专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP2175029B1 LACTIC ACID PRODUCTION METHOD 有权
公开(公告)号：EP2175029B1
公开(公告)日：2020-10-07
申请号：EP08777309.9
申请日：2008-06-18
申请人： Toray Industries, Inc.
发明人： ITO, Masateru , MINEGISHI, Shin-ichi , SHIMIZU, Eri , SAWAI, Kenji , ITO, Yohito , SAWAI, Hideki , YAMADA, Katsushige
IPC分类号： C12P7/56 , B01D61/02 , B01D61/14 , B01D71/56 , C12N15/09

2. 发明公开

EP2374895A1 METHOD FOR PRODUCING LACTIC ACID AND METHOD FOR PRODUCING POLYLACTIC ACID 审中-公开
标题翻译：用于生产乳酸和工艺制造聚乳酸
公开(公告)号：EP2374895A1
公开(公告)日：2011-10-12
申请号：EP09835018.4
申请日：2009-12-25
申请人： Toray Industries, Inc.
发明人： SAWAI, Kenji , SAWAI, Hideki , MIMITSUKA, Takashi , ITO, Masateru , YAMADA, Katsushige , KAWAMURA, Kenji , MINEGISHI, Shin-ichi , NAKAGAWA, Izumi , NAGANO, Tatsuya
IPC分类号： C12P7/56 , C07C59/08 , C08G63/06 , C08G63/08 , C12N15/09
CPC分类号： C07C59/08 , B01D61/027 , B01D71/56 , B01D2311/04 , B01D2311/06 , B01D2311/18 , B01D2311/2669 , B01D2311/2688 , C07B2200/07 , C07C51/42 , C08G63/06 , C12P7/56
摘要： Lactic acid obtained by a method for producing lactic acid, the method comprising: (A) a step of continuous fermentation wherein a fermentation culture medium of a microorganism having an ability of lactic acid fermentation is filtered through a porous membrane having an average pore size of not less than 0.01 µm and less than 1 µm with a transmembrane pressure difference within the range of 0.1 to 20 kPa, and the permeate is collected, while retaining the non-permeated liquid in or returning the non-permeated liquid to the culture, and adding a fermentation feedstock to the culture; (B) a step of filtering the permeate obtained in Step (A) through a nanofiltration membrane; and (C) a step of distilling the permeate obtained in Step (B) under a pressure of not less than 1 Pa and not more than atmospheric pressure, at 25°C to 200°C to recover lactic acid; comprises only small amounts of impurities, and a polylactic acid obtained using the lactic acid as a raw material has excellent thermal stability, mechanical strength and hue.
摘要翻译：通过一种用于生产乳酸得到的乳酸，所述方法包括：（A）worin通过具有上的平均孔径的多孔膜过滤具有乳酸发酵的能力的微生物的发酵培养基中连续发酵的步骤不小于0时01微米，小于1微米与0.1至20千帕的范围内的跨膜压力差，并且渗透物被收集，同时保留在非渗透液体或不渗透液体返回到培养，并加入发酵原料的培养物; （B）过滤在通过纳滤膜工序（A）中获得的渗透物的步骤; 和（C）不小于1Pa的和压力不大于大气压以上下蒸馏在步骤（B）中得到的渗透物的步骤，在25℃至200℃以回收乳酸; 仅包含杂质的少量，和聚乳酸使用乳酸作为原料具有优异的热稳定性，机械强度和色调得到。

3. 发明授权

EP2330209B1 METHOD AND APPARATUS FOR PRODUCING A CHEMICAL AND CONTINUOUS CULTURE SYSTEM 有权
标题翻译：生产化学和连续培养系统的方法和设备
公开(公告)号：EP2330209B1
公开(公告)日：2017-07-19
申请号：EP09817650.6
申请日：2009-09-16
申请人： Toray Industries, Inc.
发明人： MIMITSUKA, Takashi , ISHII, kentaro , MORITA, Ken , HIGASA, Masashi , SAWAI, Kenji , SAWAI, Hideki , YAMADA, Katsushige , MINEGISHI, Shinichi
IPC分类号： C12P1/00 , C12M1/00 , C12M3/00 , C12N15/09
CPC分类号： C12P7/56 , C12M29/18 , C12M47/10 , C12N9/00 , C12P1/00 , C12P7/02 , C12P7/40 , C12P13/001 , C12P13/04 , C12P13/08 , C12P19/34 , C12P21/02

