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1. 发明公开

EP2569070A4 PRESSURE SENSING AND FLOW CONTROL IN DIFFUSION- BONDED PLANAR DEVICES FOR FLUID CHROMATOGRAPHY 审中-公开
标题翻译： DRUCKERFASSUNG UND FLUSSSTEUERUNG IN DIFFUSIONSGEBUNDENEN PLANAREN VORRICHTUNGENFÜRFLÜSSIGCHROMATOGRAPHIE
公开(公告)号：EP2569070A4
公开(公告)日：2014-12-10
申请号：EP11781179
申请日：2011-05-10
申请人： WATERS TECHNOLOGIES CORP
发明人： BUNNER BERNARD , GERHARDT GEOFF C , DOURDEVILLE THEODORE A
IPC分类号： B01D15/10 , B01D15/16 , B01L3/00 , G01L9/00 , G01L15/00 , G01L19/00 , G01N30/00 , G01N30/32 , G01N30/34 , G05D7/06
CPC分类号： G01N30/32 , B01D15/163 , B01L3/502746 , B01L2200/0605 , B01L2200/146 , B01L2300/0663 , B01L2300/0867 , B01L2300/0883 , B01L2300/14 , B01L2400/0487 , B01L2400/082 , B01L2400/086 , G01L9/0026 , G01L9/0042 , G01L9/0055 , G01L13/02 , G01L13/025 , G01L15/00 , G01L19/0023 , G01N30/00 , G01N30/34 , G01N30/36 , G01N2030/326 , G05D7/0676 , Y10T137/7762 , B01D15/40
摘要： Flow through pressure sensors for use in fluid chromatography systems include a planar device formed from diffusion bonding of a plurality of metallic sheets and at least one sensing element. The planar device has a top surface, a bottom surface and a flow through channel. A diaphragm formed from a portion of one of the top or bottom surfaces is located adjacent to a sensing region of the flow through channel and is attached to the sensing element. The diaphragm is sized to deflect a distance in response to fluid pressure in the sensing region, which has an internal volume of less than about 25 microliters. The diaphragm and attached sensing element form a pressure sensor that measures strain or deflection of the diaphragm to calculate a pressure within the sensing region.
摘要翻译：用于流体色谱系统的通过压力传感器的流动包括由多个金属片和至少一个感测元件的扩散结合形成的平面装置。平面装置具有顶表面，底表面和流通通道。由所述顶表面或底表面中的一个的一部分形成的隔膜位于所述流通通道的感测区域附近并附接到所述感测元件。隔膜的尺寸适于响应于感测区域中的流体压力而偏转一段距离，其具有小于约25微升的内部体积。隔膜和附接的感应元件形成压力传感器，其测量隔膜的应变或偏转以计算感测区域内的压力。

2. 发明公开

EP1838967A4 TEMPERATURE-CONTROLLED VARIABLE FLUIDIC RESISTANCE DEVICE 有权转让
标题翻译：具有可变液体电阻温控装置
公开(公告)号：EP1838967A4
公开(公告)日：2011-11-02
申请号：EP06718617
申请日：2006-01-18
申请人： WATERS TECHNOLOGIES CORP
发明人： GERHARDT GEOFF C , CHARLTON CHRISTOPHER C
IPC分类号： F15C1/04 , F16K13/10 , F16K99/00
CPC分类号： F16K99/0001 , F15C1/04 , F16K13/10 , F16K99/0021 , F16K99/0032 , F16K99/0036 , F16K2099/0084 , G01N30/6095 , G01N2030/3038 , G01N2030/324 , Y10T137/0391 , Y10T137/6416
摘要： A thermally controlled variable restrictor device provides variable restriction of fluid flow by temperature-induced viscosity changes. The thermally controlled variable restrictor device allows fast variable fluid control by employing a thermo-electric heater-cooler in intimate contact with a fluid channel containing a fluid thereby effecting rapid viscosity changes in the flowing fluid. The permeability and flow rate of fluids through the variable restrictor device can be manipulated by changing the temperature of a restriction element.

