G01N35/04 , B01L9/06
CPC分类号： B01L9/06 , B01L2200/025 , G01N35/026 , G01N35/04 , G01N2035/00752 , G01N2035/0467 , G01N2035/0477
摘要： A magnetic conveyor system for transporting test samples in tubes disposed in a sample rack having a magnetic or magnetically attractive region is described. The magnetic conveyor system includes a drive system, a magnet coupled to the drive system and movable in response to the drive system and a tray having a first surface adapted to receive the sample rack. The magnet is spaced a predetermined distance from the first surface of the tray such that the magnet provides a magnetic force at the surface of the tray. The magnetic force engages the magnetically attractive region of the sample rack disposed on the tray to thereby move the sample rack along the first surface of the tray in response to movement of the drive system. When the tray reaches the end of the rack it is moved onto a processing queue tray where it is available for test purposes. A barcode reader reads a bar code on each test sample as it is placed on the process queue to identify one or more tests to perform. When all samples have received the individual tests the rack exits to an output queue for disposal. When a test must be made on an immediate basis out of normal processing order a sample rack can be inserted into the process queue via a priority rack feed. In the indicated manner, testing can continue without interruption as new racks are added and completed racks removed.

6. 发明授权

EP0716740B1 METHOD FOR ACTIVATION OF POLYANIONIC FLUORESCENT DYES IN LOW DIELECTRIC MEDIA WITH QUATERNARY ONIUM COMPOUNDS 失效
标题翻译：一种用于多阴离子荧光染料在低介电常数介质中的活化与季鎓化合物的方法
公开(公告)号：EP0716740B1
公开(公告)日：1997-02-05
申请号：EP94923826.5
申请日：1994-08-30
申请人： Ciba Corning Diagnostics Corp.
发明人： MUNKHOLM, Christiane
IPC分类号： G01N21/64 , C09K11/06
CPC分类号： G01N21/643 , G01N21/648 , G01N31/221 , G01N33/0047 , Y10T436/102499 , Y10T436/16 , Y10T436/173845 , Y10T436/175383 , Y10T436/204998 , Y10T436/207497
摘要： The invention pertains to a method for generating the fluorescence of polyanionic fluorophores in low dielectric media with fluorescence activation produced by specific quaternary onium compounds. The method may be used for measuring an analyte and may be useful in sensor devices.

7. 发明公开

EP0754241A1 HIBRIDIZATION-LIGATION ASSAYS FOR THE DETECTION OF SPECIFIC NUCLEIC ACID SEQUENCES 失效
标题翻译：杂交诉讼，检测方法的特定DNA序列
公开(公告)号：EP0754241A1
公开(公告)日：1997-01-22
申请号：EP95912383.0
申请日：1995-04-03
申请人： Ciba Corning Diagnostics Corp.
发明人： MARTINELLI, Richard, A. , ARRUDA, John, C.
IPC分类号： C07K14 , C12Q1
CPC分类号： C12Q1/6823 , C07K14/4712 , C12Q1/682 , C12Q1/6827 , C12Q1/6862
摘要： A new method has been developed for conducting a gene probe assay. The preferred technique involves (1) using a gene amplification technique (e.g., PCR) to multiply the gene sequence of interest and (2) using a hybridization-ligation detection methodology, wherein the sequences of probes hybridized to the target sequence allow for separation and detection (e.g., probes might contain a combination of magnetic particles and acridinium esters) to determine if a specific sequence is present,

8. 发明公开

EP0753750A2 Method and apparatus for aspirating and dispensing sample fluids 失效
标题翻译： Verfahren und Vorrichtung zum Aufsaugen und Abgeben vonProbenflüssigkeiten
公开(公告)号：EP0753750A2
公开(公告)日：1997-01-15
申请号：EP96305121.4
申请日：1996-07-11
申请人： Ciba Corning Diagnostics Corp.
发明人： Dorenkott, Jeffrey S. , Wilder, Steven E. , Nguyen, Dinh , Murthy, Kurukundi Ramesh
IPC分类号： G01N35/10
CPC分类号： G01N35/1009 , G01F11/021 , G01F11/029 , G01F23/14 , G01M3/26 , G01N1/38 , G01N2035/1025
摘要： A method and apparatus for aspirating and dispensing a sample fluid. The apparatus includes an air source having an output port coupled to a first port of a flow through pressure transducer. A second port of the flow through pressure transducer is coupled to a first port of a sample probe. The flow through pressure transducer provides transducer signals to a detector circuit. In response to the transducer signals provided thereto, the detector detects the occurrence or non-occurrence of a plurality of different events.
摘要翻译：用于抽吸和分配样品流体的方法和装置。该装置包括具有连接到流过压力传感器的第一端口的输出端口的空气源。流过压力传感器的第二端口耦合到样品探针的第一端口。通过压力传感器的流量将检测器信号提供给检测器电路。响应于提供给它的换能器信号，检测器检测多个不同事件的发生或不发生。

9. 发明授权

EP0481704B1 Amplification of midivariant DNA templates 失效
标题翻译：的midivariant DNA模板扩增
公开(公告)号：EP0481704B1
公开(公告)日：1996-09-25
申请号：EP91309430.6
申请日：1991-10-14
申请人： Ciba Corning Diagnostics Corp.
发明人： Martinelli, Richard M. , Donahue, Jeffrey J. , Unger, John T.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/682 , C12Q1/6867 , C12Q2561/125 , C12Q2531/149 , C12Q2521/501

10. 发明公开

EP0643306A3 Method for non-competitive binding assays 失效
标题翻译：处理程序对非竞争结合试验。
公开(公告)号：EP0643306A3
公开(公告)日：1996-01-24
申请号：EP94306702.5
申请日：1994-09-13
申请人： Ciba Corning Diagnostics Corp.
发明人： Piran, Uri , Livshin, Laurie Ann , Riordan, William J.
IPC分类号： G01N33/543 , G01N33/58 , C12Q1/68 , G01N33/76 , G01N33/94
CPC分类号： C12Q1/6813 , C12Q1/6834 , G01N33/54306 , G01N2033/008
摘要： Inter alia , a binding assay for determination of an analyte characterised in that it is conducted in one container and comprises:
(a) mixing an analyte-containing solution with a labelled specific binder which binds to a first binding site on the analyte to form an analyte-labelled specific binder complex; (b) contacting the solution from (a) with one or more materials comprising:
(1) a reagent which contains an insoluble material to which is attached an analyte derivative or an analyte mimic that binds the labelled specific binder that had not bound analyte;
and
(2) a reagent that contains a second binder which binds to one portion of the analyte-labelled specific binder complex, such second binder being bound to a solid phase, such that the insoluble material, by binding to the labelled specific binder that had not bound analyte, inhibits the binding of the unreacted labelled specific binder to the second binder and allows the measurement of the label bound to the second binder when the label is bound to the second binder, but substantially prevents the measurement of the label bound to the insoluble material; (c) measuring the label associated with the second binder;
and
(d) determining the amount of analyte by comparing the amount of the label measured to that in a reference solution is disclosed.

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