4. 发明公开

EP2837687A1 METHOD FOR PRODUCING CHEMICAL BY MEANS OF CONTINUOUS FERMENTATION AND CONTINUOUS FERMENTATION DEVICE 有权
标题翻译：用于生产化学品，通过连续发酵和装置用于实现连续发酵
公开(公告)号：EP2837687A1
公开(公告)日：2015-02-18
申请号：EP13770154.6
申请日：2013-03-27
申请人： Toray Industries, Inc.
发明人： KANAMORI, Satoko , SAWAI, Hideki , TAKEUCHI, Norihiro
IPC分类号： C12P13/04 , C12M1/00 , C12P7/56 , C12P13/02 , C12R1/01 , C12R1/13 , C12R1/15 , C12R1/19 , C12R1/43
CPC分类号： C12P13/24 , C12M29/04 , C12M33/14 , C12M41/34 , C12P7/56 , C12P13/001 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227
摘要： Provided is a method of producing a chemical by a continuous fermentation method in which a washing effect of a separation membrane by a gas is enhanced by a simple operation procedure and high productivity can be stably maintained for a long time. The method of producing a chemical of the present invention includes: a chemical production step of culturing cells to ferment a feedstock to produce a chemical; a culture solution supply step of supplying a culture solution containing the chemical to a separation membrane unit; a filtration step of filtering the culture solution to separate a permeate containing the chemical; a reflux step of refluxing a retentate that is not filtered to the fermentor; and a washing step of supplying a gas containing oxygen to the separation membrane unit while the amount is changed to at least two different values to perform scrubbing, wherein the supply amount and time of the gas containing oxygen supplied in the chemical production step and the washing step are set so that a kLa value is within a predetermined range from an optimal kLa value for the cells cultured in the chemical production step.
摘要翻译：提供的是生产通过连续发酵方法，其中，分离膜的由气体的洗涤作用是通过一个简单的操作过程和高的生产率提高的化学的方法可以稳定地保持很长时间。制造本发明的化学品的方法，包括：培养细胞发酵原料以产生一种化学的化学品生产工序; 供给含有化学的分离膜单元的培养液的培养液的供给步骤; 过滤所述培养液中分离的渗透物含有化学的过滤步骤; 回流一滞留物的回流的步骤并没有被过滤到发酵罐中; 和供给含有气体的氧分离膜单元，而量变为至少两个不同的值来执行洗涤，worin在化学生产步骤和洗涤供给的含有气体的氧的供给量和时间的洗涤步骤步骤是这样设定做了起亚值是从在化学生产步骤中培养的细胞最佳起亚值在预定范围内。

5. 发明公开

EP2500083A1 HOLLOW FIBER MEMBRANE MODULE FOR USE IN PRODUCTION OF CHEMICAL SUBSTANCE, AND PROCESS FOR PRODUCTION OF CHEMICAL SUBSTANCE 审中-公开
标题翻译：中空纤维膜组件FOR USE IN的化学物质和方法的生产用于制造化学物质
公开(公告)号：EP2500083A1
公开(公告)日：2012-09-19
申请号：EP10829942.1
申请日：2010-11-10
申请人： Toray Industries, Inc.
发明人： TAKEUCHI, Norihiro , MINEGISHI, Shin-ichi , CHEON, Jihoon , NISHIDA, Makoto , MIMITSUKA, Takashi , SUZUKI, Hironobu , YAMADA, Katsushige , SAWAI, Hideki , KUMO, Ichiro
IPC分类号： B01D63/04 , B01D63/00 , B01D71/34 , C12M1/12 , C12M3/06 , C12N15/09 , C12P7/56
CPC分类号： B01D63/04 , B01D63/022 , B01D63/023 , C12M29/16 , C12P7/56
摘要： A hollow fiber membrane module for use in production of a chemical substance, which is used in continuous fermentation including filtering a fermentation broth of a microorganism or a cultured cell through a hollow fiber membrane, collecting a chemical substance from a filtrate, retaining a concentrated solution in the fermentation broth or refluxing the concentrated solution, and adding a fermentation raw material to the fermentation broth, wherein a large number of hollow fiber membrane bundles are accommodated in a tubular case, at least one end part of each of the hollow fiber membrane bundles is fixed on the tubular case by a hollow fiber membrane bundling member with an end face of each of the hollow fiber membranes open, and the hollow fiber membrane bundling member is made of a synthetic resin having a hardness retention rate after contact with saturated steam at 121°C for 24 hours of 95% or more. Therefore, a hollow fiber membrane module for use in the production of a chemical substance by a continuous fermentation process capable of maintaining high productivity and treating steam sterilization is provided.