3. 发明公开

EP1856518A4 VARIABLE RESISTANCE FLUID CONTROLLER 有权转让
标题翻译： STEUERUNGFÜRFLÜSSIGKEITENVON VARIABLEM WIDERSTAND
公开(公告)号：EP1856518A4
公开(公告)日：2010-09-22
申请号：EP06718616
申请日：2006-01-18
申请人： WATERS TECHNOLOGIES CORP
发明人： GERHARDT GEOFF C , CHARLTON CHRISTOPHER C
IPC分类号： G01N30/06 , G01D11/02
CPC分类号： G01N30/34 , Y10T137/7737 , Y10T137/8597 , Y10T137/85986 , Y10T137/87346 , Y10T137/87539 , G01N30/6095
摘要： A fluid controller apparatus controls fluid flow, such as a solvent gradient flow, in a chromatography system. An apparatus includes a fluid-gradient controller having a fluid reservoir for containing a pump fluid and a pumping device connected to the fluid reservoir for receiving the pump fluid. The pumping device is in fluid communication with parallel-configured first and second solvent lines. The first and second solvent lines each contain a restrictor element and a solvent reservoir. During operation, the pumping device causes the pump fluid to flow through the first and second solvent lines in relation to their respective restriction devices. The pump fluid displaces solvent within the solvent reservoirs. The displaced solvent is mixed to form a solvent gradient.
摘要翻译：流体控制器装置在色谱系统中控制流体流，例如溶剂梯度流。一种装置包括具有用于容纳泵流体的流体储存器和连接到用于接收泵流体的流体储存器的泵送装置的流体梯度控制器。泵送装置与并行配置的第一和第二溶剂管线流体连通。第一和第二溶剂管线各自包含限流元件和溶剂容器。在操作期间，泵送装置使泵流体相对于它们各自的限制装置流过第一和第二溶剂管线。泵流体置换溶剂容器内的溶剂。将置换的溶剂混合以形成溶剂梯度。

4. 发明公开

EP2809414A4 MANAGING FLUIDIC CONNECTIONS TO MICROFLUIDIC DEVICES 有权
标题翻译： WITH流体连接的微流体装置管理
公开(公告)号：EP2809414A4
公开(公告)日：2015-11-25
申请号：EP13743375
申请日：2013-01-30
申请人： WATERS TECHNOLOGIES CORP
发明人： GERHARDT GEOFF C , FADGEN KEITH EDWARD , MICHIENZI JOSEPH D , BUNNER BERNARD
IPC分类号： B01D15/08 , B62D5/083 , G01N30/20
CPC分类号： G01N30/38 , B01L3/502715 , B01L3/502738 , B01L3/567 , B01L2200/0689 , B01L2400/0622 , B01L2400/0644 , F04D15/00 , F04D29/086 , F16K99/0013 , G01N30/20 , G01N2030/202

5. 发明公开

EP1999465A4 CERAMIC-BASED CHROMATOGRAPHY APPARATUS AND METHODS FOR MAKING SAME 有权
标题翻译：色谱作为制作陶瓷基体过程
公开(公告)号：EP1999465A4
公开(公告)日：2014-09-03
申请号：EP07758780
申请日：2007-03-19
申请人： WATERS TECHNOLOGIES CORP
发明人： GERHARDT GEOFF C , MICHIENZI JOSEPH , BENEVIDES CHRISTOPHER C
IPC分类号： G01N30/60
CPC分类号： G01N30/606 , G01N30/6095
摘要： A high-performance liquid-chromatography apparatus includes a substrate that defines a separation column in fluidic communication with an inlet port of the processing unit. The processing unit is formed of sintered inorganic particles. The apparatus also includes a pump that delivers a solvent to the inlet port at a pressure sufficient for high-performance liquid-chromatography.

6. 发明公开

EP2435158A4 TEMPERATURE CONTROL OF ENRICHMENT AND SEPARATION COLUMNS IN CHROMATOGRAPHY 审中-公开
标题翻译：温度控制和分离柱富集色谱
公开(公告)号：EP2435158A4
公开(公告)日：2013-11-06
申请号：EP10781189
申请日：2010-05-27
申请人： WATERS TECHNOLOGIES CORP
发明人： MURPHY JAMES P , FADGEN KEITH , GERHARDT GEOFF C , DONEANU ANGELA , STAPELS MARTHA DEGEN
IPC分类号： B01D35/18 , C02F1/02 , G01N30/88
CPC分类号： G01N30/6095 , B01D15/22 , B01D15/424 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2300/0816 , B01L2400/0487 , G01N30/461 , G01N30/606 , G01N30/6091 , G01N30/7233 , G01N30/7266 , G01N2030/027 , G01N2030/085 , G01N2030/8881 , Y10T29/49826
摘要： A method of analyzing samples includes loading a sufficient quantity of the sample onto a trap column to overload the trap column; heating an analytical column and the trap column to a greater temperature than the analytical column; and pumping a solvent, to the trap column, having a solvent composition profile that, in cooperation with a temperature differential, causes at least some of the components to elute sequentially from the trap column to the analytical column and focus on the analytical column prior to eluting from the analytical column; or optionally: loading a small-molecule sample onto a cooled portion of an analytical column; heating the analytical column; and pumping a solvent, to the heated analytical column, to elute the components from the analytical column. Chromatographic separation includes: a trap column; a separation column; a trap-column heater; a separation-column heater; a solvent pump unit; and a control unit can be used.

7. 发明公开

EP2609351A4 VARIABLE-VOLUME INJECTION VALVE 有权
标题翻译： EINSPRITZVENTIL MIT VARIABLEM VOLUMEN
公开(公告)号：EP2609351A4
公开(公告)日：2017-08-02
申请号：EP11820698
申请日：2011-08-26
申请人： WATERS TECHNOLOGIES CORP
发明人： GERHARDT GEOFF C , FADGEN KEITH
IPC分类号： F16K11/074
CPC分类号： F16K11/00 , F16K11/0743 , Y10T137/0318 , Y10T137/86863
摘要： Variable-volume injection valves include a stator and a rotor. The stator has a first port, a second port, and a contact surface with a groove therein. The first port opens into the stator groove. The rotor has a contact surface with a groove therein. The contact surface of the rotor is urged against the contact surface of the stator such that the rotor groove opposes the stator groove with one end of the rotor groove overlapping the stator groove and the opposite end of the rotor groove overlapping the second port of the stator. The overlapping grooves of the rotor and stator provide a fluidic channel between the first and second ports of the stator. The rotor is movable with respect to the stator in order to vary a length of overlap between their overlapping grooves.
摘要翻译：可变容积的喷射阀包括定子和转子。定子具有第一端口，第二端口和其中具有凹槽的接触表面。第一个端口通向定子槽。转子具有其中具有凹槽的接触表面。转子的接触表面被推靠在定子的接触表面上，使得转子凹槽与定子凹槽相对，转子凹槽的一端与定子凹槽重叠并且转子凹槽的相对端与定子的第二端口重叠。转子和定子的重叠凹槽在定子的第一端口和第二端口之间提供流体通道。转子可相对于定子移动，以改变其重叠凹槽之间的重叠长度。

8. 发明公开

EP2344857A4 TECHNIQUES FOR PATTERNING VALVE COMPONENTS 审中-公开
标题翻译：一种筛选阀门部件
公开(公告)号：EP2344857A4
公开(公告)日：2016-02-24
申请号：EP09824085
申请日：2009-10-28
申请人： WATERS TECHNOLOGIES CORP
发明人： LUONGO JOSEPH A , BUDNICK MICHAEL , MOELLER MARK W , GERHARDT GEOFF C , MURPHY JAMES P , FADGEN KEITH , MICHIENZI JOSEPH D
IPC分类号： G01N1/10
CPC分类号： F16K11/074 , F16K25/005 , G01N2030/202

9. 发明公开

EP2748600A4 ANALYSIS OF DRIED BLOOD SPOT SAMPLES IN A MICROFLUIDIC SYSTEM WITH DILUTION OF EXTRACTED SAMPLES 审中-公开
标题翻译： ENAEM MIKROFLUIDSYSTEM MITVERDÜNNUNGEXTRAHIERTER PROBEN中的分析仪获得者BLUTFLECKPROBEN
公开(公告)号：EP2748600A4
公开(公告)日：2015-06-10
申请号：EP12826104
申请日：2012-08-22
申请人： WATERS TECHNOLOGIES CORP
发明人： MURPHY JAMES P , TOMANY MICHAEL J , MICHIENZI JOSEPH D , RAINVILLE PAUL , PLUMB ROBERT S , GERHARDT GEOFF C , JUNG MOON CHUL
IPC分类号： G01N30/06 , B01L3/00 , G01N1/38 , G01N30/16 , G01N30/46 , G01N30/60 , G01N30/88 , G01N33/96
CPC分类号： G01N30/06 , B01L3/502715 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/1827 , G01N30/16 , G01N30/6095 , G01N30/88 , G01N33/49 , G01N2001/383 , G01N2030/009 , G01N2030/062

10. 发明公开

EP2445602A4 CHROMATOGRAPHY APPARATUS HAVING AN INTEGRATED CORE 审中-公开
标题翻译：具有集成CORE色谱仪
公开(公告)号：EP2445602A4
公开(公告)日：2013-11-13
申请号：EP10792516
申请日：2010-06-11
申请人： WATERS TECHNOLOGIES CORP
发明人： GERHARDT GEOFF C , NEUE UWE DIETER , JEANNOTTE ANTHONY C , DOURDEVILLE THEODORE A
IPC分类号： B01D15/08 , G01N30/20 , G01N30/60
CPC分类号： G01N30/20 , G01N2030/202 , G01N2030/347 , G01N2030/6013 , G01N30/6095

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