6. 发明公开

EP2439271A1 POLYPEPTIDE HAVING D-LACTATE DEHYDROGENASE ACTIVITY, POLYNUCLEOTIDE ENCODING THE POLYPEPTIDE, AND PROCESS FOR PRODUCTION OF D-LACTIC ACID 有权
标题翻译：与D-乳酸脱氢酶活性用于生产D-乳酸的多肽的多核苷酸编码AND METHOD多肽
公开(公告)号：EP2439271A1
公开(公告)日：2012-04-11
申请号：EP10783384.0
申请日：2010-06-02
申请人： Toray Industries, Inc.
发明人： SAWAI, Kenji , SUDA, Kazumi , SAWAI, Hideki , YAMADA, Katsushige , YAMAGISHI, Junya
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/04 , C12P7/56
CPC分类号： C12P7/56 , C12N9/0006
摘要： Highly productive D-lactic acid fermentation is achieved by using a transformant obtained by introducing into a host cell a polynucleotide encoding a polypeptide according to any one of the following (A) to (C) in such a manner that the polypeptide is expressed, which polypeptide has a D-Iactate dehydrogenase activity higher than those of conventional polypeptides: (A) a polypeptide having the amino acid sequence shown in SEQ ID NO:1 or 2; (B) a polypeptide having the same amino acid sequence as shown in SEQ ID NO:1 or 2 except that one or several amino acids are substituted, deleted, inserted and/or added, which polypeptide has a D-lactate dehydrogenase activity; and (C) a polypeptide having an amino acid sequence which has a sequence identity of not less than 80% to the amino acid sequence shown in SEQ ID NO:1 or 2, which polypeptide has a D-lactate dehydrogenase activity.
摘要翻译：高生产力的D-乳酸发酵是通过使用由在寻求的方式引入到宿主细胞中编码雅丁的多肽的任何一种下述（A）的多核苷酸（C）中获得的转化体取得没有所述多肽过表达时，哪多肽具有比常规多肽更高的D-Iactate脱氢酶活性：（A）具有SEQ ID NO：2所示的氨基酸序列的多肽：1或2; （B）具有如SEQ ID NO相同的氨基酸序列的多肽：1或2不同的是一个或几个氨基酸是substituiertem，缺失，插入和/或添加，其中多肽具有D-乳酸脱氢酶活性; 和（C）具有多肽氨基酸序列都具有不小于80％的序列同一性的SEQ ID NO：2所示的氨基酸序列：1或2，该多肽具有D-乳酸脱氢酶活性。

7. 发明公开

EP1975232A1 YEAST AND METHOD OF PRODUCING L-LACTIC ACID 审中-公开
标题翻译： HEFE UND VERFAHREN ZUR HERSTELLUNG VON L-MILCHSÄURE
公开(公告)号：EP1975232A1
公开(公告)日：2008-10-01
申请号：EP06797371.9
申请日：2006-09-04
申请人： TORAY INDUSTRIES, INC.
发明人： SAWAI, Hideki , SAWAI, Kenji , SONOKI, Tomonori , HATAHIRA, Satoko
IPC分类号： C12N15/09 , C12N1/21 , C12P7/40 , C12P7/56
CPC分类号： C12N9/0006 , C12P7/56
摘要： The yeast according to the present invention is yeast comprising an introduced gene coding a Homo sapiens- or frog-derived L-lactate dehydrogenase. It is possible to produce lactic acid, which has a variety of applications, efficiently and more cost-effectively by using the yeast and the method of producing lactic acid by using the yeast according to the present invention.
摘要翻译：根据本发明的酵母是包含编码智人或蛙类L-乳酸脱氢酶的引入基因的酵母。通过使用酵母和通过使用本发明的酵母生产乳酸的方法，可以有效地并且更具成本效益地生产各种应用的乳酸。

8. 发明授权

EP2221373B1 EXPRESSION CASSETTE FOR LACTASE DEHYDROGENASE, TRANSFORMED YEAST AND METHOD OF PRODUCING LACTIC ACID 有权
标题翻译：表达盒乳酸脱氢酶，转化的酵母及其制备方法乳酸
公开(公告)号：EP2221373B1
公开(公告)日：2017-02-15
申请号：EP08856191.5
申请日：2008-12-05
申请人： Toray Industries, Inc.
发明人： SAWAI, Kenji , SAWAI, Hideki
IPC分类号： C12N15/09 , C12N1/19 , C12P7/56
CPC分类号： C12P7/56 , C12N9/0006 , C12N15/81

9. 发明授权

EP2439271B1 POLYPEPTIDE HAVING D-LACTATE DEHYDROGENASE ACTIVITY, POLYNUCLEOTIDE ENCODING THE POLYPEPTIDE, AND PROCESS FOR PRODUCTION OF D-LACTIC ACID 有权
标题翻译：与D-乳酸脱氢酶活性用于生产D-乳酸的多肽的多核苷酸编码AND METHOD多肽
公开(公告)号：EP2439271B1
公开(公告)日：2013-11-20
申请号：EP10783384.0
申请日：2010-06-02
申请人： Toray Industries, Inc.
发明人： SAWAI, Kenji , SUDA, Kazumi , SAWAI, Hideki , YAMADA, Katsushige , YAMAGISHI, Junya
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/04 , C12P7/56 , C12N9/00
CPC分类号： C12P7/56 , C12N9/0006
摘要： Highly productive D-lactic acid fermentation is achieved by using a transformant obtained by introducing into a host cell a polynucleotide encoding a polypeptide according to any one of the following (A) to (C) in such a manner that the polypeptide is expressed, which polypeptide has a D-Iactate dehydrogenase activity higher than those of conventional polypeptides: (A) a polypeptide having the amino acid sequence shown in SEQ ID NO:1 or 2; (B) a polypeptide having the same amino acid sequence as shown in SEQ ID NO:1 or 2 except that one or several amino acids are substituted, deleted, inserted and/or added, which polypeptide has a D-lactate dehydrogenase activity; and (C) a polypeptide having an amino acid sequence which has a sequence identity of not less than 80% to the amino acid sequence shown in SEQ ID NO:1 or 2, which polypeptide has a D-lactate dehydrogenase activity.

10. 发明公开

EP2650374A1 METHOD FOR PRODUCING CADAVERINE 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG VON CADAVERIN
公开(公告)号：EP2650374A1
公开(公告)日：2013-10-16
申请号：EP11846664.8
申请日：2011-12-08
申请人： Toray Industries, Inc.
发明人： SASAKI, Nanami , MIMITSUKA, Takashi , SAWAI, Hideki , SAWAI, Kenji
IPC分类号： C12P13/00 , C12N15/09
CPC分类号： C12P13/001 , C12Y401/01018
摘要： Disclosed is a novel method for producing cadaverine, which method is capable of producing cadaverine more efficiently and at a higher yield than production methods by the conventional fermentation methods. The method for producing cadaverine includes culturing coryneform bacterium/bacteria having an ability to produce cadaverine and having a resistance to 2,2'-thiobis(ethylamine). Preferably, the coryneform bacterium/bacteria has/have lysine decarboxylase activity, and preferably, the coryneform bacterium/bacteria has/have homoserine auxotrophy and/or a resistance to S-(2-aminoethyl)-L-cysteine.
摘要翻译：本发明公开了一种生产尸体素的新方法，该方法能够通过常规发酵方法比生产方法更有效地和以更高的产率生产尸胺。生产尸胺的方法包括培养具有产生尸胺的能力并具有对2,2'-硫代双（乙胺）的抗性的棒状细菌/细菌。优选地，棒状细菌/细菌具有赖氨酸脱羧酶活性，优选棒状细菌/细菌具有高丝氨酸营养缺陷型和/或对S-（2-氨基乙基）-L-半胱氨酸的抗性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式